PAX5 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description paired box 5|This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 5079)
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Genes

325 genes differentially expressed following the PAX5 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PRB2 proline-rich protein BstNI subfamily 2 3.00512
ACADL acyl-CoA dehydrogenase, long chain 3.00512
AREG amphiregulin 3.00512
SPATA9 spermatogenesis associated 9 3.00512
ADAD2 adenosine deaminase domain containing 2 3.00512
GREM1 gremlin 1, DAN family BMP antagonist 3.00512
GPR179 G protein-coupled receptor 179 3.00512
PGM5 phosphoglucomutase 5 3.00512
PDYN prodynorphin 3.00512
NXPH3 neurexophilin 3 3.00512
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 3.00512
IL10RA interleukin 10 receptor, alpha 3.00512
FAM186A family with sequence similarity 186, member A 3.00512
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 3.00512
FGF21 fibroblast growth factor 21 3.00512
CARNS1 carnosine synthase 1 3.00512
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 3.00512
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 3.00512
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 3.00512
CCDC163 CCDC163 homolog 3.00512
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 3.00512
MYLK2 myosin light chain kinase 2 3.00512
ODAPH odontogenesis associated phosphoprotein 3.00512
CPB1 carboxypeptidase B1 (tissue) 3.00512
GRM6 glutamate receptor, metabotropic 6 3.00512
VN1R1 vomeronasal 1 receptor 1 3.00512
TRPV6 transient receptor potential cation channel, subfamily V, member 6 3.00512
IL15 interleukin 15 2.89624
TRIM42 tripartite motif containing 42 2.86071
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 2.86071
IL22RA1 interleukin 22 receptor, alpha 1 2.86071
ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7 2.86071
SPNS2 spinster homolog 2 (Drosophila) 2.86071
ASPDH aspartate dehydrogenase domain containing 2.86071
NAPSA napsin A aspartic peptidase 2.86071
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.86071
TREM2 triggering receptor expressed on myeloid cells 2 2.86071
CHADL chondroadherin-like 2.86071
SCN2B sodium channel, voltage gated, type II beta subunit 2.86071
CD209 CD209 molecule 2.86071
TMEM176B transmembrane protein 176B 2.86071
SLC23A3 solute carrier family 23, member 3 2.86071
ADGB androglobin 2.86071
MKI67 marker of proliferation Ki-67 2.86071
C1ORF141 chromosome 1 open reading frame 141 2.86071
RSPO3 R-spondin 3 2.86071
NFAM1 NFAT activating protein with ITAM motif 1 2.86071
FOLR2 folate receptor 2 (fetal) 2.86071
MTTP microsomal triglyceride transfer protein 2.86071
ARRDC5 arrestin domain containing 5 2.86071
HES3 hes family bHLH transcription factor 3 2.86071
MUC6 mucin 6, oligomeric mucus/gel-forming 2.86071
C8ORF48 chromosome 8 open reading frame 48 2.86071
RFPL2 ret finger protein-like 2 2.86071
HCRTR1 hypocretin (orexin) receptor 1 2.86071
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 2.86071
CFHR3 complement factor H-related 3 2.86071
WASL-DT WASL divergent transcript 2.86071
H3-5 H3.5 histone 2.86071
GPAT3 glycerol-3-phosphate acyltransferase 3 2.86071
KY kyphoscoliosis peptidase 2.86071
ZAR1 zygote arrest 1 2.86071
UNC93A unc-93 homolog A (C. elegans) 2.86071
ROPN1B rhophilin associated tail protein 1B 2.86071
AVPR1B arginine vasopressin receptor 1B 2.86071
LY6S lymphocyte antigen 6 family member S 2.86071
FMO2 flavin containing monooxygenase 2 (non-functional) 2.86071
CCDC9B coiled-coil domain containing 9B 2.86071
TMEM275 transmembrane protein 275 2.86071
MYOCOS myocilin opposite strand 2.86071
REELD1 reeler domain containing 1 2.86071
INSYN1 inhibitory synaptic factor 1 2.86071
SMIM35 small integral membrane protein 35 2.86071
CFAP276 cilia and flagella associated protein 276 2.86071
DEFB131B defensin beta 131B 2.86071
TRARG1 trafficking regulator of GLUT4 (SLC2A4) 1 2.86071
MAB21L4 mab-21 like 4 2.86071
CCN5 cellular communication network factor 5 2.86071
DEPP1 DEPP autophagy regulator 1 2.86071
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.86071
