| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | p21 protein (Cdc42/Rac)-activated kinase 6|This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013] (NCBI Entrez Gene Database, 56924) |
| External Link | https://ncbi.nlm.nih.gov/gene/56924 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the PAK6 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TFF3 | trefoil factor 3 (intestinal) | 0.0227101 |
| MT1E | metallothionein 1E | 0.0169853 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | 0.016355 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0160856 |
| MT1X | metallothionein 1X | 0.0160038 |
| MAGEA3 | melanoma antigen family A3 | 0.0158451 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.015737 |
| S100P | S100 calcium binding protein P | 0.0152898 |
| ABAT | 4-aminobutyrate aminotransferase | 0.0152237 |
| AGR2 | anterior gradient 2 | 0.0150471 |
| MT1M | metallothionein 1M | 0.0148155 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0142814 |
| MMP2 | matrix metallopeptidase 2 | 0.0136839 |
| THBS4 | thrombospondin 4 | 0.013281 |
| CD163 | CD163 molecule | 0.0131693 |
| TFF1 | trefoil factor 1 | 0.0131494 |
| MGLL | monoglyceride lipase | 0.0127735 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.0122201 |
| SFRP1 | secreted frizzled-related protein 1 | 0.0121328 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.0119175 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | 0.0118579 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | 0.0117924 |
| CST3 | cystatin C | 0.0116761 |
| ACKR3 | atypical chemokine receptor 3 | 0.0116563 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0116487 |
| MT1H | metallothionein 1H | 0.0115659 |
| ANXA3 | annexin A3 | 0.0115056 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | 0.0114911 |
| NBPF10 | neuroblastoma breakpoint family, member 10 | 0.0114577 |
| SPRY2 | sprouty homolog 2 (Drosophila) | 0.011436 |
| CNTN1 | contactin 1 | 0.0111947 |
| VSIG4 | V-set and immunoglobulin domain containing 4 | 0.0111493 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0111304 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0111122 |
| IQGAP2 | IQ motif containing GTPase activating protein 2 | 0.0108974 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0108302 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0107362 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.0106597 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.010642 |
| BTBD3 | BTB (POZ) domain containing 3 | 0.0105843 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0105643 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0105583 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0105278 |
| RGS16 | regulator of G-protein signaling 16 | 0.0104065 |
| GPC3 | glypican 3 | 0.0103113 |
| LAMA2 | laminin, alpha 2 | 0.0102802 |
| MGP | matrix Gla protein | 0.0102622 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | 0.0102114 |
| MT1G | metallothionein 1G | 0.0102029 |
| G0S2 | G0/G1 switch 2 | 0.0101602 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | 0.0100993 |
| F13A1 | coagulation factor XIII, A1 polypeptide | 0.0100938 |
| CFD | complement factor D (adipsin) | 0.0100397 |
| MT1F | metallothionein 1F | 0.00987281 |
| SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | 0.00981488 |
| MET | MET proto-oncogene, receptor tyrosine kinase | 0.00980717 |
| COL15A1 | collagen, type XV, alpha 1 | 0.00977644 |
| C1QB | complement component 1, q subcomponent, B chain | 0.00975126 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.00972162 |
| MECOM | MDS1 and EVI1 complex locus | 0.00966905 |
| LYZ | lysozyme | 0.00964248 |
| POLR2D | polymerase (RNA) II (DNA directed) polypeptide D | 0.00961741 |
| MT2A | metallothionein 2A | 0.00961728 |
| MT1HL1 | metallothionein 1H-like 1 | 0.00959492 |
| GAS7 | growth arrest-specific 7 | 0.00954683 |
| GLUL | glutamate-ammonia ligase | 0.0095417 |
| LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 | 0.00951512 |
| TPBG | trophoblast glycoprotein | 0.00951037 |
| LRPAP1 | low density lipoprotein receptor-related protein associated protein 1 | 0.00948521 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.00946754 |
