PAX8 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description paired box 8|This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010] (NCBI Entrez Gene Database, 7849)
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Genes

327 genes differentially expressed following the PAX8 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CFI complement factor I 2.61083
CARD18 caspase recruitment domain family, member 18 2.61083
FBXO39 F-box protein 39 2.61083
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.61083
AMPD1 adenosine monophosphate deaminase 1 2.61083
REN renin 2.61083
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 2.61083
LRRC15 leucine rich repeat containing 15 2.61083
CFAP45 cilia and flagella associated protein 45 2.61083
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 2.61083
S100B S100 calcium binding protein B 2.61083
PARD3 par-3 family cell polarity regulator 2.61083
MAB21L3 mab-21-like 3 (C. elegans) 2.61083
PRB2 proline-rich protein BstNI subfamily 2 2.61083
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 2.61083
CBY3 chibby homolog 3 (Drosophila) 2.61083
CIMAP1D CIMAP1 family member D 2.61083
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 2.61083
GLYATL1B glycine-N-acyltransferase like 1B 2.61083
FNDC11 fibronectin type III domain containing 11 2.61083
ODAPH odontogenesis associated phosphoprotein 2.61083
PCDHGA5 protocadherin gamma subfamily A, 5 2.61083
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 2.61083
DYTN dystrotelin 2.61083
MILR1 mast cell immunoglobulin-like receptor 1 2.54122
NRN1 neuritin 1 2.54122
SIX6 SIX homeobox 6 2.54122
RAX retina and anterior neural fold homeobox 2.54122
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.54122
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 2.54122
CD163 CD163 molecule 2.54122
LRRD1 leucine-rich repeats and death domain containing 1 2.54122
TMEM176A transmembrane protein 176A 2.54122
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 2.54122
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.54122
PRICKLE4 prickle homolog 4 (Drosophila) 2.54122
UPK3A uroplakin 3A 2.54122
SSTR1 somatostatin receptor 1 2.54122
OTUD6A OTU deubiquitinase 6A 2.54122
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 2.54122
ADAMTSL5 ADAMTS-like 5 2.54122
SFTPB surfactant protein B 2.54122
LRRC10B leucine rich repeat containing 10B 2.54122
TMEM217 transmembrane protein 217 2.54122
PARP16 poly (ADP-ribose) polymerase family, member 16 2.54122
OCM2 oncomodulin 2 2.54122
CX3CR1 chemokine (C-X3-C motif) receptor 1 2.54122
COPZ2 coatomer protein complex, subunit zeta 2 2.54122
ANKRD34A ankyrin repeat domain 34A 2.54122
GYPB glycophorin B (MNS blood group) 2.54122
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.54122
UMOD uromodulin 2.54122
NRAP nebulin-related anchoring protein 2.54122
TMEM191B transmembrane protein 191B 2.54122
SKOR2 SKI family transcriptional corepressor 2 2.54122
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.54122
PAX3 paired box 3 2.54122
CEP295NL CEP295 N-terminal like 2.54122
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.54122
ASPA aspartoacylase 2.54122
S100A7 S100 calcium binding protein A7 2.54122
TAS2R4 taste receptor, type 2, member 4 2.54122
CIROZ ciliated left-right organizer protein containing ZP-N domains 2.54122
LTB4R2 leukotriene B4 receptor 2 2.54122
SPRR2F small proline-rich protein 2F 2.54122
FMO3 flavin containing monooxygenase 3 2.54122
C9ORF43 chromosome 9 open reading frame 43 2.54122
C20ORF202 chromosome 20 open reading frame 202 2.54122
TMEM190 transmembrane protein 190 2.54122
GAPT GRB2-binding adaptor protein, transmembrane 2.54122
LOC124906892 uncharacterized LOC124906892 2.54122
MROH5 maestro heat-like repeat family member 5 2.54122
PARVA parvin, alpha 2.54122
ERVW-1 endogenous retrovirus group W, member 1 2.54122
LITAFD LITAF domain containing 2.54122
CPNE8-AS1 CPNE8 antisense RNA 1 2.54122
KIF1C-AS1 KIF1C antisense RNA 1 2.54122
FAM246C family with sequence similarity 246 member C (gene/pseudogene) 2.54122
ELOA2 elongin A2 2.54122
CCDC187 coiled-coil domain containing 187 2.54122
