PAX7 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description paired box 7|This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] (NCBI Entrez Gene Database, 5081)
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Genes

355 genes differentially expressed following the PAX7 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ADAMTSL2 ADAMTS-like 2 3.39549
TREML2 triggering receptor expressed on myeloid cells-like 2 3.39549
NT5E 5'-nucleotidase, ecto (CD73) 3.39549
PTK6 protein tyrosine kinase 6 3.39549
OXT oxytocin/neurophysin I prepropeptide 3.39549
CAPS calcyphosine 3.39549
CHD5 chromodomain helicase DNA binding protein 5 3.39549
LGALS9 lectin, galactoside-binding, soluble, 9 3.39549
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 3.39549
MYO1A myosin IA 3.39549
KRT80 keratin 80, type II 3.39549
LRRIQ4 leucine-rich repeats and IQ motif containing 4 3.39549
RIMBP3C RIMS binding protein 3C 3.39549
TRIM47 tripartite motif containing 47 3.39549
GSG1 germ cell associated 1 3.39549
TMPRSS3 transmembrane protease, serine 3 3.39549
SRGN serglycin 3.39549
TDRD7 tudor domain containing 7 3.39549
TDRD9 tudor domain containing 9 3.39549
TMEM217 transmembrane protein 217 3.39549
LCN15 lipocalin 15 3.39549
KCNIP2 Kv channel interacting protein 2 3.39549
RLN1 relaxin 1 3.39549
ACVRL1 activin A receptor type II-like 1 3.39549
THSD1 thrombospondin, type I, domain containing 1 3.39549
GRP gastrin-releasing peptide 3.39549
KRT86 keratin 86, type II 3.39549
RBP4 retinol binding protein 4, plasma 3.39549
WFDC11 WAP four-disulfide core domain 11 3.39549
ANKRD30B ankyrin repeat domain 30B 3.39549
ASCL3 achaete-scute family bHLH transcription factor 3 3.39549
NLRP7 NLR family, pyrin domain containing 7 3.39549
C3AR1 complement component 3a receptor 1 3.39549
ANGPTL3 angiopoietin-like 3 3.39549
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 3.39549
ANXA1 annexin A1 3.39549
CPHXL2 cytoplasmic polyadenylated homeobox like 2 3.39549
NRSN1 neurensin 1 3.39549
HRG histidine-rich glycoprotein 3.39549
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 3.39549
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 3.39549
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 3.39549
HIC1 hypermethylated in cancer 1 3.39549
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 3.39549
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 3.39549
PANO1 proapoptotic nucleolar protein 1 3.39549
PCDHGA12 protocadherin gamma subfamily A, 12 3.39549
BNC1 basonuclin 1 3.39549
PRSS22 protease, serine, 22 3.39549
PRSS27 protease, serine 27 3.39549
TGM3 transglutaminase 3 3.39549
TRPV2 transient receptor potential cation channel, subfamily V, member 2 3.39549
PNPLA1 patatin-like phospholipase domain containing 1 3.39549
TRIM60 tripartite motif containing 60 3.39549
VIT vitrin 3.39549
ACTL8 actin-like 8 3.39549
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 3.39549
KBTBD13 kelch repeat and BTB (POZ) domain containing 13 3.39549
SYCP2 synaptonemal complex protein 2 3.39549
ACR acrosin 3.39549
MYT1L myelin transcription factor 1-like 3.39549
GJA5 gap junction protein, alpha 5, 40kDa 3.39549
HRH1 histamine receptor H1 3.39549
NXPE1 neurexophilin and PC-esterase domain family, member 1 3.39549
NR1I2 nuclear receptor subfamily 1, group I, member 2 3.39549
MSX1 msh homeobox 1 3.39549
RGS22 regulator of G-protein signaling 22 3.39549
CNTFR ciliary neurotrophic factor receptor 3.39549
SBSN suprabasin 3.39549
