PAK5 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description p21 protein (Cdc42/Rac)-activated kinase 7|The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 57144)
Similar Terms
Downloads & Tools

Genes

100 substrates of the kinase PAK5 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
NUMA1 nuclear mitotic apparatus protein 1
SCAF1 SR-related CTD-associated factor 1
KMT2A lysine (K)-specific methyltransferase 2A
OSBPL5 oxysterol binding protein-like 5
ZBTB44 zinc finger and BTB domain containing 44
PPP1R10 protein phosphatase 1, regulatory subunit 10
MYBPC3 myosin binding protein C, cardiac
MAP7D1 MAP7 domain containing 1
PKP3 plakophilin 3
TOR4A torsin family 4, member A
SACK1B scaffolding CK1 anchoring protein B
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE3A phosphodiesterase 3A, cGMP-inhibited
TRA2A transformer 2 alpha homolog (Drosophila)
DGKZ diacylglycerol kinase, zeta
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
CDK18 cyclin-dependent kinase 18
CDK13 cyclin-dependent kinase 13
CDK17 cyclin-dependent kinase 17
LARP1 La ribonucleoprotein domain family, member 1
KIF2C kinesin family member 2C
KIF23 kinesin family member 23
KAT5 K(lysine) acetyltransferase 5
SACK1E scaffolding CK1 anchoring protein E
WDR81 WD repeat domain 81
MRVI1 murine retrovirus integration site 1 homolog
CCDC120 coiled-coil domain containing 120
GLI1 GLI family zinc finger 1
CCDC88C coiled-coil domain containing 88C
LTF lactotransferrin
LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
GATA3 GATA binding protein 3
LIN9 lin-9 DREAM MuvB core complex component
CAPN2 calpain 2, (m/II) large subunit
CAPN1 calpain 1, (mu/I) large subunit
RASAL2 RAS protein activator like 2
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
DMXL1 Dmx-like 1
DEPDC1B DEP domain containing 1B
SEPT1 septin 1
MYO7B myosin VIIB
ZC3H11A zinc finger CCCH-type containing 11A
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2
SRSF2 serine/arginine-rich splicing factor 2
ATR ATR serine/threonine kinase
ASPHD1 aspartate beta-hydroxylase domain containing 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PLEKHA6 pleckstrin homology domain containing, family A member 6
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SRBD1 S1 RNA binding domain 1
LIMCH1 LIM and calponin homology domains 1
ATRX alpha thalassemia/mental retardation syndrome X-linked
DRD2 dopamine receptor D2
ANKRD33B ankyrin repeat domain 33B
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
PRKDC protein kinase, DNA-activated, catalytic polypeptide
HBP1 HMG-box transcription factor 1
TP53BP1 tumor protein p53 binding protein 1
GRK7 G protein-coupled receptor kinase 7
SLC14A2 solute carrier family 14 (urea transporter), member 2
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
AEBP2 AE binding protein 2
CHERP calcium homeostasis endoplasmic reticulum protein
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
KCTD15 potassium channel tetramerization domain containing 15
RLTPR RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
TRAK1 trafficking protein, kinesin binding 1
CDCA2 cell division cycle associated 2
CDCA8 cell division cycle associated 8
ZNF337 zinc finger protein 337
DOCK2 dedicator of cytokinesis 2
RGCC regulator of cell cycle
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
C6ORF25 chromosome 6 open reading frame 25
FAM214B family with sequence similarity 214, member B
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PPP1R12C protein phosphatase 1, regulatory subunit 12C
EI24 etoposide induced 2.4
RBM15B RNA binding motif protein 15B
PRDX5 peroxiredoxin 5
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
POLR1E polymerase (RNA) I polypeptide E, 53kDa
SHKBP1 SH3KBP1 binding protein 1
MAP3K2 mitogen-activated protein kinase kinase kinase 2
SETD2 SET domain containing 2
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PFAS phosphoribosylformylglycinamidine synthase
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RSBN1 round spermatid basic protein 1
CLK3 CDC-like kinase 3
ZNF212 zinc finger protein 212
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
TESK2 testis-specific kinase 2
NCAPH non-SMC condensin I complex, subunit H
UBR5 ubiquitin protein ligase E3 component n-recognin 5
CDC25B cell division cycle 25B
CDC25A cell division cycle 25A
MAST3 microtubule associated serine/threonine kinase 3