PAX1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description paired box 1|This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. This gene plays a role in pattern formation during embryogenesis and may be essential for development of the vertebral column. This gene is silenced by methylation in ovarian and cervical cancers and may be a tumor suppressor gene. Mutations in this gene are also associated with vertebral malformations. [provided by RefSeq, Mar 2012] (NCBI Entrez Gene Database, 5075)
Similar Terms
Downloads & Tools

Genes

320 genes differentially expressed following the PAX1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CFAP99 cilia and flagella associated protein 99 3.64186
CEMP1 cementum protein 1 3.64186
ASB15 ankyrin repeat and SOCS box containing 15 3.64186
ZNF503 zinc finger protein 503 3.64186
SLC26A4 solute carrier family 26 (anion exchanger), member 4 3.64186
FBXL8 F-box and leucine-rich repeat protein 8 3.64186
IZUMO3 IZUMO family member 3 3.64186
CD163 CD163 molecule 3.64186
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 3.64186
GLUD2 glutamate dehydrogenase 2 3.64186
SIX2 SIX homeobox 2 3.64186
SYCP2 synaptonemal complex protein 2 3.64186
HBA2 hemoglobin, alpha 2 3.64186
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 3.64186
OR1F1 olfactory receptor, family 1, subfamily F, member 1 3.64186
CCIN calicin 3.64186
FOXD1 forkhead box D1 3.64186
IZUMO4 IZUMO family member 4 3.64186
RLBP1 retinaldehyde binding protein 1 3.64186
OR2A5 olfactory receptor, family 2, subfamily A, member 5 3.64186
RGS9BP regulator of G protein signaling 9 binding protein 3.64186
FPR1 formyl peptide receptor 1 3.64186
SLC35G5 solute carrier family 35, member G5 3.64186
SLC35G6 solute carrier family 35, member G6 3.64186
CLEC19A C-type lectin domain family 19, member A 3.64186
KHDC3L KH domain containing 3-like, subcortical maternal complex member 3.64186
CX3CR1 chemokine (C-X3-C motif) receptor 1 3.64186
CCDC39 coiled-coil domain containing 39 3.64186
GNRH2 gonadotropin-releasing hormone 2 3.64186
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 3.64186
ATOH8 atonal homolog 8 (Drosophila) 3.64186
TAS2R10 taste receptor, type 2, member 10 3.64186
MYO1G myosin IG 3.64186
GALR2 galanin receptor 2 3.64186
ARRDC5 arrestin domain containing 5 3.64186
C1ORF141 chromosome 1 open reading frame 141 3.64186
ZNF556 zinc finger protein 556 3.64186
C6ORF58 chromosome 6 open reading frame 58 3.64186
OLIG3 oligodendrocyte transcription factor 3 3.64186
SIGLEC7 sialic acid binding Ig-like lectin 7 3.64186
UCN2 urocortin 2 3.64186
MUSK muscle, skeletal, receptor tyrosine kinase 3.64186
OPRL1 opiate receptor-like 1 3.64186
GFI1 growth factor independent 1 transcription repressor 3.64186
TMPRSS3 transmembrane protease, serine 3 3.64186
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 3.64186
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 3.64186
KRABD1 KRAB domain containing 1 3.64186
RTL9 retrotransposon Gag like 9 3.64186
STYXL2 serine/threonine/tyrosine interacting like 2 3.64186
RAX2 retina and anterior neural fold homeobox 2 3.64186
TRAPPC3L trafficking protein particle complex 3-like 3.64186
PKD2L1 polycystic kidney disease 2-like 1 3.64186
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 3.64186
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 3.64186
TFF2 trefoil factor 2 3.64186
PROX2 prospero homeobox 2 3.64186
VXN vexin 3.64186
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 3.64186
H2AP H2A.P histone 3.64186
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 3.64186
FAM240A family with sequence similarity 240 member A 3.64186
WASH8P WAS protein family homolog 8, pseudogene 3.64186
ZNF593OS ZNF593 opposite strand 3.64186
EZHIP EZH inhibitory protein 3.64186
PEAK3 PEAK family member 3 3.64186
ARMH2 armadillo like helical domain containing 2 3.64186
NFILZ NFIL3 like basic leucine zipper 3.64186
ODAPH odontogenesis associated phosphoprotein 3.64186
WDR64 WD repeat domain 64 3.64186
PROZ protein Z, vitamin K-dependent plasma glycoprotein 3.64186
MIOX myo-inositol oxygenase 3.64186
