| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | p21 protein (Cdc42/Rac)-activated kinase 4|PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 10298) |
| External Link | https://ncbi.nlm.nih.gov/gene/10298 |
| Similar Terms | |
| Downloads & Tools |
498 genes differentially expressed following the PAK4 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MAP7 | microtubule-associated protein 7 | 0.0176362 |
| S100A8 | S100 calcium binding protein A8 | 0.0168505 |
| NRCAM | neuronal cell adhesion molecule | 0.0130122 |
| PEG10 | paternally expressed 10 | 0.0125662 |
| CLDN3 | claudin 3 | 0.0123685 |
| DNMT3A | DNA (cytosine-5-)-methyltransferase 3 alpha | 0.011845 |
| PMP22 | peripheral myelin protein 22 | 0.0113962 |
| DEPTOR | DEP domain containing MTOR-interacting protein | 0.0105228 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0103795 |
| GNAS | GNAS complex locus | 0.0102982 |
| WDR7 | WD repeat domain 7 | 0.0102601 |
| SPINK2 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | 0.0100837 |
| PROM1 | prominin 1 | 0.010038 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | 0.00991058 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.00943024 |
| HK2 | hexokinase 2 | 0.00942335 |
| JCHAIN | joining chain of multimeric IgA and IgM | 0.00923446 |
| EML3 | echinoderm microtubule associated protein like 3 | 0.00907611 |
| PTN | pleiotrophin | 0.00905292 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 0.00899727 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0088831 |
| MYB | v-myb avian myeloblastosis viral oncogene homolog | 0.0088763 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | 0.00883432 |
| NPEPL1 | aminopeptidase-like 1 | 0.00881934 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 | 0.00878649 |
| PDGFRL | platelet-derived growth factor receptor-like | 0.00859787 |
| CPE | carboxypeptidase E | 0.00859365 |
| CTSZ | cathepsin Z | 0.00855006 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | 0.00847992 |
| FAIM | Fas apoptotic inhibitory molecule | 0.00843528 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.00833267 |
| CADM1 | cell adhesion molecule 1 | 0.00832229 |
| LDOC1 | leucine zipper, down-regulated in cancer 1 | 0.00831017 |
| MUC2 | mucin 2, oligomeric mucus/gel-forming | 0.00828775 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0082741 |
| NEBL | nebulette | 0.00823017 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | 0.00810708 |
| GPER1 | G protein-coupled estrogen receptor 1 | 0.00804756 |
| REG1A | regenerating islet-derived 1 alpha | 0.00803492 |
| IGLL1 | immunoglobulin lambda-like polypeptide 1 | 0.0079921 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.00798824 |
| CD93 | CD93 molecule | 0.00795901 |
| TLK2 | tousled-like kinase 2 | 0.00793966 |
| XYLT1 | xylosyltransferase I | 0.0079213 |
| PCP4 | Purkinje cell protein 4 | 0.0079136 |
| GOLIM4 | golgi integral membrane protein 4 | 0.00778923 |
| LAT2 | linker for activation of T cells family, member 2 | 0.00778326 |
| PTK2B | protein tyrosine kinase 2 beta | 0.00776535 |
| FSD1 | fibronectin type III and SPRY domain containing 1 | 0.00773165 |
| PLCB4 | phospholipase C, beta 4 | 0.00767872 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.00763682 |
| PLXNC1 | plexin C1 | 0.00763479 |
| CHKB | choline kinase beta | 0.00759738 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.00756374 |
| SPATA20 | spermatogenesis associated 20 | 0.00751668 |
| MTCL1 | microtubule crosslinking factor 1 | 0.00751423 |
| BAMBI | BMP and activin membrane-bound inhibitor | 0.00749503 |
| PLEKHM1 | pleckstrin homology domain containing, family M (with RUN domain) member 1 | 0.00749229 |
| SGCE | sarcoglycan, epsilon | 0.00740451 |
| SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | 0.00737759 |
| COMT | catechol-O-methyltransferase | 0.00732401 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.00731398 |
| SMYD3 | SET and MYND domain containing 3 | 0.0072744 |
| FHL1 | four and a half LIM domains 1 | 0.0072454 |
| GUSB | glucuronidase, beta | 0.00723642 |
