PAK3 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description p21 protein (Cdc42/Rac)-activated kinase 3|PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5063)
External Link http://www.ncbi.nlm.nih.gov/gene/5063
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61 interacting proteins for PAK3 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTB actin, beta
ACTBL2 actin, beta-like 2
ACTC1 actin, alpha, cardiac muscle 1
ACTG1 actin gamma 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
CDC42 cell division cycle 42
CDH5 cadherin 5, type 2 (vascular endothelium)
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
EFNB1 ephrin-B1
EFNB2 ephrin-B2
EFNB3 ephrin-B3
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
EPHB3 EPH receptor B3
EPHB4 EPH receptor B4
EPHB6 EPH receptor B6
FES FES proto-oncogene, tyrosine kinase
FYN FYN proto-oncogene, Src family tyrosine kinase
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
ITSN1 intersectin 1 (SH3 domain protein)
JUP junction plakoglobin
LIMK1 LIM domain kinase 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAPK10 mitogen-activated protein kinase 10
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYO6 myosin VI
NCK1 NCK adaptor protein 1
NCK2 NCK adaptor protein 2
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NRP1 neuropilin 1
PLK1 polo-like kinase 1
PLXNA1 plexin A1
PLXNA2 plexin A2
PLXNA3 plexin A3
PLXNA4 plexin A4
PXN paxillin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RHOU ras homolog family member U
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STMN1 stathmin 1
STMN4 stathmin-like 4
SYN1 synapsin I
TRIO trio Rho guanine nucleotide exchange factor
UBC ubiquitin C