PARP1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description poly (ADP-ribose) polymerase 1|This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 142)
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Genes

330 genes differentially expressed following the PARP1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PARP3 poly (ADP-ribose) polymerase family, member 3 3.23991
CXORF65 chromosome X open reading frame 65 3.23991
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 3.23991
GFAP glial fibrillary acidic protein 3.23991
NFAM1 NFAT activating protein with ITAM motif 1 3.23991
TUBB8 tubulin, beta 8 class VIII 3.23991
C19ORF67 chromosome 19 open reading frame 67 3.23991
GPR20 G protein-coupled receptor 20 3.23991
TAL2 T-cell acute lymphocytic leukemia 2 3.23991
PEAR1 platelet endothelial aggregation receptor 1 3.23991
UNC13B unc-13 homolog B (C. elegans) 3.23991
PGBDF plakoglobin binding and degradation factor 3.23991
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 3.23991
SCG2 secretogranin II 3.23991
FBXL8 F-box and leucine-rich repeat protein 8 3.23991
SPINK1 serine peptidase inhibitor, Kazal type 1 3.23991
NANOS2 nanos homolog 2 (Drosophila) 3.23991
NXPH3 neurexophilin 3 3.23991
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 3.23991
HES4 hes family bHLH transcription factor 4 3.23991
BIRC3 baculoviral IAP repeat containing 3 3.23991
ZNF556 zinc finger protein 556 3.23991
EDDM3A epididymal protein 3A 3.23991
SERTM1 serine-rich and transmembrane domain containing 1 3.23991
KIAA1755 KIAA1755 3.23991
LHX1 LIM homeobox 1 3.23991
CCDC87 coiled-coil domain containing 87 3.23991
TSHR thyroid stimulating hormone receptor 3.23991
PODN podocan 3.23991
CTAG2 cancer/testis antigen 2 3.23991
WFDC13 WAP four-disulfide core domain 13 3.23991
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 3.23991
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 3.23991
C2ORF78 chromosome 2 open reading frame 78 3.23991
SPDYE11 speedy/RINGO cell cycle regulator family member E11 3.23991
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 3.23991
MUC22 mucin 22 3.23991
MMP20 matrix metallopeptidase 20 3.23991
ATOH1 atonal homolog 1 (Drosophila) 3.23991
SMAD4 SMAD family member 4 3.23991
SLC39A12 solute carrier family 39 (zinc transporter), member 12 3.23991
SPHK1 sphingosine kinase 1 3.23991
AMIGO3 adhesion molecule with Ig-like domain 3 3.23991
NAPSA napsin A aspartic peptidase 3.23991
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 3.23991
CAPN9 calpain 9 3.23991
CCER2 coiled-coil glutamate-rich protein 2 3.23991
GPR35 G protein-coupled receptor 35 3.23991
RHCG Rh family, C glycoprotein 3.23991
DNAAF1 dynein, axonemal, assembly factor 1 3.23991
OR2T8 olfactory receptor, family 2, subfamily T, member 8 3.23991
TMPRSS7 transmembrane protease, serine 7 3.23991
BST1 bone marrow stromal cell antigen 1 3.23991
AVPR1A arginine vasopressin receptor 1A 3.23991
ROPN1B rhophilin associated tail protein 1B 3.23991
UNC93A unc-93 homolog A (C. elegans) 3.23991
MINDY4B MINDY family member 4B 3.23991
PPP1R2C PPP1R2C family member C 3.23991
RTL9 retrotransposon Gag like 9 3.23991
CBLIF cobalamin binding intrinsic factor 3.23991
PLAAT2 phospholipase A and acyltransferase 2 3.23991
GK3 glycerol kinase 3 3.23991
SMIM36 small integral membrane protein 36 3.23991
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) 3.23991
MAGIX MAGI family member, X-linked 3.23991
NGEF neuronal guanine nucleotide exchange factor 3.23991
TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like 3.23991
CHRD chordin 3.23991
CLDN9 claudin 9 3.23991
CCDC13 coiled-coil domain containing 13 3.23991
TAS2R5 taste receptor, type 2, member 5 3.23991
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.23991
NDRG1 N-myc downstream regulated 1 3.23991
TMPRSS11A transmembrane protease, serine 11A 3.23991
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 3.23991
MAG myelin associated glycoprotein 3.23991
SCRT2 scratch family zinc finger 2 3.23991
C1ORF162 chromosome 1 open reading frame 162 3.23991
CSAG1 chondrosarcoma associated gene 1 3.23991
