PAK4 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description p21 protein (Cdc42/Rac)-activated kinase 4|PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 10298)
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100 substrates of the kinase PAK4 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
SHKBP1 SH3KBP1 binding protein 1
PDE3B phosphodiesterase 3B, cGMP-inhibited
SCAF1 SR-related CTD-associated factor 1
WASF2 WAS protein family, member 2
ARHGAP30 Rho GTPase activating protein 30
OSBPL5 oxysterol binding protein-like 5
LMO7 LIM domain 7
ZBTB44 zinc finger and BTB domain containing 44
PPP1R10 protein phosphatase 1, regulatory subunit 10
MYBPC3 myosin binding protein C, cardiac
MAP7D1 MAP7 domain containing 1
PDE3A phosphodiesterase 3A, cGMP-inhibited
MKI67 marker of proliferation Ki-67
KAT5 K(lysine) acetyltransferase 5
MAP3K2 mitogen-activated protein kinase kinase kinase 2
SETD2 SET domain containing 2
MAST2 microtubule associated serine/threonine kinase 2
MAST3 microtubule associated serine/threonine kinase 3
NUMA1 nuclear mitotic apparatus protein 1
DGKZ diacylglycerol kinase, zeta
SSH3 slingshot protein phosphatase 3
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
KIF23 kinesin family member 23
PKP3 plakophilin 3
PALB2 partner and localizer of BRCA2
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
PLEKHA6 pleckstrin homology domain containing, family A member 6
DMXL1 Dmx-like 1
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
MRVI1 murine retrovirus integration site 1 homolog
CCDC120 coiled-coil domain containing 120
GLI1 GLI family zinc finger 1
CCDC88C coiled-coil domain containing 88C
LTF lactotransferrin
LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
ASPHD1 aspartate beta-hydroxylase domain containing 1
SRSF2 serine/arginine-rich splicing factor 2
TOR4A torsin family 4, member A
SACK1H scaffolding CK1 anchoring protein H
SACK1B scaffolding CK1 anchoring protein B
SACK1E scaffolding CK1 anchoring protein E
WDR81 WD repeat domain 81
DEPDC1B DEP domain containing 1B
SEPT1 septin 1
MYO7B myosin VIIB
ZC3H11A zinc finger CCCH-type containing 11A
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2
LIN9 lin-9 DREAM MuvB core complex component
SRBD1 S1 RNA binding domain 1
DOCK2 dedicator of cytokinesis 2
RGCC regulator of cell cycle
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
AEBP2 AE binding protein 2
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
DRD2 dopamine receptor D2
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
PRKDC protein kinase, DNA-activated, catalytic polypeptide
TP53BP1 tumor protein p53 binding protein 1
GRK7 G protein-coupled receptor kinase 7
ZNF337 zinc finger protein 337
CDCA8 cell division cycle associated 8
CDCA2 cell division cycle associated 2
FHOD3 formin homology 2 domain containing 3
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
MARK4 MAP/microtubule affinity-regulating kinase 4
MARK3 MAP/microtubule affinity-regulating kinase 3
KCTD15 potassium channel tetramerization domain containing 15
RIF1 replication timing regulatory factor 1
FCHSD2 FCH and double SH3 domains 2
RLTPR RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
TRAK1 trafficking protein, kinesin binding 1
SLC14A2 solute carrier family 14 (urea transporter), member 2
C6ORF25 chromosome 6 open reading frame 25
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
PFAS phosphoribosylformylglycinamidine synthase
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PPP1R12C protein phosphatase 1, regulatory subunit 12C
EI24 etoposide induced 2.4
RBM15B RNA binding motif protein 15B
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
PRDX5 peroxiredoxin 5
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
CDC25B cell division cycle 25B
UBR5 ubiquitin protein ligase E3 component n-recognin 5
NCAPH non-SMC condensin I complex, subunit H
FAM214B family with sequence similarity 214, member B
PKD1 polycystic kidney disease 1 (autosomal dominant)
SCAF11 SR-related CTD-associated factor 11
LLGL2 lethal giant larvae homolog 2 (Drosophila)
PHC2 polyhomeotic homolog 2 (Drosophila)
INCENP inner centromere protein antigens 135/155kDa
ZNF212 zinc finger protein 212
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
TESK2 testis-specific kinase 2
POLR1E polymerase (RNA) I polypeptide E, 53kDa