PCDH1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description protocadherin 1|This gene belongs to the protocadherin subfamily within the cadherin superfamily. The encoded protein is a membrane protein found at cell-cell boundaries. It is involved in neural cell adhesion, suggesting a possible role in neuronal development. The protein includes an extracelllular region, containing 7 cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Cells expressing the protein showed cell aggregation activity. Alternative splicing occurs in this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5097)
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Genes

323 genes differentially expressed following the PCDH1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
OR52D1 olfactory receptor, family 52, subfamily D, member 1 2.77052
SIX6 SIX homeobox 6 2.77052
OR5P3 olfactory receptor, family 5, subfamily P, member 3 2.77052
LAPTM5 lysosomal protein transmembrane 5 2.77052
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) 2.77052
ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7 2.77052
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 2.77052
VTN vitronectin 2.77052
TREM2 triggering receptor expressed on myeloid cells 2 2.77052
SLC26A9 solute carrier family 26 (anion exchanger), member 9 2.77052
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.77052
SBK3 SH3 domain binding kinase family, member 3 2.77052
HNF4A hepatocyte nuclear factor 4, alpha 2.77052
IDO2 indoleamine 2,3-dioxygenase 2 2.77052
COL6A6 collagen, type VI, alpha 6 2.77052
OR6C4 olfactory receptor, family 6, subfamily C, member 4 2.77052
DEFB1 defensin, beta 1 2.77052
TUBA3D tubulin, alpha 3d 2.77052
TUBA3E tubulin, alpha 3e 2.77052
PRB4 proline-rich protein BstNI subfamily 4 2.77052
KLHL33 kelch-like family member 33 2.77052
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.77052
ACTL10 actin-like 10 2.77052
CABP4 calcium binding protein 4 2.77052
SOX18 SRY (sex determining region Y)-box 18 2.77052
ADGB androglobin 2.77052
AVPR2 arginine vasopressin receptor 2 2.77052
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.77052
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 2.77052
PSCA prostate stem cell antigen 2.77052
S100A9 S100 calcium binding protein A9 2.77052
PTK6 protein tyrosine kinase 6 2.77052
LGALS4 lectin, galactoside-binding, soluble, 4 2.77052
C21ORF140 chromosome 21 open reading frame 140 2.77052
HMX3 H6 family homeobox 3 2.77052
TMEM212 transmembrane protein 212 2.77052
TRIM74 tripartite motif containing 74 2.77052
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.77052
PNMA5 paraneoplastic Ma antigen family member 5 2.77052
DRICH1 aspartate-rich 1 2.77052
TKTL1 transketolase-like 1 2.77052
MUC5B mucin 5B, oligomeric mucus/gel-forming 2.77052
MTTP microsomal triglyceride transfer protein 2.77052
FETUB fetuin B 2.77052
SLC30A4 solute carrier family 30 (zinc transporter), member 4 2.77052
SSTR5 somatostatin receptor 5 2.77052
PLXNB3 plexin B3 2.77052
HMX1 H6 family homeobox 1 2.77052
CATSPERT catsper channel auxiliary subunit tau 2.77052
MAB21L4 mab-21 like 4 2.77052
ANKRD40CL ANKRD40 C-terminal like 2.77052
EEF1AKMT2 EEF1A lysine methyltransferase 2 2.77052
H2BC1 H2B clustered histone 1 2.77052
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 2.77052
HAO2 hydroxyacid oxidase 2 (long chain) 2.77052
ZNF728 zinc finger protein 728 2.77052
ROPN1B rhophilin associated tail protein 1B 2.77052
CLDN14 claudin 14 2.77052
STMN4 stathmin-like 4 2.77052
DUSP29 dual specificity phosphatase 29 2.77052
CFAP97D1 CFAP97 domain containing 1 2.77052
FAM90A11 family with sequence similarity 90 member A11 2.77052
EPCIP exosomal polycystin 1 interacting protein 2.77052
ANKRD42-DT ANKRD42 divergent transcript 2.77052
PPIAP39 peptidylprolyl isomerase A pseudogene 39 2.77052
C1ORF232 chromosome 1 open reading frame 230 2.77052
SMIM45 small integral membrane protein 45 2.77052
H3C4 H3 clustered histone 4 2.77052
CIBAR2 CBY1 interacting BAR domain containing 2 2.77052
H2BW2 H2B.W histone 2 2.77052
CBY2 chibby family member 2 2.77052
TBC1D3B TBC1 domain family, member 3B 2.77052
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.77052
ACE2 angiotensin I converting enzyme 2 2.77052
GDF7 growth differentiation factor 7 2.77052
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 2.77052
SAA4 serum amyloid A4, constitutive 2.77052
S100B S100 calcium binding protein B 2.77052
CCR3 chemokine (C-C motif) receptor 3 2.77052
FAM186A family with sequence similarity 186, member A 2.77052
C1QTNF8 C1q and tumor necrosis factor related protein 8 2.77052
S1PR4 sphingosine-1-phosphate receptor 4 2.77052