| CRABP1 | cellular retinoic acid binding protein 1 | 0.00721039 |
| GOLGA8H | golgin A8 family, member H | 0.00720364 |
| KIAA0930 | KIAA0930 | 0.00719208 |
| AUTS2 | autism susceptibility candidate 2 | 0.00716525 |
| OLFM4 | olfactomedin 4 | 0.00716385 |
| SCPEP1 | serine carboxypeptidase 1 | 0.00715732 |
| CD163 | CD163 molecule | 0.00712216 |
| SORBS1 | sorbin and SH3 domain containing 1 | 0.00708924 |
| GLUL | glutamate-ammonia ligase | 0.00706733 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.00702629 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.00702163 |
| PRAME | preferentially expressed antigen in melanoma | 0.00700628 |
| PDGFD | platelet derived growth factor D | 0.00697303 |
| STAB1 | stabilin 1 | 0.00694953 |
| AEBP1 | AE binding protein 1 | 0.00694305 |
| MLPH | melanophilin | 0.00691751 |
| SIRPA | signal-regulatory protein alpha | 0.00691725 |
| AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | 0.00690883 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.00688957 |
| HPCAL1 | hippocalcin-like 1 | 0.00684953 |
| G6PD | glucose-6-phosphate dehydrogenase | 0.00684867 |
| RAP1GAP2 | RAP1 GTPase activating protein 2 | 0.00683792 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | 0.00681674 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.00680463 |
| ELN | elastin | 0.00677875 |
| GREM1 | gremlin 1, DAN family BMP antagonist | 0.00676368 |
| EFR3A | EFR3 homolog A (S. cerevisiae) | 0.00674867 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 0.00667882 |
| NBEA | neurobeachin | 0.00667155 |
| CCR1 | chemokine (C-C motif) receptor 1 | 0.00666747 |
| SPINK4 | serine peptidase inhibitor, Kazal type 4 | 0.00665531 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.00664971 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | 0.00664653 |
| TNS3 | tensin 3 | 0.00664043 |
| FCGBP | Fc fragment of IgG binding protein | 0.00661248 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.00660975 |
| HOPX | HOP homeobox | 0.00660369 |
| EMX2 | empty spiracles homeobox 2 | 0.0066021 |
| GUSBP3 | glucuronidase, beta pseudogene 3 | 0.00659726 |
| BSG | basigin (Ok blood group) | 0.00658454 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.00658069 |
| GGT1 | gamma-glutamyltransferase 1 | 0.0065803 |
| ITGA8 | integrin, alpha 8 | 0.00656544 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | 0.00655514 |
| RGS5 | regulator of G-protein signaling 5 | 0.00651624 |
| PCOLCE | procollagen C-endopeptidase enhancer | 0.00648806 |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 | 0.00647457 |
| IFT57 | intraflagellar transport 57 | 0.0064737 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.00644555 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | 0.00643259 |
| CD36 | CD36 molecule (thrombospondin receptor) | 0.00641695 |
| NUAK1 | NUAK family, SNF1-like kinase, 1 | 0.00641195 |
| ABHD11 | abhydrolase domain containing 11 | 0.00640402 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | 0.0063848 |
| TYMS | thymidylate synthetase | 0.00638275 |
| COMP | cartilage oligomeric matrix protein | 0.00637945 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.00637393 |
| ZG16 | zymogen granule protein 16 | 0.00637376 |
| MTARC1 | mitochondrial amidoxime reducing component 1 | 0.0063483 |
| STX3 | syntaxin 3 | 0.00634381 |
| OPN3 | opsin 3 | 0.00632791 |
| PLN | phospholamban | 0.00629481 |
| PDZRN3 | PDZ domain containing ring finger 3 | 0.00629377 |
| HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | 0.00625582 |
| KBTBD11 | kelch repeat and BTB (POZ) domain containing 11 | 0.00625312 |
| CPA3 | carboxypeptidase A3 (mast cell) | 0.00624117 |
| HIRA | histone cell cycle regulator | 0.0062358 |
| SLC25A4 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 | 0.00621367 |
| PUF60 | poly-U binding splicing factor 60KDa | 0.00620796 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.00620183 |
| ARHGAP44 | Rho GTPase activating protein 44 | 0.006199 |
| COQ8A | coenzyme Q8A | 0.0061922 |