EXOC3L4 exocyst complex component 3-like 4 3.64186
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 3.64186
C6ORF118 chromosome 6 open reading frame 118 3.64186
FAM186A family with sequence similarity 186, member A 3.64186
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 3.64186
GZMM granzyme M (lymphocyte met-ase 1) 3.64186
NR1I3 nuclear receptor subfamily 1, group I, member 3 3.64186
CATSPER1 cation channel, sperm associated 1 3.64186
C3ORF80 chromosome 3 open reading frame 80 3.64186
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 3.64186
GLIPR1L2 GLI pathogenesis-related 1 like 2 3.64186
NR0B1 nuclear receptor subfamily 0, group B, member 1 3.64186
FOXC2 forkhead box C2 3.64186
RTL1 retrotransposon-like 1 3.64186
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 3.64186
CSAG1 chondrosarcoma associated gene 1 3.64186
DYNAP dynactin associated protein 3.64186
DLK1 delta-like 1 homolog (Drosophila) 3.64186
GDF6 growth differentiation factor 6 3.64186
GDF9 growth differentiation factor 9 3.64186
UTS2 urotensin 2 3.64186
IRF5 interferon regulatory factor 5 3.64186
PCDHGB2 protocadherin gamma subfamily B, 2 3.64186
ODF4 outer dense fiber of sperm tails 4 3.64186
PSORS1C1 psoriasis susceptibility 1 candidate 1 3.64186
GH1 growth hormone 1 3.64186
MUCL1 mucin-like 1 3.64186
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 3.64186
VWA7 von Willebrand factor A domain containing 7 3.64186
IL1A interleukin 1, alpha 3.64186
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 3.64186
HRCT1 histidine rich carboxyl terminus 1 3.64186
GRAPL GRB2-related adaptor protein-like 3.64186
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3.64186
LY6G5C lymphocyte antigen 6 complex, locus G5C 3.64186
IRGM immunity-related GTPase family, M 3.64186
MEFV Mediterranean fever 3.64186
BPIFB1 BPI fold containing family B, member 1 3.64186
PCDHGB1 protocadherin gamma subfamily B, 1 3.64186
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 3.64186
PCDHGB4 protocadherin gamma subfamily B, 4 3.64186
GAL3ST2 galactose-3-O-sulfotransferase 2 3.64186
LRRC46 leucine rich repeat containing 46 3.64186
MBOAT4 membrane bound O-acyltransferase domain containing 4 3.64186
BRDT bromodomain, testis-specific 3.64186
DMTN dematin actin binding protein 3.64186
OR56A4 olfactory receptor, family 56, subfamily A, member 4 3.64186
FZD1 frizzled class receptor 1 3.64186
AQP3 aquaporin 3 (Gill blood group) 3.64186
TAS2R50 taste receptor, type 2, member 50 3.64186
SLC36A3 solute carrier family 36, member 3 3.64186
METTL24 methyltransferase like 24 3.64186
TGM1 transglutaminase 1 3.64186
TMPRSS11A transmembrane protease, serine 11A 3.64186
SNAI2 snail family zinc finger 2 3.64186
RNASE9 ribonuclease, RNase A family, 9 (non-active) 3.64186
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 3.64186
HPGDS hematopoietic prostaglandin D synthase 3.64186
LMX1B LIM homeobox transcription factor 1, beta 3.64186
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 3.64186
TTC24 tetratricopeptide repeat domain 24 3.64186
SYT5 synaptotagmin V 3.64186
MB myoglobin 3.64186
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 3.64186
AMPD1 adenosine monophosphate deaminase 1 3.64186
IL25 interleukin 25 3.64186
LYPD2 LY6/PLAUR domain containing 2 3.64186
CD28 CD28 molecule 3.64186
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 3.64186
CDH17 cadherin 17, LI cadherin (liver-intestine) 3.64186
ZPLD1 zona pellucida-like domain containing 1 3.64186
AOC1 amine oxidase, copper containing 1 3.64186
OR13G1 olfactory receptor, family 13, subfamily G, member 1 3.64186
FAIM2 Fas apoptotic inhibitory molecule 2 3.64186
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 3.64186
POU4F1 POU class 4 homeobox 1 3.64186
PAGE4 P antigen family, member 4 (prostate associated) 3.64186
TAS2R43 taste receptor, type 2, member 43 3.64186
IL4I1 interleukin 4 induced 1 3.60321
ARHGAP40 Rho GTPase activating protein 40 3.60321
NFE2 nuclear factor, erythroid 2 3.39933
SSH1 slingshot protein phosphatase 1 3.38682
GPHRB golgi pH regulator B 3.36802
METTL16 methyltransferase like 16 3.3268
FAM169A family with sequence similarity 169, member A 3.28223