| STK39 | serine threonine kinase 39 | 0.00936379 |
| PLBD1 | phospholipase B domain containing 1 | 0.00934233 |
| TSPAN8 | tetraspanin 8 | 0.00926209 |
| AUTS2 | autism susceptibility candidate 2 | 0.00924855 |
| FMOD | fibromodulin | 0.00922019 |
| S100A11 | S100 calcium binding protein A11 | 0.00921352 |
| PLCB4 | phospholipase C, beta 4 | 0.0091446 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.00914409 |
| ACADVL | acyl-CoA dehydrogenase, very long chain | 0.00911052 |
| C2CD5 | C2 calcium-dependent domain containing 5 | 0.00910505 |
| SOBP | sine oculis binding protein homolog (Drosophila) | 0.00909577 |
| IL1R1 | interleukin 1 receptor, type I | 0.00904813 |
| AREG | amphiregulin | 0.00902381 |
| FSTL1 | follistatin-like 1 | 0.00896304 |
| VWF | von Willebrand factor | 0.00895251 |
| HYOU1 | hypoxia up-regulated 1 | 0.00886265 |
| CD14 | CD14 molecule | 0.00880595 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.00875928 |
| SPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | 0.00875279 |
| PHACTR2 | phosphatase and actin regulator 2 | 0.00870067 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.00869506 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | 0.00866769 |
| COL14A1 | collagen, type XIV, alpha 1 | 0.00865047 |
| ALB | albumin | 0.00863638 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.00862936 |
| C1QA | complement component 1, q subcomponent, A chain | 0.00860114 |
| DOCK9 | dedicator of cytokinesis 9 | 0.00859622 |
| TGIF1 | TGFB-induced factor homeobox 1 | 0.00859058 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | 0.00857895 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | 0.00852432 |
| MX1 | MX dynamin-like GTPase 1 | 0.00852194 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.00852079 |
| IRS1 | insulin receptor substrate 1 | 0.00851873 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0085128 |
| DYNLL1 | dynein, light chain, LC8-type 1 | 0.00851201 |
| PTCH1 | patched 1 | 0.00851003 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0084958 |
| H1-0 | H1.0 linker histone | 0.00848297 |
| ANPEP | alanyl (membrane) aminopeptidase | 0.00848248 |
| APOB | apolipoprotein B | 0.00846772 |
| PLIN2 | perilipin 2 | 0.00846671 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 0.00844875 |
| NIT1 | nitrilase 1 | 0.0084485 |
| ADSL | adenylosuccinate lyase | 0.00837312 |
| TBL1X | transducin (beta)-like 1X-linked | 0.0083571 |
| GOLIM4 | golgi integral membrane protein 4 | 0.00834063 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.00832909 |
| FBN2 | fibrillin 2 | 0.00830655 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 0.00828623 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | 0.00827559 |
| PLTP | phospholipid transfer protein | 0.00826718 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.00825911 |
| DCHS1 | dachsous cadherin-related 1 | 0.0082349 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.00821845 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.00819851 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.00819144 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.00816141 |
| WLS | wntless Wnt ligand secretion mediator | 0.00812091 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.00811698 |
| ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | 0.00806731 |
| MAGEA12 | melanoma antigen family A12 | 0.00805706 |
| AOX1 | aldehyde oxidase 1 | 0.00803831 |
| GPM6B | glycoprotein M6B | 0.00803021 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.00793329 |
| MFAP4 | microfibrillar-associated protein 4 | 0.00792641 |
| BRD4 | bromodomain containing 4 | 0.00792206 |
| NCSTN | nicastrin | 0.00792078 |
| MB | myoglobin | 0.0079096 |
| SLC38A1 | solute carrier family 38, member 1 | 0.00782785 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | 0.00779752 |
| EPB41L4B | erythrocyte membrane protein band 4.1 like 4B | 0.00779323 |
| FABP4 | fatty acid binding protein 4, adipocyte | 0.00777987 |
| APOD | apolipoprotein D | 0.00777404 |
| PFDN2 | prefoldin subunit 2 | 0.00774832 |
| NAV2 | neuron navigator 2 | 0.00773988 |
