PAPSS1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description 3'-phosphoadenosine 5'-phosphosulfate synthase 1|Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008] (NCBI Entrez Gene Database, 9061)
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Genes

341 genes differentially expressed following the PAPSS1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PTPRC protein tyrosine phosphatase, receptor type, C 4.0682
NAPSA napsin A aspartic peptidase 4.0682
LRRD1 leucine-rich repeats and death domain containing 1 4.0682
NPAP1 nuclear pore associated protein 1 4.0682
FGD2 FYVE, RhoGEF and PH domain containing 2 4.0682
FAM167A family with sequence similarity 167, member A 4.0682
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 4.0682
SCG2 secretogranin II 4.0682
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 4.0682
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 4.0682
PGBDF plakoglobin binding and degradation factor 4.0682
HLX H2.0-like homeobox 4.0682
TMEM212 transmembrane protein 212 4.0682
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 4.0682
RAB44 RAB44, member RAS oncogene family 4.0682
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 4.0682
TMEM229B transmembrane protein 229B 4.0682
ELAVL4 ELAV like neuron-specific RNA binding protein 4 4.0682
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 4.0682
TAS2R39 taste receptor, type 2, member 39 4.0682
KLHL34 kelch-like family member 34 4.0682
NCBP2L nuclear cap binding protein subunit 2-like 4.0682
FER1L6 fer-1-like family member 6 4.0682
PNMA5 paraneoplastic Ma antigen family member 5 4.0682
SIRPB1 signal-regulatory protein beta 1 4.0682
ZBTB42 zinc finger and BTB domain containing 42 4.0682
GCKR glucokinase (hexokinase 4) regulator 4.0682
TRPV2 transient receptor potential cation channel, subfamily V, member 2 4.0682
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 4.0682
UBA7 ubiquitin-like modifier activating enzyme 7 4.0682
ACTL7A actin-like 7A 4.0682
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 4.0682
S100A5 S100 calcium binding protein A5 4.0682
NPIPA3 nuclear pore complex interacting protein family, member A3 4.0682
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 4.0682
BFSP2 beaded filament structural protein 2, phakinin 4.0682
FAM221B family with sequence similarity 221, member B 4.0682
GPR22 G protein-coupled receptor 22 4.0682
UMOD uromodulin 4.0682
OR10A4 olfactory receptor, family 10, subfamily A, member 4 4.0682
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 4.0682
CABS1 calcium-binding protein, spermatid-specific 1 4.0682
LRRC55 leucine rich repeat containing 55 4.0682
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 4.0682
PAX6 paired box 6 4.0682
PAX7 paired box 7 4.0682
NEU4 sialidase 4 4.0682
SHCBP1L SHC SH2-domain binding protein 1-like 4.0682
TAS2R13 taste receptor, type 2, member 13 4.0682
LOC124901449 uncharacterized LOC124901449 4.0682
SMIM38 small integral membrane protein 38 4.0682
ANGPTL8 angiopoietin like 8 4.0682
SQOR sulfide quinone oxidoreductase 4.0682
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 4.0682
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 4.0682
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 4.0682
GBP2 guanylate binding protein 2, interferon-inducible 4.0682
C2ORF72 chromosome 2 open reading frame 72 4.0682
CLDN16 claudin 16 4.0682
GPR35 G protein-coupled receptor 35 4.0682
NSG2 neuronal vesicle trafficking associated 2 4.0682
ANKRD40CL ANKRD40 C-terminal like 4.0682
LOC107986837 uncharacterized LOC107986837 4.0682
CIMIP2A ciliary microtubule inner protein 2A 4.0682
EPCIP exosomal polycystin 1 interacting protein 4.0682
H2BK1 H2B.K variant histone 1 4.0682
LOC122526780 uncharacterized LOC122526780 4.0682
SMIM35 small integral membrane protein 35 4.0682
PPDPFL pancreatic progenitor cell differentiation and proliferation factor like 4.0682
DEFB131B defensin beta 131B 4.0682
VXN vexin 4.0682
AJM1 apical junction component 1 homolog 4.0682
MYH1 myosin, heavy chain 1, skeletal muscle, adult 4.0682
BNC1 basonuclin 1 4.0682
TBC1D3L TBC1 domain family, member 3L 4.0682
CCR8 chemokine (C-C motif) receptor 8 4.0682
