PALB2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description partner and localizer of BRCA2|This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 79728)
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Genes

328 genes differentially expressed following the PALB2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 3.3664
FAM86B1 family with sequence similarity 86, member B1 3.3664
FCRL5 Fc receptor-like 5 3.3664
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 3.3664
FBXO4 F-box protein 4 3.3664
ZNF184 zinc finger protein 184 3.3664
TMEM217 transmembrane protein 217 3.3664
SPNS2 spinster homolog 2 (Drosophila) 3.3664
KCNIP2 Kv channel interacting protein 2 3.3664
GPR183 G protein-coupled receptor 183 3.3664
MANSC4 MANSC domain containing 4 3.3664
GFAP glial fibrillary acidic protein 3.3664
OR51A7 olfactory receptor, family 51, subfamily A, member 7 3.3664
PRELP proline/arginine-rich end leucine-rich repeat protein 3.3664
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 3.3664
PCDHB6 protocadherin beta 6 3.3664
NCF2 neutrophil cytosolic factor 2 3.3664
CCNB3 cyclin B3 3.3664
UMOD uromodulin 3.3664
FCGBP Fc fragment of IgG binding protein 3.3664
FREM3 FRAS1 related extracellular matrix 3 3.3664
TTPA tocopherol (alpha) transfer protein 3.3664
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 3.3664
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.3664
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 3.3664
SGCZ sarcoglycan, zeta 3.3664
FAM161B family with sequence similarity 161, member B 3.3664
MEIG1 meiosis/spermiogenesis associated 1 3.3664
CYGB cytoglobin 3.3664
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 3.3664
KRTAP13-4 keratin associated protein 13-4 3.3664
IRX5 iroquois homeobox 5 3.3664
PRR27 proline rich 27 3.3664
C2ORF78 chromosome 2 open reading frame 78 3.3664
OC90 otoconin 90 3.3664
IFI6 interferon, alpha-inducible protein 6 3.3664
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 3.3664
HEPHL1 hephaestin-like 1 3.3664
CORO6 coronin 6 3.3664
LGALS3 lectin, galactoside-binding, soluble, 3 3.3664
ATG4A autophagy related 4A, cysteine peptidase 3.3664
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 3.3664
SPX spexin hormone 3.3664
NRG4 neuregulin 4 3.3664
CATSPERQ catsper channel auxiliary subunit theta 3.3664
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 3.3664
KY kyphoscoliosis peptidase 3.3664
RAG1 recombination activating gene 1 3.3664
C1ORF74 chromosome 1 open reading frame 74 3.3664
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 3.3664
ZNF441 zinc finger protein 441 3.3664
SPATA22 spermatogenesis associated 22 3.3664
ZNF705D zinc finger protein 705D 3.3664
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 3.3664
SEPTIN4 septin 4 3.3664
POU2AF3 POU class 2 homeobox associating factor 3 3.3664
SPMAP2L sperm microtubule associated protein 2 like 3.3664
ZNF593OS ZNF593 opposite strand 3.3664
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 3.3664
FYB2 FYN binding protein 2 3.3664
TEX46 testis expressed 46 3.3664
H4C13 H4 clustered histone 13 3.3664
ALKAL1 ALK and LTK ligand 1 3.3664
KASH5 KASH domain containing 5 3.3664
BNIP5 BCL2 interacting protein 5 3.3664
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 3.3664
PCDHGC3 protocadherin gamma subfamily C, 3 3.3664
BBS5 Bardet-Biedl syndrome 5 3.3664
ACMSD aminocarboxymuconate semialdehyde decarboxylase 3.3664
CLDN2 claudin 2 3.3664
TMIE transmembrane inner ear 3.3664
KLHL31 kelch-like family member 31 3.3664
CAPN11 calpain 11 3.3664
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 3.3664
JOSD2 Josephin domain containing 2 3.3664
VTN vitronectin 3.3664
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 3.3664
CLIP4 CAP-GLY domain containing linker protein family, member 4 3.3664
CFAP52 cilia and flagella associated protein 52 3.3664
PNPLA1 patatin-like phospholipase domain containing 1 3.3664
ZAR1L zygote arrest 1-like 3.3664
