PBX1 Gene Set

Dataset JASPAR Predicted Transcription Factor Targets
Category genomics
Type transcription factor
Description pre-B-cell leukemia homeobox 1|This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] (NCBI Entrez Gene Database, 5087)
External Link http://www.ncbi.nlm.nih.gov/gene/5087
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Genes

46 target genes of the PBX1 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.

Symbol Name
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ARHGAP28 Rho GTPase activating protein 28
ATP6V1G2-DDX39B ATP6V1G2-DDX39B readthrough (NMD candidate)
BRD2 bromodomain containing 2
CSN1S2AP casein alpha s2-like A, pseudogene
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
EHMT2 euchromatic histone-lysine N-methyltransferase 2
FAM101B family with sequence similarity 101, member B
FAM21A family with sequence similarity 21, member A
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FLOT1 flotillin 1
GMEB1 glucocorticoid modulatory element binding protein 1
GNL1 guanine nucleotide binding protein-like 1
GPC4 glypican 4
GPHRB golgi pH regulator B
GTPBP6 GTP binding protein 6 (putative)
HCG26 HLA complex group 26 (non-protein coding)
HCP5 HLA complex P5 (non-protein coding)
HLA-E major histocompatibility complex, class I, E
LINC00685 long intergenic non-protein coding RNA 685
LOC401242 uncharacterized LOC401242
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYN LYN proto-oncogene, Src family tyrosine kinase
MCRS1 microspherule protein 1
MILR1 mast cell immunoglobulin-like receptor 1
MIR3648-1 microRNA 3648-1
MIR3687-1 microRNA 3687-1
NBPF14 neuroblastoma breakpoint family, member 14
NEU1 sialidase 1 (lysosomal sialidase)
PRRC2A proline-rich coiled-coil 2A
PRY PTPN13-like, Y-linked
PRY2 PTPN13-like, Y-linked 2
REXO1L1P REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 1, pseudogene
REXO1L2P REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 2, pseudogene
RNF39 ring finger protein 39
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26
TCF19 transcription factor 19
TNF tumor necrosis factor
TNXB tenascin XB
TRIM26 tripartite motif containing 26
TRIM40 tripartite motif containing 40
UGT2B11 UDP glucuronosyltransferase 2 family, polypeptide B11
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VARS valyl-tRNA synthetase
ZFP57 ZFP57 zinc finger protein