RNF183 ring finger protein 183 3.23991
CCDC42 coiled-coil domain containing 42 3.23991
TAS1R2 taste receptor, type 1, member 2 3.23991
PTCHD3 patched domain containing 3 3.23991
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 3.23991
AWAT2 acyl-CoA wax alcohol acyltransferase 2 3.23991
ZNF575 zinc finger protein 575 3.23991
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 3.23991
PLGLB1 plasminogen-like B1 3.23991
GNG8 guanine nucleotide binding protein (G protein), gamma 8 3.23991
SCNN1D sodium channel, non voltage gated 1 delta subunit 3.23991
BMX BMX non-receptor tyrosine kinase 3.23991
PCDHGB2 protocadherin gamma subfamily B, 2 3.23991
ARL13A ADP-ribosylation factor-like 13A 3.23991
VSTM1 V-set and transmembrane domain containing 1 3.23991
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 3.23991
CSTA cystatin A (stefin A) 3.23991
SIGLEC11 sialic acid binding Ig-like lectin 11 3.23991
ZNF474 zinc finger protein 474 3.23991
STMND1 stathmin domain containing 1 3.23991
CA5A carbonic anhydrase VA, mitochondrial 3.23991
ALOX15B arachidonate 15-lipoxygenase, type B 3.23991
GPR68 G protein-coupled receptor 68 3.23991
NTN5 netrin 5 3.23991
CD177 CD177 molecule 3.23991
FAM177B family with sequence similarity 177, member B 3.23991
PRSS55 protease, serine, 55 3.23991
EBLN1 endogenous Bornavirus-like nucleoprotein 1 3.23991
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 3.23991
EHF ets homologous factor 3.23991
NPFFR1 neuropeptide FF receptor 1 3.23991
PKDREJ polycystin (PKD) family receptor for egg jelly 3.23991
CDH10 cadherin 10, type 2 (T2-cadherin) 3.23991
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 3.23991
GCSAM germinal center-associated, signaling and motility 3.23991
IL19 interleukin 19 3.23991
AGXT2 alanine--glyoxylate aminotransferase 2 3.23991
C2CD4B C2 calcium-dependent domain containing 4B 3.23991
RNASE11 ribonuclease, RNase A family, 11 (non-active) 3.23991
SIAH3 siah E3 ubiquitin protein ligase family member 3 3.23991
THTPA thiamine triphosphatase 3.23991
BTNL2 butyrophilin-like 2 3.23991
BTNL9 butyrophilin-like 9 3.23991
ETNPPL ethanolamine-phosphate phospho-lyase 3.23991
LRRC15 leucine rich repeat containing 15 3.23991
KLK3 kallikrein-related peptidase 3 3.23991
CYSLTR1 cysteinyl leukotriene receptor 1 3.23991
GLOD5 glyoxalase domain containing 5 3.23991
NUPR1 nuclear protein, transcriptional regulator, 1 3.23991
PLGLB2 plasminogen-like B2 3.23991
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 3.23991
TMPRSS13 transmembrane protease, serine 13 3.23991
TGM7 transglutaminase 7 3.23991
PCDH20 protocadherin 20 3.23991
PPP1R27 protein phosphatase 1, regulatory subunit 27 3.23991
PPP1R3G protein phosphatase 1, regulatory subunit 3G 3.23991
NPY2R neuropeptide Y receptor Y2 3.23991
ZNF541 zinc finger protein 541 3.23991
ADAM21 ADAM metallopeptidase domain 21 3.23991
WNT9A wingless-type MMTV integration site family, member 9A 3.23991
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 3.23991
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 3.23991
TSKS testis-specific serine kinase substrate 3.23991
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 3.23991
NLRP3 NLR family, pyrin domain containing 3 3.23991
CCL5 chemokine (C-C motif) ligand 5 3.23991
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 3.23991
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 3.23991
CCNO cyclin O 3.23991
OR56B1 olfactory receptor, family 56, subfamily B, member 1 3.23991
ZNF534 zinc finger protein 534 3.23991
CHAD chondroadherin 3.23991
FAT2 FAT atypical cadherin 2 3.23991
HPGDS hematopoietic prostaglandin D synthase 3.23991
BCL2L15 BCL2-like 15 3.23991
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 3.23991
CGA glycoprotein hormones, alpha polypeptide 3.23991
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 3.23991
TRIM7 tripartite motif containing 7 3.23991
SPC24 SPC24, NDC80 kinetochore complex component 2.90751
KANSL1 KAT8 regulatory NSL complex subunit 1 2.88502
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21 2.87443