WNT5A wingless-type MMTV integration site family, member 5A 3.2097
YAF2 YY1 associated factor 2 3.16912
ATP10D ATPase, class V, type 10D 3.14655
PIAS2 protein inhibitor of activated STAT, 2 3.03601
ERVFRD-1 endogenous retrovirus group FRD, member 1 2.99035
PGS1 phosphatidylglycerophosphate synthase 1 2.8962
DUSP18 dual specificity phosphatase 18 2.80079
PREPL prolyl endopeptidase-like 2.75179
NIPSNAP1 nipsnap homolog 1 (C. elegans) 2.72033
MBD3 methyl-CpG binding domain protein 3 2.70962
NRIP2 nuclear receptor interacting protein 2 2.69359
ACVRL1 activin A receptor type II-like 1 2.69359
RAI2 retinoic acid induced 2 2.69359
IRX3 iroquois homeobox 3 2.69359
SPEF1 sperm flagellar 1 2.69359
FAM13B family with sequence similarity 13, member B 2.67941
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 2.64865
DTX3 deltex 3, E3 ubiquitin ligase 2.63336
USP48 ubiquitin specific peptidase 48 2.57593
DNHD1 dynein heavy chain domain 1 2.44133
EMP2 epithelial membrane protein 2 2.44133
FBXO46 F-box protein 46 2.40892
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 2.40881
PGBD5 piggyBac transposable element derived 5 2.40881
ARID4B AT rich interactive domain 4B (RBP1-like) 2.40881
TBL1X transducin (beta)-like 1X-linked 2.40881
SND1 staphylococcal nuclease and tudor domain containing 1 2.39025
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 2.39025
PPP1R13L protein phosphatase 1, regulatory subunit 13 like 2.36633
KAT2A K(lysine) acetyltransferase 2A 2.34958
NLRP14 NLR family, pyrin domain containing 14 2.33531
CCER2 coiled-coil glutamate-rich protein 2 2.33531
COL26A1 collagen, type XXVI, alpha 1 2.31006
CEP295NL CEP295 N-terminal like 2.29552
FUCA1 fucosidase, alpha-L- 1, tissue 2.25803
ANO9 anoctamin 9 2.25803
TCF25 transcription factor 25 (basic helix-loop-helix) 2.24465
FNBP1L formin binding protein 1-like 2.23188
PLEC plectin 2.23188
PEX2 peroxisomal biogenesis factor 2 2.22529
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 2.21263
ENTR1 endosome associated trafficking regulator 1 2.20577
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 2.20234
ASB14 ankyrin repeat and SOCS box containing 14 2.16077
GULP1 GULP, engulfment adaptor PTB domain containing 1 2.14543
NFASC neurofascin 2.12218
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 2.11246
MTNAP1 mitochondrial nucleoid associated protein 1 2.10741
C2ORF68 chromosome 2 open reading frame 68 2.10099
FBXO42 F-box protein 42 2.09472
CCDC9 coiled-coil domain containing 9 2.09224
SESN2 sestrin 2 2.07819
NLGN3 neuroligin 3 2.07617
MAP4 microtubule-associated protein 4 2.07402
NUP88 nucleoporin 88kDa 2.05628
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 2.05628
INPPL1 inositol polyphosphate phosphatase-like 1 2.05628
RTKN2 rhotekin 2 2.03228
CLSTN1 calsyntenin 1 2.02741
ERC2 ELKS/RAB6-interacting/CAST family member 2 2.02741
MGA MGA, MAX dimerization protein 2.01976
ZNF654 zinc finger protein 654 2.01906
CLDN23 claudin 23 2.01906
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 2.01906
SLC4A3 solute carrier family 4 (anion exchanger), member 3 2.00681
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 2.00301
DUSP26 dual specificity phosphatase 26 (putative) 2.00152

decreased expression

Symbol Name Standardized Value
PPP1R36 protein phosphatase 1, regulatory subunit 36 -3.64186
RTP1 receptor (chemosensory) transporter protein 1 -3.64186
PUF60 poly-U binding splicing factor 60KDa -3.64186
SIAH3 siah E3 ubiquitin protein ligase family member 3 -3.64186
TMEM45B transmembrane protein 45B -3.64186
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 -3.50849
MFAP4 microfibrillar-associated protein 4 -3.50849
APOC4 apolipoprotein C-IV -3.50849
APOC2 apolipoprotein C-II -3.50849
HIPK4 homeodomain interacting protein kinase 4 -3.50849
BRICD5 BRICHOS domain containing 5 -3.50849
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) -3.50849
GABRD gamma-aminobutyric acid (GABA) A receptor, delta -3.50849
C22ORF42 chromosome 22 open reading frame 42 -3.50849
ADGRE3 adhesion G protein-coupled receptor E3 -3.50849
CCR9 chemokine (C-C motif) receptor 9 -3.50849
