PAX9 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description paired box 9|This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 9 gene is unknown but it may involve development of stratified squamous epithelia as well as various organs and skeletal elements. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5083)
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Genes

350 genes differentially expressed following the PAX9 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CLCA2 chloride channel accessory 2 4.17143
CFAP53 cilia and flagella associated protein 53 4.17143
NMUR2 neuromedin U receptor 2 4.17143
OR2A12 olfactory receptor, family 2, subfamily A, member 12 4.17143
SCRT2 scratch family zinc finger 2 4.17143
TMC3 transmembrane channel-like 3 4.17143
CLEC14A C-type lectin domain family 14, member A 4.17143
ADH6 alcohol dehydrogenase 6 (class V) 4.17143
CORO6 coronin 6 4.17143
TAS2R19 taste receptor, type 2, member 19 4.17143
CXCL16 chemokine (C-X-C motif) ligand 16 4.17143
CD79A CD79a molecule, immunoglobulin-associated alpha 4.17143
MISP mitotic spindle positioning 4.17143
GNRH2 gonadotropin-releasing hormone 2 4.17143
CALCA calcitonin-related polypeptide alpha 4.17143
WNT11 wingless-type MMTV integration site family, member 11 4.17143
MTNR1B melatonin receptor 1B 4.17143
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 4.17143
PDE1B phosphodiesterase 1B, calmodulin-dependent 4.17143
OR5A1 olfactory receptor, family 5, subfamily A, member 1 4.17143
CLCA1 chloride channel accessory 1 4.17143
TRPM5 transient receptor potential cation channel, subfamily M, member 5 4.17143
GATA1 GATA binding protein 1 (globin transcription factor 1) 4.17143
MAGEA10 melanoma antigen family A10 4.17143
HNF1A HNF1 homeobox A 4.17143
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 4.17143
TTC36 tetratricopeptide repeat domain 36 4.17143
PNPLA1 patatin-like phospholipase domain containing 1 4.17143
NKPD1 NTPase, KAP family P-loop domain containing 1 4.17143
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 4.17143
FOXB2 forkhead box B2 4.17143
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 4.17143
ARMC12 armadillo repeat containing 12 4.17143
IRX1 iroquois homeobox 1 4.17143
CLEC2A C-type lectin domain family 2, member A 4.17143
PSD2 pleckstrin and Sec7 domain containing 2 4.17143
S100G S100 calcium binding protein G 4.17143
UMODL1 uromodulin-like 1 4.17143
CCIN calicin 4.17143
TDRD6 tudor domain containing 6 4.17143
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 4.17143
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 4.17143
SH2D6 SH2 domain containing 6 4.17143
OR10A2 olfactory receptor, family 10, subfamily A, member 2 4.17143
CEMP1 cementum protein 1 4.17143
RIMBP2 RIMS binding protein 2 4.17143
OSGIN1 oxidative stress induced growth inhibitor 1 4.17143
PPP3R2 protein phosphatase 3, regulatory subunit B, beta 4.17143
OR52H1 olfactory receptor, family 52, subfamily H, member 1 4.17143
INSM2 insulinoma-associated 2 4.17143
CD163 CD163 molecule 4.17143
ZFP57 ZFP57 zinc finger protein 4.17143
ADRB2 adrenoceptor beta 2, surface 4.17143
OR52A5 olfactory receptor, family 52, subfamily A, member 5 4.17143
SIGLECL1 SIGLEC family like 1 4.17143
ENTHD1 ENTH domain containing 1 4.17143
RAI2 retinoic acid induced 2 4.17143
PAX8 paired box 8 4.17143
CD300A CD300a molecule 4.17143
USH1G Usher syndrome 1G (autosomal recessive) 4.17143
BIRC3 baculoviral IAP repeat containing 3 4.17143
