| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/11302540 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in PAP-1 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| BCORL1 | BCL6 corepressor-like 1 | 3.16 |
| MAST1 | microtubule associated serine/threonine kinase 1 | 3.09 |
| LRP1 | low density lipoprotein receptor-related protein 1 | 3.02 |
| IFRD1 | interferon-related developmental regulator 1 | 2.07 |
| FRY | furry homolog (Drosophila) | 1.75 |
| AFAP1L1 | actin filament associated protein 1-like 1 | 1.57 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 1.49 |
| HSP90AB4P | heat shock protein 90kDa alpha (cytosolic), class B member 4, pseudogene | 1.49 |
| TINF2 | TERF1 (TRF1)-interacting nuclear factor 2 | 1.44 |
| ARFIP1 | ADP-ribosylation factor interacting protein 1 | 1.25 |
| RAB24 | RAB24, member RAS oncogene family | 1.23 |
| PHLDB3 | pleckstrin homology-like domain, family B, member 3 | 1.23 |
| SH3BGRL2 | SH3 domain binding glutamate-rich protein like 2 | 1.22 |
| GPRC5C | G protein-coupled receptor, class C, group 5, member C | 1.13 |
| MADD | MAP-kinase activating death domain | 1.13 |
| FOXJ3 | forkhead box J3 | 1.0 |
| TMEM38B | transmembrane protein 38B | 0.95 |
| HSPB1 | heat shock 27kDa protein 1 | 0.92 |
| PITRM1 | pitrilysin metallopeptidase 1 | 0.86 |
| TAF1B | TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa | 0.85 |
| LAMB1 | laminin, beta 1 | 0.81 |
| COBLL1 | cordon-bleu WH2 repeat protein-like 1 | 0.8 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.78 |
| PIP4P2 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 | 0.78 |
| AHR | aryl hydrocarbon receptor | 0.77 |
| PPP1R16A | protein phosphatase 1, regulatory subunit 16A | 0.72 |
| RMDN3 | regulator of microtubule dynamics 3 | 0.71 |
| FBXL14 | F-box and leucine-rich repeat protein 14 | 0.71 |
| TMEM205 | transmembrane protein 205 | 0.68 |
| ZBTB44 | zinc finger and BTB domain containing 44 | 0.67 |
| WDR41 | WD repeat domain 41 | 0.67 |
| JAK3 | Janus kinase 3 | 0.66 |
| ZBTB40 | zinc finger and BTB domain containing 40 | 0.66 |
| HSCB | HscB mitochondrial iron-sulfur cluster co-chaperone | 0.63 |
| ZRANB3 | zinc finger, RAN-binding domain containing 3 | 0.61 |
| ALG5 | ALG5, dolichyl-phosphate beta-glucosyltransferase | 0.6 |
| OTX1 | orthodenticle homeobox 1 | 0.59 |
| CDC42BPB | CDC42 binding protein kinase beta (DMPK-like) | 0.59 |
| DGCR2 | DiGeorge syndrome critical region gene 2 | 0.58 |
| MPV17 | MpV17 mitochondrial inner membrane protein | 0.58 |
| EEF1AKMT4-ECE2 | EEF1AKMT4-ECE2 readthrough | 0.55 |
| ACTN2 | actinin, alpha 2 | 0.55 |
| MGAT4B | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B | 0.53 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.53 |
| SEPTIN7 | septin 7 | 0.53 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.52 |
| TMEM135 | transmembrane protein 135 | 0.51 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.5 |
| AKAP17A | A kinase (PRKA) anchor protein 17A | 0.5 |
| IL10RB | interleukin 10 receptor, beta | 0.5 |
| POLQ | polymerase (DNA directed), theta | 0.49 |
| PVR | poliovirus receptor | 0.49 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.49 |
| POLR2M | polymerase (RNA) II (DNA directed) polypeptide M | 0.49 |
| GDA | guanine deaminase | 0.48 |
| C12ORF4 | chromosome 12 open reading frame 4 | 0.48 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | 0.48 |
| SECISBP2L | SECIS binding protein 2-like | 0.48 |
| CCDC57 | coiled-coil domain containing 57 | 0.47 |
| TMEM183B | transmembrane protein 183B | 0.47 |
| RAB5B | RAB5B, member RAS oncogene family | 0.47 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.46 |
