PC14 Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
Description Lung Adenocarcinoma cell line (Cancer Dependency Map)
External Link https://depmap.org/portal/cell_line/ACH-000030
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Genes

209 gene knockdowns changing fitness of PC14 relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
CYB5A cytochrome b5 type A (microsomal) 30.5321
CYB5R3 cytochrome b5 reductase 3 20.7186
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 12.8493
SENP8 SUMO/sentrin specific peptidase family member 8 11.3867
MYO10 myosin X 9.89885
TP53 tumor protein p53 8.21055
HAS1 hyaluronan synthase 1 7.70906
USP54 ubiquitin specific peptidase 54 7.53935
UBE2F ubiquitin-conjugating enzyme E2F (putative) 7.20039
DNAL4 dynein, axonemal, light chain 4 6.89513
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 6.72736
CDH23 cadherin-related 23 5.89649
MYOZ1 myozenin 1 5.83559
DUSP13 dual specificity phosphatase 13 5.57108
UNC5B unc-5 homolog B (C. elegans) 5.54006
SEC23B Sec23 homolog B (S. cerevisiae) 5.36747
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 5.33011
INSL3 insulin-like 3 (Leydig cell) 5.28361
PLA2G12B phospholipase A2, group XIIB 5.27823
NODAL nodal growth differentiation factor 5.20588
ASB3 ankyrin repeat and SOCS box containing 3 5.14305
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) 5.10841
FLOT2 flotillin 2 5.07091
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 5.07054
ZDHHC5 zinc finger, DHHC-type containing 5 5.01729
MPI mannose phosphate isomerase 5.00717
ZNF697 zinc finger protein 697 4.92295
LRRC20 leucine rich repeat containing 20 4.85118
KDM4A lysine (K)-specific demethylase 4A 4.81015
NLRP4 NLR family, pyrin domain containing 4 4.79939
ALAD aminolevulinate dehydratase 4.75595
EPN1 epsin 1 4.74328
TET1 tet methylcytosine dioxygenase 1 4.7311
ZNF503 zinc finger protein 503 4.72574
CALM2 calmodulin 2 (phosphorylase kinase, delta) 4.63626
MPST mercaptopyruvate sulfurtransferase 4.58517
SEC24C SEC24 family member C 4.57954
TMEM189 transmembrane protein 189 4.51614
PPOX protoporphyrinogen oxidase 4.43463
ALAS1 5'-aminolevulinate synthase 1 4.38324
GDF2 growth differentiation factor 2 4.37394
OGDHL oxoglutarate dehydrogenase-like 4.24286
DUPD1 dual specificity phosphatase and pro isomerase domain containing 1 4.22704
NEUROG3 neurogenin 3 4.20635
SLC30A10 solute carrier family 30, member 10 4.17966
ANXA8 annexin A8 4.1615
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 4.14562
CDC42EP5 CDC42 effector protein (Rho GTPase binding) 5 4.08918
SEC31A SEC31 homolog A (S. cerevisiae) 4.07933
SLTM SAFB-like, transcription modulator 4.00314
GPSM2 G-protein signaling modulator 2 3.99911
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria 3.98365
DRG2 developmentally regulated GTP binding protein 2 3.95055
FBXO10 F-box protein 10 3.93104
C12ORF49 chromosome 12 open reading frame 49 3.88739
CFAP70 cilia and flagella associated protein 70 3.86495
PEX2 peroxisomal biogenesis factor 2 3.8374
PSAP prosaposin 3.82996
TPK1 thiamin pyrophosphokinase 1 3.81349
C1QL4 complement component 1, q subcomponent-like 4 3.79944
PEX26 peroxisomal biogenesis factor 26 3.77029
TARM1 T cell-interacting, activating receptor on myeloid cells 1 3.75013
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 3.72462
TACR2 tachykinin receptor 2 3.66317
ZNF32 zinc finger protein 32 3.66112
FKBPL FK506 binding protein like 3.51566
CCDC106 coiled-coil domain containing 106 3.49325
HMBS hydroxymethylbilane synthase 3.48803