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 4.17143
WEE2 WEE1 homolog 2 (S. pombe) 4.17143
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 4.17143
SIX1 SIX homeobox 1 4.17143
TNIP3 TNFAIP3 interacting protein 3 4.17143
ALPK2 alpha-kinase 2 4.17143
HRH4 histamine receptor H4 4.17143
ADAD2 adenosine deaminase domain containing 2 4.17143
SSTR5 somatostatin receptor 5 4.17143
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 4.17143
ASB12 ankyrin repeat and SOCS box containing 12 4.17143
XCL2 chemokine (C motif) ligand 2 4.17143
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 4.17143
GFAP glial fibrillary acidic protein 4.17143
TYRP1 tyrosinase-related protein 1 4.17143
PI16 peptidase inhibitor 16 4.17143
EIF4E1B eukaryotic translation initiation factor 4E family member 1B 4.17143
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 4.17143
CPHXL cytoplasmic polyadenylated homeobox like 4.17143
CHIT1 chitinase 1 (chitotriosidase) 4.17143
UTS2R urotensin 2 receptor 4.17143
SAMD7 sterile alpha motif domain containing 7 4.17143
SAMD9 sterile alpha motif domain containing 9 4.17143
FSHR follicle stimulating hormone receptor 4.17143
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 4.17143
LRRK2 leucine-rich repeat kinase 2 4.17143
TEKT2 tektin 2 (testicular) 4.17143
CFAP97D1 CFAP97 domain containing 1 4.17143
DUSP29 dual specificity phosphatase 29 4.17143
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 4.17143
CCN5 cellular communication network factor 5 4.17143
EVPLL envoplakin-like 4.17143
DRD2 dopamine receptor D2 4.17143
GASK1B golgi associated kinase 1B 4.17143
NTN5 netrin 5 4.17143
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 4.17143
SYNGR4 synaptogyrin 4 4.17143
EPCIP exosomal polycystin 1 interacting protein 4.17143
SPEGNB SPEG neighbor 4.17143
WASL-DT WASL divergent transcript 4.17143
BTG4 B-cell translocation gene 4 4.17143
ZNF837 zinc finger protein 837 4.17143
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 4.17143
CPNE8-AS1 CPNE8 antisense RNA 1 4.17143
DEFB109B defensin beta 109B 4.17143
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 4.17143
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 4.17143
NKX6-1 NK6 homeobox 1 4.17143
DCN decorin 4.17143
RGS4 regulator of G-protein signaling 4 4.17143
RGS8 regulator of G-protein signaling 8 4.17143
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 4.17143
CTSS cathepsin S 4.17143
PRSS33 protease, serine, 33 4.17143
CGB8 chorionic gonadotropin, beta polypeptide 8 4.17143
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 4.17143
KRT15 keratin 15, type I 4.17143
TFF2 trefoil factor 2 4.17143
ACSL5 acyl-CoA synthetase long-chain family member 5 4.17143
ASB9 ankyrin repeat and SOCS box containing 9 4.17143
TTR transthyretin 4.17143
OR13A1 olfactory receptor, family 13, subfamily A, member 1 4.17143
ECM1 extracellular matrix protein 1 4.17143
CSF3R colony stimulating factor 3 receptor (granulocyte) 4.17143
PTGDR prostaglandin D2 receptor (DP) 4.17143
DOK7 docking protein 7 4.17143
TSPAN1 tetraspanin 1 4.17143
MC5R melanocortin 5 receptor 4.17143
OR51M1 olfactory receptor, family 51, subfamily M, member 1 4.17143
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 4.17143
TBX10 T-box 10 4.17143
FAM228A family with sequence similarity 228, member A 4.17143
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 4.17143
AVPR1B arginine vasopressin receptor 1B 4.17143
CPO carboxypeptidase O 4.17143
APLNR apelin receptor 4.17143