| TPSAB1 | tryptase alpha/beta 1 | 0.00619093 |
| MB | myoglobin | 0.00618646 |
| RXYLT1 | ribitol xylosyltransferase 1 | 0.00617836 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.00615313 |
| KLHL24 | kelch-like family member 24 | 0.00613651 |
| CFD | complement factor D (adipsin) | 0.00609197 |
| RIN2 | Ras and Rab interactor 2 | 0.0060838 |
| OXCT1 | 3-oxoacid CoA transferase 1 | 0.00608206 |
| IL1RN | interleukin 1 receptor antagonist | 0.00607618 |
| NDRG4 | NDRG family member 4 | 0.00602085 |
| MAGEA3 | melanoma antigen family A3 | 0.0060064 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.00595779 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.00595627 |
| DIPK1A | divergent protein kinase domain 1A | 0.005955 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.00595464 |
| RHOBTB1 | Rho-related BTB domain containing 1 | 0.00594857 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | 0.00593227 |
| SYNM | synemin, intermediate filament protein | 0.00593173 |
| CD44 | CD44 molecule (Indian blood group) | 0.00593113 |
| TUBA1A | tubulin, alpha 1a | 0.00592158 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | 0.00591948 |
| TRIB3 | tribbles pseudokinase 3 | 0.00591915 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | 0.00591888 |
| CNN1 | calponin 1, basic, smooth muscle | 0.00591533 |
| TTC39A | tetratricopeptide repeat domain 39A | 0.00591498 |
| MKNK1 | MAP kinase interacting serine/threonine kinase 1 | 0.00590775 |
| HPGDS | hematopoietic prostaglandin D synthase | 0.00588708 |
| WASL | Wiskott-Aldrich syndrome-like | 0.00586978 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.00584431 |
| CKM | creatine kinase, muscle | 0.00584036 |
| AKAP1 | A kinase (PRKA) anchor protein 1 | 0.00583139 |
| ACAT1 | acetyl-CoA acetyltransferase 1 | 0.00582114 |
| MYH11 | myosin, heavy chain 11, smooth muscle | 0.00581882 |
| CYBB | cytochrome b-245, beta polypeptide | 0.00581378 |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 0.00580053 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.00579982 |
| STK39 | serine threonine kinase 39 | 0.00579082 |
| S100A9 | S100 calcium binding protein A9 | 0.00578872 |
| EDNRA | endothelin receptor type A | 0.00578793 |
| CCND2 | cyclin D2 | 0.00578397 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | 0.0057737 |
| PLXND1 | plexin D1 | 0.00574827 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.00572247 |
| CTSD | cathepsin D | 0.0057204 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 0.00572013 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | 0.0056983 |
| TCF4 | transcription factor 4 | 0.0056938 |
| HTRA1 | HtrA serine peptidase 1 | 0.0056864 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.00568415 |
| STAU2 | staufen double-stranded RNA binding protein 2 | 0.00568362 |
| GFAP | glial fibrillary acidic protein | 0.00567961 |
| LMOD1 | leiomodin 1 (smooth muscle) | 0.00567362 |
| WLS | wntless Wnt ligand secretion mediator | 0.00565832 |
| PLCH1 | phospholipase C, eta 1 | 0.00565223 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | 0.00564529 |
| LDB3 | LIM domain binding 3 | 0.00564395 |
| ENG | endoglin | 0.00563121 |
| CD38 | CD38 molecule | 0.00561859 |
| TPD52L2 | tumor protein D52-like 2 | 0.00559976 |
| CLCN7 | chloride channel, voltage-sensitive 7 | 0.00559903 |
| NBPF10 | neuroblastoma breakpoint family, member 10 | 0.0055975 |
| GGCT | gamma-glutamylcyclotransferase | 0.00559094 |
| ANGPT1 | angiopoietin 1 | 0.00558961 |
| FAM189A2 | family with sequence similarity 189, member A2 | 0.00557953 |
| MN1 | meningioma (disrupted in balanced translocation) 1 | 0.00557379 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.00556419 |
| PLPP3 | phospholipid phosphatase 3 | 0.0055355 |
| PAX5 | paired box 5 | 0.0055325 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | 0.0055192 |
| FBN2 | fibrillin 2 | 0.0055121 |
| TNNT1 | troponin T type 1 (skeletal, slow) | 0.00550251 |
| TLE4 | transducin-like enhancer of split 4 | 0.0054717 |