LMNTD1 lamin tail domain containing 1 2.86071
ACSL5 acyl-CoA synthetase long-chain family member 5 2.86071
C1QL3 complement component 1, q subcomponent-like 3 2.86071
CFAP45 cilia and flagella associated protein 45 2.86071
GDF10 growth differentiation factor 10 2.86071
TLR1 toll-like receptor 1 2.86071
DMBX1 diencephalon/mesencephalon homeobox 1 2.86071
HPR haptoglobin-related protein 2.86071
ZSWIM2 zinc finger, SWIM-type containing 2 2.86071
PTPRH protein tyrosine phosphatase, receptor type, H 2.86071
OR2A1 olfactory receptor, family 2, subfamily A, member 1 2.86071
PRR4 proline rich 4 (lacrimal) 2.86071
CELA2A chymotrypsin-like elastase family, member 2A 2.86071
PGA5 pepsinogen 5, group I (pepsinogen A) 2.86071
MYEOV myeloma overexpressed 2.86071
FOXC1 forkhead box C1 2.86071
RAB36 RAB36, member RAS oncogene family 2.86071
TSPAN1 tetraspanin 1 2.86071
TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like 2.86071
TUBA4B tubulin, alpha 4b 2.86071
TAS1R1 taste receptor, type 1, member 1 2.86071
TIMD4 T-cell immunoglobulin and mucin domain containing 4 2.86071
ARHGAP15 Rho GTPase activating protein 15 2.86071
SRL sarcalumenin 2.86071
TBC1D28 TBC1 domain family, member 28 2.86071
CTAGE4 CTAGE family, member 4 2.86071
NANOGNB NANOG neighbor homeobox 2.86071
C2ORF66 chromosome 2 open reading frame 66 2.86071
WFDC6 WAP four-disulfide core domain 6 2.86071
GOLGA6B golgin A6 family, member B 2.86071
ARG1 arginase 1 2.86071
FIBIN fin bud initiation factor homolog (zebrafish) 2.86071
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.86071
HHLA2 HERV-H LTR-associating 2 2.86071
KLHL1 kelch-like family member 1 2.86071
CSF3R colony stimulating factor 3 receptor (granulocyte) 2.86071
CALML6 calmodulin-like 6 2.86071
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.86071
BMX BMX non-receptor tyrosine kinase 2.86071
MYF6 myogenic factor 6 (herculin) 2.86071
TCEA3 transcription elongation factor A (SII), 3 2.86071
NLRC4 NLR family, CARD domain containing 4 2.86071
OLFML1 olfactomedin-like 1 2.86071
TEKT1 tektin 1 2.86071
RGCC regulator of cell cycle 2.86071
CD300LF CD300 molecule-like family member f 2.86071
IBSP integrin-binding sialoprotein 2.86071
RGS8 regulator of G-protein signaling 8 2.86071
CYTH4 cytohesin 4 2.86071
RBBP8NL RBBP8 N-terminal like 2.86071
TYR tyrosinase 2.86071
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 2.86071
GJB6 gap junction protein, beta 6, 30kDa 2.86071
STH saitohin 2.86071
LY9 lymphocyte antigen 9 2.86071
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 2.86071
ITGA8 integrin, alpha 8 2.86071
FAM135B family with sequence similarity 135, member B 2.86071
ZNF843 zinc finger protein 843 2.86071
ZNF841 zinc finger protein 841 2.86071
CD200R1 CD200 receptor 1 2.86071
TPPP2 tubulin polymerization-promoting protein family member 2 2.86071
GFRAL GDNF family receptor alpha like 2.86071
GSTA1 glutathione S-transferase alpha 1 2.86071
GOLGA8N golgin A8 family, member N 2.86071
PRR15L proline rich 15-like 2.86071
CD22 CD22 molecule 2.86071
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.86071
LY6G5C lymphocyte antigen 6 complex, locus G5C 2.86071
GPR61 G protein-coupled receptor 61 2.86071
TMPRSS15 transmembrane protease, serine 15 2.86071
TMEM88 transmembrane protein 88 2.86071
RAB7B RAB7B, member RAS oncogene family 2.86071
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 2.86071
GPR17 G protein-coupled receptor 17 2.86071
ISX intestine-specific homeobox 2.86071
PADI4 peptidyl arginine deiminase, type IV 2.86071
SYTL5 synaptotagmin-like 5 2.86071
ANXA2R annexin A2 receptor 2.86071
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 2.86071
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 2.86071
TEX35 testis expressed 35 2.86071
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 2.86071
PPP1R3C protein phosphatase 1, regulatory subunit 3C 2.86071
TLDC2 TBC/LysM-associated domain containing 2 2.86071
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 2.86071
OR5A1 olfactory receptor, family 5, subfamily A, member 1 2.86071