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 3.47008
GPRIN2 G protein regulated inducer of neurite outgrowth 2 3.45817
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 3.44805
UNC45A unc-45 homolog A (C. elegans) 3.44656
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 3.43448
ZNF417 zinc finger protein 417 3.42261
ANTXRL anthrax toxin receptor-like 3.37601
CAMSAP3 calmodulin regulated spectrin-associated protein family, member 3 3.37081
PTPRH protein tyrosine phosphatase, receptor type, H 3.28269
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12 3.2811
TSPAN15 tetraspanin 15 3.20072
ANXA7 annexin A7 3.1967
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 3.17839
ZNF524 zinc finger protein 524 3.17632
BAIAP2L2 BAI1-associated protein 2-like 2 3.17344
ZSWIM8 zinc finger, SWIM-type containing 8 3.13343
GATA3 GATA binding protein 3 3.11359
MACROH2A2 macroH2A.2 histone 3.11059
TEAD3 TEA domain family member 3 3.10059
ACOX1 acyl-CoA oxidase 1, palmitoyl 3.07145
FPR2 formyl peptide receptor 2 3.05096
STK40 serine/threonine kinase 40 3.04845
COL13A1 collagen, type XIII, alpha 1 2.99522
SH3BP1 SH3-domain binding protein 1 2.98793
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 2.94961
SHISA9 shisa family member 9 2.94779
WASHC2C WASH complex subunit 2C 2.91259
ANXA8L1 annexin A8-like 1 2.90373
RBP3 retinol binding protein 3, interstitial 2.86305
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 2.862
TEX33 testis expressed 33 2.83455
CCDC144A coiled-coil domain containing 144A 2.82713
ACSL4 acyl-CoA synthetase long-chain family member 4 2.76692
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 2.75827
CCS copper chaperone for superoxide dismutase 2.75213
GAL3ST3 galactose-3-O-sulfotransferase 3 2.7509
PPCDC phosphopantothenoylcysteine decarboxylase 2.74523
FLOT1 flotillin 1 2.72729
TYSND1 trypsin domain containing 1 2.70258
RIC8A RIC8 guanine nucleotide exchange factor A 2.67493
DSP desmoplakin 2.66936
PEX10 peroxisomal biogenesis factor 10 2.65833
PEX6 peroxisomal biogenesis factor 6 2.65175
FADS2 fatty acid desaturase 2 2.64879
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 2.64627
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 2.632
TECR trans-2,3-enoyl-CoA reductase 2.61079
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 2.60748
TMEM127 transmembrane protein 127 2.60452
DCAF15 DDB1 and CUL4 associated factor 15 2.59705
CBY1 chibby homolog 1 (Drosophila) 2.59491
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 2.58285
MYPN myopalladin 2.58226
PALD1 phosphatase domain containing, paladin 1 2.53628
CSDC2 cold shock domain containing C2, RNA binding 2.51657
ANAPC16 anaphase promoting complex subunit 16 2.51543
CTNNA3 catenin (cadherin-associated protein), alpha 3 2.50822
ANKRD23 ankyrin repeat domain 23 2.50663
TMEM14B transmembrane protein 14B 2.49877
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 2.48577
MAT1A methionine adenosyltransferase I, alpha 2.47724
SOCS5 suppressor of cytokine signaling 5 2.47719
PDLIM7 PDZ and LIM domain 7 (enigma) 2.46984
EGFR epidermal growth factor receptor 2.46753
TNNI3 troponin I type 3 (cardiac) 2.45237
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 2.44717
COMTD1 catechol-O-methyltransferase domain containing 1 2.44451
ADAT2 adenosine deaminase, tRNA-specific 2 2.42358
DET1 de-etiolated homolog 1 (Arabidopsis) 2.42102
ZNF2 zinc finger protein 2 2.42092
ZNF219 zinc finger protein 219 2.42057
TGIF1 TGFB-induced factor homeobox 1 2.40955