| TPP2 | tripeptidyl peptidase II | 0.00547152 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.00546828 |
| REG3A | regenerating islet-derived 3 alpha | 0.00546563 |
| RCAN2 | regulator of calcineurin 2 | 0.00545951 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.00545408 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | 0.00544563 |
| CLDN7 | claudin 7 | 0.0054452 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | 0.0054169 |
| FOXA1 | forkhead box A1 | 0.00540695 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.00540664 |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 | 0.00540492 |
| DES | desmin | 0.00539383 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0053857 |
| IRAK1 | interleukin-1 receptor-associated kinase 1 | 0.00538202 |
| MAPK9 | mitogen-activated protein kinase 9 | 0.00537928 |
| PTP4A3 | protein tyrosine phosphatase type IVA, member 3 | 0.00537334 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | 0.00536584 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.00535216 |
| ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | 0.00534025 |
| HDHD5 | haloacid dehalogenase like hydrolase domain containing 5 | 0.00533887 |
| PDCD6 | programmed cell death 6 | 0.00531579 |
| ATP9A | ATPase, class II, type 9A | 0.00531216 |
| SPDEF | SAM pointed domain containing ETS transcription factor | 0.00528369 |
| PDLIM3 | PDZ and LIM domain 3 | 0.00527714 |
| ANKRD36 | ankyrin repeat domain 36 | 0.00525755 |
| COL16A1 | collagen, type XVI, alpha 1 | 0.00524414 |
| DACH1 | dachshund family transcription factor 1 | 0.00523154 |
| CRYAB | crystallin, alpha B | 0.00522752 |
| LAMA5 | laminin, alpha 5 | 0.00521681 |
| RRAGD | Ras-related GTP binding D | 0.00521465 |
| GPR37 | G protein-coupled receptor 37 (endothelin receptor type B-like) | 0.00520302 |
| PDE8B | phosphodiesterase 8B | 0.00520266 |
| AREG | amphiregulin | 0.00519607 |
| NXN | nucleoredoxin | 0.00519386 |
| PRPF8 | pre-mRNA processing factor 8 | 0.00518367 |
| ASRGL1 | asparaginase like 1 | 0.00518322 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.00517402 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 0.00516633 |
| ASS1 | argininosuccinate synthase 1 | 0.00515556 |
| RAB31 | RAB31, member RAS oncogene family | 0.00514097 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0156543 |
| TMEM45A | transmembrane protein 45A | -0.0144831 |
| DEFB1 | defensin, beta 1 | -0.0144137 |
| TSPAN8 | tetraspanin 8 | -0.0120682 |
| S100P | S100 calcium binding protein P | -0.0118363 |
| CLDN1 | claudin 1 | -0.0116954 |
| ANXA10 | annexin A10 | -0.0115997 |
| CAV2 | caveolin 2 | -0.0115453 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -0.0110677 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0110157 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | -0.0106033 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0103726 |
| KRT17 | keratin 17, type I | -0.0102624 |
| CA2 | carbonic anhydrase II | -0.00987236 |
| IL32 | interleukin 32 | -0.00985508 |
| PAK4 | p21 protein (Cdc42/Rac)-activated kinase 4 | -0.00952003 |
| ADGRG2 | adhesion G protein-coupled receptor G2 | -0.00951321 |
| DAXX | death-domain associated protein | -0.00946692 |
| PRDX2 | peroxiredoxin 2 | -0.00939147 |
| LY6D | lymphocyte antigen 6 complex, locus D | -0.00931388 |
| ALDOB | aldolase B, fructose-bisphosphate | -0.00912543 |
| TM4SF4 | transmembrane 4 L six family member 4 | -0.00909179 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | -0.00882539 |
| ARG1 | arginase 1 | -0.00874458 |
| NRN1 | neuritin 1 | -0.0085224 |
| ARG2 | arginase 2 | -0.00822234 |
| NPY1R | neuropeptide Y receptor Y1 | -0.00821897 |
| BCL11B | B-cell CLL/lymphoma 11B (zinc finger protein) | -0.00821133 |
| C7 | complement component 7 | -0.00809885 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.00807262 |
| HP | haptoglobin | -0.00804358 |
| NDN | necdin, melanoma antigen (MAGE) family member | -0.00792672 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.00789219 |
| CDH3 | cadherin 3, type 1, P-cadherin (placental) | -0.00782239 |
