PAWR Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description PRKC, apoptosis, WT1, regulator|The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5074)
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Genes

327 genes differentially expressed following the PAWR gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CFI complement factor I 3.15055
PKD2L1 polycystic kidney disease 2-like 1 3.15055
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 3.15055
RBM24 RNA binding motif protein 24 3.15055
DOK2 docking protein 2, 56kDa 3.15055
PARP15 poly (ADP-ribose) polymerase family, member 15 3.15055
NAPSA napsin A aspartic peptidase 3.15055
KLF1 Kruppel-like factor 1 (erythroid) 3.15055
CCL25 chemokine (C-C motif) ligand 25 3.15055
BARX2 BARX homeobox 2 3.15055
AKNAD1 AKNA domain containing 1 3.15055
AQP1 aquaporin 1 (Colton blood group) 3.15055
LMOD2 leiomodin 2 (cardiac) 3.15055
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 3.15055
AGXT2 alanine--glyoxylate aminotransferase 2 3.15055
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 3.15055
CFAP107 cilia and flagella associated protein 107 3.15055
TPPP tubulin polymerization promoting protein 3.15055
FAM3D family with sequence similarity 3, member D 3.15055
DNAAF6 dynein axonemal assembly factor 6 3.15055
OXER1 oxoeicosanoid (OXE) receptor 1 3.15055
PI15 peptidase inhibitor 15 3.13426
UCN urocortin 3.13426
PAX9 paired box 9 3.13426
UCN2 urocortin 2 3.13426
TUBB1 tubulin, beta 1 class VI 3.13426
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 3.13426
PLCH2 phospholipase C, eta 2 3.13426
PAX6 paired box 6 3.13426
CELA3B chymotrypsin-like elastase family, member 3B 3.13426
PEX13 peroxisomal biogenesis factor 13 3.13426
DDO D-aspartate oxidase 3.13426
GNLY granulysin 3.13426
TSGA13 testis specific, 13 3.13426
TM4SF4 transmembrane 4 L six family member 4 3.13426
CASP4 caspase 4, apoptosis-related cysteine peptidase 3.13426
GRIA2 glutamate receptor, ionotropic, AMPA 2 3.13426
IL23R interleukin 23 receptor 3.13426
FGF3 fibroblast growth factor 3 3.13426
FAM9C family with sequence similarity 9, member C 3.13426
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 3.13426
TAS2R13 taste receptor, type 2, member 13 3.13426
NOD2 nucleotide-binding oligomerization domain containing 2 3.13426
CRYGA crystallin, gamma A 3.13426
OC90 otoconin 90 3.13426
PCDH8 protocadherin 8 3.13426
NOTUM notum pectinacetylesterase homolog (Drosophila) 3.13426
GADL1 glutamate decarboxylase-like 1 3.13426
TNIP3 TNFAIP3 interacting protein 3 3.13426
SPINT3 serine peptidase inhibitor, Kunitz type, 3 3.13426
PBOV1 prostate and breast cancer overexpressed 1 3.13426
HES2 hes family bHLH transcription factor 2 3.13426
RPE65 retinal pigment epithelium-specific protein 65kDa 3.13426
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 3.13426
OR5A1 olfactory receptor, family 5, subfamily A, member 1 3.13426
FAM237A family with sequence similarity 237 member A 3.13426
H2BC1 H2B clustered histone 1 3.13426
FRG2C FSHD region gene 2 family, member C 3.13426
TMPRSS3 transmembrane protease, serine 3 3.13426
TRIM31 tripartite motif containing 31 3.13426
SPATA31H1 SPATA31 subfamily H member 1 3.13426
PRDM7 PR domain containing 7 3.13426
SYT15 synaptotagmin XV 3.13426
ROPN1 rhophilin associated tail protein 1 3.13426
HTD2 hydroxyacyl-thioester dehydratase type 2 3.13426
RAB6D RAB6D, member RAS oncogene family 3.13426
H2BK1 H2B.K variant histone 1 3.13426
SPAAR small regulatory polypeptide of amino acid response 3.13426
MINDY4B MINDY family member 4B 3.13426
ACP4 acid phosphatase 4 3.13426
CFAP276 cilia and flagella associated protein 276 3.13426
TEX13C TEX13 family member C 3.13426
BNIP5 BCL2 interacting protein 5 3.13426
LORICRIN loricrin cornified envelope precursor protein 3.13426
CLEC17A C-type lectin domain family 17, member A 3.13426
PGLYRP2 peptidoglycan recognition protein 2 3.13426
TACR2 tachykinin receptor 2 3.13426
ACTL10 actin-like 10 3.13426
