PAK7 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description p21 protein (Cdc42/Rac)-activated kinase 7|The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 57144)
External Link http://www.ncbi.nlm.nih.gov/gene/57144
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194 interacting proteins for PAK7 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTB actin, beta
ACTBL2 actin, beta-like 2
ACTC1 actin, alpha, cardiac muscle 1
ACTG1 actin gamma 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ALYREF Aly/REF export factor
ANXA2 annexin A2
AP2A1 adaptor-related protein complex 2, alpha 1 subunit
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
AP3B2 adaptor-related protein complex 3, beta 2 subunit
ARHGAP17 Rho GTPase activating protein 17
ARHGAP21 Rho GTPase activating protein 21
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
BAD BCL2-associated agonist of cell death
BCLAF1 BCL2-associated transcription factor 1
BOLA2 bolA family member 2
BSN bassoon presynaptic cytomatrix protein
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAPN1 calpain 1, (mu/I) large subunit
CCDC59 coiled-coil domain containing 59
CDC42 cell division cycle 42
CDK13 cyclin-dependent kinase 13
CDK3 cyclin-dependent kinase 3
CDK4 cyclin-dependent kinase 4
CDK7 cyclin-dependent kinase 7
CENPF centromere protein F, 350/400kDa
CFL1 cofilin 1 (non-muscle)
CHUK conserved helix-loop-helix ubiquitous kinase
CLTA clathrin, light chain A
CLTB clathrin, light chain B
CPNE1 copine I
CSN2 casein beta
CSNK1A1L casein kinase 1, alpha 1-like
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CUL5 cullin 5
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DGKE diacylglycerol kinase, epsilon 64kDa
DGKZ diacylglycerol kinase, zeta
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4
EIF4B eukaryotic translation initiation factor 4B
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERH enhancer of rudimentary homolog (Drosophila)
FHL3 four and a half LIM domains 3
FLNA filamin A, alpha
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GSN gelsolin
H1FX H1 histone family, member X
H2AFX H2A histone family, member X
HDAC2 histone deacetylase 2
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HIST1H1A histone cluster 1, H1a
HIST1H1C histone cluster 1, H1c
HIST2H2AB histone cluster 2, H2ab
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPK heterogeneous nuclear ribonucleoprotein K
HNRNPM heterogeneous nuclear ribonucleoprotein M
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1B heat shock 70kDa protein 1B
HSPA1L heat shock 70kDa protein 1-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HTATSF1 HIV-1 Tat specific factor 1
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
KPNB1 karyopherin (importin) beta 1
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
LIMK1 LIM domain kinase 1
LRP11 low density lipoprotein receptor-related protein 11
LZTS2 leucine zipper, putative tumor suppressor 2
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MOB1A MOB kinase activator 1A
MYH9 myosin, heavy chain 9, non-muscle
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYO1C myosin IC
MYOCD myocardin
NOLC1 nucleolar and coiled-body phosphoprotein 1
NONO non-POU domain containing, octamer-binding
NOP10 NOP10 ribonucleoprotein
NOP56 NOP56 ribonucleoprotein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NSUN2 NOP2/Sun RNA methyltransferase family, member 2
NUCLEOLIN nucleolin multifunctional protein
PABPC1 poly(A) binding protein, cytoplasmic 1
PDE4D phosphodiesterase 4D, cAMP-specific
PDLIM7 PDZ and LIM domain 7 (enigma)
PHKA2 phosphorylase kinase, alpha 2 (liver)
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PKM pyruvate kinase, muscle
POLR1A polymerase (RNA) I polypeptide A, 194kDa
POLR1C polymerase (RNA) I polypeptide C, 30kDa
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRMT5 protein arginine methyltransferase 5
PRPF4B pre-mRNA processing factor 4B
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RANGAP1 Ran GTPase activating protein 1
RBM10 RNA binding motif protein 10
RHOU ras homolog family member U
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RPA1 replication protein A1, 70kDa
RPA3 replication protein A3, 14kDa
RPL11 ribosomal protein L11
RPL12 ribosomal protein L12
RPL18 ribosomal protein L18
RPL19 ribosomal protein L19
RPL21 ribosomal protein L21
RPL22 ribosomal protein L22
RPL26 ribosomal protein L26
RPL30 ribosomal protein L30
RPL31 ribosomal protein L31
RPL35 ribosomal protein L35
RPL35A ribosomal protein L35a
RPL36 ribosomal protein L36
RPL4 ribosomal protein L4
RPL7 ribosomal protein L7
RPL7A ribosomal protein L7a
RPLP0 ribosomal protein, large, P0
RPLP1 ribosomal protein, large, P1
RPLP2 ribosomal protein, large, P2
RPS17 ribosomal protein S17
RPS19 ribosomal protein S19
RPS3 ribosomal protein S3
RPS3A ribosomal protein S3A
RPS4X ribosomal protein S4, X-linked
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SAG S-antigen; retina and pineal gland (arrestin)
SCYL2 SCY1-like 2 (S. cerevisiae)
SF3B1 splicing factor 3b, subunit 1, 155kDa
SF3B2 splicing factor 3b, subunit 2, 145kDa
SFPQ splicing factor proline/glutamine-rich
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa
SPIN1 spindlin 1
SPIN3 spindlin family, member 3
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRPK2 SRSF protein kinase 2
SRRM2 serine/arginine repetitive matrix 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STK38 serine/threonine kinase 38
STMN1 stathmin 1
STMN4 stathmin-like 4
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TCOF1 Treacher Collins-Franceschetti syndrome 1
THRAP3 thyroid hormone receptor associated protein 3
TMOD3 tropomodulin 3 (ubiquitous)
TMPO thymopoietin
TRIM28 tripartite motif containing 28
TUBA1C tubulin, alpha 1c
TUBA3C tubulin, alpha 3c
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TUBGCP4 tubulin, gamma complex associated protein 4
UBB ubiquitin B
VCP valosin containing protein
VIM vimentin
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae)
WDR77 WD repeat domain 77
WEE1 WEE1 G2 checkpoint kinase
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YBX1 Y box binding protein 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
ZRANB2 zinc finger, RAN-binding domain containing 2