PBX1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description pre-B-cell leukemia homeobox 1|This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] (NCBI Entrez Gene Database, 5087)
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Genes

336 genes differentially expressed following the PBX1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SLC25A34 solute carrier family 25, member 34 2.73047
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) 2.73047
AMPD1 adenosine monophosphate deaminase 1 2.73047
DISP2 dispatched homolog 2 (Drosophila) 2.73047
SPINK1 serine peptidase inhibitor, Kazal type 1 2.73047
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 2.73047
NGEF neuronal guanine nucleotide exchange factor 2.73047
SH2D4B SH2 domain containing 4B 2.73047
POTEI POTE ankyrin domain family, member I 2.73047
IQCJ IQ motif containing J 2.73047
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 2.73047
TRPM1 transient receptor potential cation channel, subfamily M, member 1 2.73047
SVOP SV2 related protein homolog (rat) 2.73047
NPY neuropeptide Y 2.73047
CD80 CD80 molecule 2.73047
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 2.73047
STRC stereocilin 2.73047
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 2.73047
TNMD tenomodulin 2.73047
NPIPA5 nuclear pore complex interacting protein family, member A5 2.73047
LRRIQ4 leucine-rich repeats and IQ motif containing 4 2.73047
SLC22A14 solute carrier family 22, member 14 2.73047
FAM3D family with sequence similarity 3, member D 2.73047
MPL MPL proto-oncogene, thrombopoietin receptor 2.73047
VXN vexin 2.73047
IGFL3 IGF-like family member 3 2.61513
CD96 CD96 molecule 2.61513
MMS22L MMS22-like, DNA repair protein 2.61513
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 2.61513
PRSS41 protease, serine, 41 2.61513
AKR1C2 aldo-keto reductase family 1, member C2 2.61513
NKAPL NFKB activating protein-like 2.61513
USP26 ubiquitin specific peptidase 26 2.61513
CABP4 calcium binding protein 4 2.61513
ZSCAN5B zinc finger and SCAN domain containing 5B 2.61513
MC4R melanocortin 4 receptor 2.61513
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 2.61513
SSTR5 somatostatin receptor 5 2.61513
MYOM2 myomesin 2 2.61513
SSU72L3 SSU72 like 3 2.61513
ANKRD34A ankyrin repeat domain 34A 2.61513
C3ORF22 chromosome 3 open reading frame 22 2.61513
PCDH8 protocadherin 8 2.61513
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 2.61513
RGPD3 RANBP2-like and GRIP domain containing 3 2.61513
CRYGN crystallin, gamma N 2.61513
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 2.61513
DIRAS3 DIRAS family, GTP-binding RAS-like 3 2.61513
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.61513
GLYAT glycine-N-acyltransferase 2.61513
DPEP2 dipeptidase 2 2.61513
RIMBP2 RIMS binding protein 2 2.61513
OR10A3 olfactory receptor, family 10, subfamily A, member 3 2.61513
MTTP microsomal triglyceride transfer protein 2.61513
BRICD5 BRICHOS domain containing 5 2.61513
OLIG1 oligodendrocyte transcription factor 1 2.61513
NFAM1 NFAT activating protein with ITAM motif 1 2.61513
OLFM4 olfactomedin 4 2.61513
MYOM3 myomesin 3 2.61513
LY6S lymphocyte antigen 6 family member S 2.61513
CAPN9 calpain 9 2.61513
STMN4 stathmin-like 4 2.61513
KRT81 keratin 81, type II 2.61513
LMNTD1 lamin tail domain containing 1 2.61513
ADRB1 adrenoceptor beta 1 2.61513
WDR64 WD repeat domain 64 2.61513
ASB4 ankyrin repeat and SOCS box containing 4 2.61513
SPATA25 spermatogenesis associated 25 2.61513
MAGIX MAGI family member, X-linked 2.61513
TBX10 T-box 10 2.61513
KY kyphoscoliosis peptidase 2.61513
GBP6 guanylate binding protein family, member 6 2.61513
CIMIP7 ciliary microtubule inner protein 7 2.61513
LRRC8C-DT LRRC8C divergent transcript 2.61513
C1ORF232 chromosome 1 open reading frame 230 2.61513
PRRT1B proline rich transmembrane protein 1B 2.61513
H2AC20 H2A clustered histone 20 2.61513
LHFPL7 LHFPL tetraspan subfamily member 7 2.61513
IHO1 interactor of HORMAD1 1 2.61513
CHCT1 CHD1 helical C-terminal domain containing 1 2.61513
SELE selectin E 2.61513
HAO2 hydroxyacid oxidase 2 (long chain) 2.61513
TRPA1 transient receptor potential cation channel, subfamily A, member 1 2.61513
OSTN osteocrin 2.61513
AKR1D1 aldo-keto reductase family 1, member D1 2.61513
MAGEB3 melanoma antigen family B3 2.61513
LGALS7B lectin, galactoside-binding, soluble, 7B 2.61513
LRTM3 leucine rich repeat transmembrane protein 3 2.61513
C5ORF52 chromosome 5 open reading frame 52 2.61513
ACTL8 actin-like 8 2.61513
ATP13A4 ATPase type 13A4 2.61513
PRB1 proline-rich protein BstNI subfamily 1 2.61513
TAS2R3 taste receptor, type 2, member 3 2.61513
GOSR1 golgi SNAP receptor complex member 1 2.61513
AXDND1 axonemal dynein light chain domain containing 1 2.61513
CATSPER4 cation channel, sperm associated 4 2.61513
HNF1B HNF1 homeobox B 2.61513
PXDC1 PX domain containing 1 2.61513
HAL histidine ammonia-lyase 2.61513
SHC4 SHC (Src homology 2 domain containing) family, member 4 2.61513
NR0B1 nuclear receptor subfamily 0, group B, member 1 2.61513
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 2.61513
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.61513
PGC progastricsin (pepsinogen C) 2.61513
TLR6 toll-like receptor 6 2.61513
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 2.61513
GOLGA2 golgin A2 2.61513
PRSS57 protease, serine, 57 2.61513
LCN1 lipocalin 1 2.61513
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 2.61513
MAB21L3 mab-21-like 3 (C. elegans) 2.61513
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 2.61513
PLA1A phospholipase A1 member A 2.61513
SFRP5 secreted frizzled-related protein 5 2.61513
CTXN2 cortexin 2 2.61513
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 2.61513
SCML4 sex comb on midleg-like 4 (Drosophila) 2.61513
LGALS14 lectin, galactoside-binding, soluble, 14 2.61513
AQP8 aquaporin 8 2.61513
MAGEB17 melanoma antigen family B17 2.61513
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.61513
KRT15 keratin 15, type I 2.61513
GP1BA glycoprotein Ib (platelet), alpha polypeptide 2.61513
LRRC43 leucine rich repeat containing 43 2.61513
CCL27 chemokine (C-C motif) ligand 27 2.61513
KCNK7 potassium channel, two pore domain subfamily K, member 7 2.61513
C11ORF96 chromosome 11 open reading frame 96 2.61513
ARL13A ADP-ribosylation factor-like 13A 2.61513
AMN amnion associated transmembrane protein 2.61513
SMIM17 small integral membrane protein 17 2.61513
MSMP microseminoprotein, prostate associated 2.61513
ESPNL espin-like 2.61513