OR5H2 olfactory receptor, family 5, subfamily H, member 2 3.13426
HHEX hematopoietically expressed homeobox 3.13426
OR2A25 olfactory receptor, family 2, subfamily A, member 25 3.13426
PRB1 proline-rich protein BstNI subfamily 1 3.13426
SLC22A14 solute carrier family 22, member 14 3.13426
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 3.13426
FOXL1 forkhead box L1 3.13426
ACOT4 acyl-CoA thioesterase 4 3.13426
RAB41 RAB41, member RAS oncogene family 3.13426
SPDYC speedy/RINGO cell cycle regulator family member C 3.13426
INSRR insulin receptor-related receptor 3.13426
KLRF2 killer cell lectin-like receptor subfamily F, member 2 3.13426
TBX5 T-box 5 3.13426
GDF10 growth differentiation factor 10 3.13426
PSAPL1 prosaposin-like 1 (gene/pseudogene) 3.13426
DAO D-amino-acid oxidase 3.13426
ITK IL2-inducible T-cell kinase 3.13426
CD6 CD6 molecule 3.13426
CD22 CD22 molecule 3.13426
KCNK9 potassium channel, two pore domain subfamily K, member 9 3.13426
CD244 CD244 molecule, natural killer cell receptor 2B4 3.13426
CGB7 chorionic gonadotropin, beta polypeptide 7 3.13426
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 3.13426
C5AR2 complement component 5a receptor 2 3.13426
ERP27 endoplasmic reticulum protein 27 3.13426
AMER3 APC membrane recruitment protein 3 3.13426
HRCT1 histidine rich carboxyl terminus 1 3.13426
SLITRK2 SLIT and NTRK-like family, member 2 3.13426
KLK12 kallikrein-related peptidase 12 3.13426
DCSTAMP dendrocyte expressed seven transmembrane protein 3.13426
CDRT15L2 CMT1A duplicated region transcript 15-like 2 3.13426
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 3.13426
WFDC10A WAP four-disulfide core domain 10A 3.13426
CDH19 cadherin 19, type 2 3.13426
MC5R melanocortin 5 receptor 3.13426
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 3.13426
KLK15 kallikrein-related peptidase 15 3.13426
FNDC8 fibronectin type III domain containing 8 3.13426
ENDOU endonuclease, polyU-specific 3.13426
ARR3 arrestin 3, retinal (X-arrestin) 3.13426
RETNLB resistin like beta 3.13426
HHATL hedgehog acyltransferase-like 3.13426
CRYBB2 crystallin, beta B2 3.13426
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 3.13426
ERICH6B glutamate-rich 6B 3.13426
OGFRL1 opioid growth factor receptor-like 1 3.13426
GOLGA6A golgin A6 family, member A 3.13426
OR13A1 olfactory receptor, family 13, subfamily A, member 1 3.13426
TEX12 testis expressed 12 3.13426
SST somatostatin 3.13426
LEUTX leucine twenty homeobox 3.13426
C1ORF105 chromosome 1 open reading frame 105 3.13426
MMP13 matrix metallopeptidase 13 3.13426
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 3.13426
LPO lactoperoxidase 3.13426
CAPSL calcyphosine-like 3.13426
NLRP9 NLR family, pyrin domain containing 9 3.13426
IL26 interleukin 26 3.13426
GAS2L2 growth arrest-specific 2 like 2 3.13426
OR6B1 olfactory receptor, family 6, subfamily B, member 1 3.13426
LAMB3 laminin, beta 3 3.13426
EOMES eomesodermin 3.13426
GOLGA8K golgin A8 family, member K 3.13426
TAS2R43 taste receptor, type 2, member 43 3.13426
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 3.13426
TBX1 T-box 1 3.13426
ITPKA inositol-trisphosphate 3-kinase A 3.13426
SNTN sentan, cilia apical structure protein 3.13426
CGA glycoprotein hormones, alpha polypeptide 3.13426
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 3.13426
SYTL5 synaptotagmin-like 5 3.13426
NT5DC4 5'-nucleotidase domain containing 4 3.13426
MSLN mesothelin 3.13426
NNMT nicotinamide N-methyltransferase 3.13426
SPNS3 spinster homolog 3 (Drosophila) 3.13426
DLX3 distal-less homeobox 3 3.13426
UBXN10 UBX domain protein 10 3.13426
PF4V1 platelet factor 4 variant 1 3.13426
R3HDML R3H domain containing-like 3.13426
XKRX XK, Kell blood group complex subunit-related, X-linked 3.06334
SFTPD surfactant protein D 3.06334
AFF1 AF4/FMR2 family, member 1 2.95684
MSMP microseminoprotein, prostate associated 2.87243
OSBPL3 oxysterol binding protein-like 3 2.79543
MMP23B matrix metallopeptidase 23B 2.77866
