PAX2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description paired box 2|PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014] (NCBI Entrez Gene Database, 5076)
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Genes

318 genes differentially expressed following the PAX2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FOXD1 forkhead box D1 3.27358
CD38 CD38 molecule 3.27358
TMPRSS4 transmembrane protease, serine 4 3.27358
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 3.27358
GJB5 gap junction protein, beta 5, 31.1kDa 3.27358
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 3.27358
EGFL6 EGF-like-domain, multiple 6 3.27358
GNRHR gonadotropin-releasing hormone receptor 3.27358
MST1R macrophage stimulating 1 receptor 3.27358
GREM1 gremlin 1, DAN family BMP antagonist 3.27358
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 3.27358
C1QTNF8 C1q and tumor necrosis factor related protein 8 3.27358
LDB3 LIM domain binding 3 3.27358
RNF17 ring finger protein 17 3.27358
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 3.27358
CD300LF CD300 molecule-like family member f 3.27358
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 3.27358
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 3.27358
CCDC83 coiled-coil domain containing 83 3.27358
MAJIN membrane anchored junction protein 3.27358
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 3.27358
NSG2 neuronal vesicle trafficking associated 2 3.27358
BTBD16 BTB (POZ) domain containing 16 3.27358
LPAR5 lysophosphatidic acid receptor 5 3.27358
GNAT3 guanine nucleotide binding protein, alpha transducing 3 3.27358
RHEX regulator of hemoglobinization and erythroid cell expansion 3.27358
RGS4 regulator of G-protein signaling 4 3.27358
GPR52 G protein-coupled receptor 52 3.17526
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 3.17526
USP26 ubiquitin specific peptidase 26 3.17526
LRRD1 leucine-rich repeats and death domain containing 1 3.17526
OCSTAMP osteoclast stimulatory transmembrane protein 3.17526
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung) 3.17526
NDRG1 N-myc downstream regulated 1 3.17526
WEE2 WEE1 homolog 2 (S. pombe) 3.17526
ENTHD1 ENTH domain containing 1 3.17526
OVGP1 oviductal glycoprotein 1, 120kDa 3.17526
NRN1 neuritin 1 3.17526
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 3.17526
PI16 peptidase inhibitor 16 3.17526
DUXB double homeobox B 3.17526
RFPL3 ret finger protein-like 3 3.17526
CCDC190 coiled-coil domain containing 190 3.17526
TAS2R1 taste receptor, type 2, member 1 3.17526
FABP4 fatty acid binding protein 4, adipocyte 3.17526
SCNN1G sodium channel, non voltage gated 1 gamma subunit 3.17526
LRRC53 leucine rich repeat containing 53 3.17526
TKTL1 transketolase-like 1 3.17526
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 3.17526
ADTRP androgen-dependent TFPI-regulating protein 3.17526
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 3.17526
C3ORF22 chromosome 3 open reading frame 22 3.17526
ANKRD22 ankyrin repeat domain 22 3.17526
OTUD6A OTU deubiquitinase 6A 3.17526
GNLY granulysin 3.17526
LOC390937 Ets2 repressor factor-like 3.17526
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 3.17526
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 3.17526
OTOA otoancorin 3.17526
GBP1 guanylate binding protein 1, interferon-inducible 3.17526
RUNX3 runt-related transcription factor 3 3.17526
SPATA31C1 SPATA31 subfamily C, member 1 3.17526
SRGN serglycin 3.17526
TTR transthyretin 3.17526
SPATA22 spermatogenesis associated 22 3.17526
PHF24 PHD finger protein 24 3.17526
H2BC1 H2B clustered histone 1 3.17526
TTLL13 tubulin tyrosine ligase like 13 3.17526
TEKTL1 tektin like 1 3.17526
C3ORF85 chromosome 3 open reading frame 85 3.17526
LOC124906010 uncharacterized LOC124906010 3.17526
ARMH2 armadillo like helical domain containing 2 3.17526
CCDC197 coiled-coil domain containing 197 3.17526