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 2.85151
COL5A2 collagen, type V, alpha 2 2.78668
OSBPL2 oxysterol binding protein-like 2 2.7805
CGNL1 cingulin-like 1 2.74364
MTERF1 mitochondrial transcription termination factor 1 2.71532
MEX3A mex-3 RNA binding family member A 2.68081
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.67774
JUN jun proto-oncogene 2.67774
ANK2 ankyrin 2, neuronal 2.55361
SCYL3 SCY1-like 3 (S. cerevisiae) 2.54946
CYSRT1 cysteine-rich tail protein 1 2.52718
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 2.52718
MEIOB meiosis specific with OB domains 2.52298
FGD1 FYVE, RhoGEF and PH domain containing 1 2.51993
CTIF CBP80/20-dependent translation initiation factor 2.51271
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 2.47381
CA1 carbonic anhydrase I 2.46975
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 2.46087
SMIM22 small integral membrane protein 22 2.40896
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) 2.38967
ZNF446 zinc finger protein 446 2.37344
IL6ST-DT IL6ST divergent transcript 2.37344
GAL3ST4 galactose-3-O-sulfotransferase 4 2.37344
OSTN osteocrin 2.37344
UPK2 uroplakin 2 2.37344
IL11RA interleukin 11 receptor, alpha 2.37116
SOS2 son of sevenless homolog 2 (Drosophila) 2.36899
HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2.32588
IL17RE interleukin 17 receptor E 2.32588
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 2.32487
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 2.31405
TMEM131L transmembrane 131 like 2.30077
SNX19 sorting nexin 19 2.28118
INPP5F inositol polyphosphate-5-phosphatase F 2.23182
POR P450 (cytochrome) oxidoreductase 2.20912
TOM1 target of myb1 (chicken) 2.20213
HAGHL hydroxyacylglutathione hydrolase-like 2.184
PHTF1 putative homeodomain transcription factor 1 2.15881
MACC1 metastasis associated in colon cancer 1 2.15325
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 2.13945
SIK3 SIK family kinase 3 2.13537
MTARC1 mitochondrial amidoxime reducing component 1 2.12947
PHOSPHO2-KLHL23 PHOSPHO2-KLHL23 readthrough 2.10477
GAB2 GRB2-associated binding protein 2 2.09268
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 2.09268
PTK2 protein tyrosine kinase 2 2.09268
WIPF1 WAS/WASL interacting protein family, member 1 2.08457
TPGS1 tubulin polyglutamylase complex subunit 1 2.07613
ZFX zinc finger protein, X-linked 2.06959
ZNF600 zinc finger protein 600 2.06908
MXD4 MAX dimerization protein 4 2.0671
SLC38A12 solute carrier family 38 member 12 2.05081
RAB3C RAB3C, member RAS oncogene family 2.03732
CALN1 calneuron 1 2.03249
PER2 period circadian clock 2 2.03229
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 2.0275
MTMR4 myotubularin related protein 4 2.02246
CTSV cathepsin V 2.00622
IFT70B intraflagellar transport 70B 2.00622

decreased expression

Symbol Name Standardized Value
PARP1 poly (ADP-ribose) polymerase 1 -3.23991
GPER1 G protein-coupled estrogen receptor 1 -3.23991
EBF4 early B-cell factor 4 -3.23991
MYL11 myosin light chain 11 -3.23991
LYG2 lysozyme G-like 2 -3.23991
RUMY1 regulator of UNG2 and MKLN1 interacting yippee protein 1 -3.23991
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) -3.23991
FKBP8 FK506 binding protein 8, 38kDa -3.19035
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa -3.05656
BAMBI BMP and activin membrane-bound inhibitor -3.01188
IPO8 importin 8 -2.98805
IRX3 iroquois homeobox 3 -2.88502
NRG2 neuregulin 2 -2.88502
ARMC12 armadillo repeat containing 12 -2.88502
MCOLN3 mucolipin 3 -2.88502
AADACL3 arylacetamide deacetylase-like 3 -2.88502
SDSL serine dehydratase-like -2.88502
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic -2.88502
HCST hematopoietic cell signal transducer -2.88502
CPED1 cadherin-like and PC-esterase domain containing 1 -2.88502
NXPH4 neurexophilin 4 -2.88502
PTX3 pentraxin 3, long -2.88502
FGF23 fibroblast growth factor 23 -2.88502
WDR87 WD repeat domain 87 -2.88502
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 -2.88502
WNK4 WNK lysine deficient protein kinase 4 -2.88502
ADRB2 adrenoceptor beta 2, surface -2.88502
