PAM Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description peptidylglycine alpha-amidating monooxygenase|This gene encodes a multifunctional protein. It has two enzymatically active domains with catalytic activities - peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL). These catalytic domains work sequentially to catalyze neuroendocrine peptides to active alpha-amidated products. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene but some of their full length sequences are not yet known. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5066)
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Genes

331 genes differentially expressed following the PAM gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2.24973
WDR97 WD repeat domain 97 2.24973
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2.24973
INHBC inhibin, beta C 2.24973
WAS Wiskott-Aldrich syndrome 2.24973
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 2.24973
RIPPLY2 ripply transcriptional repressor 2 2.24973
TMEM86B transmembrane protein 86B 2.24973
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 2.24973
GPR149 G protein-coupled receptor 149 2.24973
PTGFR prostaglandin F receptor (FP) 2.24973
FBXO39 F-box protein 39 2.24973
TGFB2 transforming growth factor, beta 2 2.24973
ZFYVE27 zinc finger, FYVE domain containing 27 2.24973
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.24973
UNC13C unc-13 homolog C (C. elegans) 2.24973
WNT2 wingless-type MMTV integration site family member 2 2.24973
ADRB1 adrenoceptor beta 1 2.24973
ABRA actin binding Rho activating protein 2.24973
PI16 peptidase inhibitor 16 2.23902
A4GALT alpha 1,4-galactosyltransferase 2.23902
DUXB double homeobox B 2.23902
AKR1C2 aldo-keto reductase family 1, member C2 2.23902
ZEB2 zinc finger E-box binding homeobox 2 2.23902
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.23902
UHMK1 U2AF homology motif (UHM) kinase 1 2.23902
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 2.23902
MBNL3 muscleblind-like splicing regulator 3 2.23902
TMPRSS11F transmembrane protease, serine 11F 2.23902
TMPRSS11E transmembrane protease, serine 11E 2.23902
RNF17 ring finger protein 17 2.23902
CD5 CD5 molecule 2.23902
SOX1 SRY (sex determining region Y)-box 1 2.23902
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 2.23902
FGF21 fibroblast growth factor 21 2.23902
ADRB2 adrenoceptor beta 2, surface 2.23902
PON1 paraoxonase 1 2.23902
TCAF2 TRPM8 channel-associated factor 2 2.23902
FAM221B family with sequence similarity 221, member B 2.23902
ADAMTSL5 ADAMTS-like 5 2.23902
SHD Src homology 2 domain containing transforming protein D 2.23902
PNOC prepronociceptin 2.23902
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 2.23902
IL2RG interleukin 2 receptor, gamma 2.23902
MPL MPL proto-oncogene, thrombopoietin receptor 2.23902
HCRTR2 hypocretin (orexin) receptor 2 2.23902
TMEM151A transmembrane protein 151A 2.23902
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 2.23902
OSGIN1 oxidative stress induced growth inhibitor 1 2.23902
PNMA5 paraneoplastic Ma antigen family member 5 2.23902
PERM1 PPARGC1 and ESRR induced regulator, muscle 1 2.23902
LRRC52 leucine rich repeat containing 52 2.23902
APOA2 apolipoprotein A-II 2.23902
CEP295NL CEP295 N-terminal like 2.23902
ASB17 ankyrin repeat and SOCS box containing 17 2.23902
OLFM4 olfactomedin 4 2.23902
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 2.23902
PRB4 proline-rich protein BstNI subfamily 4 2.23902
LRTM3 leucine rich repeat transmembrane protein 3 2.23902
GOLGA6L7 golgin A6 family like 7 2.23902
TYROBP TYRO protein tyrosine kinase binding protein 2.23902
CLDN14 claudin 14 2.23902
CXCL13 chemokine (C-X-C motif) ligand 13 2.23902
SPEM1 spermatid maturation 1 2.23902
TCERG1L transcription elongation regulator 1-like 2.23902
RNF227 ring finger protein 227 2.23902
POM121L2 POM121 transmembrane nucleoporin-like 2 2.23902
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 2.23902
MIOX myo-inositol oxygenase 2.23902
H1-6 H1.6 linker histone, cluster member 2.23902
H3-5 H3.5 histone 2.23902
FAM90A11 family with sequence similarity 90 member A11 2.23902
SPMAP2L sperm microtubule associated protein 2 like 2.23902
OR2I1 olfactory receptor family 2 subfamily I member 1 (gene/pseudogene) 2.23902
