PAK6 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description p21 protein (Cdc42/Rac)-activated kinase 6|This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013] (NCBI Entrez Gene Database, 56924)
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100 substrates of the kinase PAK6 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
MAST3 microtubule associated serine/threonine kinase 3
PDE3B phosphodiesterase 3B, cGMP-inhibited
SCAF1 SR-related CTD-associated factor 1
WNK2 WNK lysine deficient protein kinase 2
WNK1 WNK lysine deficient protein kinase 1
OSBPL5 oxysterol binding protein-like 5
FAM131B family with sequence similarity 131, member B
PPP1R10 protein phosphatase 1, regulatory subunit 10
MYBPC3 myosin binding protein C, cardiac
PKP3 plakophilin 3
PALB2 partner and localizer of BRCA2
IRS1 insulin receptor substrate 1
MKI67 marker of proliferation Ki-67
KAT5 K(lysine) acetyltransferase 5
DGKZ diacylglycerol kinase, zeta
SPAG1 sperm associated antigen 1
ETV6 ets variant 6
MYO1C myosin IC
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
KIF2C kinesin family member 2C
KIF23 kinesin family member 23
SGOL1 shugoshin-like 1 (S. pombe)
STRADA STE20-related kinase adaptor alpha
TMEM217 transmembrane protein 217
SACK1H scaffolding CK1 anchoring protein H
SACK1B scaffolding CK1 anchoring protein B
MRVI1 murine retrovirus integration site 1 homolog
CCDC120 coiled-coil domain containing 120
GLI1 GLI family zinc finger 1
PPP1R16B protein phosphatase 1, regulatory subunit 16B
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
MSH6 mutS homolog 6
CCDC88C coiled-coil domain containing 88C
GATA3 GATA binding protein 3
LIN9 lin-9 DREAM MuvB core complex component
PANK2 pantothenate kinase 2
DMXL1 Dmx-like 1
PLEKHA6 pleckstrin homology domain containing, family A member 6
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha
SACK1E scaffolding CK1 anchoring protein E
WDR81 WD repeat domain 81
DEPDC1B DEP domain containing 1B
PLEC plectin
MYO7B myosin VIIB
ZC3H11A zinc finger CCCH-type containing 11A
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1
ASPHD1 aspartate beta-hydroxylase domain containing 1
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
SRBD1 S1 RNA binding domain 1
RGCC regulator of cell cycle
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
AEBP2 AE binding protein 2
ATRX alpha thalassemia/mental retardation syndrome X-linked
DRD2 dopamine receptor D2
ANKRD33B ankyrin repeat domain 33B
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
WDR43 WD repeat domain 43
PRKDC protein kinase, DNA-activated, catalytic polypeptide
TP53BP2 tumor protein p53 binding protein 2
CDCA8 cell division cycle associated 8
CDCA2 cell division cycle associated 2
GOLGB1 golgin B1
PPP1R13B protein phosphatase 1, regulatory subunit 13B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
KCTD15 potassium channel tetramerization domain containing 15
SPAST spastin
RIF1 replication timing regulatory factor 1
RLTPR RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
XIRP2 xin actin binding repeat containing 2
TRAK1 trafficking protein, kinesin binding 1
RAD54L RAD54-like (S. cerevisiae)
GRK7 G protein-coupled receptor kinase 7
STXBP5L syntaxin binding protein 5-like
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
PFAS phosphoribosylformylglycinamidine synthase
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP1R12B protein phosphatase 1, regulatory subunit 12B
RBM15B RNA binding motif protein 15B
WNK4 WNK lysine deficient protein kinase 4
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
POLR1E polymerase (RNA) I polypeptide E, 53kDa
MAP3K2 mitogen-activated protein kinase kinase kinase 2
SETD2 SET domain containing 2
CDC25B cell division cycle 25B
UBR5 ubiquitin protein ligase E3 component n-recognin 5
TESK2 testis-specific kinase 2
C6ORF25 chromosome 6 open reading frame 25
FAM214B family with sequence similarity 214, member B
PKD1 polycystic kidney disease 1 (autosomal dominant)
SCAF11 SR-related CTD-associated factor 11
ALPK3 alpha-kinase 3
LLGL2 lethal giant larvae homolog 2 (Drosophila)
PRPF4B pre-mRNA processing factor 4B
ZNF212 zinc finger protein 212
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
MAST2 microtubule associated serine/threonine kinase 2