DUSP10 dual specificity phosphatase 10 -2.88502
DCST1 DC-STAMP domain containing 1 -2.88502
RSPO3 R-spondin 3 -2.88502
LMNTD2 lamin tail domain containing 2 -2.88502
SPATA46 spermatogenesis associated 46 -2.88502
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 -2.88502
GARIN1A golgi associated RAB2 interactor 1A -2.88502
TEX46 testis expressed 46 -2.88502
GBX1 gastrulation brain homeobox 1 -2.88502
TMEM255A transmembrane protein 255A -2.88502
CIMAP3 ciliary microtubule associated protein 3 -2.88502
LRRC8C-DT LRRC8C divergent transcript -2.88502
DAND5 DAN domain family member 5, BMP antagonist -2.88502
CRACDL CRACD like -2.88502
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 -2.88502
GH2 growth hormone 2 -2.88502
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -2.88502
PCDHGA9 protocadherin gamma subfamily A, 9 -2.88502
TMOD4 tropomodulin 4 (muscle) -2.88502
CLIC5 chloride intracellular channel 5 -2.88502
MAMDC4 MAM domain containing 4 -2.88502
THSD8 thrombospondin type 1 domain containing 8 -2.88502
SPIB Spi-B transcription factor (Spi-1/PU.1 related) -2.87623
SNX4 sorting nexin 4 -2.8687
TBC1D24 TBC1 domain family, member 24 -2.85308
DCDC2 doublecortin domain containing 2 -2.83455
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit -2.80651
DENND4C DENN/MADD domain containing 4C -2.7838
RETREG1 reticulophagy regulator 1 -2.7805
ZNF440 zinc finger protein 440 -2.7737
COA3 cytochrome c oxidase assembly factor 3 -2.66289
HPS3 Hermansky-Pudlak syndrome 3 -2.62892
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 -2.59758
IQSEC3 IQ motif and Sec7 domain 3 -2.59758
TRIML2 tripartite motif family-like 2 -2.57955
PPM1M protein phosphatase, Mg2+/Mn2+ dependent, 1M -2.55361
CNTD1 cyclin N-terminal domain containing 1 -2.55361
ZNF552 zinc finger protein 552 -2.54272
SS18 synovial sarcoma translocation, chromosome 18 -2.50542
PHB1 prohibitin 1 -2.49078
ECT2 epithelial cell transforming 2 -2.48808
ENSA endosulfine alpha -2.43694
ALKBH5 AlkB family member 5, RNA demethylase -2.41461
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A -2.40896
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F -2.36899
NOXO1 NADPH oxidase organizer 1 -2.36899
DUOX1 dual oxidase 1 -2.36899
VSTM2B V-set and transmembrane domain containing 2B -2.36899
CLTRN collectrin, amino acid transport regulator -2.36899
TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase -2.36606
H3C7 H3 clustered histone 7 -2.33153
CMTM4 CKLF-like MARVEL transmembrane domain containing 4 -2.3221
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -2.32129
TPRKB TP53RK binding protein -2.31951
NT5C3B 5'-nucleotidase, cytosolic IIIB -2.30346
AK3 adenylate kinase 3 -2.29202
ATP5ME ATP synthase membrane subunit e -2.28438
VBP1 von Hippel-Lindau binding protein 1 -2.28342
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) -2.25817
CAMK2D calcium/calmodulin-dependent protein kinase II delta -2.24255
ANK1 ankyrin 1, erythrocytic -2.20912
H4C2 H4 clustered histone 2 -2.20019
ANPEP alanyl (membrane) aminopeptidase -2.20019
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 -2.15664
PDCD11 programmed cell death 11 -2.13677
LUC7L2 LUC7-like 2 (S. cerevisiae) -2.11611
MARVELD2 MARVEL domain containing 2 -2.10477
XRN2 5'-3' exoribonuclease 2 -2.09277
PNRC1 proline-rich nuclear receptor coactivator 1 -2.09277
GALK1 galactokinase 1 -2.09268
PSKH1 protein serine kinase H1 -2.0816
BLOC1S4 biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino -2.07613
MKKS McKusick-Kaufman syndrome -2.07125
NFE2L3 nuclear factor, erythroid 2-like 3 -2.06959
CADPS2 Ca++-dependent secretion activator 2 -2.06439
PTPN11 protein tyrosine phosphatase, non-receptor type 11 -2.06412
TDRD3 tudor domain containing 3 -2.06412
DCTN3 dynactin 3 (p22) -2.06412
CKS2 CDC28 protein kinase regulatory subunit 2 -2.03229
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) -2.02869
RAMACL RNA guanine-7 methyltransferase activating subunit like -2.01839
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -2.01574
BMPR1A bone morphogenetic protein receptor, type IA -2.0067