PAK6 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description p21 protein (Cdc42/Rac)-activated kinase 6|This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013] (NCBI Entrez Gene Database, 56924)
External Link http://www.ncbi.nlm.nih.gov/gene/56924
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35 interacting proteins for PAK6 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTB actin, beta
ACTBL2 actin, beta-like 2
ACTC1 actin, alpha, cardiac muscle 1
ACTG1 actin gamma 1
ACTG2 actin, gamma 2, smooth muscle, enteric
AKT1 v-akt murine thymoma viral oncogene homolog 1
APP amyloid beta (A4) precursor protein
AR androgen receptor
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
ESR1 estrogen receptor 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
LIMK1 LIM domain kinase 1
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase
LRRK1 leucine-rich repeat kinase 1
LRRK2 leucine-rich repeat kinase 2
MAP2K6 mitogen-activated protein kinase kinase 6
MAPK14 mitogen-activated protein kinase 14
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
NEK6 NIMA-related kinase 6
PACSIN1 protein kinase C and casein kinase substrate in neurons 1
PKM pyruvate kinase, muscle
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RHOU ras homolog family member U
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SNX2 sorting nexin 2
STMN1 stathmin 1
STMN4 stathmin-like 4
TPD52L1 tumor protein D52-like 1
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta