PCCA Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description propionyl CoA carboxylase, alpha polypeptide|The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010] (NCBI Entrez Gene Database, 5095)
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Genes

352 genes differentially expressed following the PCCA gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CBLN3 cerebellin 3 precursor 2.82611
GJA3 gap junction protein, alpha 3, 46kDa 2.82611
RNF17 ring finger protein 17 2.82611
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.82611
STKLD1 serine/threonine kinase-like domain containing 1 2.82611
CD5 CD5 molecule 2.82611
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.82611
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 2.82611
WDR87 WD repeat domain 87 2.82611
DUXB double homeobox B 2.82611
IZUMO3 IZUMO family member 3 2.82611
FABP9 fatty acid binding protein 9, testis 2.82611
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 2.82611
ANXA10 annexin A10 2.82611
OR51B5 olfactory receptor, family 51, subfamily B, member 5 2.82611
HPR haptoglobin-related protein 2.82611
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.82611
IRF8 interferon regulatory factor 8 2.82611
PTPRC protein tyrosine phosphatase, receptor type, C 2.82611
OASL 2'-5'-oligoadenylate synthetase-like 2.82611
FOXD1 forkhead box D1 2.82611
SLFN14 schlafen family member 14 2.82611
ACTL10 actin-like 10 2.82611
CD1C CD1c molecule 2.82611
SPINK4 serine peptidase inhibitor, Kazal type 4 2.82611
ZEB2 zinc finger E-box binding homeobox 2 2.82611
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.82611
CELA1 chymotrypsin-like elastase family, member 1 2.82611
CLEC5A C-type lectin domain family 5, member A 2.82611
ANKK1 ankyrin repeat and kinase domain containing 1 2.82611
PLK5 polo-like kinase 5 2.82611
TMEM121 transmembrane protein 121 2.82611
PNOC prepronociceptin 2.82611
ATOH8 atonal homolog 8 (Drosophila) 2.82611
ACOT12 acyl-CoA thioesterase 12 2.82611
MPL MPL proto-oncogene, thrombopoietin receptor 2.82611
LCN10 lipocalin 10 2.82611
TJP2 tight junction protein 2 2.82611
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.82611
PCDHB4 protocadherin beta 4 2.82611
RRAD Ras-related associated with diabetes 2.82611
HBA1 hemoglobin, alpha 1 2.82611
FETUB fetuin B 2.82611
GFAP glial fibrillary acidic protein 2.82611
OPRL1 opiate receptor-like 1 2.82611
SLC39A5 solute carrier family 39 (zinc transporter), member 5 2.82611
ANKRD34A ankyrin repeat domain 34A 2.82611
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.82611
CPLX3 complexin 3 2.82611
HAPLN2 hyaluronan and proteoglycan link protein 2 2.82611
CIMIP2B ciliary microtubule inner protein 2B 2.82611
NHLH2 nescient helix loop helix 2 2.82611
HBG2 hemoglobin, gamma G 2.82611
ALX4 ALX homeobox 4 2.82611
SPEM1 spermatid maturation 1 2.82611
RHCG Rh family, C glycoprotein 2.82611
TCERG1L transcription elongation regulator 1-like 2.82611
DUSP9 dual specificity phosphatase 9 2.82611
ELOVL3 ELOVL fatty acid elongase 3 2.82611
OTOR otoraplin 2.82611
FRG2C FSHD region gene 2 family, member C 2.82611
PTH1R parathyroid hormone 1 receptor 2.82611
LORICRIN loricrin cornified envelope precursor protein 2.82611
DRC5 dynein regulatory complex subunit 5 2.82611
TEX53 testis expressed 53 2.82611
LITAFD LITAF domain containing 2.82611
EXOC1L exocyst complex component 1 like 2.82611
LOC124902436 talanin 2.82611
MEIOSIN meiosis initiator 2.82611