SQOR sulfide quinone oxidoreductase 2.54122
H2BC1 H2B clustered histone 1 2.54122
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 2.54122
TUBA4B tubulin, alpha 4b 2.54122
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 2.54122
GDF10 growth differentiation factor 10 2.54122
SLC22A25 solute carrier family 22, member 25 2.54122
GOLGA6L4 golgin A6 family-like 4 2.54122
AXDND1 axonemal dynein light chain domain containing 1 2.54122
VSX2 visual system homeobox 2 2.54122
NXPE2 neurexophilin and PC-esterase domain family, member 2 2.54122
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.54122
RLBP1 retinaldehyde binding protein 1 2.54122
FAM153A family with sequence similarity 153, member A 2.54122
C1QTNF8 C1q and tumor necrosis factor related protein 8 2.54122
INSRR insulin receptor-related receptor 2.54122
IL16 interleukin 16 2.54122
ASIC3 acid sensing (proton gated) ion channel 3 2.54122
PNPLA1 patatin-like phospholipase domain containing 1 2.54122
GPR132 G protein-coupled receptor 132 2.54122
SAMD15 sterile alpha motif domain containing 15 2.54122
BARX2 BARX homeobox 2 2.54122
SBSN suprabasin 2.54122
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 2.54122
ARMS2 age-related maculopathy susceptibility 2 2.54122
HBA2 hemoglobin, alpha 2 2.54122
WNT8A wingless-type MMTV integration site family, member 8A 2.54122
TAS2R50 taste receptor, type 2, member 50 2.54122
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.54122
MAGED4B melanoma antigen family D4B 2.54122
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 2.54122
FITM1 fat storage-inducing transmembrane protein 1 2.54122
DLX3 distal-less homeobox 3 2.54122
MMP3 matrix metallopeptidase 3 2.54122
IGLL1 immunoglobulin lambda-like polypeptide 1 2.54122
ZNF534 zinc finger protein 534 2.54122
CTAGE4 CTAGE family, member 4 2.54122
SH2D1B SH2 domain containing 1B 2.54122
RERGL RERG/RAS-like 2.54122
CD84 CD84 molecule 2.54122
DMRTC1 DMRT-like family C1 2.54122
FOXP3 forkhead box P3 2.54122
FCAR Fc fragment of IgA receptor 2.54122
ALLC allantoicase 2.54122
HK3 hexokinase 3 (white cell) 2.54122
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 2.54122
S100Z S100 calcium binding protein Z 2.54122
EFCAB3 EF-hand calcium binding domain 3 2.54122
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 2.54122
KCNK3 potassium channel, two pore domain subfamily K, member 3 2.54122
LLGL2 lethal giant larvae homolog 2 (Drosophila) 2.54122
NPFFR1 neuropeptide FF receptor 1 2.54122
CGB7 chorionic gonadotropin, beta polypeptide 7 2.54122
PCDHGA2 protocadherin gamma subfamily A, 2 2.54122
MPC1L mitochondrial pyruvate carrier 1-like 2.54122
PMP2 peripheral myelin protein 2 2.54122
NGFR nerve growth factor receptor 2.54122
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 2.54122
TEKT2 tektin 2 (testicular) 2.54122
INF2 inverted formin, FH2 and WH2 domain containing 2.54122
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 2.54122
HSF4 heat shock transcription factor 4 2.54122
TTC36 tetratricopeptide repeat domain 36 2.54122
QRFP pyroglutamylated RFamide peptide 2.54122
IRX4 iroquois homeobox 4 2.54122
CPN2 carboxypeptidase N, polypeptide 2 2.54122
OPALIN oligodendrocytic myelin paranodal and inner loop protein 2.54122
FXYD2 FXYD domain containing ion transport regulator 2 2.54122
DSPP dentin sialophosphoprotein 2.54122
TWIST1 twist family bHLH transcription factor 1 2.54122
NMUR1 neuromedin U receptor 1 2.54122
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 2.54122
SPACA5 sperm acrosome associated 5 2.54122
NPY2R neuropeptide Y receptor Y2 2.54122
TEX26 testis expressed 26 2.54122
JCHAIN joining chain of multimeric IgA and IgM 2.54122
TRIML1 tripartite motif family-like 1 2.54122
UPK1B uroplakin 1B 2.54122
HEPHL1 hephaestin-like 1 2.54122
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 2.54122
NPC1L1 NPC1-like 1 2.54122
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 2.54122
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 2.54122
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.54122
ZPLD1 zona pellucida-like domain containing 1 2.54122
