| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | paired box 5|This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 5079) |
| External Link | https://ncbi.nlm.nih.gov/gene/5079 |
| Similar Terms | |
| Downloads & Tools |
498 genes differentially expressed following the PAX5 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0146236 |
| S100P | S100 calcium binding protein P | 0.0144124 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0126287 |
| ADI1 | acireductone dioxygenase 1 | 0.011914 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | 0.0112827 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0109408 |
| OLFM4 | olfactomedin 4 | 0.0108954 |
| AZU1 | azurocidin 1 | 0.0105418 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0104503 |
| CLU | clusterin | 0.010272 |
| MEN1 | multiple endocrine neoplasia I | 0.00975503 |
| CHGB | chromogranin B | 0.00975347 |
| ADIRF | adipogenesis regulatory factor | 0.00971237 |
| TOB1 | transducer of ERBB2, 1 | 0.00936508 |
| TAC1 | tachykinin, precursor 1 | 0.00936179 |
| ATP9A | ATPase, class II, type 9A | 0.00934532 |
| PROM1 | prominin 1 | 0.00925642 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.00924692 |
| STMN2 | stathmin 2 | 0.00915187 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.00911366 |
| JAG1 | jagged 1 | 0.00908507 |
| NEBL | nebulette | 0.00904692 |
| SH3YL1 | SH3 and SYLF domain containing 1 | 0.00902465 |
| DLK1 | delta-like 1 homolog (Drosophila) | 0.00895621 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0088824 |
| HSPA1A | heat shock 70kDa protein 1A | 0.00865895 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.00863773 |
| NEFH | neurofilament, heavy polypeptide | 0.00863145 |
| KRT7 | keratin 7, type II | 0.00858571 |
| ZIC1 | Zic family member 1 | 0.00857771 |
| BAMBI | BMP and activin membrane-bound inhibitor | 0.00847283 |
| PRUNE2 | prune homolog 2 (Drosophila) | 0.00846955 |
| ELANE | elastase, neutrophil expressed | 0.00839171 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.00835569 |
| BCL11A | B-cell CLL/lymphoma 11A (zinc finger protein) | 0.00821571 |
| VLDLR | very low density lipoprotein receptor | 0.00813061 |
| PTGDS | prostaglandin D2 synthase 21kDa (brain) | 0.00803202 |
| RNASE3 | ribonuclease, RNase A family, 3 | 0.00800499 |
| TFRC | transferrin receptor | 0.00793561 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.00790937 |
| GALC | galactosylceramidase | 0.00790881 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.00785602 |
| KRT14 | keratin 14, type I | 0.00777859 |
| GPX2 | glutathione peroxidase 2 | 0.00770258 |
| PRTN3 | proteinase 3 | 0.00769561 |
| MS4A3 | membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) | 0.00766153 |
| BEX1 | brain expressed, X-linked 1 | 0.00765128 |
| KRT15 | keratin 15, type I | 0.00755339 |
| COG7 | component of oligomeric golgi complex 7 | 0.0075255 |
| LITAF | lipopolysaccharide-induced TNF factor | 0.0075102 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.00748517 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0074307 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.00738366 |
| RNASE2 | ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) | 0.00734671 |
| CRABP1 | cellular retinoic acid binding protein 1 | 0.00734602 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.00734093 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 0.00731787 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.00728556 |
| TRIM16 | tripartite motif containing 16 | 0.00727803 |
| MYB | v-myb avian myeloblastosis viral oncogene homolog | 0.00723596 |