| PAN2 | PAN2 poly(A) specific ribonuclease subunit | 0.00771957 |
| RGS13 | regulator of G-protein signaling 13 | 0.0077152 |
| RB1 | retinoblastoma 1 | 0.00768774 |
| SDC2 | syndecan 2 | 0.00768372 |
| ZCCHC14 | zinc finger, CCHC domain containing 14 | 0.00766271 |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 | 0.00765849 |
| FBN1 | fibrillin 1 | 0.00764123 |
| ABCA8 | ATP-binding cassette, sub-family A (ABC1), member 8 | 0.00763183 |
| COLEC12 | collectin sub-family member 12 | 0.00762298 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.00759776 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.00759702 |
| ITGA6 | integrin, alpha 6 | 0.00758197 |
| DLK1 | delta-like 1 homolog (Drosophila) | 0.00757973 |
| EFNB2 | ephrin-B2 | 0.00756019 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 0.00755817 |
| ZNF91 | zinc finger protein 91 | 0.00755043 |
| PRSS3 | protease, serine, 3 | 0.00754276 |
| ZIC1 | Zic family member 1 | 0.00751315 |
| RRBP1 | ribosome binding protein 1 | 0.00749013 |
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 | 0.00748753 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.00746888 |
| FOXO1 | forkhead box O1 | 0.00746223 |
| YAP1 | Yes-associated protein 1 | 0.0074546 |
| ANKS1A | ankyrin repeat and sterile alpha motif domain containing 1A | 0.00743843 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.00742932 |
| COL9A3 | collagen, type IX, alpha 3 | 0.00741852 |
| KANK1 | KN motif and ankyrin repeat domains 1 | 0.00741501 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | 0.00741023 |
| HK2 | hexokinase 2 | 0.00740265 |
| KRT18 | keratin 18, type I | 0.00739423 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.00738578 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | 0.00736756 |
| CCND2 | cyclin D2 | 0.00735552 |
| CDC20 | cell division cycle 20 | 0.00732899 |
| PAM | peptidylglycine alpha-amidating monooxygenase | 0.00730536 |
| QKI | QKI, KH domain containing, RNA binding | 0.00729012 |
| PCSK6 | proprotein convertase subtilisin/kexin type 6 | 0.0072579 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.00724527 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.00723239 |
| GPSM2 | G-protein signaling modulator 2 | 0.00723175 |
| BCL2L2 | BCL2-like 2 | 0.00722898 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | 0.00719589 |
| C1R | complement component 1, r subcomponent | 0.00717937 |
| ISLR | immunoglobulin superfamily containing leucine-rich repeat | 0.0071687 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.00714329 |
| STC2 | stanniocalcin 2 | 0.00713545 |
| PROM1 | prominin 1 | 0.00713238 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | 0.00710591 |
| PTGER4 | prostaglandin E receptor 4 (subtype EP4) | 0.0070815 |
| TAGLN | transgelin | 0.00704967 |
| KIF5B | kinesin family member 5B | 0.00701456 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | 0.0070094 |
| ADCY9 | adenylate cyclase 9 | 0.0070061 |
| AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | 0.00699501 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.00697739 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.0069652 |
| CDO1 | cysteine dioxygenase type 1 | 0.00695774 |
| APOA1 | apolipoprotein A-I | 0.00695422 |
| USP22 | ubiquitin specific peptidase 22 | 0.00693375 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.00691962 |
| KRAS | Kirsten rat sarcoma viral oncogene homolog | 0.00691471 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.00690452 |
| MS4A4A | membrane-spanning 4-domains, subfamily A, member 4A | 0.0068891 |
| MARCH3 | membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase | 0.00688905 |
| HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) | 0.00688356 |
| STK25 | serine/threonine kinase 25 | 0.00684228 |
| FBLN2 | fibulin 2 | 0.00683948 |
| CILP | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | 0.00683733 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | 0.00683639 |
| XAF1 | XIAP associated factor 1 | 0.00683364 |
| P2RX5 | purinergic receptor P2X, ligand gated ion channel, 5 | 0.0068164 |
| KLF9 | Kruppel-like factor 9 | 0.00681232 |
