PC Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description pyruvate carboxylase|This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5091)
External Link http://www.ncbi.nlm.nih.gov/gene/5091
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204 interacting proteins for PC from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACACB acetyl-CoA carboxylase beta
ACTB actin, beta
ACTG1 actin gamma 1
ADRB2 adrenoceptor beta 2, surface
ALB albumin
ANXA2 annexin A2
ANXA5 annexin A5
ATXN2L ataxin 2-like
BAG2 BCL2-associated athanogene 2
C1QBP complement component 1, q subcomponent binding protein
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1
CAPZB capping protein (actin filament) muscle Z-line, beta
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CCT7 chaperonin containing TCP1, subunit 7 (eta)
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CDC42 cell division cycle 42
CDCA4 cell division cycle associated 4
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
DAZAP1 DAZ associated protein 1
DCD dermcidin
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DSG1 desmoglein 1
DSP desmoplakin
ECH1 enoyl CoA hydratase 1, peroxisomal
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EEF1B2 eukaryotic translation elongation factor 1 beta 2
ELAVL1 ELAV like RNA binding protein 1
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
HCFC1 host cell factor C1
HCFC2 host cell factor C2
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
HIST1H1E histone cluster 1, H1e
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HNRNPF heterogeneous nuclear ribonucleoprotein F
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPK heterogeneous nuclear ribonucleoprotein K
HNRNPL heterogeneous nuclear ribonucleoprotein L
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1B heat shock 70kDa protein 1B
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
ILF2 interleukin enhancer binding factor 2
ILF3 interleukin enhancer binding factor 3, 90kDa
IQGAP1 IQ motif containing GTPase activating protein 1
IRS4 insulin receptor substrate 4
JUN jun proto-oncogene
JUP junction plakoglobin
KPNB1 karyopherin (importin) beta 1
KRT1 keratin 1, type II
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT2 keratin 2, type II
KRT31 keratin 31, type I
KRT32 keratin 32, type I
KRT33B keratin 33B, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KRT78 keratin 78, type II
KRT81 keratin 81, type II
KRT85 keratin 85, type II
KRT9 keratin 9, type I
LSM12 LSM12 homolog (S. cerevisiae)
MAP7 microtubule-associated protein 7
MATR3 matrin 3
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha)
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MCM5 minichromosome maintenance complex component 5
MDH2 malate dehydrogenase 2, NAD (mitochondrial)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MKI67 marker of proliferation Ki-67
MOV10 Mov10 RISC complex RNA helicase
MRPL12 mitochondrial ribosomal protein L12
MRPS27 mitochondrial ribosomal protein S27
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
NACA nascent polypeptide-associated complex alpha subunit
NME2 NME/NM23 nucleoside diphosphate kinase 2
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NUCLEOLIN nucleolin multifunctional protein
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OSBP2 oxysterol binding protein 2
P4HB prolyl 4-hydroxylase, beta polypeptide
PABPC1 poly(A) binding protein, cytoplasmic 1
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PCCA propionyl CoA carboxylase, alpha polypeptide
PCCB propionyl CoA carboxylase, beta polypeptide
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PPP4C protein phosphatase 4, catalytic subunit
PPT2 palmitoyl-protein thioesterase 2
PRDX1 peroxiredoxin 1
PRDX3 peroxiredoxin 3
PRDX4 peroxiredoxin 4
PRKCDBP protein kinase C, delta binding protein
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PRSS1 protease, serine, 1 (trypsin 1)
PSD4 pleckstrin and Sec7 domain containing 4
PTK2B protein tyrosine kinase 2 beta
R3HCC1 R3H domain and coiled-coil containing 1
RAN RAN, member RAS oncogene family
RBM25 RNA binding motif protein 25
RBM7 RNA binding motif protein 7
RBMXL1 RNA binding motif protein, X-linked-like 1
RECQL4 RecQ protein-like 4
RPL11 ribosomal protein L11
RPL12 ribosomal protein L12
RPL14 ribosomal protein L14
RPL17 ribosomal protein L17
RPL19 ribosomal protein L19
RPL21 ribosomal protein L21
RPL23 ribosomal protein L23
RPL24 ribosomal protein L24
RPL30 ribosomal protein L30
RPL4 ribosomal protein L4
RPL6 ribosomal protein L6
RPL7A ribosomal protein L7a
RPLP0 ribosomal protein, large, P0
RPLP1 ribosomal protein, large, P1
RPLP2 ribosomal protein, large, P2
RPS11 ribosomal protein S11
RPS14 ribosomal protein S14
RPS23 ribosomal protein S23
RPS27 ribosomal protein S27
RPS27L ribosomal protein S27-like
RPS3A ribosomal protein S3A
RPS4X ribosomal protein S4, X-linked
RPS6 ribosomal protein S6
RPS8 ribosomal protein S8
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERBP1 SERPINE1 mRNA binding protein 1
SERTAD4 SERTA domain containing 4
SGOL2 shugoshin-like 2 (S. pombe)
SIK2 salt-inducible kinase 2
SKA1 spindle and kinetochore associated complex subunit 1
SKA2 spindle and kinetochore associated complex subunit 2
SKA3 spindle and kinetochore associated complex subunit 3
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SMC4 structural maintenance of chromosomes 4
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1)
SNRPA small nuclear ribonucleoprotein polypeptide A
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPB2 small nuclear ribonucleoprotein polypeptide B
SNRPC small nuclear ribonucleoprotein polypeptide C
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa
SNRPE small nuclear ribonucleoprotein polypeptide E
SNRPF small nuclear ribonucleoprotein polypeptide F
SUGP2 SURP and G patch domain containing 2
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
TCP1 t-complex 1
TGM1 transglutaminase 1
TMPO thymopoietin
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOE1 target of EGR1, member 1 (nuclear)
TRIM28 tripartite motif containing 28
TUBA1B tubulin, alpha 1b
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TUFM Tu translation elongation factor, mitochondrial
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBC ubiquitin C
UBE2N ubiquitin-conjugating enzyme E2N
VIM vimentin
YBX1 Y box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZCCHC8 zinc finger, CCHC domain containing 8