TESPA1 thymocyte expressed, positive selection associated 1 4.17143
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 4.17143
BTNL9 butyrophilin-like 9 4.17143
SMIM38 small integral membrane protein 38 4.17143
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 4.17143
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 4.17143
CDH10 cadherin 10, type 2 (T2-cadherin) 4.17143
HTD2 hydroxyacyl-thioester dehydratase type 2 4.17143
AKR1B15 aldo-keto reductase family 1, member B15 4.17143
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 4.17143
ERVW-1 endogenous retrovirus group W, member 1 4.17143
SPATS1 spermatogenesis associated, serine-rich 1 4.17143
GP1BB glycoprotein Ib (platelet), beta polypeptide 4.17143
GIPC3 GIPC PDZ domain containing family, member 3 4.17143
JAKMIP1 janus kinase and microtubule interacting protein 1 4.12735
LACTB lactamase, beta 3.74843
ZC3H12C zinc finger CCCH-type containing 12C 3.63644
POMGNT2 protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) 3.33985
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 3.29675
NTF4 neurotrophin 4 3.1979
CHL1 cell adhesion molecule L1-like 3.1979
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 3.1979
PEAR1 platelet endothelial aggregation receptor 1 3.1979
ATP8B4 ATPase, class I, type 8B, member 4 3.1979
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 3.1979
LCA5L Leber congenital amaurosis 5-like 3.14935
ICMT isoprenylcysteine carboxyl methyltransferase 3.14535
GIP gastric inhibitory polypeptide 2.93875
TBC1D20 TBC1 domain family, member 20 2.84186
SGSM3 small G protein signaling modulator 3 2.78364
HMOX2 heme oxygenase 2 2.75416
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 2.71139
IRF1 interferon regulatory factor 1 2.67787
PPP1R36 protein phosphatase 1, regulatory subunit 36 2.67787
CLK2 CDC-like kinase 2 2.64278
DCLRE1A DNA cross-link repair 1A 2.60035
NADK NAD kinase 2.50315
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 2.49037
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2.48228
TSPYL1 TSPY-like 1 2.4192
FBXO16 F-box protein 16 2.4192
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 2.41494
ARSA arylsulfatase A 2.40702
F8A1 coagulation factor VIII-associated 1 2.40522
ZDHHC18 zinc finger, DHHC-type containing 18 2.39536
FBXO32 F-box protein 32 2.38767
CALR3 calreticulin 3 2.34059
TMEM43 transmembrane protein 43 2.33734
GYS2 glycogen synthase 2 (liver) 2.3367
ZC3HC1 zinc finger, C3HC-type containing 1 2.33645
MTSS1 metastasis suppressor 1 2.33634
DNAH5 dynein, axonemal, heavy chain 5 2.32546
LDLRAP1 low density lipoprotein receptor adaptor protein 1 2.32325
SF1 splicing factor 1 2.29815
RBFA ribosome binding factor A (putative) 2.29283
PDLIM4 PDZ and LIM domain 4 2.28929
RAPSN receptor-associated protein of the synapse 2.28833
SPNS1 spinster homolog 1 (Drosophila) 2.28833
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.27901
CD19 CD19 molecule 2.27901
S100A2 S100 calcium binding protein A2 2.27697
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 2.27697
CD48 CD48 molecule 2.27697
ANKRD34B ankyrin repeat domain 34B 2.27328
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 2.25573
ZNF304 zinc finger protein 304 2.25055
PISD phosphatidylserine decarboxylase 2.2478
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 2.2478
MTG1 mitochondrial ribosome-associated GTPase 1 2.22374
NPAS3 neuronal PAS domain protein 3 2.22345
RASGEF1B RasGEF domain family, member 1B 2.21937
PTPN2 protein tyrosine phosphatase, non-receptor type 2 2.21937