BARX1 BARX homeobox 1 3.3664
TACR2 tachykinin receptor 2 3.3664
CFAP45 cilia and flagella associated protein 45 3.3664
TACSTD2 tumor-associated calcium signal transducer 2 3.3664
CD79B CD79b molecule, immunoglobulin-associated beta 3.3664
ACTA1 actin, alpha 1, skeletal muscle 3.3664
CHRND cholinergic receptor, nicotinic, delta (muscle) 3.3664
JSRP1 junctional sarcoplasmic reticulum protein 1 3.3664
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 3.3664
PCDHGB6 protocadherin gamma subfamily B, 6 3.3664
ZNF365 zinc finger protein 365 3.3664
MYADML2 myeloid-associated differentiation marker-like 2 3.3664
IRGM immunity-related GTPase family, M 3.3664
BMX BMX non-receptor tyrosine kinase 3.3664
SNX31 sorting nexin 31 3.3664
CEACAM19 carcinoembryonic antigen-related cell adhesion molecule 19 3.3664
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 3.3664
KLK2 kallikrein-related peptidase 2 3.3664
PRSS55 protease, serine, 55 3.3664
EBF2 early B-cell factor 2 3.3664
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 3.3664
TBC1D26 TBC1 domain family, member 26 3.3664
ARHGAP20 Rho GTPase activating protein 20 3.3664
GAB4 GRB2-associated binding protein family, member 4 3.3664
C1ORF105 chromosome 1 open reading frame 105 3.3664
MAP3K19 mitogen-activated protein kinase kinase kinase 19 3.3664
TIGD6 tigger transposable element derived 6 3.3664
DCLK3 doublecortin-like kinase 3 3.3664
DPRX divergent-paired related homeobox 3.3664
OR4D1 olfactory receptor, family 4, subfamily D, member 1 3.3664
AGXT2 alanine--glyoxylate aminotransferase 2 3.3664
CD53 CD53 molecule 3.3664
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 3.3664
EDN3 endothelin 3 3.3664
PRSS33 protease, serine, 33 3.3664
CRHBP corticotropin releasing hormone binding protein 3.3664
LDLRAD2 low density lipoprotein receptor class A domain containing 2 3.3664
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 3.3664
CLIC2 chloride intracellular channel 2 3.3664
AK8 adenylate kinase 8 3.3664
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 3.3664
CD101 CD101 molecule 3.3664
PARP15 poly (ADP-ribose) polymerase family, member 15 3.3664
SLCO1C1 solute carrier organic anion transporter family, member 1C1 3.3664
ASCL3 achaete-scute family bHLH transcription factor 3 3.3664
NTF4 neurotrophin 4 3.3664
NELL1 NEL-like 1 (chicken) 3.3664
PF4V1 platelet factor 4 variant 1 3.3664
PGM5 phosphoglucomutase 5 3.3664
ANGPTL7 angiopoietin-like 7 3.3664
MMP19 matrix metallopeptidase 19 3.3664
SDSL serine dehydratase-like 3.3664
TNMD tenomodulin 3.3664
MYOZ1 myozenin 1 3.3664
TM4SF19 transmembrane 4 L six family member 19 3.3664
KIF12 kinesin family member 12 3.3664
ASCL5 achaete-scute family bHLH transcription factor 5 3.3664
PCDHA13 protocadherin alpha 13 3.3664
ADRA2B adrenoceptor alpha 2B 3.3664
ALS2CL ALS2 C-terminal like 3.3664
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B 3.3664
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 3.3664
MEIS1 Meis homeobox 1 3.3664
ROM1 retinal outer segment membrane protein 1 3.3664
BCO1 beta-carotene oxygenase 1 3.3664
PLA1A phospholipase A1 member A 3.3664
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 3.3664
TICAM1 toll-like receptor adaptor molecule 1 3.3664
FSTL3 follistatin-like 3 (secreted glycoprotein) 3.3664
SCUBE2 signal peptide, CUB domain, EGF-like 2 3.26554
TRPV4 transient receptor potential cation channel, subfamily V, member 4 3.26554
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 3.23023
ZBTB44 zinc finger and BTB domain containing 44 3.19387
BICD1 bicaudal D homolog 1 (Drosophila) 3.19387
ANKRD10 ankyrin repeat domain 10 3.17738
SYT14 synaptotagmin XIV 3.14372
GCN1 GCN1 activator of EIF2AK4 3.12454
TRIP11 thyroid hormone receptor interactor 11 3.04033
MACO1 macoilin 1 2.76649
ELL elongation factor RNA polymerase II 2.72999
SHLD2 shieldin complex subunit 2 2.71361
FBXO6 F-box protein 6 2.64251
CLDN15 claudin 15 2.62687
H2BC18 H2B clustered histone 18 2.62687