| PENK | proenkephalin | 0.00723107 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.00722187 |
| KRT81 | keratin 81, type II | 0.00721657 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.00718775 |
| TFF1 | trefoil factor 1 | 0.00717611 |
| EGR1 | early growth response 1 | 0.00717595 |
| SCAND1 | SCAN domain containing 1 | 0.00715308 |
| PRPF4 | pre-mRNA processing factor 4 | 0.00714047 |
| TIMP4 | TIMP metallopeptidase inhibitor 4 | 0.0071164 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.00711536 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.00710672 |
| KRT10 | keratin 10, type I | 0.0070705 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 | 0.00705921 |
| PEG10 | paternally expressed 10 | 0.00700423 |
| MT1X | metallothionein 1X | 0.00698814 |
| PITX3 | paired-like homeodomain 3 | 0.0069563 |
| FGF1 | fibroblast growth factor 1 (acidic) | 0.00694221 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.00693174 |
| DNAJC6 | DnaJ (Hsp40) homolog, subfamily C, member 6 | 0.00691188 |
| CHMP4A | charged multivesicular body protein 4A | 0.00691021 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.00690213 |
| APLP1 | amyloid beta (A4) precursor-like protein 1 | 0.00684942 |
| COCH | cochlin | 0.00684763 |
| IFT20 | intraflagellar transport 20 | 0.00681336 |
| SELE | selectin E | 0.00675198 |
| KRT5 | keratin 5, type II | 0.00669702 |
| GALNT1 | polypeptide N-acetylgalactosaminyltransferase 1 | 0.00669095 |
| GRB7 | growth factor receptor-bound protein 7 | 0.00660541 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.00658367 |
| PMP2 | peripheral myelin protein 2 | 0.00657717 |
| PKIA | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | 0.00657293 |
| RGS2 | regulator of G-protein signaling 2 | 0.00655831 |
| GPM6B | glycoprotein M6B | 0.00655741 |
| KRT13 | keratin 13, type I | 0.00649228 |
| LRRN3 | leucine rich repeat neuronal 3 | 0.00647692 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.00645619 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | 0.00645241 |
| JUNB | jun B proto-oncogene | 0.00644562 |
| GAP43 | growth associated protein 43 | 0.00643551 |
| SLC25A14 | solute carrier family 25 (mitochondrial carrier, brain), member 14 | 0.00643214 |
| CTSG | cathepsin G | 0.00642969 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.00642825 |
| SPIB | Spi-B transcription factor (Spi-1/PU.1 related) | 0.00640393 |
| LXN | latexin | 0.0064012 |
| INA | internexin neuronal intermediate filament protein, alpha | 0.0063716 |
| LCN2 | lipocalin 2 | 0.0063484 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | 0.00633199 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | 0.00630565 |
| TICAM1 | toll-like receptor adaptor molecule 1 | 0.00629965 |
| BCAS1 | breast carcinoma amplified sequence 1 | 0.00628884 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | 0.00628294 |
| PGAP3 | post-GPI attachment to proteins 3 | 0.00628253 |
| NOC3L | nucleolar complex associated 3 homolog (S. cerevisiae) | 0.00623695 |
| KIAA0100 | KIAA0100 | 0.00623132 |
| TSPO | translocator protein (18kDa) | 0.00622803 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | 0.00621761 |
| PADI2 | peptidyl arginine deiminase, type II | 0.006151 |
| LPAR1 | lysophosphatidic acid receptor 1 | 0.00604935 |
| GPI | glucose-6-phosphate isomerase | 0.00603033 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 0.00602111 |
| RPP40 | ribonuclease P/MRP 40kDa subunit | 0.00601493 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0060112 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.00599405 |
| TSNAX | translin-associated factor X | 0.00598266 |
| C3ORF14 | chromosome 3 open reading frame 14 | 0.00596362 |