TBC1D25 TBC1 domain family, member 25 2.21937
MAPK6 mitogen-activated protein kinase 6 2.20046
MPHOSPH9 M-phase phosphoprotein 9 2.20046
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 2.18555
PCNX3 pecanex 3 2.1818
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 2.171
LY75 lymphocyte antigen 75 2.16908
GRAMD2B GRAM domain containing 2B 2.13677
C9ORF72 chromosome 9 open reading frame 72 2.13132
DTX1 deltex 1, E3 ubiquitin ligase 2.1296
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2 2.1243
INO80 INO80 complex subunit 2.11111
ANTKMT adenine nucleotide translocase lysine methyltransferase 2.10773
TMEM35B transmembrane protein 35B 2.09132
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 2.09132
VMA22 vacuolar ATPase assembly factor VMA22 2.0829
COPA coatomer protein complex, subunit alpha 2.06905
CDH8 cadherin 8, type 2 2.05575
DTWD1 DTW domain containing 1 2.05541
FASTKD3 FAST kinase domains 3 2.05199
FGF4 fibroblast growth factor 4 2.04868
SP4 Sp4 transcription factor 2.0372
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 2.0231
PCDHB5 protocadherin beta 5 2.01736
NMD3 NMD3 ribosome export adaptor 2.00579
GPBP1 GC-rich promoter binding protein 1 2.00339

decreased expression

Symbol Name Standardized Value
MROH6 maestro heat-like repeat family member 6 -4.17143
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 -4.17143
CCDC158 coiled-coil domain containing 158 -4.17143
CDC42EP5 CDC42 effector protein (Rho GTPase binding) 5 -4.17143
C5AR2 complement component 5a receptor 2 -4.12735
FNDC7 fibronectin type III domain containing 7 -4.12735
SHOX short stature homeobox -4.12735
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion -4.12735
ECEL1 endothelin converting enzyme-like 1 -4.12735
NIM1K NIM1 serine/threonine protein kinase -4.12735
HES4 hes family bHLH transcription factor 4 -4.12735
SLC14A2 solute carrier family 14 (urea transporter), member 2 -4.12735
ADIRF adipogenesis regulatory factor -4.12735
FAM221B family with sequence similarity 221, member B -4.12735
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 -4.12735
MYL7 myosin, light chain 7, regulatory -4.12735
LOC105378220 macrophage receptor MARCO-like -4.12735
CD226 CD226 molecule -4.12735
HBZ hemoglobin, zeta -4.12735
NPIPA7 nuclear pore complex interacting protein family, member A7 -4.12735
TMEM156 transmembrane protein 156 -4.12735
CLCNKB chloride channel, voltage-sensitive Kb -4.12735
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 -4.12735
MUC5B mucin 5B, oligomeric mucus/gel-forming -4.12735
AMIGO1 adhesion molecule with Ig-like domain 1 -4.12735
GPR12 G protein-coupled receptor 12 -4.12735
BTC betacellulin -4.12735
ITPRID1 ITPR interacting domain containing 1 -4.12735
CBLIF cobalamin binding intrinsic factor -4.12735
PNMA8B PNMA family member 8B -4.12735
F10 coagulation factor X -4.12735
MGAM maltase-glucoamylase -4.12735
CD27 CD27 molecule -4.12735
TMEM196 transmembrane protein 196 -4.12735
TIMD4 T-cell immunoglobulin and mucin domain containing 4 -4.12735
ART1 ADP-ribosyltransferase 1 -4.12735
RNF17 ring finger protein 17 -4.12735
TSSK6 testis-specific serine kinase 6 -4.12735
C9ORF43 chromosome 9 open reading frame 43 -4.12735
IZUMO1 izumo sperm-egg fusion 1 -4.12735
DCDC2B doublecortin domain containing 2B -4.12735
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 -4.03048
WAS Wiskott-Aldrich syndrome -4.03048
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A -4.03048
R3HDM2 R3H domain containing 2 -3.89644