EXOC3L4 exocyst complex component 3-like 4 4.0682
AWAT1 acyl-CoA wax alcohol acyltransferase 1 4.0682
C1ORF162 chromosome 1 open reading frame 162 4.0682
CXCL16 chemokine (C-X-C motif) ligand 16 4.0682
CD79A CD79a molecule, immunoglobulin-associated alpha 4.0682
GOLGA6L4 golgin A6 family-like 4 4.0682
MAG myelin associated glycoprotein 4.0682
ITK IL2-inducible T-cell kinase 4.0682
TUBA3D tubulin, alpha 3d 4.0682
CNTFR ciliary neurotrophic factor receptor 4.0682
TACR2 tachykinin receptor 2 4.0682
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 4.0682
OR1C1 olfactory receptor, family 1, subfamily C, member 1 4.0682
CFC1 cripto, FRL-1, cryptic family 1 4.0682
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 4.0682
KL klotho 4.0682
LTK leukocyte receptor tyrosine kinase 4.0682
COX8C cytochrome c oxidase subunit VIIIC 4.0682
LGSN lengsin, lens protein with glutamine synthetase domain 4.0682
ZAR1L zygote arrest 1-like 4.0682
UTS2 urotensin 2 4.0682
C1ORF87 chromosome 1 open reading frame 87 4.0682
LMOD3 leiomodin 3 (fetal) 4.0682
ERICH6 glutamate-rich 6 4.0682
SHOX2 short stature homeobox 2 4.0682
CCDC152 coiled-coil domain containing 152 4.0682
TG thyroglobulin 4.0682
CIDEA cell death-inducing DFFA-like effector a 4.0682
ANKRD62 ankyrin repeat domain 62 4.0682
TMIGD2 transmembrane and immunoglobulin domain containing 2 4.0682
RBM24 RNA binding motif protein 24 4.0682
PRRX1 paired related homeobox 1 4.0682
C22ORF42 chromosome 22 open reading frame 42 4.0682
FADS6 fatty acid desaturase 6 4.0682
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 4.0682
GLT6D1 glycosyltransferase 6 domain containing 1 4.0682
APOL3 apolipoprotein L, 3 4.0682
TRPM2 transient receptor potential cation channel, subfamily M, member 2 4.0682
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 4.0682
NTN5 netrin 5 4.0682
ZNF703 zinc finger protein 703 4.0682
OCM oncomodulin 4.0682
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 4.0682
LIME1 Lck interacting transmembrane adaptor 1 4.0682
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B 4.0682
FOXE3 forkhead box E3 4.0682
PRDM9 PR domain containing 9 4.0682
SFRP5 secreted frizzled-related protein 5 4.0682
PCDHGA3 protocadherin gamma subfamily A, 3 4.0682
EMP1 epithelial membrane protein 1 4.0682
ALOXE3 arachidonate lipoxygenase 3 4.0682
NPBWR1 neuropeptides B/W receptor 1 4.0682
FBXO40 F-box protein 40 4.0682
CD52 CD52 molecule 4.0682
CD53 CD53 molecule 4.0682
HPX hemopexin 4.0682
PHOX2A paired-like homeobox 2a 4.0682
NOX1 NADPH oxidase 1 4.0682
NOX3 NADPH oxidase 3 4.0682
EDN2 endothelin 2 4.0682
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 4.0682
LY9 lymphocyte antigen 9 4.0682
ACOT12 acyl-CoA thioesterase 12 4.0682
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 4.0682
ESPNL espin-like 4.0682
HIGD1C HIG1 hypoxia inducible domain family, member 1C 4.0682
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 4.0682
BTBD19 BTB (POZ) domain containing 19 4.0682
CTSS cathepsin S 4.0682
ETV3L ets variant 3-like 4.0682
STAP1 signal transducing adaptor family member 1 4.0682
NMUR1 neuromedin U receptor 1 4.0682
SPACA5 sperm acrosome associated 5 4.0682
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 4.0682
MYO1A myosin IA 4.0682
DRC7 dynein regulatory complex subunit 7 4.0682
SPHK1 sphingosine kinase 1 4.0682
TSHZ1 teashirt zinc finger homeobox 1 4.0682
MB myoglobin 4.0682
GJC2 gap junction protein, gamma 2, 47kDa 4.0682
OR52A1 olfactory receptor, family 52, subfamily A, member 1 4.0682
NFE2 nuclear factor, erythroid 2 4.0682
KCNK15 potassium channel, two pore domain subfamily K, member 15 4.0682
ACAN aggrecan 4.0682
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 4.0682
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 4.0682
TCAP titin-cap 4.0682
CCNI2 cyclin I family, member 2 4.0682
MAGEC3 melanoma antigen family C3 4.0682
ICAM2 intercellular adhesion molecule 2 4.0682
CLEC1B C-type lectin domain family 1, member B 4.0682
GPR62 G protein-coupled receptor 62 4.0682
OR6B1 olfactory receptor, family 6, subfamily B, member 1 4.0682
KLHDC1 kelch domain containing 1 4.0682
C1ORF216 chromosome 1 open reading frame 216 4.0587
CNTN2 contactin 2 (axonal) 3.94272
WDR64 WD repeat domain 64 3.94272