| ABCA2 | ATP-binding cassette, sub-family A (ABC1), member 2 | 0.00681017 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | 0.00679567 |
| GSTA1 | glutathione S-transferase alpha 1 | 0.00679401 |
| MN1 | meningioma (disrupted in balanced translocation) 1 | 0.00679395 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | 0.00679315 |
| MAEA | macrophage erythroblast attacher | 0.00678466 |
| MAOB | monoamine oxidase B | 0.00678242 |
| DPT | dermatopontin | 0.00677178 |
| SLC39A6 | solute carrier family 39 (zinc transporter), member 6 | 0.00675622 |
| SPARCL1 | SPARC-like 1 (hevin) | 0.00675433 |
| LYVE1 | lymphatic vessel endothelial hyaluronan receptor 1 | 0.00675202 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | 0.00675006 |
| IFITM2 | interferon induced transmembrane protein 2 | 0.00674446 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.00674078 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.00673368 |
| REG3A | regenerating islet-derived 3 alpha | 0.00669968 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.00669539 |
| WDR19 | WD repeat domain 19 | 0.00667355 |
| SLTM | SAFB-like, transcription modulator | 0.00663935 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.00655532 |
| PDE3B | phosphodiesterase 3B, cGMP-inhibited | 0.00654999 |
| CFTR | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) | 0.00654936 |
| ZZEF1 | zinc finger, ZZ-type with EF-hand domain 1 | 0.00653626 |
| REXO2 | RNA exonuclease 2 | 0.00653541 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | 0.00653279 |
| TFF2 | trefoil factor 2 | 0.00652668 |
| FLII | flightless I homolog (Drosophila) | 0.00651627 |
| MFAP2 | microfibrillar-associated protein 2 | 0.00650511 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 0.00649303 |
| EPHA2 | EPH receptor A2 | 0.00648877 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.00648608 |
| GSTM3 | glutathione S-transferase mu 3 (brain) | 0.0064765 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NVL | nuclear VCP-like | -0.0178119 |
| CDCA4 | cell division cycle associated 4 | -0.0160782 |
| GRB7 | growth factor receptor-bound protein 7 | -0.0142603 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -0.0137614 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0134024 |
| ALDH5A1 | aldehyde dehydrogenase 5 family, member A1 | -0.0129353 |
| TXNDC9 | thioredoxin domain containing 9 | -0.012908 |
| RGS10 | regulator of G-protein signaling 10 | -0.0127197 |
| DIPK1A | divergent protein kinase domain 1A | -0.0122925 |
| S100A7 | S100 calcium binding protein A7 | -0.0118063 |
| CLDN8 | claudin 8 | -0.0117721 |
| JCHAIN | joining chain of multimeric IgA and IgM | -0.0115143 |
| EAF2 | ELL associated factor 2 | -0.0109959 |
| PDZK1IP1 | PDZK1 interacting protein 1 | -0.0109772 |
| KYNU | kynureninase | -0.0109242 |
| TNFRSF17 | tumor necrosis factor receptor superfamily, member 17 | -0.00983453 |
| ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) | -0.00975225 |
| CD200 | CD200 molecule | -0.00968663 |
| GNPTAB | N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits | -0.00963072 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | -0.0095207 |
| CD52 | CD52 molecule | -0.00943572 |
| FBXO28 | F-box protein 28 | -0.00942729 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.00932959 |
| BAMBI | BMP and activin membrane-bound inhibitor | -0.00930278 |
| CSTA | cystatin A (stefin A) | -0.00925823 |
| BHLHE41 | basic helix-loop-helix family, member e41 | -0.00925558 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | -0.00921638 |
| FABP7 | fatty acid binding protein 7, brain | -0.00909628 |
| AHCY | adenosylhomocysteinase | -0.00905128 |
| LAMP3 | lysosomal-associated membrane protein 3 | -0.0089962 |
| FXYD2 | FXYD domain containing ion transport regulator 2 | -0.00881621 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.00881516 |
| CD27 | CD27 molecule | -0.0087923 |
| AQP3 | aquaporin 3 (Gill blood group) | -0.00879136 |
| GLRX5 | glutaredoxin 5 | -0.0086655 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | -0.0086545 |
| LGALS2 | lectin, galactoside-binding, soluble, 2 | -0.00864273 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | -0.00862987 |