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 3.17526
DIPK1C divergent protein kinase domain 1C 3.17526
CBLIF cobalamin binding intrinsic factor 3.17526
LY6H lymphocyte antigen 6 complex, locus H 3.17526
IMPG1 interphotoreceptor matrix proteoglycan 1 3.17526
SELL selectin L 3.17526
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 3.17526
TMEM235 transmembrane protein 235 3.17526
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 3.17526
MAGEB3 melanoma antigen family B3 3.17526
PCDHA3 protocadherin alpha 3 3.17526
RAB44 RAB44, member RAS oncogene family 3.17526
IZUMO4 IZUMO family member 4 3.17526
ATP13A5 ATPase type 13A5 3.17526
SCRT2 scratch family zinc finger 2 3.17526
SLAMF8 SLAM family member 8 3.17526
SPDYC speedy/RINGO cell cycle regulator family member C 3.17526
DYNLRB2 dynein, light chain, roadblock-type 2 3.17526
GATA1 GATA binding protein 1 (globin transcription factor 1) 3.17526
NDP Norrie disease (pseudoglioma) 3.17526
COX8C cytochrome c oxidase subunit VIIIC 3.17526
WNT9B wingless-type MMTV integration site family, member 9B 3.17526
OPN4 opsin 4 3.17526
LRRC3C leucine rich repeat containing 3C 3.17526
CCR4 chemokine (C-C motif) receptor 4 3.17526
PTTG2 pituitary tumor-transforming 2 3.17526
HBB hemoglobin, beta 3.17526
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 3.17526
MRLN myoregulin 3.17526
ZNF541 zinc finger protein 541 3.17526
CDC20B cell division cycle 20B 3.17526
EBLN1 endogenous Bornavirus-like nucleoprotein 1 3.17526
ADAM7 ADAM metallopeptidase domain 7 3.17526
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 3.17526
MAB21L1 mab-21-like 1 (C. elegans) 3.17526
CGB2 chorionic gonadotropin, beta polypeptide 2 3.17526
IL17REL interleukin 17 receptor E-like 3.17526
CABP7 calcium binding protein 7 3.17526
NGB neuroglobin 3.17526
USP17L7 ubiquitin specific peptidase 17-like family member 7 3.17526
FADS6 fatty acid desaturase 6 3.17526
STMND1 stathmin domain containing 1 3.17526
NLRP14 NLR family, pyrin domain containing 14 3.17526
ACSM1 acyl-CoA synthetase medium-chain family member 1 3.17526
AGR2 anterior gradient 2 3.17526
GPR50 G protein-coupled receptor 50 3.17526
SMIM22 small integral membrane protein 22 3.17526
C22ORF42 chromosome 22 open reading frame 42 3.17526
THBD thrombomodulin 3.17526
LHX5 LIM homeobox 5 3.17526
CD28 CD28 molecule 3.17526
GSC2 goosecoid homeobox 2 3.17526
EFCC1 EF-hand and coiled-coil domain containing 1 3.17526
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 3.17526
OTP orthopedia homeobox 3.17526
DRC7 dynein regulatory complex subunit 7 3.17526
GOLGA8R golgin A8 family, member R 3.17526
PENK proenkephalin 3.17526
LYZ lysozyme 3.17526
DLX3 distal-less homeobox 3 3.17526
PLA1A phospholipase A1 member A 3.17526
CFI complement factor I 3.17526
SAMD9 sterile alpha motif domain containing 9 3.17526
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 3.17526
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.17526
ARL13A ADP-ribosylation factor-like 13A 3.17526
ZC3H12D zinc finger CCCH-type containing 12D 3.17526
DMRT2 doublesex and mab-3 related transcription factor 2 3.17526
PDK4 pyruvate dehydrogenase kinase, isozyme 4 3.17526
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 3.17526
FCAR Fc fragment of IgA receptor 3.17526
BPIFC BPI fold containing family C 3.17526
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 3.17526
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 3.17526
NXF2 nuclear RNA export factor 2 3.17526
CPLX3 complexin 3 3.17526
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene) 3.17526
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 3.17526
ARSH arylsulfatase family, member H 3.17526
SCIN scinderin 3.17526
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 3.17526
SNAI2 snail family zinc finger 2 3.17526
GALP galanin-like peptide 3.17526
GALR2 galanin receptor 2 3.17526
FOXP3 forkhead box P3 3.17526