PPDPFL pancreatic progenitor cell differentiation and proliferation factor like 2.82611
GARIN6 golgi associated RAB2 interactor family member 6 2.82611
JAML junction adhesion molecule like 2.82611
CRACDL CRACD like 2.82611
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.82611
ACSL5 acyl-CoA synthetase long-chain family member 5 2.82611
FOXC2 forkhead box C2 2.82611
HAL histidine ammonia-lyase 2.82611
C7ORF57 chromosome 7 open reading frame 57 2.82611
UTS2 urotensin 2 2.82611
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 2.82611
CLDN22 claudin 22 2.82611
CCR3 chemokine (C-C motif) receptor 3 2.82611
PRR4 proline rich 4 (lacrimal) 2.82611
MYOT myotilin 2.82611
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.82611
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 2.82611
GPR85 G protein-coupled receptor 85 2.82611
COX8C cytochrome c oxidase subunit VIIIC 2.82611
DOK2 docking protein 2, 56kDa 2.82611
TSPAN1 tetraspanin 1 2.82611
SPATA22 spermatogenesis associated 22 2.82611
OR51M1 olfactory receptor, family 51, subfamily M, member 1 2.82611
GCSAM germinal center-associated, signaling and motility 2.82611
GATA1 GATA binding protein 1 (globin transcription factor 1) 2.82611
KL klotho 2.82611
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 2.82611
LTB lymphotoxin beta (TNF superfamily, member 3) 2.82611
ASIC3 acid sensing (proton gated) ion channel 3 2.82611
SLAMF1 signaling lymphocytic activation molecule family member 1 2.82611
SP5 Sp5 transcription factor 2.82611
ZNF474 zinc finger protein 474 2.82611
MKRN3 makorin ring finger protein 3 2.82611
WFDC6 WAP four-disulfide core domain 6 2.82611
WFDC8 WAP four-disulfide core domain 8 2.82611
ADAM2 ADAM metallopeptidase domain 2 2.82611
OAZ3 ornithine decarboxylase antizyme 3 2.82611
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 2.82611
MAB21L2 mab-21-like 2 (C. elegans) 2.82611
CYS1 cystin 1 2.82611
TRIM55 tripartite motif containing 55 2.82611
PCDHGA7 protocadherin gamma subfamily A, 7 2.82611
FOXE3 forkhead box E3 2.82611
EMX2 empty spiracles homeobox 2 2.82611
SCML4 sex comb on midleg-like 4 (Drosophila) 2.82611
GNG8 guanine nucleotide binding protein (G protein), gamma 8 2.82611
LRRC32 leucine rich repeat containing 32 2.82611
EDN2 endothelin 2 2.82611
CLDN34 claudin 34 2.82611
CDC20B cell division cycle 20B 2.82611
EFCAB9 EF-hand calcium binding domain 9 2.82611
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.82611
AQP7 aquaporin 7 2.82611
CRYBB2 crystallin, beta B2 2.82611
CLRN2 clarin 2 2.82611
KRT222 keratin 222, type II 2.82611
COL17A1 collagen, type XVII, alpha 1 2.82611
TIPE2 TNF alpha induced protein 8 like 2 2.82611
TSPAN16 tetraspanin 16 2.82611
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 2.82611
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 2.82611
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 2.82611
TM4SF19 transmembrane 4 L six family member 19 2.82611
PPP1R27 protein phosphatase 1, regulatory subunit 27 2.82611
WNT2 wingless-type MMTV integration site family member 2 2.82611
SFTA2 surfactant associated 2 2.82611
EVI2A ecotropic viral integration site 2A 2.82611
GOLGA8O golgin A8 family, member O 2.82611
RAD9B RAD9 homolog B (S. pombe) 2.82611
SH2D1B SH2 domain containing 1B 2.82611
LHX3 LIM homeobox 3 2.82611
LY96 lymphocyte antigen 96 2.82611
TF transferrin 2.82611
PIP prolactin-induced protein 2.82611
TPPP2 tubulin polymerization-promoting protein family member 2 2.82611