PLAGL1 pleiomorphic adenoma gene-like 1 2.61736
ZNF225 zinc finger protein 225 2.58018
NPFFR2 neuropeptide FF receptor 2 2.58018
POU2F3 POU class 2 homeobox 3 2.58018
API5 apoptosis inhibitor 5 2.54924
LZTR1 leucine-zipper-like transcription regulator 1 2.48402
LRRN3 leucine rich repeat neuronal 3 2.48402
ZNF57 zinc finger protein 57 2.48402
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 2.48402
RHBDF1 rhomboid 5 homolog 1 (Drosophila) 2.48402
GAS1 growth arrest-specific 1 2.48402
SSTR2 somatostatin receptor 2 2.48402
ADGRL3 adhesion G protein-coupled receptor L3 2.38613
SP3 Sp3 transcription factor 2.38276
SLC44A2 solute carrier family 44 (choline transporter), member 2 2.36261
TMEM60 transmembrane protein 60 2.29737
NSFL1C NSFL1 (p97) cofactor (p47) 2.29169
WNT2B wingless-type MMTV integration site family, member 2B 2.27611
RAB4B RAB4B, member RAS oncogene family 2.26291
FKBP7 FK506 binding protein 7 2.24026
RMDN2 regulator of microtubule dynamics 2 2.22505
TMEM276 transmembrane protein 276 2.22501
SVIP small VCP/p97-interacting protein 2.22501
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 2.21236
RGS14 regulator of G-protein signaling 14 2.21064
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 2.1987
FBXO31 F-box protein 31 2.19488
RABGGTB Rab geranylgeranyltransferase, beta subunit 2.17546
HAAO 3-hydroxyanthranilate 3,4-dioxygenase 2.1656
FAM227A family with sequence similarity 227, member A 2.15643
PDXP pyridoxal (pyridoxine, vitamin B6) phosphatase 2.12424
MRPL30 mitochondrial ribosomal protein L30 2.1193
KNL1 kinetochore scaffold 1 2.11731
NOS1 nitric oxide synthase 1 (neuronal) 2.10603
XRN1 5'-3' exoribonuclease 1 2.10033
IFT57 intraflagellar transport 57 2.10033
NUP98 nucleoporin 98kDa 2.10033
CCNT1 cyclin T1 2.09722
WDR19 WD repeat domain 19 2.09014
LCA5L Leber congenital amaurosis 5-like 2.08834
GPBP1L1 GC-rich promoter binding protein 1-like 1 2.08159
PARL presenilin associated, rhomboid-like 2.06736
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.06446
GSTCD glutathione S-transferase, C-terminal domain containing 2.05179
PDZD11 PDZ domain containing 11 2.04587
PODXL podocalyxin-like 2.04113
GOLIM4 golgi integral membrane protein 4 2.03283
ADD2 adducin 2 (beta) 2.031
CTNS cystinosin, lysosomal cystine transporter 2.031
TMEM67 transmembrane protein 67 2.02537
ASIC2 acid sensing (proton gated) ion channel 2 2.02431
PRMT9 protein arginine methyltransferase 9 2.02358
CCDC88A coiled-coil domain containing 88A 2.01933

decreased expression

Symbol Name Standardized Value
PROCR protein C receptor, endothelial -3.3664
DXO decapping exoribonuclease -3.3664
HDAC11 histone deacetylase 11 -3.3664
JUNB jun B proto-oncogene -3.3664
FAM174A family with sequence similarity 174, member A -3.3664
ANKRD34B ankyrin repeat domain 34B -3.3664
SMOX spermine oxidase -3.3664
WFDC10B WAP four-disulfide core domain 10B -3.3664
GPR153 G protein-coupled receptor 153 -3.3664
WFDC3 WAP four-disulfide core domain 3 -3.3664
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -3.26536
MTX2 metaxin 2 -3.18017
TOGARAM2 TOG array regulator of axonemal microtubules 2 -3.17197
COL4A1 collagen, type IV, alpha 1 -2.94736
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.90998
UBXN11 UBX domain protein 11 -2.7463
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma -2.74032
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa -2.73369
THPO thrombopoietin -2.58018
PPM1M protein phosphatase, Mg2+/Mn2+ dependent, 1M -2.58018
SNPH syntaphilin -2.58018
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F -2.58018
PGBD2 piggyBac transposable element derived 2 -2.58018
MYO1H myosin IH -2.58018
ZNF572 zinc finger protein 572 -2.58018
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 -2.58018
APC2 adenomatosis polyposis coli 2 -2.58018
ARSD arylsulfatase D -2.58018
SLC16A6 solute carrier family 16, member 6 -2.58018
DUSP15 dual specificity phosphatase 15 -2.58018