| PCNX1 | pecanex 1 | 0.46 |
| CIC | capicua transcriptional repressor | 0.46 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.45 |
| CHD8 | chromodomain helicase DNA binding protein 8 | 0.45 |
| WRB | tryptophan rich basic protein | 0.45 |
| HTATSF1 | HIV-1 Tat specific factor 1 | 0.45 |
| LRRC8D | leucine rich repeat containing 8 family, member D | 0.44 |
| MPDU1 | mannose-P-dolichol utilization defect 1 | 0.44 |
| HSP90AA4P | heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene | 0.44 |
| ZBTB45 | zinc finger and BTB domain containing 45 | 0.43 |
| FCHO1 | FCH domain only 1 | 0.43 |
| RNF170 | ring finger protein 170 | 0.43 |
| NAV3 | neuron navigator 3 | 0.41 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.41 |
| ZNF142 | zinc finger protein 142 | 0.4 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.39 |
| NDUFB7 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa | 0.39 |
| CRLF1 | cytokine receptor-like factor 1 | 0.39 |
| FBLIM1 | filamin binding LIM protein 1 | 0.39 |
| CLCN7 | chloride channel, voltage-sensitive 7 | 0.39 |
| GLRX | glutaredoxin (thioltransferase) | 0.38 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.38 |
| RAB8B | RAB8B, member RAS oncogene family | 0.38 |
| KIFC3 | kinesin family member C3 | 0.38 |
| KPNA5 | karyopherin alpha 5 (importin alpha 6) | 0.37 |
| ZNF706 | zinc finger protein 706 | 0.37 |
| GHDC | GH3 domain containing | 0.37 |
| TRIML2 | tripartite motif family-like 2 | 0.37 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.36 |
| TMEM208 | transmembrane protein 208 | 0.36 |
| TAF10 | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa | 0.36 |
| TP73 | tumor protein p73 | 0.36 |
| PRMT2IP | PRMT2 interacting protein | 0.36 |
| GOLGA4 | golgin A4 | 0.36 |
| CHKB | choline kinase beta | 0.35 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.35 |
| GCH1 | GTP cyclohydrolase 1 | 0.35 |
| FAU | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | 0.35 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FADS1 | fatty acid desaturase 1 | -1.34 |
| PIP | prolactin-induced protein | -1.3 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -1.29 |
| DUS4L | dihydrouridine synthase 4-like (S. cerevisiae) | -0.96 |
| WASF3 | WAS protein family, member 3 | -0.96 |
| DNPEP | aspartyl aminopeptidase | -0.84 |
| NCS1 | neuronal calcium sensor 1 | -0.82 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.81 |
| CAMK1 | calcium/calmodulin-dependent protein kinase I | -0.76 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.7 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.68 |
| SIRT7 | sirtuin 7 | -0.67 |
| LAMA3 | laminin, alpha 3 | -0.67 |
| FAM110C | family with sequence similarity 110, member C | -0.64 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | -0.62 |
| AGTRAP | angiotensin II receptor-associated protein | -0.62 |
| MRPS18C | mitochondrial ribosomal protein S18C | -0.61 |
| PRSS8 | protease, serine, 8 | -0.6 |
| ABCA7 | ATP-binding cassette, sub-family A (ABC1), member 7 | -0.56 |
| CALD1 | caldesmon 1 | -0.56 |
| NUTF2 | nuclear transport factor 2 | -0.55 |
| DENND2D | DENN/MADD domain containing 2D | -0.54 |
| SPTBN2 | spectrin, beta, non-erythrocytic 2 | -0.54 |
| TBX3 | T-box 3 | -0.54 |
| ARMCX5 | armadillo repeat containing, X-linked 5 | -0.53 |
| VIRMA | vir like m6A methyltransferase associated | -0.53 |
| EAPP | E2F-associated phosphoprotein | -0.52 |
| SPIN1 | spindlin 1 | -0.51 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -0.51 |
| GDF15 | growth differentiation factor 15 | -0.5 |
| ENO1 | enolase 1, (alpha) | -0.5 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.49 |
| HMGB2 | high mobility group box 2 | -0.49 |