LY6S lymphocyte antigen 6 family member S 2.23902
C19ORF85 chromosome 19 open reading frame 85 2.23902
PNMA8C PNMA family member 8C 2.23902
CALHM4 calcium homeostasis modulator family member 4 2.23902
IHO1 interactor of HORMAD1 1 2.23902
CCN6 cellular communication network factor 6 2.23902
ANGPTL8 angiopoietin like 8 2.23902
C10ORF53 chromosome 10 open reading frame 53 2.23902
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 2.23902
ZNF257 zinc finger protein 257 2.23902
TLR7 toll-like receptor 7 2.23902
PRKCD protein kinase C, delta 2.23902
C1ORF162 chromosome 1 open reading frame 162 2.23902
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.23902
PTP4A1 protein tyrosine phosphatase type IVA, member 1 2.23902
CATSPER3 cation channel, sperm associated 3 2.23902
LIX1 Lix1 homolog (chicken) 2.23902
SCN10A sodium channel, voltage gated, type X alpha subunit 2.23902
GAS1 growth arrest-specific 1 2.23902
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.23902
STK24 serine/threonine kinase 24 2.23902
GATA1 GATA binding protein 1 (globin transcription factor 1) 2.23902
MROH5 maestro heat-like repeat family member 5 2.23902
LTB lymphotoxin beta (TNF superfamily, member 3) 2.23902
RBPMS RNA binding protein with multiple splicing 2.23902
TMEM117 transmembrane protein 117 2.23902
LRRC71 leucine rich repeat containing 71 2.23902
HAL histidine ammonia-lyase 2.23902
C7 complement component 7 2.23902
NR0B1 nuclear receptor subfamily 0, group B, member 1 2.23902
PIWIL3 piwi-like RNA-mediated gene silencing 3 2.23902
ZSWIM2 zinc finger, SWIM-type containing 2 2.23902
MYO1A myosin IA 2.23902
PRSS54 protease, serine, 54 2.23902
C11ORF97 chromosome 11 open reading frame 97 2.23902
ZNF783 zinc finger family member 783 2.23902
PCP2 Purkinje cell protein 2 2.23902
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.23902
TBC1D10C TBC1 domain family, member 10C 2.23902
TDRD10 tudor domain containing 10 2.23902
NPFFR1 neuropeptide FF receptor 1 2.23902
PSKH2 protein serine kinase H2 2.23902
TTC9B tetratricopeptide repeat domain 9B 2.23902
GPR12 G protein-coupled receptor 12 2.23902
EFCAB3 EF-hand calcium binding domain 3 2.23902
EDN3 endothelin 3 2.23902
ZNF670 zinc finger protein 670 2.23902
TSPAN32 tetraspanin 32 2.23902
SPRN shadow of prion protein homolog (zebrafish) 2.23902
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.23902
ZNF474 zinc finger protein 474 2.23902
LRRC32 leucine rich repeat containing 32 2.23902
TMCC3 transmembrane and coiled-coil domain family 3 2.23902
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 2.23902
OR56A3 olfactory receptor, family 56, subfamily A, member 3 2.23902
DRD2 dopamine receptor D2 2.23902
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) 2.23902
URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase 2.23902
CLEC1A C-type lectin domain family 1, member A 2.23902
TSPAN19 tetraspanin 19 2.23902
CLMP CXADR-like membrane protein 2.23902
GJB6 gap junction protein, beta 6, 30kDa 2.23902
DIAPH2 diaphanous-related formin 2 2.23902
ADAM18 ADAM metallopeptidase domain 18 2.23902
CLEC18A C-type lectin domain family 18, member A 2.23902
EOMES eomesodermin 2.23902
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 2.23902
CLEC1B C-type lectin domain family 1, member B 2.23902
HAND2 heart and neural crest derivatives expressed 2 2.23902
OTOP1 otopetrin 1 2.23902
PRR23A proline rich 23A 2.23902
TAT tyrosine aminotransferase 2.23902
PCDH17 protocadherin 17 2.23902
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 2.23902
SVOP SV2 related protein homolog (rat) 2.23902
TBX1 T-box 1 2.23902
LY96 lymphocyte antigen 96 2.23902
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) 2.23902
RASL11B RAS-like, family 11, member B 2.23902
PHOX2A paired-like homeobox 2a 2.23902
DMTN dematin actin binding protein 2.23902
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 2.23902
DNAH8 dynein, axonemal, heavy chain 8 2.23902
NKPD1 NTPase, KAP family P-loop domain containing 1 2.23902
TAS2R41 taste receptor, type 2, member 41 2.23902
PADI4 peptidyl arginine deiminase, type IV 2.23902
LARP1B La ribonucleoprotein domain family, member 1B 2.23902
FRMPD1 FERM and PDZ domain containing 1 2.23902
GHRH growth hormone releasing hormone 2.23902