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 -2.58018
GGT7 gamma-glutamyltransferase 7 -2.58018
HID1 HID1 domain containing -2.58018
LCMT2 leucine carboxyl methyltransferase 2 -2.58018
RP1L1 retinitis pigmentosa 1-like 1 -2.58018
ADPRHL1 ADP-ribosylhydrolase like 1 -2.58018
ZNF774 zinc finger protein 774 -2.58018
H4C4 H4 clustered histone 4 -2.58018
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -2.58018
SPDYE21 speedy/RINGO cell cycle regulator family member E21 -2.58018
ACKR4 atypical chemokine receptor 4 -2.58018
CCDC158 coiled-coil domain containing 158 -2.58018
UNC5CL unc-5 homolog C (C. elegans)-like -2.58018
KRTDAP keratinocyte differentiation-associated protein -2.58018
P2RY12 purinergic receptor P2Y, G-protein coupled, 12 -2.58018
TMSB15C thymosin beta 15C -2.58018
CD247 CD247 molecule -2.58018
C6ORF47 chromosome 6 open reading frame 47 -2.58018
H3C6 H3 clustered histone 6 -2.58018
FCRLB Fc receptor-like B -2.58018
DYDC2 DPY30 domain containing 2 -2.58018
FAM89B family with sequence similarity 89, member B -2.48144
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 -2.48144
IL7 interleukin 7 -2.48144
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 -2.48144
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -2.48144
ZBTB32 zinc finger and BTB domain containing 32 -2.48144
VRK3 vaccinia related kinase 3 -2.42934
PRDX4 peroxiredoxin 4 -2.41999
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -2.41284
TTC1 tetratricopeptide repeat domain 1 -2.40304
SMAD7 SMAD family member 7 -2.40304
NEMP1 nuclear envelope integral membrane protein 1 -2.32228
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 -2.31451
DDR1 discoidin domain receptor tyrosine kinase 1 -2.31451
CHLSN cholesin -2.31451
WNK2 WNK lysine deficient protein kinase 2 -2.31095
EDC3 enhancer of mRNA decapping 3 -2.30868
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -2.29737
EFNA4 ephrin-A4 -2.29109
METRNL meteorin, glial cell differentiation regulator-like -2.28908
CKS2 CDC28 protein kinase regulatory subunit 2 -2.27294
ZFP37 ZFP37 zinc finger protein -2.26529
CUTC cutC copper transporter -2.26291
PPDPF pancreatic progenitor cell differentiation and proliferation factor -2.25117
NIP7 NIP7, nucleolar pre-rRNA processing protein -2.24495
CRBN cereblon -2.21064
GPRC5C G protein-coupled receptor, class C, group 5, member C -2.21064
SMG9 SMG9 nonsense mediated mRNA decay factor -2.21064
CD163L1 CD163 molecule-like 1 -2.21064
FAM241A family with sequence similarity 241 member A -2.21064
PPP1R37 protein phosphatase 1, regulatory subunit 37 -2.21064
BTBD6 BTB (POZ) domain containing 6 -2.21064
PPP1R17 protein phosphatase 1, regulatory subunit 17 -2.21064
PILRA paired immunoglobin-like type 2 receptor alpha -2.20665
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -2.15984
NAE1 NEDD8 activating enzyme E1 subunit 1 -2.14752
HSPA9 heat shock 70kDa protein 9 (mortalin) -2.14077
PHF5A PHD finger protein 5A -2.08941
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -2.05169
ZNF439 zinc finger protein 439 -2.04587
MXD1 MAX dimerization protein 1 -2.03741
LRFN2 leucine rich repeat and fibronectin type III domain containing 2 -2.031
GOLGA1 golgin A1 -2.031
PLEC plectin -2.031
FDX1 ferredoxin 1 -2.031
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) -2.02854
ZNF142 zinc finger protein 142 -2.02571
RECQL5 RecQ protein-like 5 -2.02537
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.02537
C4ORF36 chromosome 4 open reading frame 36 -2.02537
H1-1 H1.1 linker histone, cluster member -2.02537
ANKRD42 ankyrin repeat domain 42 -2.02537
HLA-F major histocompatibility complex, class I, F -2.02537
DEPTOR DEP domain containing MTOR-interacting protein -2.02358
HELZ2 helicase with zinc finger 2, transcriptional coactivator -2.02358
DGKI diacylglycerol kinase, iota -2.02358
ZDHHC16 zinc finger, DHHC-type containing 16 -2.02358
MADD MAP-kinase activating death domain -2.01315
PHKG2 phosphorylase kinase, gamma 2 (testis) -2.01055