NMUR1 neuromedin U receptor 1 3.17526
SPDEF SAM pointed domain containing ETS transcription factor 3.17526
TMPRSS15 transmembrane protease, serine 15 3.17526
NLRP7 NLR family, pyrin domain containing 7 3.05534
GMFG glia maturation factor, gamma 3.0401
KLF5 Kruppel-like factor 5 (intestinal) 3.03534
RPS11 ribosomal protein S11 2.97412
TRPC3 transient receptor potential cation channel, subfamily C, member 3 2.82766
MMP16 matrix metallopeptidase 16 (membrane-inserted) 2.80057
FGF11 fibroblast growth factor 11 2.80057
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 2.74534
TASOR2 transcription activation suppressor family member 2 2.7146
EPHA1 EPH receptor A1 2.51443
CTF1 cardiotrophin 1 2.48097
RLIG1 RNA 5'-phosphate and 3'-OH ligase 1 2.46835
CAPZB capping protein (actin filament) muscle Z-line, beta 2.454
BBS9 Bardet-Biedl syndrome 9 2.44141
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 2.43963
RGS16 regulator of G-protein signaling 16 2.43561
SYK spleen tyrosine kinase 2.4085
TMEM185B transmembrane protein 185B 2.4085
POFUT2 protein O-fucosyltransferase 2 2.40335
MYZAP myocardial zonula adherens protein 2.38078
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 2.3756
SNX33 sorting nexin 33 2.34153
FGF16 fibroblast growth factor 16 2.33911
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 2.32517
RC3H2 ring finger and CCCH-type domains 2 2.31624
CDC23 cell division cycle 23 2.31307
PDE10A phosphodiesterase 10A 2.30017
KIAA0319L KIAA0319-like 2.27851
DHFR2 dihydrofolate reductase 2 2.27553
DEXI Dexi homolog (mouse) 2.26642
CRAMP1 cramped chromatin regulator homolog 1 2.24664
BGN biglycan 2.24664
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 2.23558
C11ORF16 chromosome 11 open reading frame 16 2.23193
SNU13 small nuclear ribonucleoprotein 13 2.2258
RBM39 RNA binding motif protein 39 2.2205
EGLN2 egl-9 family hypoxia-inducible factor 2 2.2205
CNTFR ciliary neurotrophic factor receptor 2.20633
PLEKHA7 pleckstrin homology domain containing, family A member 7 2.20566
TSPAN4 tetraspanin 4 2.18694
NECTIN2 nectin cell adhesion molecule 2 2.18074
ATF5 activating transcription factor 5 2.17094
PABPN1 poly(A) binding protein, nuclear 1 2.15716
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 2.15455
ARHGAP39 Rho GTPase activating protein 39 2.15351
ASPN asporin 2.14784
ZNF43 zinc finger protein 43 2.11295
TMEM41A transmembrane protein 41A 2.10921
FAM227B family with sequence similarity 227, member B 2.10569
ADGRB3 adhesion G protein-coupled receptor B3 2.05753
SCIMP SLP adaptor and CSK interacting membrane protein 2.05326
BMP8A bone morphogenetic protein 8a 2.05326
PARVG parvin, gamma 2.05326
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 2.03493
TFPI2 tissue factor pathway inhibitor 2 2.02981
SNX9 sorting nexin 9 2.02981
SNX32 sorting nexin 32 2.0041
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 2.0041
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.002

decreased expression

Symbol Name Standardized Value
DDIT4L DNA-damage-inducible transcript 4-like -3.27358
CLDN5 claudin 5 -3.27358
UNC13C unc-13 homolog C (C. elegans) -3.17526
RASA4B RAS p21 protein activator 4B -3.17526
SHC4 SHC (Src homology 2 domain containing) family, member 4 -3.17526
RNF39 ring finger protein 39 -3.17526
SOST sclerostin -3.17526
SPINT4 serine peptidase inhibitor, Kunitz type 4 -3.17526
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 -3.17526
STAB1 stabilin 1 -3.17526
VAX2 ventral anterior homeobox 2 -3.17526
GBP4 guanylate binding protein 4 -3.17526
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 -3.17526
LAT linker for activation of T cells -3.17526
VN1R1 vomeronasal 1 receptor 1 -3.17526
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) -3.17526
CDX4 caudal type homeobox 4 -3.17526
DEFB131B defensin beta 131B -3.17526
ZNF98 zinc finger protein 98 -3.17526
TMPRSS11A transmembrane protease, serine 11A -3.17526