| PSAT1 | phosphoserine aminotransferase 1 | -0.00781708 |
| BST2 | bone marrow stromal cell antigen 2 | -0.00778666 |
| WNT5A | wingless-type MMTV integration site family, member 5A | -0.00777951 |
| PTGER3 | prostaglandin E receptor 3 (subtype EP3) | -0.00775808 |
| HOXB7 | homeobox B7 | -0.00772816 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.00771725 |
| SLC4A1 | solute carrier family 4 (anion exchanger), member 1 (Diego blood group) | -0.00771601 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.00769967 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.00769321 |
| IL6ST | interleukin 6 signal transducer | -0.00756812 |
| RNF11 | ring finger protein 11 | -0.00753517 |
| S100A2 | S100 calcium binding protein A2 | -0.00751971 |
| UBE2S | ubiquitin-conjugating enzyme E2S | -0.00748387 |
| SLC35G2 | solute carrier family 35, member G2 | -0.00747407 |
| KIF14 | kinesin family member 14 | -0.00743715 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | -0.00741826 |
| HOXC6 | homeobox C6 | -0.00741727 |
| RGCC | regulator of cell cycle | -0.00741622 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.00741038 |
| XPO7 | exportin 7 | -0.00739919 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.00737986 |
| C8ORF4 | chromosome 8 open reading frame 4 | -0.0072632 |
| HOXB2 | homeobox B2 | -0.00722397 |
| XIC | X chromosome inactivation center | -0.00721568 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.00719915 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.00714552 |
| RPS5 | ribosomal protein S5 | -0.00712552 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | -0.00707953 |
| HOXB6 | homeobox B6 | -0.00706619 |
| CD59 | CD59 molecule, complement regulatory protein | -0.00706484 |
| SIAH2 | siah E3 ubiquitin protein ligase 2 | -0.00706368 |
| GCH1 | GTP cyclohydrolase 1 | -0.00703959 |
| KIF23 | kinesin family member 23 | -0.00695345 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | -0.00692358 |
| GYPC | glycophorin C (Gerbich blood group) | -0.00691205 |
| PBK | PDZ binding kinase | -0.00690683 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | -0.00686979 |
| NCK1 | NCK adaptor protein 1 | -0.00683464 |
| PKP1 | plakophilin 1 | -0.00682744 |
| GSTO1 | glutathione S-transferase omega 1 | -0.00682548 |
| RAB21 | RAB21, member RAS oncogene family | -0.00681198 |
| PDZK1IP1 | PDZK1 interacting protein 1 | -0.00680411 |
| SELENOW | selenoprotein W | -0.00679009 |
| SORD | sorbitol dehydrogenase | -0.00677207 |
| CALML5 | calmodulin-like 5 | -0.00677119 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | -0.00674894 |
| ARPC3 | actin related protein 2/3 complex, subunit 3, 21kDa | -0.00673383 |
| NELL2 | NEL-like 2 (chicken) | -0.00668855 |
| BEX1 | brain expressed, X-linked 1 | -0.00668509 |
| PEG3 | paternally expressed 3 | -0.00666906 |
| PRNP | prion protein | -0.00666833 |
| HECA | headcase homolog (Drosophila) | -0.00665946 |
| AHSP | alpha hemoglobin stabilizing protein | -0.00664937 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | -0.00664288 |
| KLF6 | Kruppel-like factor 6 | -0.00662921 |
| UGT2B28 | UDP glucuronosyltransferase 2 family, polypeptide B28 | -0.00660472 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -0.00659318 |
| CYP2C18 | cytochrome P450, family 2, subfamily C, polypeptide 18 | -0.00658064 |
| ITGA6 | integrin, alpha 6 | -0.00657228 |
| NCOA4 | nuclear receptor coactivator 4 | -0.00657128 |
| YIPF6 | Yip1 domain family, member 6 | -0.00655979 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.00652752 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | -0.00652669 |
| HAL | histidine ammonia-lyase | -0.00652056 |
| SUB1 | SUB1 homolog (S. cerevisiae) | -0.00649716 |
| HIGD1A | HIG1 hypoxia inducible domain family, member 1A | -0.00648115 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | -0.00645357 |
| KIF5C | kinesin family member 5C | -0.00644301 |
| HSD11B1 | hydroxysteroid (11-beta) dehydrogenase 1 | -0.00642768 |
| CCR7 | chemokine (C-C motif) receptor 7 | -0.0064125 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | -0.00640268 |