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.54122
GPRC5D G protein-coupled receptor, class C, group 5, member D 2.54122
IGIP IgA-inducing protein 2.54122
DAOA D-amino acid oxidase activator 2.54122
EXD1 exonuclease 3'-5' domain containing 1 2.54122
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 2.54122
C5ORF46 chromosome 5 open reading frame 46 2.54122
IL17B interleukin 17B 2.54122
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 2.54122
RAB7B RAB7B, member RAS oncogene family 2.54122
SLC30A5 solute carrier family 30 (zinc transporter), member 5 2.5346
MRPL23 mitochondrial ribosomal protein L23 2.49623
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 2.48689
FAM186B family with sequence similarity 186, member B 2.48689
SYCE3 synaptonemal complex central element protein 3 2.48689
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 2.48689
LRGUK leucine-rich repeats and guanylate kinase domain containing 2.44749
G0S2 G0/G1 switch 2 2.42505
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma 2.41411
MPL MPL proto-oncogene, thrombopoietin receptor 2.40238
ADGRE2 adhesion G protein-coupled receptor E2 2.39793
SPDYA speedy/RINGO cell cycle regulator family member A 2.39645
MCF2L MCF.2 cell line derived transforming sequence-like 2.38668
ASGR2 asialoglycoprotein receptor 2 2.36004
NR1H4 nuclear receptor subfamily 1, group H, member 4 2.35278
NME6 NME/NM23 nucleoside diphosphate kinase 6 2.32677
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 2.30548
PIGM phosphatidylinositol glycan anchor biosynthesis, class M 2.29317
COL27A1 collagen, type XXVII, alpha 1 2.28185
PADI4 peptidyl arginine deiminase, type IV 2.26443
ZFYVE28 zinc finger, FYVE domain containing 28 2.24726
RIMKLA ribosomal modification protein rimK-like family member A 2.24726
RCOR1 REST corepressor 1 2.23846
H2BC14 H2B clustered histone 14 2.18396
PIANP PILR alpha associated neural protein 2.18017
MEAF6 MYST/Esa1-associated factor 6 2.16421
TFB1M transcription factor B1, mitochondrial 2.162
EYS eyes shut homolog (Drosophila) 2.14468
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 2.13778
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa 2.13778
MED13L mediator complex subunit 13-like 2.11321
SEC14L2 SEC14-like 2 (S. cerevisiae) 2.10709
CRMP1 collapsin response mediator protein 1 2.09817
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae) 2.09107
LRRC37B leucine rich repeat containing 37B 2.08949
KLC3 kinesin light chain 3 2.07758
CAPRIN1 cell cycle associated protein 1 2.07294
CCDC107 coiled-coil domain containing 107 2.06803
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 2.06597
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 2.06299
NEIL1 nei endonuclease VIII-like 1 (E. coli) 2.05256
AUP1 ancient ubiquitous protein 1 2.04863
HELQ helicase, POLQ-like 2.04406
KNL1 kinetochore scaffold 1 2.04207
ORC2 origin recognition complex, subunit 2 2.04207
MFAP3 microfibrillar-associated protein 3 2.04152
PANK3 pantothenate kinase 3 2.02822
H3C2 H3 clustered histone 2 2.024
PBX4 pre-B-cell leukemia homeobox 4 2.024
GULP1 GULP, engulfment adaptor PTB domain containing 1 2.00871
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 2.00871
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 2.00047

decreased expression

Symbol Name Standardized Value
BANK1 B-cell scaffold protein with ankyrin repeats 1 -2.61083
ZBBX zinc finger, B-box domain containing -2.61083
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 -2.56099
ITLN2 intelectin 2 -2.56099
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A -2.56099
ELAVL3 ELAV like neuron-specific RNA binding protein 3 -2.56099
RNF149 ring finger protein 149 -2.54122
ZNF20 zinc finger protein 20 -2.54122
ASCC1 activating signal cointegrator 1 complex subunit 1 -2.54122
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.54122
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 -2.54122
WSCD2 WSC domain containing 2 -2.54122
FES FES proto-oncogene, tyrosine kinase -2.54122
PPP1R35 protein phosphatase 1, regulatory subunit 35 -2.54122
KRTCAP2 keratinocyte associated protein 2 -2.54122