TFEC transcription factor EC -3.50849
TMEM236 transmembrane protein 236 -3.50849
FRMPD2 FERM and PDZ domain containing 2 -3.50849
LTBP2 latent transforming growth factor beta binding protein 2 -3.50849
PRB2 proline-rich protein BstNI subfamily 2 -3.50849
DMRT1 doublesex and mab-3 related transcription factor 1 -3.50849
OR2A7 olfactory receptor, family 2, subfamily A, member 7 -3.50849
NFAM1 NFAT activating protein with ITAM motif 1 -3.50849
C3ORF49 chromosome 3 open reading frame 49 -3.41104
LRFN2 leucine rich repeat and fibronectin type III domain containing 2 -3.27297
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 -3.04616
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -3.00559
LPAR3 lysophosphatidic acid receptor 3 -2.99035
WDR5 WD repeat domain 5 -2.98497
SNAP47 synaptosomal-associated protein, 47kDa -2.94469
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -2.91621
KCTD21 potassium channel tetramerization domain containing 21 -2.89803
BCL2L10 BCL2-like 10 (apoptosis facilitator) -2.87896
SLC61A1 solute carrier family 61 member 1 -2.84714
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -2.79771
TOX thymocyte selection-associated high mobility group box -2.75739
ZC3H12C zinc finger CCCH-type containing 12C -2.71389
OFD1 oral-facial-digital syndrome 1 -2.68719
HNF4G hepatocyte nuclear factor 4, gamma -2.63496
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa -2.60057
UBE2L3 ubiquitin-conjugating enzyme E2L 3 -2.59895
PARP9 poly (ADP-ribose) polymerase family, member 9 -2.59895
TRPM4 transient receptor potential cation channel, subfamily M, member 4 -2.59238
ZDHHC20 zinc finger, DHHC-type containing 20 -2.5889
TPI1 triosephosphate isomerase 1 -2.57593
NCK2 NCK adaptor protein 2 -2.54452
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -2.5296
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.5296
TMA7 translation machinery associated 7 homolog (S. cerevisiae) -2.48018
LAS1L LAS1-like (S. cerevisiae) -2.46441
COX6C cytochrome c oxidase subunit VIc -2.45669
CNTNAP1 contactin associated protein 1 -2.42092
ITM2C integral membrane protein 2C -2.39717
ALG10 ALG10, alpha-1,2-glucosyltransferase -2.39298
ASF1B anti-silencing function 1B histone chaperone -2.39025
RCAN1 regulator of calcineurin 1 -2.33503
KIAA0040 KIAA0040 -2.25803
ANKRD36C ankyrin repeat domain 36C -2.25803
C21ORF58 chromosome 21 open reading frame 58 -2.2423
COIL coilin -2.24037
PDCL2 phosducin-like 2 -2.24037
PDK1 pyruvate dehydrogenase kinase, isozyme 1 -2.24037
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -2.24037
NUDT4B nudix hydrolase 4B -2.24037
RPN1 ribophorin I -2.23188
TNMD tenomodulin -2.23147
NIPSNAP3B nipsnap homolog 3B (C. elegans) -2.23147
SP140L SP140 nuclear body protein-like -2.21499
PARD6A par-6 family cell polarity regulator alpha -2.21192
BTF3 basic transcription factor 3 -2.14543
CZIB CXXC motif containing zinc binding protein -2.14543
LMLN leishmanolysin-like (metallopeptidase M8 family) -2.14543
RAB5C RAB5C, member RAS oncogene family -2.12805
CLC Charcot-Leyden crystal galectin -2.11097
CAPN11 calpain 11 -2.11097
GJA4 gap junction protein, alpha 4, 37kDa -2.11097
PELI3 pellino E3 ubiquitin protein ligase family member 3 -2.10555
PRDX5 peroxiredoxin 5 -2.07819
UBA1 ubiquitin-like modifier activating enzyme 1 -2.07819
SLC30A6 solute carrier family 30 (zinc transporter), member 6 -2.07472
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -2.07402
CDC50B cell division cycle 50 P4-ATPase accessory subunit B -2.07252
MAGED2 melanoma antigen family D2 -2.05628
USP5 ubiquitin specific peptidase 5 (isopeptidase T) -2.05502
RACK1 receptor for activated C kinase 1 -2.05502
NFE2L2 nuclear factor, erythroid 2-like 2 -2.04692
UBE2M ubiquitin-conjugating enzyme E2M -2.04692
ZNF484 zinc finger protein 484 -2.03978
APH1A APH1A gamma secretase subunit -2.03526
INTS11 integrator complex subunit 11 -2.03146
TSPAN17 tetraspanin 17 -2.02776
LRP2 low density lipoprotein receptor-related protein 2 -2.02169
LHX4 LIM homeobox 4 -2.01906
PIWIL2 piwi-like RNA-mediated gene silencing 2 -2.00236
SRSF3 serine/arginine-rich splicing factor 3 -2.00098