DCAF6 DDB1 and CUL4 associated factor 6 -3.75211
ZIC1 Zic family member 1 -3.50315
PPAT phosphoribosyl pyrophosphate amidotransferase -3.48311
BCLAF3 BCLAF1 and THRAP3 family member 3 -3.35971
MYLK3 myosin light chain kinase 3 -3.19021
AP3S2 adaptor-related protein complex 3, sigma 2 subunit -2.95532
LIPT2-AS1 LIPT2 antisense RNA 1 -2.93526
MICALL2 MICAL-like 2 -2.91816
WNT3 wingless-type MMTV integration site family, member 3 -2.86002
NR6A1 nuclear receptor subfamily 6, group A, member 1 -2.84186
USP39 ubiquitin specific peptidase 39 -2.71495
FKBP15 FK506 binding protein 15, 133kDa -2.65826
CCDC144A coiled-coil domain containing 144A -2.64267
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -2.6228
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -2.61275
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 -2.60367
RAF1 Raf-1 proto-oncogene, serine/threonine kinase -2.5482
XDH xanthine dehydrogenase -2.47495
PLPPR3 phospholipid phosphatase related 3 -2.47044
SCUBE2 signal peptide, CUB domain, EGF-like 2 -2.45394
KLRD1 killer cell lectin-like receptor subfamily D, member 1 -2.40393
SRSF10 serine/arginine-rich splicing factor 10 -2.39584
TMEM68 transmembrane protein 68 -2.38767
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa -2.38767
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein -2.3735
P3H2 prolyl 3-hydroxylase 2 -2.34827
GZF1 GDNF-inducible zinc finger protein 1 -2.33634
GSTM2 glutathione S-transferase mu 2 (muscle) -2.33634
C1QTNF12 C1q and TNF related 12 -2.33634
STX12 syntaxin 12 -2.32602
WIZ widely interspaced zinc finger motifs -2.32325
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha -2.30698
CHMP7 charged multivesicular body protein 7 -2.29136
ETNPPL ethanolamine-phosphate phospho-lyase -2.27434
BBS5 Bardet-Biedl syndrome 5 -2.27434
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 -2.27434
CAPN6 calpain 6 -2.27207
LPAR4 lysophosphatidic acid receptor 4 -2.27142
H2BC13 H2B clustered histone 13 -2.26832
GCNT7 glucosaminyl (N-acetyl) transferase family member 7 -2.26832
CTRL chymotrypsin-like -2.26832
LTAP1 lipid transport auxiliary protein 1 -2.25573
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 -2.25573
AKAP10 A kinase (PRKA) anchor protein 10 -2.25573
MID2 midline 2 -2.25573
BHLHA15 basic helix-loop-helix family, member a15 -2.25573
KIAA0232 KIAA0232 -2.25009
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.2478
MT1F metallothionein 1F -2.22734
COA5 cytochrome c oxidase assembly factor 5 -2.22374
PHIP pleckstrin homology domain interacting protein -2.2156
RCAN2 regulator of calcineurin 2 -2.20418
RFC3 replication factor C (activator 1) 3, 38kDa -2.18376
KLHL31 kelch-like family member 31 -2.16726
CLCN1 chloride channel, voltage-sensitive 1 -2.16726
TSLIG3A tRNA splicing ligase complex subunit 3A -2.16726
LIX1 Lix1 homolog (chicken) -2.16726
MEIS3 Meis homeobox 3 -2.15771
TTC7B tetratricopeptide repeat domain 7B -2.13295
MAGEH1 melanoma antigen family H1 -2.1296
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -2.12381
B3GAT3 beta-1,3-glucuronyltransferase 3 -2.11761
XKR7 XK, Kell blood group complex subunit-related family, member 7 -2.09132
NXT1 nuclear transport factor 2-like export factor 1 -2.09132
IGSF11 immunoglobulin superfamily, member 11 -2.06905
CCSER2 coiled-coil serine-rich protein 2 -2.05199
CPE carboxypeptidase E -2.04868
PPP1R3F protein phosphatase 1, regulatory subunit 3F -2.04868
MKRN1 makorin ring finger protein 1 -2.03915
RAD54L RAD54-like (S. cerevisiae) -2.02312