TM4SF19 transmembrane 4 L six family member 19 2.61513
DRC1 dynein regulatory complex subunit 1 2.61513
TMEM255A transmembrane protein 255A 2.61513
ZPBP zona pellucida binding protein 2.61513
GOLGA8K golgin A8 family, member K 2.61513
PHACTR3 phosphatase and actin regulator 3 2.61513
NKX6-2 NK6 homeobox 2 2.61513
ORM2 orosomucoid 2 2.61513
SH2D1B SH2 domain containing 1B 2.61513
GFRAL GDNF family receptor alpha like 2.61513
PDCD1LG2 programmed cell death 1 ligand 2 2.61513
GSTA1 glutathione S-transferase alpha 1 2.61513
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 2.61513
SYNGR4 synaptogyrin 4 2.61513
OTOP3 otopetrin 3 2.61513
ADGRD1 adhesion G protein-coupled receptor D1 2.61513
IBSP integrin-binding sialoprotein 2.61513
SIDT1 SID1 transmembrane family, member 1 2.61513
VTCN1 V-set domain containing T cell activation inhibitor 1 2.61513
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 2.61513
CHRM1 cholinergic receptor, muscarinic 1 2.61513
SDSL serine dehydratase-like 2.61513
NLRP6 NLR family, pyrin domain containing 6 2.61513
KIF19 kinesin family member 19 2.61513
IL18R1 interleukin 18 receptor 1 2.61513
XCR1 chemokine (C motif) receptor 1 2.61513
MYOZ2 myozenin 2 2.61513
TDO2 tryptophan 2,3-dioxygenase 2.61513
PADI3 peptidyl arginine deiminase, type III 2.61513
ANGPTL6 angiopoietin-like 6 2.61513
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.61513
SPACA7 sperm acrosome associated 7 2.61513
VPREB3 pre-B lymphocyte 3 2.61513
EMCN endomucin 2.61513
PADI1 peptidyl arginine deiminase, type I 2.61513
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 2.61513
ABRA actin binding Rho activating protein 2.61513
MPO myeloperoxidase 2.61513
AMER3 APC membrane recruitment protein 3 2.61513
EBI3 Epstein-Barr virus induced 3 2.61513
CARNS1 carnosine synthase 1 2.61513
DCST2 DC-STAMP domain containing 2 2.61513
ADGRF4 adhesion G protein-coupled receptor F4 2.61513
SLITRK2 SLIT and NTRK-like family, member 2 2.61513
MMP13 matrix metallopeptidase 13 2.61513
KANK1 KN motif and ankyrin repeat domains 1 2.58094
DCLK2 doublecortin-like kinase 2 2.52235
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 2.52235
DAPK1 death-associated protein kinase 1 2.51853
CDK14 cyclin-dependent kinase 14 2.49818
TARS3 threonyl-tRNA synthetase 3 2.46383
KIAA2026 KIAA2026 2.45927
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 2.43654
PCDHGA6 protocadherin gamma subfamily A, 6 2.41554
SLC39A4 solute carrier family 39 (zinc transporter), member 4 2.41554
BDKRB2 bradykinin receptor B2 2.39946
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 2.3884
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 2.38699
LDOC1 leucine zipper, down-regulated in cancer 1 2.37812
BBC3 BCL2 binding component 3 2.35894
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 2.35894
IGSF21 immunoglobin superfamily, member 21 2.35426
IFT70A intraflagellar transport 70A 2.35197
WDR43 WD repeat domain 43 2.34907
HEXIM1 hexamethylene bis-acetamide inducible 1 2.34601
RGS7 regulator of G-protein signaling 7 2.33469
TRAF3IP2 TRAF3 interacting protein 2 2.33378
ZNF746 zinc finger protein 746 2.2907
LRRC19 leucine rich repeat containing 19 2.27489
RBM20 RNA binding motif protein 20 2.27489
MAPT microtubule-associated protein tau 2.27489