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) 3.74519
RASAL1 RAS protein activator like 1 (GAP1 like) 3.60673
ARSA arylsulfatase A 3.38238
COL9A1 collagen, type IX, alpha 1 3.32455
POU5F1 POU class 5 homeobox 1 3.09078
GPR3 G protein-coupled receptor 3 2.99222
TTC1 tetratricopeptide repeat domain 1 2.89852
LECT2 leukocyte cell-derived chemotaxin 2 2.81868
GPRASP1 G protein-coupled receptor associated sorting protein 1 2.81868
ZNF324 zinc finger protein 324 2.81868
SFRP2 secreted frizzled-related protein 2 2.7828
POLM polymerase (DNA directed), mu 2.6956
PIGH phosphatidylinositol glycan anchor biosynthesis, class H 2.6956
PCSK1 proprotein convertase subtilisin/kexin type 1 2.6726
TM7SF3 transmembrane 7 superfamily member 3 2.44733
BAIAP2 BAI1-associated protein 2 2.42679
F12 coagulation factor XII (Hageman factor) 2.40909
C6ORF52 chromosome 6 open reading frame 52 2.40909
HSPB1 heat shock 27kDa protein 1 2.4003
CCN1 cellular communication network factor 1 2.39863
B9D2 B9 protein domain 2 2.36415
AKAP8L A kinase (PRKA) anchor protein 8-like 2.34536
CREBRF CREB3 regulatory factor 2.32068
MLH1 mutL homolog 1 2.30605
MSN moesin 2.30605
RNASEH2A ribonuclease H2, subunit A 2.30278
PNPLA6 patatin-like phospholipase domain containing 6 2.30251
MBD2 methyl-CpG binding domain protein 2 2.30135
ANGPTL7 angiopoietin-like 7 2.23347
MMP25 matrix metallopeptidase 25 2.22391
GPR82 G protein-coupled receptor 82 2.20641
POLR1F RNA polymerase I subunit F 2.19962
TTC17 tetratricopeptide repeat domain 17 2.18188
TNPO2 transportin 2 2.16881
GALK2 galactokinase 2 2.16881
DUSP16 dual specificity phosphatase 16 2.16881
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 2.16355
ZNF169 zinc finger protein 169 2.15597
ZNF492 zinc finger protein 492 2.14866
JKAMP JNK1/MAPK8-associated membrane protein 2.14866
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 2.14866
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 2.13099
HIF3A hypoxia inducible factor 3, alpha subunit 2.11297
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 2.10729
LTAP1 lipid transport auxiliary protein 1 2.06277
CD83 CD83 molecule 2.04622
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 2.04443
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 2.04211
ACSL6 acyl-CoA synthetase long-chain family member 6 2.03634
RBM42 RNA binding motif protein 42 2.02737
SESN1 sestrin 1 2.02737
B3GNT7 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 2.02352

decreased expression

Symbol Name Standardized Value
IZUMO4 IZUMO family member 4 -4.0682
LRRC63 leucine rich repeat containing 63 -4.0682
PTK6 protein tyrosine kinase 6 -4.0682
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 -4.0682
TAS2R19 taste receptor, type 2, member 19 -4.0682
BTBD18 BTB (POZ) domain containing 18 -4.0682
F2 coagulation factor II (thrombin) -4.0682
IL18R1 interleukin 18 receptor 1 -4.0682
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled -4.0682
GPNMB glycoprotein (transmembrane) nmb -4.0682
MMD2 monocyte to macrophage differentiation-associated 2 -4.0682
LPAR6 lysophosphatidic acid receptor 6 -4.0682
DUSP26 dual specificity phosphatase 26 (putative) -4.0682
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 -4.0682
PLB1 phospholipase B1 -4.0682
PVRIG poliovirus receptor related immunoglobulin domain containing -4.0682
RHOXF2 Rhox homeobox family, member 2 -4.0682
SLC26A7 solute carrier family 26 (anion exchanger), member 7 -4.0682
OR1F1 olfactory receptor, family 1, subfamily F, member 1 -4.0682
ZEB2 zinc finger E-box binding homeobox 2 -4.0682
CD160 CD160 molecule -4.0682
SLC35D3 solute carrier family 35, member D3 -4.0682
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 -4.0682
MSX1 msh homeobox 1 -4.0682
GPR20 G protein-coupled receptor 20 -4.0682
TRIM73 tripartite motif containing 73 -4.0682
MAP3K4-AS1 MAP3K4 antisense RNA 1 -4.0682
SYT15 synaptotagmin XV -4.0682
SPI1 Spi-1 proto-oncogene -4.0682
LOC112694756 uncharaterized LOC112694756 -4.0682
SLCO2B1 solute carrier organic anion transporter family, member 2B1 -4.0682
FMO1 flavin containing monooxygenase 1 -4.0682
MAB21L2 mab-21-like 2 (C. elegans) -4.0682
CPHXL cytoplasmic polyadenylated homeobox like -4.0682