OVOL1 ovo-like zinc finger 1 3.39549
MROH5 maestro heat-like repeat family member 5 3.39549
C1QL3 complement component 1, q subcomponent-like 3 3.39549
LEF1 lymphoid enhancer-binding factor 1 3.39549
GDF10 growth differentiation factor 10 3.39549
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 3.39549
NPIPB9 nuclear pore complex interacting protein family, member B9 3.39549
MYL10 myosin, light chain 10, regulatory 3.39549
NOTO notochord homeobox 3.39549
FGF20 fibroblast growth factor 20 3.39549
C6ORF58 chromosome 6 open reading frame 58 3.39549
ASB10 ankyrin repeat and SOCS box containing 10 3.39549
SLC30A2 solute carrier family 30 (zinc transporter), member 2 3.39549
SLC30A4 solute carrier family 30 (zinc transporter), member 4 3.39549
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 3.39549
BEST2 bestrophin 2 3.39549
MYOM3 myomesin 3 3.39549
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 3.39549
GFI1 growth factor independent 1 transcription repressor 3.39549
BDKRB2 bradykinin receptor B2 3.39549
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 3.39549
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 3.39549
AADACL3 arylacetamide deacetylase-like 3 3.39549
MAP3K7CL MAP3K7 C-terminal like 3.39549
NPAP1 nuclear pore associated protein 1 3.39549
USP26 ubiquitin specific peptidase 26 3.39549
GRAP GRB2-related adaptor protein 3.39549
PLIN1 perilipin 1 3.39549
CD160 CD160 molecule 3.39549
BTLA B and T lymphocyte associated 3.39549
PGBDF plakoglobin binding and degradation factor 3.39549
OR2AG2 olfactory receptor, family 2, subfamily AG, member 2 3.39549
TMEM100 transmembrane protein 100 3.39549
ANKRD34A ankyrin repeat domain 34A 3.39549
GARIN6 golgi associated RAB2 interactor family member 6 3.39549
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) 3.39549
TEKT5 tektin 5 3.39549
KISS1 KiSS-1 metastasis-suppressor 3.39549
PCDH17 protocadherin 17 3.39549
TIPE2 TNF alpha induced protein 8 like 2 3.39549
KLK14 kallikrein-related peptidase 14 3.39549
FBXO40 F-box protein 40 3.39549
TTC16 tetratricopeptide repeat domain 16 3.39549
UTS2R urotensin 2 receptor 3.39549
SLCO2B1 solute carrier organic anion transporter family, member 2B1 3.39549
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 3.39549
TMEM139 transmembrane protein 139 3.39549
XK X-linked Kx blood group 3.39549
LRRIQ3 leucine-rich repeats and IQ motif containing 3 3.39549
MEIOSIN meiosis initiator 3.39549
BPIFB1 BPI fold containing family B, member 1 3.39549
GOLGA6D golgin A6 family, member D 3.39549
CALHM1 calcium homeostasis modulator 1 3.39549
IQCN IQ motif containing N 3.39549
PEAK3 PEAK family member 3 3.39549
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 3.39549
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 3.39549
RANBP3L RAN binding protein 3-like 3.39549
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 3.39549
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 3.39549
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 3.39549
OPALIN oligodendrocytic myelin paranodal and inner loop protein 3.39549
LMX1B LIM homeobox transcription factor 1, beta 3.39549
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 3.39549
FAM240A family with sequence similarity 240 member A 3.39549
NICN1 nicolin 1 3.39549
CIMIP7 ciliary microtubule inner protein 7 3.39549
GJC2 gap junction protein, gamma 2, 47kDa 3.39549
GOLGA8H golgin A8 family, member H 3.39549
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 3.39549