LENG9 leukocyte receptor cluster (LRC) member 9 2.26158
HSPA1A heat shock 70kDa protein 1A 2.25697
TRIM2 tripartite motif containing 2 2.25218
NOMO1 NODAL modulator 1 2.23871
RNF208 ring finger protein 208 2.20988
RPRD2 regulation of nuclear pre-mRNA domain containing 2 2.19328
BCL10 B-cell CLL/lymphoma 10 2.17749
PRKCQ protein kinase C, theta 2.16722
DHRSX dehydrogenase/reductase (SDR family) X-linked 2.13133
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 2.11436
RAB9A RAB9A, member RAS oncogene family 2.11239
FCGRT Fc fragment of IgG, receptor, transporter, alpha 2.10591
FKBP7 FK506 binding protein 7 2.10172
TRIO trio Rho guanine nucleotide exchange factor 2.08921
MTOR mechanistic target of rapamycin (serine/threonine kinase) 2.05974
EDEM2 ER degradation enhancer, mannosidase alpha-like 2 2.05934
TMEM9 transmembrane protein 9 2.05684
BOLA1 bolA family member 1 2.0524
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 2.0524
COPA coatomer protein complex, subunit alpha 2.03473
SDCCAG8 serologically defined colon cancer antigen 8 2.02176
ZNF324 zinc finger protein 324 2.02176
PEX11G peroxisomal biogenesis factor 11 gamma 2.02111
PACC1 proton activated chloride channel 1 2.01376
SPATA33 spermatogenesis associated 33 2.00008

decreased expression

Symbol Name Standardized Value
PBX1 pre-B-cell leukemia homeobox 1 -2.73047
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 -2.73047
FAM86B2 family with sequence similarity 86, member B2 -2.73047
PRSS27 protease, serine 27 -2.73047
HFE hemochromatosis -2.73047
C1QTNF3 C1q and tumor necrosis factor related protein 3 -2.73047
ABRAXAS2 abraxas 2, BRISC complex subunit -2.61745
WLS wntless Wnt ligand secretion mediator -2.61513
TMEM100 transmembrane protein 100 -2.61513
GCKR glucokinase (hexokinase 4) regulator -2.61513
TIMCC TIM double twin CX3C motif chaperone -2.61513
TTC6 tetratricopeptide repeat domain 6 -2.61513
INSYN1 inhibitory synaptic factor 1 -2.61513
SPAG8 sperm associated antigen 8 -2.61513
RPL37 ribosomal protein L37 -2.61513
TPH1 tryptophan hydroxylase 1 -2.61513
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -2.61513
CCDC63 coiled-coil domain containing 63 -2.61513
CARD14 caspase recruitment domain family, member 14 -2.61513
CRYAB crystallin, alpha B -2.61513
CFAP91 cilia and flagella associated protein 91 -2.61513
RNF227 ring finger protein 227 -2.61513
TAMALIN trafficking regulator and scaffold protein tamalin -2.61513
ZNF70 zinc finger protein 70 -2.61513
PCDHGA9 protocadherin gamma subfamily A, 9 -2.61513
YIPF7 Yip1 domain family, member 7 -2.61513
LDB3 LIM domain binding 3 -2.61513
SPRR2F small proline-rich protein 2F -2.61513
PPM1K protein phosphatase, Mg2+/Mn2+ dependent, 1K -2.61513
RBM46 RNA binding motif protein 46 -2.61513
GHRHR growth hormone releasing hormone receptor -2.61513
FAM43B family with sequence similarity 43, member B -2.61513
SLC35D3 solute carrier family 35, member D3 -2.61513
MMRN2 multimerin 2 -2.61513
PCDHGB7 protocadherin gamma subfamily B, 7 -2.61513
FAT2 FAT atypical cadherin 2 -2.61513
LMOD3 leiomodin 3 (fetal) -2.61513
RPS23 ribosomal protein S23 -2.61513
NPFFR1 neuropeptide FF receptor 1 -2.61513
CNBD2 cyclic nucleotide binding domain containing 2 -2.61513
FHL3 four and a half LIM domains 3 -2.61513