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 2.86071
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase 2.86071
RERGL RERG/RAS-like 2.86071
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 2.84166
SLC39A14 solute carrier family 39 (zinc transporter), member 14 2.79944
TMEM100 transmembrane protein 100 2.71771
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 2.61155
TIMM29 translocase of inner mitochondrial membrane 29 2.6079
EMD emerin 2.59816
ERI1 exoribonuclease 1 2.58239
DPH6 diphthamine biosynthesis 6 2.55946
ATXN7 ataxin 7 2.53666
BAZ1A bromodomain adjacent to zinc finger domain, 1A 2.51015
MCM4 minichromosome maintenance complex component 4 2.48875
ACSF2 acyl-CoA synthetase family member 2 2.48875
NF1 neurofibromin 1 2.46112
KRT7 keratin 7, type II 2.46112
LAMC2 laminin, gamma 2 2.45195
RANBP3L RAN binding protein 3-like 2.43656
CTRL chymotrypsin-like 2.43656
SRP9 signal recognition particle 9kDa 2.43656
PARP15 poly (ADP-ribose) polymerase family, member 15 2.39884
CKM creatine kinase, muscle 2.39884
PLEKHO1 pleckstrin homology domain containing, family O member 1 2.3832
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 2.3733
ZNF786 zinc finger protein 786 2.35931
WDR27 WD repeat domain 27 2.35475
UBE2G2 ubiquitin-conjugating enzyme E2G 2 2.35233
BEX5 brain expressed, X-linked 5 2.33396
LEP leptin 2.29412
CREB3L2 cAMP responsive element binding protein 3-like 2 2.2541
NFIA nuclear factor I/A 2.23344
NTF3 neurotrophin 3 2.18521
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 2.18232
HDAC4 histone deacetylase 4 2.15127
PCCB propionyl CoA carboxylase, beta polypeptide 2.15127
RCAN2 regulator of calcineurin 2 2.12705
ZBTB9 zinc finger and BTB domain containing 9 2.12389
MACF1 microtubule-actin crosslinking factor 1 2.11235
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 2.07985
TMEM183A transmembrane protein 183A 2.07633
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 2.06995
GSS glutathione synthetase 2.06794
CLDND2 claudin domain containing 2 2.05802
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 2.05169
ADAT2 adenosine deaminase, tRNA-specific 2 2.04667
E2F2 E2F transcription factor 2 2.03387
NBPF9 neuroblastoma breakpoint family, member 9 2.00753
ZNF397 zinc finger protein 397 2.00753
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 2.00753

decreased expression

Symbol Name Standardized Value
H2BC13 H2B clustered histone 13 -3.00512
C3ORF49 chromosome 3 open reading frame 49 -3.00512
LBP lipopolysaccharide binding protein -3.00512
LPAR2 lysophosphatidic acid receptor 2 -3.00512
XIRP2 xin actin binding repeat containing 2 -3.00512
SNAP91 synaptosomal-associated protein, 91kDa -3.00512
NEXMIF neurite extension and migration factor -3.00512
GOLGA6L7 golgin A6 family like 7 -2.86071
FBXO6 F-box protein 6 -2.86071
SLC39A12 solute carrier family 39 (zinc transporter), member 12 -2.86071
VCX variable charge, X-linked -2.86071
CORO2A coronin, actin binding protein, 2A -2.86071
ELF4 E74-like factor 4 (ets domain transcription factor) -2.86071
PPP1R3A protein phosphatase 1, regulatory subunit 3A -2.86071
CD8B CD8b molecule -2.86071
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -2.86071
TLCD2 TLC domain containing 2 -2.86071
ATP5MGL ATP synthase membrane subunit g like -2.86071
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -2.86071
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 -2.86071
SIM1 single-minded family bHLH transcription factor 1 -2.86071
LMNTD2 lamin tail domain containing 2 -2.86071
EOLA1 endothelium and lymphocyte associated ASCH domain 1 -2.86071
BHLHE41 basic helix-loop-helix family, member e41 -2.86071
TRPA1 transient receptor potential cation channel, subfamily A, member 1 -2.86071
GDF6 growth differentiation factor 6 -2.86071
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 -2.86071
THPO thrombopoietin -2.86071
LBHD1 LBH domain containing 1 -2.86071
PCDHB9 protocadherin beta 9 -2.86071
LRRTM2 leucine rich repeat transmembrane neuronal 2 -2.86071
FGF18 fibroblast growth factor 18 -2.86071