SPMIP3 sperm microtubule inner protein 3 3.39549
KLHL10 kelch-like family member 10 3.39549
MYADML2 myeloid-associated differentiation marker-like 2 3.39549
ANKRD55 ankyrin repeat domain 55 3.39549
TRIM75 tripartite motif containing 75 3.39549
LOC124903233 uncharacterized LOC124903233 3.39549
ADGRD1 adhesion G protein-coupled receptor D1 3.39549
UBXN10 UBX domain protein 10 3.39549
CLEC4A C-type lectin domain family 4, member A 3.39549
RGS8 regulator of G-protein signaling 8 3.39549
CDH22 cadherin 22, type 2 3.39549
RIBC1 RIB43A domain with coiled-coils 1 3.39549
CFAP126 cilia and flagella associated protein 126 3.39549
TRHR thyrotropin-releasing hormone receptor 3.39549
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 3.39549
MT1A metallothionein 1A 3.39549
OR2H1 olfactory receptor, family 2, subfamily H, member 1 3.39549
IFIH1 interferon induced with helicase C domain 1 3.39549
TCF21 transcription factor 21 3.39549
HSPB9 heat shock protein, alpha-crystallin-related, B9 3.39549
FOXP3 forkhead box P3 3.39549
FADS6 fatty acid desaturase 6 3.39549
CFAP157 cilia and flagella associated protein 157 3.39549
KPNA7 karyopherin alpha 7 (importin alpha 8) 3.39549
KANK4 KN motif and ankyrin repeat domains 4 3.39549
CD8A CD8a molecule 3.39549
MC5R melanocortin 5 receptor 3.39549
PXT1 peroxisomal, testis specific 1 3.39549
SPRN shadow of prion protein homolog (zebrafish) 3.39549
ANKRD40CL ANKRD40 C-terminal like 3.39549
GLTPD2 glycolipid transfer protein domain containing 2 3.39549
FGF16 fibroblast growth factor 16 3.39549
EPX eosinophil peroxidase 3.39549
POU3F3 POU class 3 homeobox 3 3.39549
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 3.39549
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 3.39549
GARIN1A golgi associated RAB2 interactor 1A 3.39549
JAML junction adhesion molecule like 3.39549
ERICH4 glutamate-rich 4 3.39549
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 3.39549
TCEA3 transcription elongation factor A (SII), 3 3.39549
KCNK9 potassium channel, two pore domain subfamily K, member 9 3.39549
CXCR2 chemokine (C-X-C motif) receptor 2 3.39549
CRTAC1 cartilage acidic protein 1 3.39549
ANKRD63 ankyrin repeat domain 63 3.39549
EOLA1 endothelium and lymphocyte associated ASCH domain 1 3.39549
DCLK2 doublecortin-like kinase 2 3.39549
APOD apolipoprotein D 3.39549
CABP7 calcium binding protein 7 3.39549
SMIM23 small integral membrane protein 23 3.39549
TGM1 transglutaminase 1 3.39549
AMIGO1 adhesion molecule with Ig-like domain 1 3.39549
ABI3 ABI family, member 3 3.3017
PLIN5 perilipin 5 3.3017
TJP1 tight junction protein 1 3.11464
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 3.03863
WDR41 WD repeat domain 41 3.00643
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.83747
IQCC IQ motif containing C 2.83747
CAB39 calcium binding protein 39 2.80668
ZNF75A zinc finger protein 75a 2.78301
SBNO2 strawberry notch homolog 2 (Drosophila) 2.75716
VCX variable charge, X-linked 2.75487
POC5 POC5 centriolar protein 2.75
UBB ubiquitin B 2.67171
ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein 2.63588
TMEM200B transmembrane protein 200B 2.58671
FOXO3 forkhead box O3 2.53174
OTUD4 OTU deubiquitinase 4 2.5157
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 2.48674
LINC02798 long intergenic non-protein coding RNA 2798 2.48396
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 2.48396
ERFE erythroferrone 2.48396
MFGE8 milk fat globule-EGF factor 8 protein 2.47457
