PAPPA Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description pregnancy-associated plasma protein A, pappalysin 1|This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5069)
External Link http://www.ncbi.nlm.nih.gov/gene/5069
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Genes

72 interacting proteins for PAPPA from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACPP acid phosphatase, prostate
ADRA1B adrenoceptor alpha 1B
ALB albumin
AOAH acyloxyacyl hydrolase (neutrophil)
APOA1 apolipoprotein A-I
APOC1 apolipoprotein C-I
APOL1 apolipoprotein L, 1
ARMC2 armadillo repeat containing 2
ATF7IP activating transcription factor 7 interacting protein
BAZ1B bromodomain adjacent to zinc finger domain, 1B
C3 complement component 3
CDH12 cadherin 12, type 2 (N-cadherin 2)
CLU clusterin
CP ceruloplasmin (ferroxidase)
CTR9 CTR9, Paf1/RNA polymerase II complex component
ELAVL1 ELAV like RNA binding protein 1
ELN elastin
FASN fatty acid synthase
FGA fibrinogen alpha chain
FGFR1 fibroblast growth factor receptor 1
FN1 fibronectin 1
H2AFX H2A histone family, member X
HBA2 hemoglobin, alpha 2
HBB hemoglobin, beta
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IGFALS insulin-like growth factor binding protein, acid labile subunit
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGLC1 immunoglobulin lambda constant 1 (Mcg marker)
IGLL1 immunoglobulin lambda-like polypeptide 1
KLK3 kallikrein-related peptidase 3
KRT1 keratin 1, type II
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT7 keratin 7, type II
KRT9 keratin 9, type I
LTBP4 latent transforming growth factor beta binding protein 4
NUP214 nucleoporin 214kDa
OR5H6 olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)
OR8D2 olfactory receptor, family 8, subfamily D, member 2 (gene/pseudogene)
PDPK1 3-phosphoinositide dependent protein kinase 1
PLG plasminogen
PNMA2 paraneoplastic Ma antigen 2
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1
RFX7 regulatory factor X, 7
RTKN2 rhotekin 2
RUNX1 runt-related transcription factor 1
SAA4 serum amyloid A4, constitutive
SCAF1 SR-related CTD-associated factor 1
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SETDB2 SET domain, bifurcated 2
SKIL SKI-like proto-oncogene
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD9 SMAD family member 9
TGM4 transglutaminase 4
TIAM1 T-cell lymphoma invasion and metastasis 1
TNNI3 troponin I type 3 (cardiac)
TNS3 tensin 3
TTN titin
TTR transthyretin