| DCUN1D1 | DCN1, defective in cullin neddylation 1, domain containing 1 | -0.00850757 |
| TFRC | transferrin receptor | -0.00850719 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.00844238 |
| TBX2 | T-box 2 | -0.00843501 |
| XPO7 | exportin 7 | -0.00836348 |
| IL7R | interleukin 7 receptor | -0.00835089 |
| CD1E | CD1e molecule | -0.00831059 |
| KCNJ16 | potassium channel, inwardly rectifying subfamily J, member 16 | -0.00829314 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.00825126 |
| BBOX1 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | -0.00821187 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -0.00809431 |
| PTGES | prostaglandin E synthase | -0.00800033 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | -0.00799712 |
| EVI2A | ecotropic viral integration site 2A | -0.00798591 |
| KLHL9 | kelch-like family member 9 | -0.00795775 |
| RFC5 | replication factor C (activator 1) 5, 36.5kDa | -0.00794452 |
| TMEM38B | transmembrane protein 38B | -0.00779346 |
| KMO | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | -0.00777413 |
| TNFSF13B | tumor necrosis factor (ligand) superfamily, member 13b | -0.00776776 |
| SPON1 | spondin 1, extracellular matrix protein | -0.00775298 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | -0.00769475 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.00766793 |
| CHST1 | carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 | -0.00764504 |
| KCTD12 | potassium channel tetramerization domain containing 12 | -0.00760398 |
| IL15 | interleukin 15 | -0.00754531 |
| CD86 | CD86 molecule | -0.00754481 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.00753647 |
| LXN | latexin | -0.0075302 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | -0.0075068 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | -0.00750019 |
| DNTT | DNA nucleotidylexotransferase | -0.00748774 |
| TEAD4 | TEA domain family member 4 | -0.00742441 |
| TSNAX | translin-associated factor X | -0.00741159 |
| CETN2 | centrin, EF-hand protein, 2 | -0.00740838 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.00739404 |
| MEF2C | myocyte enhancer factor 2C | -0.00729561 |
| GSTO1 | glutathione S-transferase omega 1 | -0.00728942 |
| CRIP2 | cysteine-rich protein 2 | -0.00726732 |
| CXADR | coxsackie virus and adenovirus receptor | -0.00725362 |
| PSPH | phosphoserine phosphatase | -0.00721068 |
| CD48 | CD48 molecule | -0.00720874 |
| CALML5 | calmodulin-like 5 | -0.00720135 |
| MZB1 | marginal zone B and B1 cell-specific protein | -0.00718034 |
| SMCO4 | single-pass membrane protein with coiled-coil domains 4 | -0.00716286 |
| ATOX1 | antioxidant 1 copper chaperone | -0.00710001 |
| ADA | adenosine deaminase | -0.00707845 |
| FZD1 | frizzled class receptor 1 | -0.00707394 |
| WT1 | Wilms tumor 1 | -0.00704559 |
| MSMO1 | methylsterol monooxygenase 1 | -0.00703623 |
| COPS2 | COP9 signalosome subunit 2 | -0.00703516 |
| HIST1H2AC | histone cluster 1, H2ac | -0.00702227 |
| COG7 | component of oligomeric golgi complex 7 | -0.00702141 |
| NPTXR | neuronal pentraxin receptor | -0.00701996 |
| SELL | selectin L | -0.00701709 |
| NDUFB5 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa | -0.00700569 |
| HOPX | HOP homeobox | -0.00697939 |
| IL2RG | interleukin 2 receptor, gamma | -0.0069441 |
| MAL | mal, T-cell differentiation protein | -0.00692733 |
| EXO1 | exonuclease 1 | -0.00692 |
| UROS | uroporphyrinogen III synthase | -0.00691578 |
| POPDC3 | popeye domain containing 3 | -0.0069072 |
| RBM38 | RNA binding motif protein 38 | -0.00688274 |
| ACP5 | acid phosphatase 5, tartrate resistant | -0.00687774 |
| CST6 | cystatin E/M | -0.00686348 |
| MLF1 | myeloid leukemia factor 1 | -0.00684281 |
| GDI2 | GDP dissociation inhibitor 2 | -0.00683648 |
| KRT81 | keratin 81, type II | -0.00681917 |
| CNIH4 | cornichon family AMPA receptor auxiliary protein 4 | -0.00678635 |
| AMDHD2 | amidohydrolase domain containing 2 | -0.00678129 |
| PLGRKT | plasminogen receptor, C-terminal lysine transmembrane protein | -0.0067159 |
| CCNF | cyclin F | -0.00670694 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.00670122 |