PCDHGA1 protocadherin gamma subfamily A, 1 2.45406
AKT3 v-akt murine thymoma viral oncogene homolog 3 2.45406
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 2.45406
RERGL RERG/RAS-like 2.45406
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 2.45406
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa 2.45061
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae) 2.43817
SCAP SREBF chaperone 2.40609
C9ORF78 chromosome 9 open reading frame 78 2.39307
CLSTN1 calsyntenin 1 2.39241
FOXN3 forkhead box N3 2.38655
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 2.377
CTRL chymotrypsin-like 2.37243
C1ORF146 chromosome 1 open reading frame 146 2.32827
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 2.32827
ZNF365 zinc finger protein 365 2.32827
TMEM190 transmembrane protein 190 2.32827
UBE2L3 ubiquitin-conjugating enzyme E2L 3 2.32009
FAM163B family with sequence similarity 163, member B 2.29632
GPC3 glypican 3 2.28592
DTX2 deltex 2, E3 ubiquitin ligase 2.28497
CD96 CD96 molecule 2.27792
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 2.27012
STK4 serine/threonine kinase 4 2.27012
ADAM22 ADAM metallopeptidase domain 22 2.26249
RNF138 ring finger protein 138, E3 ubiquitin protein ligase 2.24371
MAP3K2 mitogen-activated protein kinase kinase kinase 2 2.17868
PPP1R12B protein phosphatase 1, regulatory subunit 12B 2.17868
SLC35F2 solute carrier family 35, member F2 2.14602
RAB33A RAB33A, member RAS oncogene family 2.14053
CCDC102B coiled-coil domain containing 102B 2.13444
CCNH cyclin H 2.12913
PRXL2A peroxiredoxin like 2A 2.12913
TMEM205 transmembrane protein 205 2.11979
ILF3 interleukin enhancer binding factor 3, 90kDa 2.09923
SH3GL3 SH3-domain GRB2-like 3 2.09344
ATCAY ataxia, cerebellar, Cayman type 2.08529
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 2.08434
ISY1 ISY1 splicing factor homolog (S. cerevisiae) 2.07793
PPIF peptidylprolyl isomerase F 2.05814
LIAS lipoic acid synthetase 2.0429
HINT1 histidine triad nucleotide binding protein 1 2.0429
RAD21 RAD21 homolog (S. pombe) 2.02319
MARCKSL1 MARCKS-like 1 2.0215
POLM polymerase (DNA directed), mu 2.01496
FSAF1 40S small subunit processome assembly factor 1 2.00142

decreased expression

Symbol Name Standardized Value
KCNK10 potassium channel, two pore domain subfamily K, member 10 -3.39549
ENDOD1 endonuclease domain containing 1 -3.39549
KLF1 Kruppel-like factor 1 (erythroid) -3.39549
DNAH1 dynein, axonemal, heavy chain 1 -3.39549
LACTB lactamase, beta -3.39549
NME8 NME/NM23 family member 8 -3.39549
LRRC8B leucine rich repeat containing 8 family, member B -3.39549
PGA5 pepsinogen 5, group I (pepsinogen A) -3.35953
NHLH1 nescient helix loop helix 1 -3.35953
EPN3 epsin 3 -3.35953
NOS2 nitric oxide synthase 2, inducible -3.35953
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 -3.35953
TLCD2 TLC domain containing 2 -3.35953
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -3.35953
PAN3 PAN3 poly(A) specific ribonuclease subunit -3.35953
CFAP90 cilia and flagella associated protein 90 -3.35953
RASL10A RAS-like, family 10, member A -3.35953
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 -3.35953
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 -3.35953
MMD2 monocyte to macrophage differentiation-associated 2 -3.35953
TSPEAR thrombospondin-type laminin G domain and EAR repeats -3.35953
NLRP1 NLR family, pyrin domain containing 1 -3.35953
TMEM88 transmembrane protein 88 -3.35953