| MAP2K6 | mitogen-activated protein kinase kinase 6 | 0.00596125 |
| CA12 | carbonic anhydrase XII | 0.00596042 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | 0.0059602 |
| MLF1 | myeloid leukemia factor 1 | 0.00594739 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.00591967 |
| TRIM29 | tripartite motif containing 29 | 0.00588077 |
| S100A8 | S100 calcium binding protein A8 | 0.00587985 |
| SDHAF3 | succinate dehydrogenase complex assembly factor 3 | 0.00586988 |
| GPX7 | glutathione peroxidase 7 | 0.00586223 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.00585982 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 0.00585527 |
| KCNJ2 | potassium channel, inwardly rectifying subfamily J, member 2 | 0.00584808 |
| PLCB4 | phospholipase C, beta 4 | 0.0058434 |
| SGCG | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) | 0.00584069 |
| MMP1 | matrix metallopeptidase 1 | 0.00583943 |
| LYRM4 | LYR motif containing 4 | 0.00583442 |
| NEFM | neurofilament, medium polypeptide | 0.00583429 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | 0.00582398 |
| KCNK3 | potassium channel, two pore domain subfamily K, member 3 | 0.00582014 |
| KRT19 | keratin 19, type I | 0.00581668 |
| DSP | desmoplakin | 0.00580423 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | 0.00576348 |
| TAGLN3 | transgelin 3 | 0.00576058 |
| RHOBTB1 | Rho-related BTB domain containing 1 | 0.00575903 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.00575808 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | 0.00575126 |
| SMYD3 | SET and MYND domain containing 3 | 0.00574999 |
| RCAN1 | regulator of calcineurin 1 | 0.00573839 |
| EFNB2 | ephrin-B2 | 0.00573219 |
| SRGN | serglycin | 0.00572006 |
| ADD3 | adducin 3 (gamma) | 0.00570843 |
| NFASC | neurofascin | 0.00567301 |
| RET | ret proto-oncogene | 0.00564339 |
| MPO | myeloperoxidase | 0.00564235 |
| S100A7 | S100 calcium binding protein A7 | 0.00562538 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | 0.00562352 |
| HMP19 | HMP19 protein | 0.00560881 |
| TLCD3A | TLC domain containing 3A | 0.00558829 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | 0.00558777 |
| C9ORF3 | chromosome 9 open reading frame 3 | 0.00558773 |
| TMED3 | transmembrane emp24 protein transport domain containing 3 | 0.00556757 |
| NDRG4 | NDRG family member 4 | 0.00556273 |
| WFDC1 | WAP four-disulfide core domain 1 | 0.00554702 |
| CEACAM7 | carcinoembryonic antigen-related cell adhesion molecule 7 | 0.0055363 |
| MRPL33 | mitochondrial ribosomal protein L33 | 0.00553359 |
| ASTN2 | astrotactin 2 | 0.00546858 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 0.00546328 |
| TBX3 | T-box 3 | 0.00544338 |
| VSNL1 | visinin-like 1 | 0.00543768 |
| TXNDC9 | thioredoxin domain containing 9 | 0.00543127 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0054274 |
| PRPH | peripherin | 0.00540284 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.00539994 |
| KBTBD11 | kelch repeat and BTB (POZ) domain containing 11 | 0.00539342 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.00539163 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 0.00538371 |
| ERCC1 | excision repair cross-complementation group 1 | 0.00538083 |
| MGST3 | microsomal glutathione S-transferase 3 | 0.00537843 |
| CSTA | cystatin A (stefin A) | 0.00536809 |
| HDAC9 | histone deacetylase 9 | 0.00535758 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.00535731 |
| SLC22A4 | solute carrier family 22 (organic cation/zwitterion transporter), member 4 | 0.00533297 |
| PCP4 | Purkinje cell protein 4 | 0.00533065 |
| HEBP2 | heme binding protein 2 | 0.00533049 |