| HOXD10 | homeobox D10 | -0.00669872 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | -0.0066865 |
| PSMA6 | proteasome (prosome, macropain) subunit, alpha type, 6 | -0.00666764 |
| SLC47A1 | solute carrier family 47 (multidrug and toxin extrusion), member 1 | -0.00666302 |
| YPEL5 | yippee-like 5 (Drosophila) | -0.00664527 |
| SLAMF7 | SLAM family member 7 | -0.00658672 |
| SLC15A2 | solute carrier family 15 (oligopeptide transporter), member 2 | -0.00657058 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | -0.00656194 |
| SIRT5 | sirtuin 5 | -0.00650758 |
| IRX5 | iroquois homeobox 5 | -0.00649837 |
| RPL14 | ribosomal protein L14 | -0.00647891 |
| EIF4B | eukaryotic translation initiation factor 4B | -0.00645682 |
| SPINK2 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | -0.00645171 |
| DOK5 | docking protein 5 | -0.00643758 |
| CENPU | centromere protein U | -0.00643308 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | -0.00643231 |
| NSL1 | NSL1, MIS12 kinetochore complex component | -0.00641678 |
| QRSL1 | glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 | -0.00641492 |
| ORC1 | origin recognition complex, subunit 1 | -0.00639455 |
| AKIRIN1 | akirin 1 | -0.00639296 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | -0.00638299 |
| PDK1 | pyruvate dehydrogenase kinase, isozyme 1 | -0.00637569 |
| SRGN | serglycin | -0.00637557 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.00636609 |
| PRKCQ | protein kinase C, theta | -0.00635915 |
| JAG2 | jagged 2 | -0.00633777 |
| DEFB1 | defensin, beta 1 | -0.00633464 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | -0.00632629 |
| EIF3I | eukaryotic translation initiation factor 3, subunit I | -0.0063232 |
| LTB | lymphotoxin beta (TNF superfamily, member 3) | -0.00632047 |
| HMGA1 | high mobility group AT-hook 1 | -0.00631077 |
| RPP40 | ribonuclease P/MRP 40kDa subunit | -0.00631004 |
| PLEKHF2 | pleckstrin homology domain containing, family F (with FYVE domain) member 2 | -0.00625948 |
| TPST2 | tyrosylprotein sulfotransferase 2 | -0.00625923 |
| ORC4 | origin recognition complex, subunit 4 | -0.0062364 |
| COCH | cochlin | -0.00622584 |
| NR0B1 | nuclear receptor subfamily 0, group B, member 1 | -0.00621237 |
| E2F2 | E2F transcription factor 2 | -0.00620692 |
| CD8A | CD8a molecule | -0.00620562 |
| TRMT2B | tRNA methyltransferase 2 homolog B (S. cerevisiae) | -0.00620043 |
| CCNE2 | cyclin E2 | -0.00618766 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0061863 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | -0.00617402 |
| ZNF195 | zinc finger protein 195 | -0.00617067 |
| FCMR | Fc fragment of IgM receptor | -0.00616949 |
| CRIPT | cysteine-rich PDZ-binding protein | -0.00616432 |
| AK4 | adenylate kinase 4 | -0.00615614 |
| SLC22A4 | solute carrier family 22 (organic cation/zwitterion transporter), member 4 | -0.00615209 |
| PADI2 | peptidyl arginine deiminase, type II | -0.00614663 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.00613809 |
| UBE2J1 | ubiquitin-conjugating enzyme E2, J1 | -0.00613146 |
| MAPKAPK5-AS1 | MAPKAPK5 antisense RNA 1 | -0.00611164 |
| DLEU1 | deleted in lymphocytic leukemia 1 (non-protein coding) | -0.00610156 |
| PCSK1N | proprotein convertase subtilisin/kexin type 1 inhibitor | -0.00610074 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -0.00608087 |
| MAT2B | methionine adenosyltransferase II, beta | -0.0060727 |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | -0.00605402 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.00604947 |
| MREG | melanoregulin | -0.00604291 |
| PWP1 | PWP1 homolog (S. cerevisiae) | -0.00604134 |
| PHTF2 | putative homeodomain transcription factor 2 | -0.00603926 |
| LTA4H | leukotriene A4 hydrolase | -0.0060371 |
| NOTCH3 | notch 3 | -0.00602643 |
| TUBB2A | tubulin, beta 2A class IIa | -0.00600628 |
| ADRA2A | adrenoceptor alpha 2A | -0.00599589 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | -0.00599487 |
| WFDC1 | WAP four-disulfide core domain 1 | -0.005986 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | -0.0059839 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | -0.0059737 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | -0.00597065 |