BTBD17 BTB (POZ) domain containing 17 2.77866
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 2.75111
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 2.6477
BORCS7 BLOC-1 related complex subunit 7 2.61286
NOS3 nitric oxide synthase 3 (endothelial cell) 2.60674
BBS5 Bardet-Biedl syndrome 5 2.58541
TMEM106B transmembrane protein 106B 2.58388
PRR14L proline rich 14-like 2.5807
MYO9A myosin IXA 2.52368
MLXIPL MLX interacting protein-like 2.48821
SELENON selenoprotein N 2.48733
OLFM2 olfactomedin 2 2.47971
CRPPA CDP-L-ribitol pyrophosphorylase A 2.4573
SHISAL1 shisa like 1 2.44335
CX3CL1 chemokine (C-X3-C motif) ligand 1 2.41964
CD19 CD19 molecule 2.41964
PDCD6IP programmed cell death 6 interacting protein 2.38929
NT5DC3 5'-nucleotidase domain containing 3 2.37284
RYR1 ryanodine receptor 1 (skeletal) 2.36913
MBIP MAP3K12 binding inhibitory protein 1 2.33981
MARK3 MAP/microtubule affinity-regulating kinase 3 2.29042
SLIT1 slit homolog 1 (Drosophila) 2.2862
CEP57 centrosomal protein 57kDa 2.25938
RBM11 RNA binding motif protein 11 2.25938
ATF7IP activating transcription factor 7 interacting protein 2.23882
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 2.22384
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 2.22068
EDN3 endothelin 3 2.22068
EPHA2 EPH receptor A2 2.20129
AP2M1 adaptor-related protein complex 2, mu 1 subunit 2.16474
ASPH aspartate beta-hydroxylase 2.15934
DTX4 deltex 4, E3 ubiquitin ligase 2.15389
ARHGAP29 Rho GTPase activating protein 29 2.15389
KIAA0753 KIAA0753 2.13549
SLC16A9 solute carrier family 16, member 9 2.13137
SLC35A4 solute carrier family 35, member A4 2.12493
CLIC5 chloride intracellular channel 5 2.11705
FGF4 fibroblast growth factor 4 2.11705
NWD1 NACHT and WD repeat domain containing 1 2.11705
GSDMA gasdermin A 2.11705
IRF8 interferon regulatory factor 8 2.11705
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.11705
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 2.11705
VSTM2A V-set and transmembrane domain containing 2A 2.11705
SHE Src homology 2 domain containing E 2.11705
TBXA2R thromboxane A2 receptor 2.11705
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase 2.10749
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10 2.10749
SYNC syncoilin, intermediate filament protein 2.10749
TNNT2 troponin T type 2 (cardiac) 2.09096
RHBDL3 rhomboid, veinlet-like 3 (Drosophila) 2.08896
LGALS1 lectin, galactoside-binding, soluble, 1 2.08476
EIF3E eukaryotic translation initiation factor 3, subunit E 2.07584
RBM47 RNA binding motif protein 47 2.06819
TLCD4 TLC domain containing 4 2.05133
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 2.04954
PRKCI protein kinase C, iota 2.04069
SNX4 sorting nexin 4 2.0347
MBD2 methyl-CpG binding domain protein 2 2.02445
CTNNA3 catenin (cadherin-associated protein), alpha 3 2.02183
TMEM102 transmembrane protein 102 2.02183
FBXL5 F-box and leucine-rich repeat protein 5 2.00587
FBXO33 F-box protein 33 2.00562

decreased expression

Symbol Name Standardized Value
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b -3.15055
NAP1L5 nucleosome assembly protein 1-like 5 -3.15055
IL15RA interleukin 15 receptor, alpha -3.15055
CD37 CD37 molecule -3.13426
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) -3.13426
FGF10 fibroblast growth factor 10 -3.13426
EBI3 Epstein-Barr virus induced 3 -3.13426
FCF1 FCF1 rRNA-processing protein -3.13426
ZNF703 zinc finger protein 703 -3.13426
CDC20B cell division cycle 20B -3.13426
BTBD16 BTB (POZ) domain containing 16 -3.13426
OR2A42 olfactory receptor, family 2, subfamily A, member 42 -3.13426
AIG1 androgen-induced 1 -3.13426
SPINK6 serine peptidase inhibitor, Kazal type 6 -3.13426
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa -3.13426
ZNF98 zinc finger protein 98 -3.13426
LGALS4 lectin, galactoside-binding, soluble, 4 -3.13426
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -3.13426
STEAP4 STEAP family member 4 -3.13426
SPAG8 sperm associated antigen 8 -3.13426