| TSPYL5 | TSPY-like 5 | -0.00639945 |
| KLK10 | kallikrein-related peptidase 10 | -0.00638987 |
| RIOK3 | RIO kinase 3 | -0.00636352 |
| GLCE | glucuronic acid epimerase | -0.00634936 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.00634719 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.00633287 |
| STOM | stomatin | -0.00629753 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.00627166 |
| SUCO | SUN domain containing ossification factor | -0.00626343 |
| PCGF2 | polycomb group ring finger 2 | -0.00624417 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | -0.00622656 |
| MMP1 | matrix metallopeptidase 1 | -0.00620966 |
| GZMK | granzyme K (granzyme 3; tryptase II) | -0.0061981 |
| ATP6V0B | ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b | -0.00617151 |
| UPK1B | uroplakin 1B | -0.00616281 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.00615689 |
| SEPP1 | selenoprotein P, plasma, 1 | -0.00613921 |
| DAZAP2 | DAZ associated protein 2 | -0.00612275 |
| YIPF5 | Yip1 domain family, member 5 | -0.00608453 |
| ANXA6 | annexin A6 | -0.00606829 |
| LY75 | lymphocyte antigen 75 | -0.00606559 |
| IRF1 | interferon regulatory factor 1 | -0.00603715 |
| SF3B5 | splicing factor 3b, subunit 5, 10kDa | -0.00602574 |
| RPA3 | replication protein A3, 14kDa | -0.00601961 |
| KLF10 | Kruppel-like factor 10 | -0.0060073 |
| PIR | pirin (iron-binding nuclear protein) | -0.00600393 |
| AK4 | adenylate kinase 4 | -0.00598467 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.00597082 |
| MMD | monocyte to macrophage differentiation-associated | -0.0059653 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.00596206 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.00596182 |
| CD3D | CD3d molecule, delta (CD3-TCR complex) | -0.00595145 |
| AADAC | arylacetamide deacetylase | -0.0059446 |
| VCAM1 | vascular cell adhesion molecule 1 | -0.00593835 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.00592374 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.00592296 |
| MCL1 | myeloid cell leukemia 1 | -0.00592246 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.00591235 |
| KIF20A | kinesin family member 20A | -0.00589714 |
| RNF39 | ring finger protein 39 | -0.00588555 |
| NAA50 | N(alpha)-acetyltransferase 50, NatE catalytic subunit | -0.00587702 |
| NTS | neurotensin | -0.00586846 |
| LAMC2 | laminin, gamma 2 | -0.00581045 |
| THBD | thrombomodulin | -0.00580793 |
| BTG3 | BTG family, member 3 | -0.00578959 |
| PIPOX | pipecolic acid oxidase | -0.00578113 |
| ARMCX2 | armadillo repeat containing, X-linked 2 | -0.00577359 |
| CA12 | carbonic anhydrase XII | -0.00576959 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.00572146 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | -0.00571969 |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | -0.00571811 |
| GBAP1 | glucosidase, beta, acid pseudogene 1 | -0.00571634 |
| ALB | albumin | -0.00570856 |
| CDCA3 | cell division cycle associated 3 | -0.00570596 |
| BLVRB | biliverdin reductase B | -0.00570482 |
| MARCH8 | membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase | -0.00570272 |
| SLC38A4 | solute carrier family 38, member 4 | -0.00570131 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.00569811 |
| CD8A | CD8a molecule | -0.00568683 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | -0.00568562 |
| CDSN | corneodesmosin | -0.00567189 |
| GSTM3 | glutathione S-transferase mu 3 (brain) | -0.00566955 |
| TMEM100 | transmembrane protein 100 | -0.00565994 |
| CSTB | cystatin B (stefin B) | -0.00563934 |
| TFDP1 | transcription factor Dp-1 | -0.00562296 |
| HPD | 4-hydroxyphenylpyruvate dioxygenase | -0.00561839 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.00560159 |
| ARL5A | ADP-ribosylation factor-like 5A | -0.00559774 |
| HLA-DOB | major histocompatibility complex, class II, DO beta | -0.0055949 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.00559476 |
| LOR | loricrin | -0.00557961 |
| PTCH1 | patched 1 | -0.00557957 |