| INSM1 | insulinoma-associated 1 | 0.00532716 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 0.00532466 |
| PDLIM1 | PDZ and LIM domain 1 | 0.00531963 |
| EMP2 | epithelial membrane protein 2 | 0.00531937 |
| POLG2 | polymerase (DNA directed), gamma 2, accessory subunit | 0.0053181 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.00530706 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | 0.00530507 |
| FLT3 | fms-related tyrosine kinase 3 | 0.00530489 |
| KRT6B | keratin 6B, type II | 0.00528541 |
| AGA | aspartylglucosaminidase | 0.00527048 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.00525482 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.00524006 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | 0.00522208 |
| KRT23 | keratin 23, type I | 0.00519884 |
| MATN2 | matrilin 2 | 0.00517673 |
| STC2 | stanniocalcin 2 | 0.00516358 |
| FOXC1 | forkhead box C1 | 0.00516268 |
| UFD1 | ubiquitin recognition factor in ER associated degradation 1 | 0.00515956 |
| CHGA | chromogranin A | 0.00514461 |
| RUVBL2 | RuvB-like AAA ATPase 2 | 0.00514435 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | 0.00512409 |
| COX7A2L | cytochrome c oxidase subunit VIIa polypeptide 2 like | 0.00508772 |
| ODC1 | ornithine decarboxylase 1 | 0.00508028 |
| IFI44L | interferon-induced protein 44-like | 0.00506289 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | 0.00505849 |
| TCF7 | transcription factor 7 (T-cell specific, HMG-box) | 0.00505501 |
| WIF1 | WNT inhibitory factor 1 | 0.00503845 |
| PPA1 | pyrophosphatase (inorganic) 1 | 0.00503634 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | 0.00503244 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | 0.0050215 |
| SELENOW | selenoprotein W | 0.00502007 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.00500521 |
| ICAM2 | intercellular adhesion molecule 2 | 0.0049969 |
| NMNAT2 | nicotinamide nucleotide adenylyltransferase 2 | 0.00499208 |
| MYT1L | myelin transcription factor 1-like | 0.00498881 |
| NRCAM | neuronal cell adhesion molecule | 0.00496915 |
| CDC42 | cell division cycle 42 | 0.00496213 |
| PAMR1 | peptidase domain containing associated with muscle regeneration 1 | 0.00495365 |
| BIK | BCL2-interacting killer (apoptosis-inducing) | 0.00494795 |
| TESC | tescalcin | 0.00494192 |
| VIL1 | villin 1 | 0.0049348 |
| HIST1H2BK | histone cluster 1, H2bk | 0.00492707 |
| SOSTDC1 | sclerostin domain containing 1 | 0.00492078 |
| CA4 | carbonic anhydrase IV | 0.00491807 |
| XBP1 | X-box binding protein 1 | 0.00491309 |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 | 0.00490649 |
| LHPP | phospholysine phosphohistidine inorganic pyrophosphate phosphatase | 0.00490132 |
| TTC27 | tetratricopeptide repeat domain 27 | 0.00489538 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | 0.00489099 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.00488834 |
| CORO1A | coronin, actin binding protein, 1A | 0.00488223 |
| ATP6V0E2 | ATPase, H+ transporting V0 subunit e2 | 0.00487934 |
| ANXA3 | annexin A3 | 0.00487553 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.00486449 |
| S100A9 | S100 calcium binding protein A9 | 0.00486079 |
| CRYAB | crystallin, alpha B | 0.00485814 |
| CRISP3 | cysteine-rich secretory protein 3 | 0.00485722 |
| DHDDS | dehydrodolichyl diphosphate synthase | 0.00485255 |
| NME1 | NME/NM23 nucleoside diphosphate kinase 1 | 0.00484952 |
| TP53I3 | tumor protein p53 inducible protein 3 | 0.00484699 |
| TFF3 | trefoil factor 3 (intestinal) | 0.00484192 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DAPK1 | death-associated protein kinase 1 | -0.0129226 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0118811 |