F5 coagulation factor V (proaccelerin, labile factor) -3.13426
SPEF1 sperm flagellar 1 -3.13426
SMIM38 small integral membrane protein 38 -3.13426
ZC3H11C zinc finger CCCH-type containing 11C -3.13426
AMN amnion associated transmembrane protein -3.13426
ADGRD1 adhesion G protein-coupled receptor D1 -3.13426
RBBP8NL RBBP8 N-terminal like -3.13426
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 -3.13426
LY96 lymphocyte antigen 96 -3.13426
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -3.03957
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase -2.9732
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -2.94484
EPOR erythropoietin receptor -2.93151
CAB39L calcium binding protein 39-like -2.90593
AGO3 argonaute RISC catalytic component 3 -2.8976
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B -2.88371
FAM178B family with sequence similarity 178, member B -2.78708
SGMS2 sphingomyelin synthase 2 -2.78407
SIRT4 sirtuin 4 -2.78407
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 -2.75111
ZFAND1 zinc finger, AN1-type domain 1 -2.75111
MIF4GD MIF4G domain containing -2.73334
EFCAB12 EF-hand calcium binding domain 12 -2.70725
CLVS1 clavesin 1 -2.6477
POMT2 protein-O-mannosyltransferase 2 -2.63631
FOXM1 forkhead box M1 -2.61286
SAPCD2 suppressor APC domain containing 2 -2.54267
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 -2.51402
RHBG Rh family, B glycoprotein (gene/pseudogene) -2.48417
GPS1 G protein pathway suppressor 1 -2.43668
DOHH deoxyhypusine hydroxylase/monooxygenase -2.37783
LONRF2 LON peptidase N-terminal domain and ring finger 2 -2.35655
MYL7 myosin, light chain 7, regulatory -2.35655
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 -2.34553
ZNF468 zinc finger protein 468 -2.33981
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -2.33827
VCF2 VCP nuclear cofactor family member 2 -2.2862
FANCM Fanconi anemia, complementation group M -2.28304
DND1 DND microRNA-mediated repression inhibitor 1 -2.27389
LIX1L Lix1 homolog (chicken) like -2.22384
ZNF296 zinc finger protein 296 -2.22384
MRPL24 mitochondrial ribosomal protein L24 -2.22384
C1QTNF1 C1q and tumor necrosis factor related protein 1 -2.22182
CADM4 cell adhesion molecule 4 -2.21644
RPL22L1 ribosomal protein L22-like 1 -2.21644
PWP2 PWP2 periodic tryptophan protein homolog (yeast) -2.21175
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 -2.20907
CRIPT cysteine-rich PDZ-binding protein -2.19294
MCOLN1 mucolipin 1 -2.18538
STRIP1 striatin interacting protein 1 -2.17782
CACFD1 calcium channel flower domain containing 1 -2.17698
MARCKSL1 MARCKS-like 1 -2.16474
TRIM41 tripartite motif containing 41 -2.1411
ZBTB48 zinc finger and BTB domain containing 48 -2.1392
CALCOCO1 calcium binding and coiled-coil domain 1 -2.13704
S100PBP S100P binding protein -2.13303
NSG2 neuronal vesicle trafficking associated 2 -2.13137
STRC stereocilin -2.13137
ANO3 anoctamin 3 -2.13137
DPAGT1 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) -2.13116
UBA5 ubiquitin-like modifier activating enzyme 5 -2.11705
L3MBTL4 l(3)mbt-like 4 (Drosophila) -2.11705
EPHB4 EPH receptor B4 -2.11705
ZNF75A zinc finger protein 75a -2.11705
SLC71A1 solute carrier family 71 member 1 -2.1083
NASP nuclear autoantigenic sperm protein (histone-binding) -2.10749
ZNF639 zinc finger protein 639 -2.10749
TOR3A torsin family 3, member A -2.10749
RSPO4 R-spondin 4 -2.104
ZNF586 zinc finger protein 586 -2.104
TALDO1 transaldolase 1 -2.06819
UBA2 ubiquitin-like modifier activating enzyme 2 -2.06316
ZNF530 zinc finger protein 530 -2.04049
RPSA ribosomal protein SA -2.02339
NEIL2 nei endonuclease VIII-like 2 (E. coli) -2.01869
NOP10 NOP10 ribonucleoprotein -2.01869
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -2.01868
RC3H2 ring finger and CCCH-type domains 2 -2.01868
KCNK6 potassium channel, two pore domain subfamily K, member 6 -2.00979
KBTBD3 kelch repeat and BTB (POZ) domain containing 3 -2.00587
TRIL TLR4 interactor with leucine-rich repeats -2.00587