| TRIM29 | tripartite motif containing 29 | -0.00556404 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | -0.00556009 |
| EIF1AX | eukaryotic translation initiation factor 1A, X-linked | -0.00555814 |
| CYP2E1 | cytochrome P450, family 2, subfamily E, polypeptide 1 | -0.00555548 |
| CD2 | CD2 molecule | -0.0055196 |
| ISCA1 | iron-sulfur cluster assembly 1 | -0.00551544 |
| GRB14 | growth factor receptor-bound protein 14 | -0.00551088 |
| EPB42 | erythrocyte membrane protein band 4.2 | -0.0055077 |
| SLC43A3 | solute carrier family 43, member 3 | -0.00550223 |
| TP63 | tumor protein p63 | -0.0054984 |
| TAL1 | T-cell acute lymphocytic leukemia 1 | -0.00549405 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 | -0.00548539 |
| RDX | radixin | -0.00548359 |
| TAGLN2 | transgelin 2 | -0.00547137 |
| LCE2B | late cornified envelope 2B | -0.00546936 |
| DCTN3 | dynactin 3 (p22) | -0.00546069 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.00544946 |
| CD1E | CD1e molecule | -0.00544601 |
| GRAMD1C | GRAM domain containing 1C | -0.00542153 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | -0.00539744 |
| CFH | complement factor H | -0.00538621 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.00535109 |
| ATG5 | autophagy related 5 | -0.00532975 |
| H1-10 | H1.10 linker histone | -0.00531572 |
| EMC3 | ER membrane protein complex subunit 3 | -0.00531112 |
| SST | somatostatin | -0.00529924 |
| RREB1 | ras responsive element binding protein 1 | -0.00529546 |
| MAL | mal, T-cell differentiation protein | -0.00529335 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | -0.00529045 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | -0.00528192 |
| CXCL6 | chemokine (C-X-C motif) ligand 6 | -0.00527125 |
| PSMB1 | proteasome (prosome, macropain) subunit, beta type, 1 | -0.00526973 |
| GPX2 | glutathione peroxidase 2 | -0.00526616 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | -0.0052584 |
| OPHN1 | oligophrenin 1 | -0.00524573 |
| SERPINB7 | serpin peptidase inhibitor, clade B (ovalbumin), member 7 | -0.00524449 |
| EXOC5 | exocyst complex component 5 | -0.00524364 |
| LYPD1 | LY6/PLAUR domain containing 1 | -0.00523862 |
| IVL | involucrin | -0.00523408 |
| MXI1 | MAX interactor 1, dimerization protein | -0.00522819 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -0.00522422 |
| CHN1 | chimerin 1 | -0.0052219 |
| GSTA1 | glutathione S-transferase alpha 1 | -0.0052205 |
| CTSW | cathepsin W | -0.00521401 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | -0.00521239 |
| APOL1 | apolipoprotein L, 1 | -0.00518915 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0051834 |
| DEFB4A | defensin, beta 4A | -0.00517452 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | -0.00517451 |
| TMEM14B | transmembrane protein 14B | -0.00516935 |
| MIA | melanoma inhibitory activity | -0.00516543 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.00515084 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | -0.00514959 |
| ASF1A | anti-silencing function 1A histone chaperone | -0.00513771 |
| RNASEH2A | ribonuclease H2, subunit A | -0.00512747 |
| ILK | integrin-linked kinase | -0.0051256 |
| RPS26 | ribosomal protein S26 | -0.00512077 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | -0.00511464 |
| UBB | ubiquitin B | -0.00511411 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | -0.00511225 |
| SGPP1 | sphingosine-1-phosphate phosphatase 1 | -0.00510509 |
| MXRA5 | matrix-remodelling associated 5 | -0.00510047 |
| GFUS | GDP-L-fucose synthase | -0.00509677 |
| SLC38A2 | solute carrier family 38, member 2 | -0.00509452 |
| LYPD3 | LY6/PLAUR domain containing 3 | -0.00509018 |
| DENND2D | DENN/MADD domain containing 2D | -0.00506901 |
| KLK8 | kallikrein-related peptidase 8 | -0.00506463 |
| IL1R1 | interleukin 1 receptor, type I | -0.00505986 |
| KRT2 | keratin 2, type II | -0.00505549 |
| RPL39L | ribosomal protein L39-like | -0.00504525 |
| VNN1 | vanin 1 | -0.00503497 |
| LEPROT | leptin receptor overlapping transcript | -0.00503145 |