ACSBG2 acyl-CoA synthetase bubblegum family member 2 2.82611
GFRAL GDNF family receptor alpha like 2.82611
DLX3 distal-less homeobox 3 2.82611
PRSS33 protease, serine, 33 2.82611
IP6K3 inositol hexakisphosphate kinase 3 2.82611
TRABD2B TraB domain containing 2B 2.82611
SLC38A3 solute carrier family 38, member 3 2.82611
EBF2 early B-cell factor 2 2.82611
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 2.82611
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.82611
BTBD19 BTB (POZ) domain containing 19 2.82611
SCIN scinderin 2.82611
APOL4 apolipoprotein L, 4 2.82611
EPN3 epsin 3 2.82611
CD8A CD8a molecule 2.82611
RTN4RL1 reticulon 4 receptor-like 1 2.82611
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.82611
CSNK2A3 casein kinase 2, alpha 3 polypeptide 2.82611
PARP15 poly (ADP-ribose) polymerase family, member 15 2.82611
ASCL5 achaete-scute family bHLH transcription factor 5 2.82611
PODN podocan 2.82611
A1CF APOBEC1 complementation factor 2.82611
IFITM10 interferon induced transmembrane protein 10 2.82611
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 2.82611
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.82611
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 2.82611
HAVCR1 hepatitis A virus cellular receptor 1 2.82611
RBP4 retinol binding protein 4, plasma 2.82611
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 2.82611
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.82611
CDH22 cadherin 22, type 2 2.82611
PITX1 paired-like homeodomain 1 2.82611
CD34 CD34 molecule 2.82611
ZXDC ZXD family zinc finger C 2.82611
AOC1 amine oxidase, copper containing 1 2.82611
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 2.82611
FADS6 fatty acid desaturase 6 2.82611
DSPP dentin sialophosphoprotein 2.82611
SPINT4 serine peptidase inhibitor, Kunitz type 4 2.82611
SLC39A8 solute carrier family 39 (zinc transporter), member 8 2.81809
ACAD9 acyl-CoA dehydrogenase family, member 9 2.77329
NEK1 NIMA-related kinase 1 2.76672
CUL4A cullin 4A 2.74729
PDZD7 PDZ domain containing 7 2.71944
UPP2 uridine phosphorylase 2 2.71944
ANGPT4 angiopoietin 4 2.71944
NR1I2 nuclear receptor subfamily 1, group I, member 2 2.71944
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 2.68689
SMC6 structural maintenance of chromosomes 6 2.68165
HDAC8 histone deacetylase 8 2.56897
TBC1D24 TBC1 domain family, member 24 2.52963
CALHM6 calcium homeostasis modulator family member 6 2.5082
C2CD5 C2 calcium-dependent domain containing 5 2.49101
HEATR1 HEAT repeat containing 1 2.46064
BANP BTG3 associated nuclear protein 2.44474
MARCHF6 membrane associated ring-CH-type finger 6 2.44218
PCDH8 protocadherin 8 2.43999
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 2.43999
ZBTB18 zinc finger and BTB domain containing 18 2.43231
CHMP1B charged multivesicular body protein 1B 2.42034
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 2.41729
FAM209B family with sequence similarity 209, member B 2.41729
LPIN3 lipin 3 2.35415
NTHL1 nth endonuclease III-like 1 (E. coli) 2.34745
MBLAC1 metallo-beta-lactamase domain containing 1 2.34014
PTPRG protein tyrosine phosphatase, receptor type, G 2.33254
FTSJ3 FtsJ homolog 3 (E. coli) 2.33254
TMBIM6 transmembrane BAX inhibitor motif containing 6 2.32954
BTBD3 BTB (POZ) domain containing 3 2.30593
ZRANB3 zinc finger, RAN-binding domain containing 3 2.3059
PIGS phosphatidylinositol glycan anchor biosynthesis, class S 2.29692