| RARRES2 | retinoic acid receptor responder (tazarotene induced) 2 | -0.0116931 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | -0.0112191 |
| GAS1 | growth arrest-specific 1 | -0.0110743 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.010627 |
| FGG | fibrinogen gamma chain | -0.010559 |
| CLEC2B | C-type lectin domain family 2, member B | -0.0105572 |
| COL11A1 | collagen, type XI, alpha 1 | -0.0104642 |
| AEBP1 | AE binding protein 1 | -0.0103449 |
| WT1 | Wilms tumor 1 | -0.0103391 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | -0.0101896 |
| ASPN | asporin | -0.0101853 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | -0.010066 |
| BCHE | butyrylcholinesterase | -0.0100187 |
| VCAN | versican | -0.00997803 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -0.00989475 |
| IGF1 | insulin-like growth factor 1 (somatomedin C) | -0.00979619 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.00965886 |
| CHP1 | calcineurin-like EF-hand protein 1 | -0.00951725 |
| TSPAN8 | tetraspanin 8 | -0.00939381 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.00932236 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | -0.00921024 |
| CES1 | carboxylesterase 1 | -0.00916076 |
| COL10A1 | collagen, type X, alpha 1 | -0.00913439 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | -0.00913362 |
| RB1 | retinoblastoma 1 | -0.00911801 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | -0.00902361 |
| GSTA1 | glutathione S-transferase alpha 1 | -0.00894994 |
| HSD17B6 | hydroxysteroid (17-beta) dehydrogenase 6 | -0.00874174 |
| SC5D | sterol-C5-desaturase | -0.00873854 |
| CILP | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | -0.00868199 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -0.00856556 |
| GLUL | glutamate-ammonia ligase | -0.00855631 |
| MAGEA3 | melanoma antigen family A3 | -0.0084466 |
| DIPK1A | divergent protein kinase domain 1A | -0.00838291 |
| TNNT1 | troponin T type 1 (skeletal, slow) | -0.00838119 |
| IQGAP2 | IQ motif containing GTPase activating protein 2 | -0.00834804 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0083432 |
| C1R | complement component 1, r subcomponent | -0.00820526 |
| SPON1 | spondin 1, extracellular matrix protein | -0.00812989 |
| CFI | complement factor I | -0.00802908 |
| HSD11B1 | hydroxysteroid (11-beta) dehydrogenase 1 | -0.00797886 |
| COL5A2 | collagen, type V, alpha 2 | -0.00794814 |
| KMO | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | -0.00791634 |
| FCGR2A | Fc fragment of IgG, low affinity IIa, receptor (CD32) | -0.00781567 |
| SIRT3 | sirtuin 3 | -0.00773125 |
| AQP9 | aquaporin 9 | -0.00758394 |
| CBS | cystathionine-beta-synthase | -0.00753947 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | -0.00753426 |
| RCBTB2 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 | -0.00753043 |
| CYTIP | cytohesin 1 interacting protein | -0.00751236 |
| NPL | N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) | -0.00749017 |
| ALOX5 | arachidonate 5-lipoxygenase | -0.00743628 |
| CP | ceruloplasmin (ferroxidase) | -0.00729368 |
| MMP2 | matrix metallopeptidase 2 | -0.00728242 |
| CYP2E1 | cytochrome P450, family 2, subfamily E, polypeptide 1 | -0.00727938 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | -0.00727445 |
| COL5A1 | collagen, type V, alpha 1 | -0.0071566 |
| ANPEP | alanyl (membrane) aminopeptidase | -0.00713506 |
| LEF1 | lymphoid enhancer-binding factor 1 | -0.00713257 |
| ACAD8 | acyl-CoA dehydrogenase family, member 8 | -0.00712517 |
| GOLM1 | golgi membrane protein 1 | -0.00712243 |
| SPON2 | spondin 2, extracellular matrix protein | -0.00708954 |