FOXP3 forkhead box P3 2.23902
ZNF648 zinc finger protein 648 2.23902
AMPD1 adenosine monophosphate deaminase 1 2.23902
MYL7 myosin, light chain 7, regulatory 2.23902
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 2.23902
LOC102724877 uncharacterized LOC102724877 2.23902
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 2.23902
PANO1 proapoptotic nucleolar protein 1 2.23902
CPLX4 complexin 4 2.23902
TPRX1 tetra-peptide repeat homeobox 1 2.23902
PSD2 pleckstrin and Sec7 domain containing 2 2.23902
DMRTC1 DMRT-like family C1 2.23902
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 2.23902
GLT6D1 glycosyltransferase 6 domain containing 1 2.23902
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 2.23902
LPAR5 lysophosphatidic acid receptor 5 2.23902
GPBAR1 G protein-coupled bile acid receptor 1 2.23902
C9ORF57 chromosome 9 open reading frame 57 2.23902
CD8A CD8a molecule 2.23902
ANKRD33 ankyrin repeat domain 33 2.23902
GTF3A general transcription factor IIIA 2.23902
VCAM1 vascular cell adhesion molecule 1 2.23902
PRAP1 proline-rich acidic protein 1 2.23902
TMEM86A transmembrane protein 86A 2.23902
TRIM29 tripartite motif containing 29 2.23902
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 2.19189
ANKRD12 ankyrin repeat domain 12 2.17765
RBMS1 RNA binding motif, single stranded interacting protein 1 2.14091
CCNYL1 cyclin Y-like 1 2.12816
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1 2.12435
EML3 echinoderm microtubule associated protein like 3 2.12235
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 2.09871
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 2.0938
TTC32 tetratricopeptide repeat domain 32 2.09049
PRH1 proline-rich protein HaeIII subfamily 1 2.08851
RSL1D1 ribosomal L1 domain containing 1 2.08275
CORO2B coronin, actin binding protein, 2B 2.08056
KIRREL1 kirre like nephrin family adhesion molecule 1 2.08056
RNF44 ring finger protein 44 2.0799
PDPK1 3-phosphoinositide dependent protein kinase 1 2.0799
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase 2.07568
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 2.0698
SPTB spectrin, beta, erythrocytic 2.06231
PRR3 proline rich 3 2.05992
CASC3 cancer susceptibility candidate 3 2.04992
OLFML2B olfactomedin-like 2B 2.04847
PNN pinin, desmosome associated protein 2.04111
ZNF114 zinc finger protein 114 2.03431
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 2.03355
GLMN glomulin, FKBP associated protein 2.03235
RIOK2 RIO kinase 2 2.0073
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 2.005

decreased expression

Symbol Name Standardized Value
SHMT1 serine hydroxymethyltransferase 1 (soluble) -2.24973
LCP1 lymphocyte cytosolic protein 1 (L-plastin) -2.24973
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 -2.24973
PAM peptidylglycine alpha-amidating monooxygenase -2.24973
ALG2 ALG2, alpha-1,3/1,6-mannosyltransferase -2.24973
CTDNEP1 CTD nuclear envelope phosphatase 1 -2.24973
MRPL52 mitochondrial ribosomal protein L52 -2.23902
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 -2.23902
RPS14 ribosomal protein S14 -2.23902
PCDHB12 protocadherin beta 12 -2.23902
CUEDC2 CUE domain containing 2 -2.23902
PHLDA3 pleckstrin homology-like domain, family A, member 3 -2.23902
PRDM4 PR domain containing 4 -2.23902
MAP3K10 mitogen-activated protein kinase kinase kinase 10 -2.23902
KLF12 Kruppel-like factor 12 -2.23902
EEF1G eukaryotic translation elongation factor 1 gamma -2.23902
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.23902
RYR3 ryanodine receptor 3 -2.23902
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.23902
TRAF1 TNF receptor-associated factor 1 -2.23902
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -2.23902
ALOX12 arachidonate 12-lipoxygenase -2.23902
WRNIP1 Werner helicase interacting protein 1 -2.23902
HDIP1 HDAC and MIER1 interacting protein 1 -2.23902
ARHGAP40 Rho GTPase activating protein 40 -2.23902
SDR42E1 short chain dehydrogenase/reductase family 42E, member 1 -2.23902
TMEM263 transmembrane protein 263 -2.23902
GFUS GDP-L-fucose synthase -2.23902
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 -2.23902
HPCA hippocalcin -2.23902
PCNX1 pecanex 1 -2.23902
GRHPR glyoxylate reductase/hydroxypyruvate reductase -2.23902