COL20A1 collagen, type XX, alpha 1 -3.17526
SOX7 SRY (sex determining region Y)-box 7 -3.17526
EBF4 early B-cell factor 4 -3.17526
LCNL1 lipocalin-like 1 -3.17526
FAM209A family with sequence similarity 209, member A -3.17526
CFAP126 cilia and flagella associated protein 126 -3.17526
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -3.17526
RIPPLY2 ripply transcriptional repressor 2 -3.17526
UTS2R urotensin 2 receptor -3.17526
SFRP5 secreted frizzled-related protein 5 -3.17526
SAMD5 sterile alpha motif domain containing 5 -3.17526
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 -3.17526
RGS19 regulator of G-protein signaling 19 -3.17526
PIH1D2 PIH1 domain containing 2 -3.17526
C1ORF167 chromosome 1 open reading frame 167 -3.08484
MEGF10 multiple EGF-like-domains 10 -2.91053
MCEE methylmalonyl CoA epimerase -2.87947
EXD2 exonuclease 3'-5' domain containing 2 -2.82835
TP73 tumor protein p73 -2.80844
NAP1L5 nucleosome assembly protein 1-like 5 -2.76851
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -2.74046
PAH phenylalanine hydroxylase -2.74046
MRPL3 mitochondrial ribosomal protein L3 -2.64052
NBPF3 neuroblastoma breakpoint family, member 3 -2.54015
MMP19 matrix metallopeptidase 19 -2.52063
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 -2.52063
SF3A2 splicing factor 3a, subunit 2, 66kDa -2.51443
VANGL2 VANGL planar cell polarity protein 2 -2.47363
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) -2.454
NPIPA5 nuclear pore complex interacting protein family, member A5 -2.43891
CYTIP cytohesin 1 interacting protein -2.43891
PELI1 pellino E3 ubiquitin protein ligase 1 -2.38078
GRIK2 glutamate receptor, ionotropic, kainate 2 -2.36522
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I -2.32232
GOLGA5 golgin A5 -2.27081
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 -2.27081
PYDC1 PYD (pyrin domain) containing 1 -2.26642
GPR34 G protein-coupled receptor 34 -2.26642
SNPH syntaphilin -2.26642
GJD3 gap junction protein, delta 3, 31.9kDa -2.26642
C11ORF58 chromosome 11 open reading frame 58 -2.26642
SHBG sex hormone-binding globulin -2.26642
TIGD6 tigger transposable element derived 6 -2.26642
KDM6B lysine (K)-specific demethylase 6B -2.26642
NRARP NOTCH-regulated ankyrin repeat protein -2.26164
SFR1 SWI5-dependent recombination repair 1 -2.24664
YEATS2 YEATS domain containing 2 -2.24279
ZNF594 zinc finger protein 594 -2.23731
MYO6 myosin VI -2.23558
SDC1 syndecan 1 -2.2205
COX6B2 cytochrome c oxidase subunit VIb polypeptide 2 (testis) -2.21955
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa -2.21559
CCDC127 coiled-coil domain containing 127 -2.20882
TOGARAM1 TOG array regulator of axonemal microtubules 1 -2.20795
SLC4A2 solute carrier family 4 (anion exchanger), member 2 -2.20673
AQP3 aquaporin 3 (Gill blood group) -2.20633
RHEB Ras homolog enriched in brain -2.18003
ANKRD50 ankyrin repeat domain 50 -2.17014
MFN2 mitofusin 2 -2.15351
MRPL57 mitochondrial ribosomal protein L57 -2.14784
UNC119B unc-119 homolog B (C. elegans) -2.12835
KMT5C lysine methyltransferase 5C -2.11182
CCDC6 coiled-coil domain containing 6 -2.10921
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -2.10457
CNTD1 cyclin N-terminal domain containing 1 -2.10419
TTC39C tetratricopeptide repeat domain 39C -2.07539
PEAK1 pseudopodium-enriched atypical kinase 1 -2.07239
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa -2.072
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) -2.06058
FIGNL1 fidgetin-like 1 -2.04393
CDC26 cell division cycle 26 -2.02981
IL6ST interleukin 6 signal transducer -2.02981
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.02981
TBC1D24 TBC1 domain family, member 24 -2.01305
ADSL adenylosuccinate lyase -2.01305
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis) -2.00747
RAB20 RAB20, member RAS oncogene family -2.0041
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog -2.0041