| RDX | radixin | -0.00708171 |
| ALB | albumin | -0.00707365 |
| VNN1 | vanin 1 | -0.00707017 |
| CD52 | CD52 molecule | -0.00706102 |
| C7 | complement component 7 | -0.00705336 |
| IFI30 | interferon, gamma-inducible protein 30 | -0.00699008 |
| RNF130 | ring finger protein 130 | -0.00695343 |
| COL3A1 | collagen, type III, alpha 1 | -0.00687538 |
| WLS | wntless Wnt ligand secretion mediator | -0.00686877 |
| GBAP1 | glucosidase, beta, acid pseudogene 1 | -0.00684422 |
| SFTPB | surfactant protein B | -0.00684405 |
| FAM169A | family with sequence similarity 169, member A | -0.00683475 |
| COL6A1 | collagen, type VI, alpha 1 | -0.00678247 |
| CCND2 | cyclin D2 | -0.00676959 |
| EMP3 | epithelial membrane protein 3 | -0.00676737 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.00674569 |
| GANAB | glucosidase, alpha; neutral AB | -0.00674239 |
| ADCY7 | adenylate cyclase 7 | -0.00673366 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.00670893 |
| C5AR1 | complement component 5a receptor 1 | -0.00670761 |
| CPVL | carboxypeptidase, vitellogenic-like | -0.00669678 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.00666272 |
| TDO2 | tryptophan 2,3-dioxygenase | -0.00666269 |
| CADPS2 | Ca++-dependent secretion activator 2 | -0.00666184 |
| CCR1 | chemokine (C-C motif) receptor 1 | -0.00664492 |
| WBP5 | WW domain binding protein 5 | -0.00664044 |
| NKX3-1 | NK3 homeobox 1 | -0.00663518 |
| ZC3H13 | zinc finger CCCH-type containing 13 | -0.00663218 |
| TMEM176B | transmembrane protein 176B | -0.00660574 |
| PDLIM3 | PDZ and LIM domain 3 | -0.0065673 |
| FCGR2B | Fc fragment of IgG, low affinity IIb, receptor (CD32) | -0.00655233 |
| HPSE | heparanase | -0.00655126 |
| C4BPB | complement component 4 binding protein, beta | -0.00654822 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.00654216 |
| BEX4 | brain expressed, X-linked 4 | -0.006527 |
| XIC | X chromosome inactivation center | -0.0065222 |
| PLA2G7 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | -0.00650795 |
| FILIP1L | filamin A interacting protein 1-like | -0.00649541 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | -0.00647847 |
| LAMP3 | lysosomal-associated membrane protein 3 | -0.00647382 |
| EHHADH | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | -0.00645037 |
| PXDN | peroxidasin | -0.00643359 |
| CDK5RAP3 | CDK5 regulatory subunit associated protein 3 | -0.00643287 |
| UGT2B4 | UDP glucuronosyltransferase 2 family, polypeptide B4 | -0.00642905 |
| COL6A2 | collagen, type VI, alpha 2 | -0.00641773 |
| PAN2 | PAN2 poly(A) specific ribonuclease subunit | -0.00638375 |
| PRKD3 | protein kinase D3 | -0.00636019 |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | -0.00635025 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.00631223 |
| FN1 | fibronectin 1 | -0.00629154 |
| CYP2C8 | cytochrome P450, family 2, subfamily C, polypeptide 8 | -0.00628946 |
| SAMSN1 | SAM domain, SH3 domain and nuclear localization signals 1 | -0.00628839 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.00627113 |
| ABAT | 4-aminobutyrate aminotransferase | -0.00626922 |
| MS4A4A | membrane-spanning 4-domains, subfamily A, member 4A | -0.00626796 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.00625267 |
| CD14 | CD14 molecule | -0.00620947 |
| ARMT1 | acidic residue methyltransferase 1 | -0.00619736 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.00618242 |
| NNT | nicotinamide nucleotide transhydrogenase | -0.00613463 |
| FGB | fibrinogen beta chain | -0.00611867 |
| MEF2C | myocyte enhancer factor 2C | -0.00611084 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.00609424 |