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 -4.0682
IFI35 interferon-induced protein 35 -4.0682
TMEM238L transmembrane protein 238 like -4.0682
OR52N2 olfactory receptor, family 52, subfamily N, member 2 -4.0682
MLIP muscular LMNA-interacting protein -4.0682
KCNK7 potassium channel, two pore domain subfamily K, member 7 -4.0682
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -4.0682
CCDC170 coiled-coil domain containing 170 -4.0682
GHDC GH3 domain containing -4.0682
AP3S2 adaptor-related protein complex 3, sigma 2 subunit -3.88241
PLCXD2 phosphatidylinositol-specific phospholipase C, X domain containing 2 -3.80461
RPL6 ribosomal protein L6 -3.72475
METTL13 methyltransferase like 13 -3.638
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor -3.51219
ZNF763 zinc finger protein 763 -3.48468
TMEM178A transmembrane protein 178A -3.35418
TOR4A torsin family 4, member A -3.26413
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 -3.26413
CFAP90 cilia and flagella associated protein 90 -3.26413
INSL3 insulin-like 3 (Leydig cell) -3.26413
MYL11 myosin light chain 11 -3.26413
NEIL1 nei endonuclease VIII-like 1 (E. coli) -3.26413
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 -3.15023
ARL8A ADP-ribosylation factor-like 8A -3.1461
KCTD1 potassium channel tetramerization domain containing 1 -3.1458
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 -3.12651
TMEM74B transmembrane protein 74B -3.05315
ZNF442 zinc finger protein 442 -3.05315
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -3.05118
KAT2A K(lysine) acetyltransferase 2A -3.04402
NCAN neurocan -3.01933
MMRN2 multimerin 2 -3.00897
PDS5A PDS5 cohesin associated factor A -2.8339
ADAMTSL4 ADAMTS-like 4 -2.7828
CEP350 centrosomal protein 350kDa -2.74806
NOPCHAP1 NOP protein chaperone 1 -2.72546
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 -2.70872
RUFY1 RUN and FYVE domain containing 1 -2.66227
SHMT1 serine hydroxymethyltransferase 1 (soluble) -2.65053
ZNF311 zinc finger protein 311 -2.61481
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 -2.57015
RUVBL2 RuvB-like AAA ATPase 2 -2.4479
CCKBR cholecystokinin B receptor -2.42695
ZNF524 zinc finger protein 524 -2.41049
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) -2.41049
BLTP1 bridge-like lipid transfer protein family member 1 -2.39157
ETAA1 Ewing tumor-associated antigen 1 -2.35111
ARHGAP39 Rho GTPase activating protein 39 -2.34536
EFHD1 EF-hand domain family, member D1 -2.34536
KCNK2 potassium channel, two pore domain subfamily K, member 2 -2.3337
CISH cytokine inducible SH2-containing protein -2.3337
CNTD1 cyclin N-terminal domain containing 1 -2.32873
FOXO3B forkhead box O3B pseudogene -2.30278
THBS4 thrombospondin 4 -2.29122
MRPS11 mitochondrial ribosomal protein S11 -2.28808
LRRC37A2 leucine rich repeat containing 37, member A2 -2.25544
TRRAP transformation/transcription domain-associated protein -2.25544
ADCK1 aarF domain containing kinase 1 -2.24823
ANKRD18B ankyrin repeat domain 18B -2.24031
PHACTR1 phosphatase and actin regulator 1 -2.22627
IGSF9 immunoglobulin superfamily, member 9 -2.22627
LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 -2.20444
MAPK3 mitogen-activated protein kinase 3 -2.19974
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa -2.19974
DPF1 D4, zinc and double PHD fingers family 1 -2.19903
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -2.18188
JPT2 Jupiter microtubule associated homolog 2 -2.15312
SNAP29 synaptosomal-associated protein, 29kDa -2.15111
DOK5 docking protein 5 -2.12139
GCFC2 GC-rich sequence DNA-binding factor 2 -2.10729
TGFB1I1 transforming growth factor beta 1 induced transcript 1 -2.09424
MCMDC2 minichromosome maintenance domain containing 2 -2.09424
COG7 component of oligomeric golgi complex 7 -2.09279
CCDC181 coiled-coil domain containing 181 -2.06913
CDK1 cyclin-dependent kinase 1 -2.06836
MATN1 matrilin 1, cartilage matrix protein -2.06642
RAD21 RAD21 homolog (S. pombe) -2.05869
RANBP17 RAN binding protein 17 -2.04922
EIF4H eukaryotic translation initiation factor 4H -2.02317
ADAM9 ADAM metallopeptidase domain 9 -2.01507
ACOXL acyl-CoA oxidase-like -2.01115
TRAPPC2 trafficking protein particle complex 2 -2.00995