UNG uracil-DNA glycosylase -2.23902
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 -2.23902
MRPL2 mitochondrial ribosomal protein L2 -2.23902
COQ5 coenzyme Q5 homolog, methyltransferase (S. cerevisiae) -2.19189
MBD6 methyl-CpG binding domain protein 6 -2.17148
HARBI1 harbinger transposase derived 1 -2.17148
TTLL10 tubulin tyrosine ligase-like family member 10 -2.17148
NPY5R neuropeptide Y receptor Y5 -2.17148
SSBP1 single-stranded DNA binding protein 1, mitochondrial -2.16651
ZNF263 zinc finger protein 263 -2.16143
SMIM36 small integral membrane protein 36 -2.1601
APTX aprataxin -2.1601
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 -2.1601
FAM86B2 family with sequence similarity 86, member B2 -2.1601
MFAP3 microfibrillar-associated protein 3 -2.1601
ZBTB16 zinc finger and BTB domain containing 16 -2.1601
SLC25A45 solute carrier family 25, member 45 -2.1601
GPR83 G protein-coupled receptor 83 -2.1601
CLDN5 claudin 5 -2.1601
CATSPER4 cation channel, sperm associated 4 -2.1601
LTBP3 latent transforming growth factor beta binding protein 3 -2.1601
SCRT2 scratch family zinc finger 2 -2.1601
SMIM45 small integral membrane protein 45 -2.1601
LEF1 lymphoid enhancer-binding factor 1 -2.1601
C6ORF118 chromosome 6 open reading frame 118 -2.1601
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 -2.1601
FOXI2 forkhead box I2 -2.1601
HES3 hes family bHLH transcription factor 3 -2.1601
LONRF3 LON peptidase N-terminal domain and ring finger 3 -2.1601
MRO maestro -2.1601
RELN reelin -2.1601
CIRBP cold inducible RNA binding protein -2.1601
NELFA negative elongation factor complex member A -2.1601
DIAPH1 diaphanous-related formin 1 -2.1601
MAMLD1 mastermind-like domain containing 1 -2.1601
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 -2.1601
CHAD chondroadherin -2.1601
CAMK2A calcium/calmodulin-dependent protein kinase II alpha -2.1601
S100A14 S100 calcium binding protein A14 -2.1601
ANKDD1B ankyrin repeat and death domain containing 1B -2.1601
OCM oncomodulin -2.1601
SMYD5 SMYD family member 5 -2.1601
DNAH2 dynein, axonemal, heavy chain 2 -2.1601
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 -2.1601
HUS1B HUS1 checkpoint homolog b (S. pombe) -2.1601
SYNGR3 synaptogyrin 3 -2.14364
TRAPPC9 trafficking protein particle complex 9 -2.13832
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -2.13832
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 -2.13197
ATP5PF ATP synthase peripheral stalk subunit F6 -2.12816
PHACTR1 phosphatase and actin regulator 1 -2.12135
ERC1 ELKS/RAB6-interacting/CAST family member 1 -2.11641
IFT38 intraflagellar transport 38 -2.10289
SLC25A30 solute carrier family 25, member 30 -2.10289
RELL1 RELT-like 1 -2.10289
NUMBL numb homolog (Drosophila)-like -2.10234
HMGN1 high mobility group nucleosome binding domain 1 -2.10115
SMAD4 SMAD family member 4 -2.09884
IL27RA interleukin 27 receptor, alpha -2.09871
FBXO46 F-box protein 46 -2.09635
ACTR5 ARP5 actin-related protein 5 homolog (yeast) -2.09049
ERBB3 erb-b2 receptor tyrosine kinase 3 -2.09
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 -2.0799
TRAPPC14 trafficking protein particle complex subunit 14 -2.07568
RNF123 ring finger protein 123 -2.07568
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 -2.07034
ELL3 elongation factor RNA polymerase II-like 3 -2.0698
TTLL9 tubulin tyrosine ligase-like family member 9 -2.0698
C3ORF49 chromosome 3 open reading frame 49 -2.0698
DDR1 discoidin domain receptor tyrosine kinase 1 -2.0698
PNP purine nucleoside phosphorylase -2.0698
CCNA1 cyclin A1 -2.05992
TRPV2 transient receptor potential cation channel, subfamily V, member 2 -2.05992
KCNK10 potassium channel, two pore domain subfamily K, member 10 -2.05992
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) -2.05326
SCARF1 scavenger receptor class F, member 1 -2.04111
MYOCD myocardin -2.02889
SNRPF small nuclear ribonucleoprotein polypeptide F -2.02523
CEP78 centrosomal protein 78kDa -2.02491
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa -2.01026
BNIPL BCL2/adenovirus E1B 19kD interacting protein like -2.00912
FAM186B family with sequence similarity 186, member B -2.00912
PPP2R1B protein phosphatase 2, regulatory subunit A, beta -2.00788
BCL10 B-cell CLL/lymphoma 10 -2.00171