ARHGEF33 Rho guanine nucleotide exchange factor (GEF) 33 -3.35953
CAPN3 calpain 3, (p94) -3.35953
SHBG sex hormone-binding globulin -3.35953
FAM43A family with sequence similarity 43, member A -3.35953
LPIN3 lipin 3 -3.35953
PLEKHN1 pleckstrin homology domain containing, family N member 1 -3.35953
HJV hemojuvelin BMP co-receptor -3.35953
FBXL22 F-box and leucine-rich repeat protein 22 -3.35953
VSTM1 V-set and transmembrane domain containing 1 -3.35953
RAG2 recombination activating gene 2 -3.35953
ETNPPL ethanolamine-phosphate phospho-lyase -3.35953
PLSCR2 phospholipid scramblase 2 -3.35953
LRRC3 leucine rich repeat containing 3 -3.35953
RIPPLY2 ripply transcriptional repressor 2 -3.35953
EPHA5 EPH receptor A5 -3.35953
CATSPERZ catsper channel auxiliary subunit zeta -3.35953
COL5A1 collagen, type V, alpha 1 -3.26406
SYT4 synaptotagmin IV -3.24257
CBX6 chromobox homolog 6 -3.07386
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) -3.06231
ADORA2A adenosine A2a receptor -3.06231
BCORL1 BCL6 corepressor-like 1 -3.06231
GSAP gamma-secretase activating protein -3.02229
NOCT nocturnin -2.97143
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) -2.94421
MANF mesencephalic astrocyte-derived neurotrophic factor -2.87084
PLCD1 phospholipase C, delta 1 -2.86845
LIG3 ligase III, DNA, ATP-dependent -2.79369
ZNF528 zinc finger protein 528 -2.61582
JADE3 jade family PHD finger 3 -2.56933
VWA8 von Willebrand factor A domain containing 8 -2.55459
ZNF554 zinc finger protein 554 -2.52214
C5ORF47 chromosome 5 open reading frame 47 -2.52214
GOLGB1 golgin B1 -2.5157
ACP2 acid phosphatase 2, lysosomal -2.50625
YIPF1 Yip1 domain family, member 1 -2.48904
SOX8 SRY (sex determining region Y)-box 8 -2.45406
FLYWCH2 FLYWCH family member 2 -2.42495
POMT2 protein-O-mannosyltransferase 2 -2.39387
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like -2.39005
SPTBN4 spectrin, beta, non-erythrocytic 4 -2.38935
RBM34 RNA binding motif protein 34 -2.38935
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa -2.38935
PPP1R3E protein phosphatase 1, regulatory subunit 3E -2.38935
C1R complement component 1, r subcomponent -2.38935
PDZD2 PDZ domain containing 2 -2.38601
SYVN1 synovial apoptosis inhibitor 1, synoviolin -2.36595
FBRS fibrosin -2.32298
ZNF382 zinc finger protein 382 -2.27157
MFSD8 major facilitator superfamily domain containing 8 -2.27048
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -2.27048
TTC6 tetratricopeptide repeat domain 6 -2.27048
PLPPR3 phospholipid phosphatase related 3 -2.27048
QDPR quinoid dihydropteridine reductase -2.18703
COL4A6 collagen, type IV, alpha 6 -2.17868
ZCCHC7 zinc finger, CCHC domain containing 7 -2.16208
MPZL1 myelin protein zero-like 1 -2.15842
EXOSC9 exosome component 9 -2.14648
ADAM23 ADAM metallopeptidase domain 23 -2.14568
FES FES proto-oncogene, tyrosine kinase -2.14053
ZNF600 zinc finger protein 600 -2.14053
SLC45A1 solute carrier family 45, member 1 -2.14053
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) -2.13
SORBS2 sorbin and SH3 domain containing 2 -2.12089
RUNX1 runt-related transcription factor 1 -2.11605
METTL8 methyltransferase like 8 -2.11382
CHPF2 chondroitin polymerizing factor 2 -2.0936
MAP3K21 mitogen-activated protein kinase kinase kinase 21 -2.08328
PREP prolyl endopeptidase -2.05814
REST RE1-silencing transcription factor -2.0553
HCFC2 host cell factor C2 -2.02949
NEK10 NIMA-related kinase 10 -2.0062
SAP130 Sin3A-associated protein, 130kDa -2.00032