| FECH | ferrochelatase | -0.00596321 |
| GMFG | glia maturation factor, gamma | -0.00593943 |
| MED6 | mediator complex subunit 6 | -0.00593038 |
| FGFR4 | fibroblast growth factor receptor 4 | -0.00590458 |
| SNX10 | sorting nexin 10 | -0.00589182 |
| GUK1 | guanylate kinase 1 | -0.00587491 |
| KCNN2 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 | -0.00587422 |
| NKX2-1 | NK2 homeobox 1 | -0.00586028 |
| PSAP | prosaposin | -0.00585395 |
| RRM2 | ribonucleotide reductase M2 | -0.00584033 |
| ZNF140 | zinc finger protein 140 | -0.00583875 |
| SIGIRR | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain | -0.00583534 |
| BIRC5 | baculoviral IAP repeat containing 5 | -0.00583522 |
| RMND1 | required for meiotic nuclear division 1 homolog (S. cerevisiae) | -0.00583159 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | -0.00582789 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | -0.00582545 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 | -0.00581525 |
| LBH | limb bud and heart development | -0.00580957 |
| AMZ2 | archaelysin family metallopeptidase 2 | -0.00580952 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.00580774 |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | -0.00580709 |
| HLA-DQB2 | major histocompatibility complex, class II, DQ beta 2 | -0.00579717 |
| TPM2 | tropomyosin 2 (beta) | -0.00578975 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | -0.00578494 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | -0.00577757 |
| CLIC2 | chloride intracellular channel 2 | -0.00577185 |
| PFDN5 | prefoldin subunit 5 | -0.00576411 |
| RAI14 | retinoic acid induced 14 | -0.00575419 |
| TSPAN6 | tetraspanin 6 | -0.00575032 |
| METTL8 | methyltransferase like 8 | -0.00573917 |
| RAB38 | RAB38, member RAS oncogene family | -0.00573662 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | -0.00572741 |
| NUDT11 | nudix (nucleoside diphosphate linked moiety X)-type motif 11 | -0.00571779 |
| EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 | -0.00571464 |
| CREBL2 | cAMP responsive element binding protein-like 2 | -0.00569848 |
| IL13RA1 | interleukin 13 receptor, alpha 1 | -0.00569804 |
| POU2AF1 | POU class 2 associating factor 1 | -0.00569713 |
| THBS2 | thrombospondin 2 | -0.00569274 |
| TUBA1A | tubulin, alpha 1a | -0.00568329 |
| HDAC9 | histone deacetylase 9 | -0.00567814 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | -0.00566273 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.00566229 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | -0.00564964 |
| NFYB | nuclear transcription factor Y, beta | -0.00564883 |
| CD2 | CD2 molecule | -0.00563904 |
| EPB42 | erythrocyte membrane protein band 4.2 | -0.00562223 |
| IGBP1 | immunoglobulin (CD79A) binding protein 1 | -0.00560754 |
| INAVA | innate immunity activator | -0.00560178 |
| BAD | BCL2-associated agonist of cell death | -0.00559909 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | -0.00559099 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.00558638 |
| UMOD | uromodulin | -0.00556792 |
| CCDC85B | coiled-coil domain containing 85B | -0.00556275 |
| LST1 | leukocyte specific transcript 1 | -0.00556026 |
| CLMN | calmin (calponin-like, transmembrane) | -0.0055599 |
| NELL2 | NEL-like 2 (chicken) | -0.00555648 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -0.00555567 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.00555165 |
| THBS1 | thrombospondin 1 | -0.00554686 |
| ACOX2 | acyl-CoA oxidase 2, branched chain | -0.00553111 |
| TADA2A | transcriptional adaptor 2A | -0.0055268 |
| GSDME | gasdermin E | -0.00552437 |
| INTS7 | integrator complex subunit 7 | -0.00551796 |
| NOL4 | nucleolar protein 4 | -0.00551249 |
| STYXL1 | serine/threonine/tyrosine interacting-like 1 | -0.0055105 |
| POP5 | processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) | -0.00550383 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.00550304 |
| EEF1B2 | eukaryotic translation elongation factor 1 beta 2 | -0.00548488 |
| PEX2 | peroxisomal biogenesis factor 2 | -0.00547514 |
| IFT52 | intraflagellar transport 52 | -0.00547447 |