| WWC2 | WW and C2 domain containing 2 | -0.00609078 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | -0.00607987 |
| INPP4A | inositol polyphosphate-4-phosphatase, type I, 107kDa | -0.00607071 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | -0.0060635 |
| ACP5 | acid phosphatase 5, tartrate resistant | -0.0060548 |
| AOX1 | aldehyde oxidase 1 | -0.00604696 |
| CFHR2 | complement factor H-related 2 | -0.00604443 |
| ECHDC3 | enoyl CoA hydratase domain containing 3 | -0.00603923 |
| DPYD | dihydropyrimidine dehydrogenase | -0.00600936 |
| SLC7A8 | solute carrier family 7 (amino acid transporter light chain, L system), member 8 | -0.00599766 |
| PON1 | paraoxonase 1 | -0.00599468 |
| NGFRAP1 | nerve growth factor receptor (TNFRSF16) associated protein 1 | -0.00598867 |
| CYP2C9 | cytochrome P450, family 2, subfamily C, polypeptide 9 | -0.00597199 |
| NTAN1 | N-terminal asparagine amidase | -0.00595839 |
| ADH1A | alcohol dehydrogenase 1A (class I), alpha polypeptide | -0.00595 |
| STK10 | serine/threonine kinase 10 | -0.00594849 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.00593763 |
| PLXNC1 | plexin C1 | -0.00593757 |
| GBP1 | guanylate binding protein 1, interferon-inducible | -0.00590855 |
| KCTD12 | potassium channel tetramerization domain containing 12 | -0.00589507 |
| CD163 | CD163 molecule | -0.0058847 |
| BLNK | B-cell linker | -0.00587445 |
| F2R | coagulation factor II (thrombin) receptor | -0.00587241 |
| EIF4H | eukaryotic translation initiation factor 4H | -0.00587134 |
| CARHSP1 | calcium regulated heat stable protein 1, 24kDa | -0.00586542 |
| CSF1R | colony stimulating factor 1 receptor | -0.00586177 |
| CALD1 | caldesmon 1 | -0.00585511 |
| PCLAF | PCNA clamp associated factor | -0.00584425 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.00583435 |
| CPB2 | carboxypeptidase B2 (plasma) | -0.00582768 |
| SLC43A3 | solute carrier family 43, member 3 | -0.00582545 |
| TP53BP2 | tumor protein p53 binding protein 2 | -0.00582034 |
| SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | -0.0058143 |
| VPS72 | vacuolar protein sorting 72 homolog (S. cerevisiae) | -0.00580752 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.00578449 |
| MECOM | MDS1 and EVI1 complex locus | -0.00578146 |
| MFAP5 | microfibrillar associated protein 5 | -0.0057752 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.00576704 |
| LY96 | lymphocyte antigen 96 | -0.00576556 |
| TCF12 | transcription factor 12 | -0.00574319 |
| FADS1 | fatty acid desaturase 1 | -0.00573404 |
| HS3ST1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | -0.00572188 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.00571208 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | -0.00569614 |
| IGSF6 | immunoglobulin superfamily, member 6 | -0.00569512 |
| C9 | complement component 9 | -0.00568161 |
| APCS | amyloid P component, serum | -0.00567513 |
| ABHD6 | abhydrolase domain containing 6 | -0.00566278 |
| SLC46A3 | solute carrier family 46, member 3 | -0.00562877 |
| C6 | complement component 6 | -0.00562027 |
| SLC11A1 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 | -0.0056091 |
| THBS2 | thrombospondin 2 | -0.00559761 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | -0.00557209 |
| NQO2 | NAD(P)H dehydrogenase, quinone 2 | -0.00556822 |
| CPS1 | carbamoyl-phosphate synthase 1, mitochondrial | -0.00556034 |
| POU2AF1 | POU class 2 associating factor 1 | -0.00554252 |
| ITGA4 | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | -0.00554235 |
| SLCO1B1 | solute carrier organic anion transporter family, member 1B1 | -0.00553854 |
| SLC38A4 | solute carrier family 38, member 4 | -0.00553077 |