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 2.29692
ADCY7 adenylate cyclase 7 2.21187
STK17B serine/threonine kinase 17b 2.20165
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 2.18396
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 2.16094
SNX10 sorting nexin 10 2.15542
MTA1 metastasis associated 1 2.1033
ERBB2 erb-b2 receptor tyrosine kinase 2 2.10201
IVNS1ABP influenza virus NS1A binding protein 2.06927
CPVL carboxypeptidase, vitellogenic-like 2.05124
SUN1 Sad1 and UNC84 domain containing 1 2.05124
IRGQ immunity-related GTPase family, Q 2.05124
IRF6 interferon regulatory factor 6 2.05124
PIGT phosphatidylinositol glycan anchor biosynthesis, class T 2.04167
NDC1 NDC1 transmembrane nucleoporin 2.03826
SMC1A structural maintenance of chromosomes 1A 2.03031
MOV10 Mov10 RISC complex RNA helicase 2.01627
EPSTI1 epithelial stromal interaction 1 (breast) 2.01627
DGLUCY D-glutamate cyclase 2.01523

decreased expression

Symbol Name Standardized Value
CSTL1 cystatin-like 1 -2.82611
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -2.82611
IL2RB interleukin 2 receptor, beta -2.82611
PTX3 pentraxin 3, long -2.82611
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -2.82611
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 -2.82611
PRR22 proline rich 22 -2.82611
GPR55 G protein-coupled receptor 55 -2.82611
NWD2 NACHT and WD repeat domain containing 2 -2.82611
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 -2.82611
SOX7 SRY (sex determining region Y)-box 7 -2.82611
SNAI2 snail family zinc finger 2 -2.82611
NPC1L1 NPC1-like 1 -2.82611
ZBBX zinc finger, B-box domain containing -2.82611
OPN1SW opsin 1 (cone pigments), short-wave-sensitive -2.82611
BTK Bruton agammaglobulinemia tyrosine kinase -2.82611
BTC betacellulin -2.82611
BMP8B bone morphogenetic protein 8b -2.82611
ARHGAP36 Rho GTPase activating protein 36 -2.82611
LRG1 leucine-rich alpha-2-glycoprotein 1 -2.82611
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 -2.82611
WLS wntless Wnt ligand secretion mediator -2.82611
SLC39A4 solute carrier family 39 (zinc transporter), member 4 -2.82611
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 -2.82611
HMSD histocompatibility (minor) serpin domain containing -2.82611
RIMBP2 RIMS binding protein 2 -2.82611
CA10 carbonic anhydrase X -2.82611
ZNF324B zinc finger protein 324B -2.82611
EPPIN epididymal peptidase inhibitor -2.82611
DLX4 distal-less homeobox 4 -2.82611
MAGED4 melanoma antigen family D4 -2.82611
ANXA1 annexin A1 -2.82611
PADI1 peptidyl arginine deiminase, type I -2.82611
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 -2.82611
CRHR1 corticotropin releasing hormone receptor 1 -2.82611
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -2.82611
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough -2.82611
SFT2D2 SFT2 domain containing 2 -2.82611
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 -2.82611
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 -2.82611
GPR34 G protein-coupled receptor 34 -2.82611
FDXACB1 ferredoxin-fold anticodon binding domain containing 1 -2.82611
DND1 DND microRNA-mediated repression inhibitor 1 -2.82611
INSYN2B inhibitory synaptic factor family member 2B -2.82611
ESPNL espin-like -2.82611
PCSK1 proprotein convertase subtilisin/kexin type 1 -2.82611
CXORF58 chromosome X open reading frame 58 -2.82611
LINC02798 long intergenic non-protein coding RNA 2798 -2.82611