TNS3 tensin 3 2.40355
NPFFR1 neuropeptide FF receptor 1 2.39868
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 2.39372
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 2.39049
CERS2 ceramide synthase 2 2.36365
LEMD2 LEM domain containing 2 2.35415
ZNF765 zinc finger protein 765 2.34594
FAAH fatty acid amide hydrolase 2.34271
SSC5D scavenger receptor cysteine rich family, 5 domains 2.33299
TMEM251 transmembrane protein 251 2.32236
PEX12 peroxisomal biogenesis factor 12 2.31866
TBATA thymus, brain and testes associated 2.30447
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 2.28787
MYBPC3 myosin binding protein C, cardiac 2.28711
RAB2B RAB2B, member RAS oncogene family 2.28658
SYNPO2L synaptopodin 2-like 2.2846
RASSF4 Ras association (RalGDS/AF-6) domain family member 4 2.27566
TGM7 transglutaminase 7 2.2737
MARK2 MAP/microtubule affinity-regulating kinase 2 2.24881
SREBF1 sterol regulatory element binding transcription factor 1 2.24849
HNRNPF heterogeneous nuclear ribonucleoprotein F 2.24388
CHST10 carbohydrate sulfotransferase 10 2.24064
WDR4 WD repeat domain 4 2.23373
HDAC6 histone deacetylase 6 2.23063
SPANXB1 SPANX family, member B1 2.21964
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.21762
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 2.21474
ANKLE1 ankyrin repeat and LEM domain containing 1 2.21392
TMEM247 transmembrane protein 247 2.20651
GLMN glomulin, FKBP associated protein 2.20641
MICALL1 MICAL-like 1 2.1967
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 2.18653
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.18488
MAEA macrophage erythroblast attacher 2.17643
GRHL2 grainyhead-like 2 (Drosophila) 2.17605
DESI1 desumoylating isopeptidase 1 2.17519
ASCC1 activating signal cointegrator 1 complex subunit 1 2.17502
VPS35L VPS35 endosomal protein sorting factor like 2.16669
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 2.16518
ZNF667 zinc finger protein 667 2.1623
SGMS1 sphingomyelin synthase 1 2.16173
ZFP28 ZFP28 zinc finger protein 2.15912
C10ORF10 chromosome 10 open reading frame 10 2.15291
TPPP2 tubulin polymerization-promoting protein family member 2 2.14728
ZNF239 zinc finger protein 239 2.14114
GNA13 guanine nucleotide binding protein (G protein), alpha 13 2.13618
FUBP1 far upstream element (FUSE) binding protein 1 2.13442
TRAPPC13 trafficking protein particle complex 13 2.12723
PATJ PATJ crumbs cell polarity complex component 2.12582
SKOR1 SKI family transcriptional corepressor 1 2.11621
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 2.11545
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 2.1135
DLG5 discs, large homolog 5 (Drosophila) 2.10427
ANKRD34A ankyrin repeat domain 34A 2.09751
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 2.08479
PDCL3 phosducin-like 3 2.08415
DNAJC18 DnaJ (Hsp40) homolog, subfamily C, member 18 2.06869
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2.04387
OR1M1 olfactory receptor, family 1, subfamily M, member 1 2.04344
FAM177B family with sequence similarity 177, member B 2.03486
COX6B2 cytochrome c oxidase subunit VIb polypeptide 2 (testis) 2.03094
SPAG5 sperm associated antigen 5 2.02985
RABIF RAB interacting factor 2.02818
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2.02376
PPP1R12C protein phosphatase 1, regulatory subunit 12C 2.0233
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 2.01746
RGR retinal G protein coupled receptor 2.01628
PLK3 polo-like kinase 3 2.01491
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 2.00042