HCRT hypocretin (orexin) neuropeptide precursor -2.61513
TMEM132D transmembrane protein 132D -2.61513
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) -2.61513
MEIS2 Meis homeobox 2 -2.61513
SLITRK4 SLIT and NTRK-like family, member 4 -2.61513
CXCR5 chemokine (C-X-C motif) receptor 5 -2.61513
EPHA5 EPH receptor A5 -2.61513
LAG3 lymphocyte-activation gene 3 -2.61513
SMG6 SMG6 nonsense mediated mRNA decay factor -2.61513
IRS2 insulin receptor substrate 2 -2.61494
LAD1 ladinin 1 -2.58094
PPAN peter pan homolog (Drosophila) -2.54497
FTCD formimidoyltransferase cyclodeaminase -2.5322
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.52012
OSTC oligosaccharyltransferase complex subunit (non-catalytic) -2.52012
COX5A cytochrome c oxidase subunit Va -2.5189
PANX1 pannexin 1 -2.49537
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa -2.4873
SCAF1 SR-related CTD-associated factor 1 -2.46178
DCLK1 doublecortin-like kinase 1 -2.45363
PRLR prolactin receptor -2.42784
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 -2.41178
ZNF571 zinc finger protein 571 -2.39602
CCT4 chaperonin containing TCP1, subunit 4 (delta) -2.37856
L3MBTL4 l(3)mbt-like 4 (Drosophila) -2.3652
CXORF38 chromosome X open reading frame 38 -2.36462
DAZAP1 DAZ associated protein 1 -2.3588
POLR2G polymerase (RNA) II (DNA directed) polypeptide G -2.3588
BRAT1 BRCA1-associated ATM activator 1 -2.35692
ADAM17 ADAM metallopeptidase domain 17 -2.35109
TINCR tissue differentiation-inducing non-protein coding RNA -2.34137
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 -2.30907
DPP8 dipeptidyl-peptidase 8 -2.23871
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 -2.23871
METTL1 methyltransferase like 1 -2.23661
CD101 CD101 molecule -2.22017
ZNF732 zinc finger protein 732 -2.22017
WDR81 WD repeat domain 81 -2.22017
SDC1 syndecan 1 -2.20994
KLHL21 kelch-like family member 21 -2.16722
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.16722
PHOSPHO2-KLHL23 PHOSPHO2-KLHL23 readthrough -2.16722
FOXP1 forkhead box P1 -2.16533
SMIM8 small integral membrane protein 8 -2.16533
MED13 mediator complex subunit 13 -2.16422
MTFR1L mitochondrial fission regulator 1-like -2.15817
MUS81 MUS81 structure-specific endonuclease subunit -2.15409
PSTK phosphoseryl-tRNA kinase -2.15284
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 -2.14552
ZNF770 zinc finger protein 770 -2.14358
IRF2BP2 interferon regulatory factor 2 binding protein 2 -2.13529
FLOT2 flotillin 2 -2.13223
NPHP4 nephronophthisis 4 -2.10591
ZNF12 zinc finger protein 12 -2.10053
CD247 CD247 molecule -2.06721
ARHGEF19 Rho guanine nucleotide exchange factor (GEF) 19 -2.06583
ABHD13 abhydrolase domain containing 13 -2.0567
PABPC1L poly(A) binding protein, cytoplasmic 1-like -2.0524
A2ML1 alpha-2-macroglobulin-like 1 -2.0522
COA6 cytochrome c oxidase assembly factor 6 -2.0522
ASXL2 additional sex combs like transcriptional regulator 2 -2.05044
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 -2.03473
MSRB2 methionine sulfoxide reductase B2 -2.03189
HMGN5 high mobility group nucleosome binding domain 5 -2.03146
FAIM Fas apoptotic inhibitory molecule -2.0139
CMKLR2 chemerin chemokine-like receptor 2 -2.00697
ZSWIM1 zinc finger, SWIM-type containing 1 -2.00059