NACA2 nascent polypeptide-associated complex alpha subunit 2 -2.86071
TTLL10 tubulin tyrosine ligase-like family member 10 -2.86071
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) -2.86071
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 -2.86071
SV2B synaptic vesicle glycoprotein 2B -2.86071
CNR2 cannabinoid receptor 2 (macrophage) -2.86071
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) -2.86071
PRRT1B proline rich transmembrane protein 1B -2.86071
HLA-DMB major histocompatibility complex, class II, DM beta -2.86071
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 -2.73195
ATCAY ataxia, cerebellar, Cayman type -2.70799
CSE1L CSE1 chromosome segregation 1-like (yeast) -2.68551
NPIPB12 nuclear pore complex interacting protein family member B12 -2.65504
HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 -2.6079
XPO6 exportin 6 -2.56483
CBX1 chromobox homolog 1 -2.56483
RNF103 ring finger protein 103 -2.56221
CEP350 centrosomal protein 350kDa -2.56221
MARCHF2 membrane associated ring-CH-type finger 2 -2.55018
CRHR2 corticotropin releasing hormone receptor 2 -2.53624
ZNF225 zinc finger protein 225 -2.53624
TCP11L2 t-complex 11, testis-specific-like 2 -2.53624
MVB12B multivesicular body subunit 12B -2.53114
ZCCHC2 zinc finger, CCHC domain containing 2 -2.53114
DUSP4 dual specificity phosphatase 4 -2.50973
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae) -2.50346
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein -2.48875
TRIM68 tripartite motif containing 68 -2.48875
PSD pleckstrin and Sec7 domain containing -2.48875
ZDHHC9 zinc finger, DHHC-type containing 9 -2.48603
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 -2.40569
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 -2.38324
ATAD2B ATPase family, AAA domain containing 2B -2.35436
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 -2.3453
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa -2.34132
SHANK2 SH3 and multiple ankyrin repeat domains 2 -2.33694
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase -2.32663
DACT2 dishevelled-binding antagonist of beta-catenin 2 -2.30894
EVI5L ecotropic viral integration site 5-like -2.30646
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4 -2.29634
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 -2.29412
SMIM17 small integral membrane protein 17 -2.29226
ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 -2.23486
CPM carboxypeptidase M -2.23486
ZNF439 zinc finger protein 439 -2.23324
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 -2.23324
KCTD7 potassium channel tetramerization domain containing 7 -2.22856
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme -2.22856
CCL2 chemokine (C-C motif) ligand 2 -2.2283
TMEM70 transmembrane protein 70 -2.22298
DUSP5 dual specificity phosphatase 5 -2.20148
SF3B4 splicing factor 3b, subunit 4, 49kDa -2.20148
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -2.18178
FBLIM1 filamin binding LIM protein 1 -2.14187
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 -2.12389
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 -2.1183
HAT1 histone acetyltransferase 1 -2.11141
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.10383
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase -2.09295
DENND6B DENN/MADD domain containing 6B -2.09295
BMP4 bone morphogenetic protein 4 -2.09295
ZNF771 zinc finger protein 771 -2.08748
TLE2 transducin-like enhancer of split 2 -2.07633
RARG retinoic acid receptor, gamma -2.07633
CFAP418 cilia and flagella associated protein 418 -2.07633
RCN3 reticulocalbin 3, EF-hand calcium binding domain -2.06794
KLHL26 kelch-like family member 26 -2.06794
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -2.06448
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -2.04667
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) -2.04415
SAXO1 stabilizer of axonemal microtubules 1 -2.03387
GLI2 GLI family zinc finger 2 -2.03387
EPOR erythropoietin receptor -2.02899
PDLIM1 PDZ and LIM domain 1 -2.02396
FBXO44 F-box protein 44 -2.02147
ARHGAP4 Rho GTPase activating protein 4 -2.01338