| POLR2K | polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa | -0.48 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.48 |
| GTDC1 | glycosyltransferase-like domain containing 1 | -0.48 |
| MSANTD3 | Myb/SANT-like DNA-binding domain containing 3 | -0.47 |
| RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing | -0.47 |
| TXNL1 | thioredoxin-like 1 | -0.47 |
| LTBP3 | latent transforming growth factor beta binding protein 3 | -0.47 |
| GPR107 | G protein-coupled receptor 107 | -0.46 |
| MPP1 | membrane protein, palmitoylated 1, 55kDa | -0.46 |
| ANKRD40 | ankyrin repeat domain 40 | -0.45 |
| RBM4B | RNA binding motif protein 4B | -0.45 |
| TCEA2 | transcription elongation factor A (SII), 2 | -0.44 |
| SMAD3 | SMAD family member 3 | -0.44 |
| FIZ1 | FLT3-interacting zinc finger 1 | -0.44 |
| LTV1 | LTV1 ribosome biogenesis factor | -0.44 |
| EHF | ets homologous factor | -0.43 |
| IFT52 | intraflagellar transport 52 | -0.42 |
| ILF2 | interleukin enhancer binding factor 2 | -0.42 |
| UNC13C | unc-13 homolog C (C. elegans) | -0.42 |
| TMEM63A | transmembrane protein 63A | -0.42 |
| POM121C | POM121 transmembrane nucleoporin C | -0.42 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.42 |
| CSTF1 | cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa | -0.42 |
| HAUS7 | HAUS augmin-like complex, subunit 7 | -0.41 |
| FLNB | filamin B, beta | -0.41 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.41 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.4 |
| GATA2 | GATA binding protein 2 | -0.4 |
| NDOR1 | NADPH dependent diflavin oxidoreductase 1 | -0.4 |
| UCHL3 | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) | -0.4 |
| RHBDD1 | rhomboid domain containing 1 | -0.4 |
| MYL12B | myosin, light chain 12B, regulatory | -0.4 |
| PIGX | phosphatidylinositol glycan anchor biosynthesis, class X | -0.39 |
| SET | SET nuclear proto-oncogene | -0.39 |
| GOSR2 | golgi SNAP receptor complex member 2 | -0.39 |
| MATR3 | matrin 3 | -0.39 |
| METTL26 | methyltransferase like 26 | -0.39 |
| KIAA0232 | KIAA0232 | -0.38 |
| RGN | regucalcin | -0.38 |
| ING4 | inhibitor of growth family, member 4 | -0.38 |
| FAM86B2 | family with sequence similarity 86, member B2 | -0.38 |
| HBS1L | HBS1-like translational GTPase | -0.38 |
| LIPA | lipase A, lysosomal acid, cholesterol esterase | -0.37 |
| RPS27A | ribosomal protein S27a | -0.37 |
| KRTCAP3 | keratinocyte associated protein 3 | -0.37 |
| MCEE | methylmalonyl CoA epimerase | -0.37 |
| DESI1 | desumoylating isopeptidase 1 | -0.37 |
| RPS29 | ribosomal protein S29 | -0.37 |
| MSRB2 | methionine sulfoxide reductase B2 | -0.37 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.37 |
| CFAP410 | cilia and flagella associated protein 410 | -0.36 |
| ACTR6 | ARP6 actin-related protein 6 homolog (yeast) | -0.36 |
| VGF | VGF nerve growth factor inducible | -0.36 |
| FBN3 | fibrillin 3 | -0.36 |
| ABRACL | ABRA C-terminal like | -0.36 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | -0.36 |
| COX11 | COX11 cytochrome c oxidase copper chaperone | -0.36 |
| HMGN3 | high mobility group nucleosomal binding domain 3 | -0.36 |
| LCOR | ligand dependent nuclear receptor corepressor | -0.36 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.35 |
| APRT | adenine phosphoribosyltransferase | -0.35 |
| C16ORF70 | chromosome 16 open reading frame 70 | -0.35 |
| LYRM4 | LYR motif containing 4 | -0.35 |
| NMU | neuromedin U | -0.35 |
| GPN3 | GPN-loop GTPase 3 | -0.35 |
| ENTPD5 | ectonucleoside triphosphate diphosphohydrolase 5 | -0.35 |
| MICOS13 | mitochondrial contact site and cristae organizing system subunit 13 | -0.35 |