ZNF334 zinc finger protein 334 -2.54122
GIPC1 GIPC PDZ domain containing family, member 1 -2.54122
MOGAT1 monoacylglycerol O-acyltransferase 1 -2.54122
RAB8B RAB8B, member RAS oncogene family -2.54122
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 -2.53896
MCOLN3 mucolipin 3 -2.53896
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase -2.5346
PRSS21 protease, serine, 21 (testisin) -2.52957
POTEJ POTE ankyrin domain family, member J -2.52957
CD37 CD37 molecule -2.52957
ARGFX arginine-fifty homeobox -2.52957
PRSS36 protease, serine, 36 -2.52957
GREM1 gremlin 1, DAN family BMP antagonist -2.52957
SDSL serine dehydratase-like -2.52957
ADAM20 ADAM metallopeptidase domain 20 -2.52957
FOXJ1 forkhead box J1 -2.52957
RGPD3 RANBP2-like and GRIP domain containing 3 -2.52957
CFAP144 cilia and flagella associated protein 144 -2.52957
RHCG Rh family, C glycoprotein -2.52957
CFAP52 cilia and flagella associated protein 52 -2.52957
ACAN aggrecan -2.52957
CYS1 cystin 1 -2.52957
C20ORF204 chromosome 20 open reading frame 204 -2.52957
PRM1 protamine 1 -2.52957
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 -2.52957
EBF3 early B-cell factor 3 -2.52957
LAMB3 laminin, beta 3 -2.52957
C1ORF87 chromosome 1 open reading frame 87 -2.52957
FGR FGR proto-oncogene, Src family tyrosine kinase -2.52957
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 -2.52957
ETV3L ets variant 3-like -2.52957
SIAH3 siah E3 ubiquitin protein ligase family member 3 -2.52957
TCL1A T-cell leukemia/lymphoma 1A -2.46582
ZNF469 zinc finger protein 469 -2.45078
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 -2.42115
SLC5A10 solute carrier family 5 (sodium/sugar cotransporter), member 10 -2.42115
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa -2.41411
FAM149A family with sequence similarity 149, member A -2.38622
CDK6 cyclin-dependent kinase 6 -2.36001
VPS26B vacuolar protein sorting 26 homolog B (S. pombe) -2.34673
PLA2G3 phospholipase A2, group III -2.33056
CARHSP1 calcium regulated heat stable protein 1, 24kDa -2.3202
MPC1 mitochondrial pyruvate carrier 1 -2.29015
HYLS1 hydrolethalus syndrome 1 -2.28858
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) -2.28464
GRIK3 glutamate receptor, ionotropic, kainate 3 -2.26549
P2RY11 purinergic receptor P2Y, G-protein coupled, 11 -2.23846
PROKR1 prokineticin receptor 1 -2.23846
TMEM196 transmembrane protein 196 -2.23846
ALKAL1 ALK and LTK ligand 1 -2.23846
FYB2 FYN binding protein 2 -2.23846
OLFM3 olfactomedin 3 -2.23846
KIF11 kinesin family member 11 -2.23156
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 -2.22786
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.22189
ZNF473 zinc finger protein 473 -2.19379
CXXC1 CXXC finger protein 1 -2.1918
GRIP2 glutamate receptor interacting protein 2 -2.18836
GALK1 galactokinase 1 -2.18017
CD302 CD302 molecule -2.1682
NPIPA5 nuclear pore complex interacting protein family, member A5 -2.162
RAB20 RAB20, member RAS oncogene family -2.14305
LY75 lymphocyte antigen 75 -2.13735
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.12844
WRAP73 WD repeat containing, antisense to TP73 -2.12765
MRPL51 mitochondrial ribosomal protein L51 -2.12765
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -2.10871
RGN regucalcin -2.09817
KLF7 Kruppel-like factor 7 (ubiquitous) -2.07294
TNN tenascin N -2.07294
RNF43 ring finger protein 43 -2.07294
IQCJ IQ motif containing J -2.07294
DEGS2 delta(4)-desaturase, sphingolipid 2 -2.07294
XKR8 XK, Kell blood group complex subunit-related family, member 8 -2.07294
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -2.07294
NME1 NME/NM23 nucleoside diphosphate kinase 1 -2.07056
TBC1D22B TBC1 domain family, member 22B -2.05223
EPSTI1 epithelial stromal interaction 1 (breast) -2.05103
CCDC25 coiled-coil domain containing 25 -2.04387
RPL10 ribosomal protein L10 -2.0215
LAMP1 lysosomal-associated membrane protein 1 -2.0215
FKBP2 FK506 binding protein 2, 13kDa -2.0209
NFS1 NFS1 cysteine desulfurase -2.01263
CENPF centromere protein F, 350/400kDa -2.00871
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 -2.00047