PCCA propionyl CoA carboxylase, alpha polypeptide -2.82611
ALG10B ALG10B, alpha-1,2-glucosyltransferase -2.82611
BMI1 BMI1 proto-oncogene, polycomb ring finger -2.82611
GPBAR1 G protein-coupled bile acid receptor 1 -2.82611
MYL10 myosin, light chain 10, regulatory -2.82611
BIK BCL2-interacting killer (apoptosis-inducing) -2.82611
AXDND1 axonemal dynein light chain domain containing 1 -2.82611
NDFIP2 Nedd4 family interacting protein 2 -2.82611
GOLGA6L4 golgin A6 family-like 4 -2.82611
DEPTOR DEP domain containing MTOR-interacting protein -2.82611
EBF4 early B-cell factor 4 -2.82611
CCDC152 coiled-coil domain containing 152 -2.82611
REC114 REC114 meiotic recombination protein -2.82611
SMAD9 SMAD family member 9 -2.82611
NXNL2 nucleoredoxin-like 2 -2.82611
EPPK1 epiplakin 1 -2.78711
FAM8A1 family with sequence similarity 8, member A1 -2.7785
CCDC63 coiled-coil domain containing 63 -2.75697
INKA1 inka box actin regulator 1 -2.75697
TSSK6 testis-specific serine kinase 6 -2.75697
MTG2 mitochondrial ribosome-associated GTPase 2 -2.75697
PABPC4L poly(A) binding protein, cytoplasmic 4-like -2.73401
ADRM1 adhesion regulating molecule 1 -2.70514
PLXDC1 plexin domain containing 1 -2.68689
GABPB2 GA binding protein transcription factor, beta subunit 2 -2.68689
KLF10 Kruppel-like factor 10 -2.64108
NCOA6 nuclear receptor coactivator 6 -2.63659
TSC22D2 TSC22 domain family, member 2 -2.62706
DORIP1 dopamine receptor interacting protein 1 -2.62086
MARK2 MAP/microtubule affinity-regulating kinase 2 -2.44315
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.41729
TXN2 thioredoxin 2 -2.41004
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -2.33254
PLIN5 perilipin 5 -2.32255
TMSB15C thymosin beta 15C -2.32255
KIF22 kinesin family member 22 -2.31022
YES1 YES proto-oncogene 1, Src family tyrosine kinase -2.30005
GDE1 glycerophosphodiester phosphodiesterase 1 -2.29692
JAKMIP1 janus kinase and microtubule interacting protein 1 -2.28797
UBL4A ubiquitin-like 4A -2.26109
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide -2.26021
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 -2.25033
CLU clusterin -2.24352
MBOAT1 membrane bound O-acyltransferase domain containing 1 -2.23792
ZNF365 zinc finger protein 365 -2.21208
PITHD1 PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1 -2.21187
GLTP glycolipid transfer protein -2.16789
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 -2.16259
C3ORF18 chromosome 3 open reading frame 18 -2.16103
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -2.15542
CENPX centromere protein X -2.15257
ZSCAN32 zinc finger and SCAN domain containing 32 -2.13124
KIZ kizuna centrosomal protein -2.13061
GPALPP1 GPALPP motifs containing 1 -2.12461
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 -2.12041
ZNF75A zinc finger protein 75a -2.11686
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -2.09193
RCSD1 RCSD domain containing 1 -2.08504
WRAP53 WD repeat containing, antisense to TP53 -2.08379
USP35 ubiquitin specific peptidase 35 -2.07367
ZFYVE27 zinc finger, FYVE domain containing 27 -2.07367
NCK1 NCK adaptor protein 1 -2.0714
YOD1 YOD1 deubiquitinase -2.05295
AFF3 AF4/FMR2 family, member 3 -2.05295
MRM3 mitochondrial rRNA methyltransferase 3 -2.05124
RTEL1 regulator of telomere elongation helicase 1 -2.05124
LRRC20 leucine rich repeat containing 20 -2.03826
ATXN1 ataxin 1 -2.02242
CCNE2 cyclin E2 -2.02048
SNRNP48 small nuclear ribonucleoprotein 48kDa (U11/U12) -2.00063