| CLEC7A | C-type lectin domain family 7, member A | -0.00552214 |
| CCR2 | chemokine (C-C motif) receptor 2 | -0.00552011 |
| SLBP | stem-loop binding protein | -0.00551227 |
| SGPP1 | sphingosine-1-phosphate phosphatase 1 | -0.00550266 |
| SFTPA2 | surfactant protein A2 | -0.0054847 |
| CD1D | CD1d molecule | -0.00546997 |
| DIAPH1 | diaphanous-related formin 1 | -0.00546473 |
| DAXX | death-domain associated protein | -0.00545723 |
| ZCCHC14 | zinc finger, CCHC domain containing 14 | -0.00545329 |
| TMSB15A | thymosin beta 15a | -0.00545286 |
| ADAP2 | ArfGAP with dual PH domains 2 | -0.00544024 |
| F9 | coagulation factor IX | -0.00542231 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | -0.00542045 |
| SNAI2 | snail family zinc finger 2 | -0.00541452 |
| DUSP5 | dual specificity phosphatase 5 | -0.0054019 |
| SHMT1 | serine hydroxymethyltransferase 1 (soluble) | -0.00539515 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | -0.00538942 |
| CEL | carboxyl ester lipase | -0.00538844 |
| RESF1 | retroelement silencing factor 1 | -0.00536667 |
| NELL1 | NEL-like 1 (chicken) | -0.00536585 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -0.00535691 |
| FAM3C | family with sequence similarity 3, member C | -0.00535674 |
| OLFML2B | olfactomedin-like 2B | -0.0053439 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.00534327 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.00533653 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | -0.00533454 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.00530987 |
| TMEM45A | transmembrane protein 45A | -0.0053079 |
| THY1 | Thy-1 cell surface antigen | -0.00530227 |
| LILRB2 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 | -0.00530215 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.00530068 |
| MN1 | meningioma (disrupted in balanced translocation) 1 | -0.00529197 |
| AFM | afamin | -0.00528655 |
| HP | haptoglobin | -0.00528149 |
| FPR3 | formyl peptide receptor 3 | -0.00527659 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | -0.00527148 |
| PDP1 | pyruvate dehyrogenase phosphatase catalytic subunit 1 | -0.00526835 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | -0.0052614 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | -0.00524855 |
| AADAC | arylacetamide deacetylase | -0.00523274 |
| CLIC2 | chloride intracellular channel 2 | -0.00522655 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.00521805 |
| DHCR24 | 24-dehydrocholesterol reductase | -0.00520172 |
| IRAK1 | interleukin-1 receptor-associated kinase 1 | -0.0052012 |
| DIO1 | deiodinase, iodothyronine, type I | -0.00519995 |
| CISH | cytokine inducible SH2-containing protein | -0.0051771 |
| MAGEA12 | melanoma antigen family A12 | -0.00517315 |
| IL27RA | interleukin 27 receptor, alpha | -0.00517175 |
| IFITM2 | interferon induced transmembrane protein 2 | -0.00516067 |
| MMP19 | matrix metallopeptidase 19 | -0.00515274 |
| CIAPIN1 | cytokine induced apoptosis inhibitor 1 | -0.00513371 |
| METRN | meteorin, glial cell differentiation regulator | -0.00511783 |
| ALDOB | aldolase B, fructose-bisphosphate | -0.00511754 |
| G0S2 | G0/G1 switch 2 | -0.00509855 |
| HPX | hemopexin | -0.00509798 |
| SERPINC1 | serpin peptidase inhibitor, clade C (antithrombin), member 1 | -0.00508562 |
| ARG1 | arginase 1 | -0.00508267 |
| AHNAK | AHNAK nucleoprotein | -0.00507578 |
| C4BPA | complement component 4 binding protein, alpha | -0.0050736 |
| LRRC15 | leucine rich repeat containing 15 | -0.00506799 |
| CYRIA | CYFIP related Rac1 interactor A | -0.00506787 |
| NDNF | neuron-derived neurotrophic factor | -0.00506423 |