TACSTD2 tumor-associated calcium signal transducer 2 2.77052
LTF lactotransferrin 2.77052
HTR3D 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic 2.77052
MYZAP myocardial zonula adherens protein 2.77052
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 2.77052
SAG S-antigen; retina and pineal gland (arrestin) 2.77052
ASB4 ankyrin repeat and SOCS box containing 4 2.77052
TTR transthyretin 2.77052
XKR3 XK, Kell blood group complex subunit-related family, member 3 2.77052
OR52E4 olfactory receptor, family 52, subfamily E, member 4 2.77052
OR51M1 olfactory receptor, family 51, subfamily M, member 1 2.77052
KDM4C lysine (K)-specific demethylase 4C 2.77052
FAM228A family with sequence similarity 228, member A 2.77052
CATSPER3 cation channel, sperm associated 3 2.77052
ACY3 aminoacylase 3 2.77052
ITLN1 intelectin 1 (galactofuranose binding) 2.77052
EDN1 endothelin 1 2.77052
GLOD5 glyoxalase domain containing 5 2.77052
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 2.77052
KLHL41 kelch-like family member 41 2.77052
TRADD TNFRSF1A-associated via death domain 2.77052
SPATA3 spermatogenesis associated 3 2.77052
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.77052
FIBIN fin bud initiation factor homolog (zebrafish) 2.77052
CAGE1 cancer antigen 1 2.77052
APLNR apelin receptor 2.77052
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 2.77052
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.77052
APOC3 apolipoprotein C-III 2.77052
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 2.77052
ERMN ermin, ERM-like protein 2.77052
MCIDAS multiciliate differentiation and DNA synthesis associated cell cycle protein 2.77052
SLC25A52 solute carrier family 25, member 52 2.77052
APOH apolipoprotein H (beta-2-glycoprotein I) 2.77052
PCDHGB2 protocadherin gamma subfamily B, 2 2.77052
CCL24 chemokine (C-C motif) ligand 24 2.77052
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 2.77052
SERPINA9 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 2.77052
C17ORF99 chromosome 17 open reading frame 99 2.77052
TYR tyrosinase 2.77052
HPGDS hematopoietic prostaglandin D synthase 2.77052
GAS2L2 growth arrest-specific 2 like 2 2.77052
LAMB4 laminin, beta 4 2.77052
WNT2 wingless-type MMTV integration site family member 2 2.77052
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 2.77052
SLC17A2 solute carrier family 17, member 2 2.77052
GOLGA8M golgin A8 family, member M 2.77052
CFI complement factor I 2.77052
ORM2 orosomucoid 2 2.77052
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.77052
IL19 interleukin 19 2.77052
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 2.77052
SST somatostatin 2.77052
ASTL astacin-like metallo-endopeptidase (M12 family) 2.77052
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.77052
SYNGR4 synaptogyrin 4 2.77052
PRH2 proline-rich protein HaeIII subfamily 2 2.77052
RGS4 regulator of G-protein signaling 4 2.77052
HMGB4 high mobility group box 4 2.77052
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.77052
NUTM2F NUT family member 2F 2.77052
SPACA1 sperm acrosome associated 1 2.77052
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 2.77052
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 2.77052
SPDEF SAM pointed domain containing ETS transcription factor 2.77052
NNMT nicotinamide N-methyltransferase 2.77052
NPR3 natriuretic peptide receptor 3 2.77052
NLRP6 NLR family, pyrin domain containing 6 2.77052
TMPRSS15 transmembrane protease, serine 15 2.77052
TGM6 transglutaminase 6 2.77052
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 2.77052
PADI1 peptidyl arginine deiminase, type I 2.77052
MMEL1 membrane metallo-endopeptidase-like 1 2.77052
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.77052
TAS2R43 taste receptor, type 2, member 43 2.77052
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 2.77052
IL10RA interleukin 10 receptor, alpha 2.77052
ANXA8 annexin A8 2.77052
GH1 growth hormone 1 2.77052
POTEE POTE ankyrin domain family, member E 2.77052
NRSN1 neurensin 1 2.77052
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 2.77052
PAGE2B P antigen family, member 2B 2.77052
NWD1 NACHT and WD repeat domain containing 1 2.77052
GRAPL GRB2-related adaptor protein-like 2.77052
DMRTC1 DMRT-like family C1 2.77052
OIT3 oncoprotein induced transcript 3 2.77052
ERICH1 glutamate-rich 1 2.76808
RPL18A ribosomal protein L18a 2.75588
SH3GL3 SH3-domain GRB2-like 3 2.75193
RPL36A ribosomal protein L36a 2.74654
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.73244
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.73244
KIAA1191 KIAA1191 2.71855
CDH23 cadherin-related 23 2.63997
PNPLA6 patatin-like phospholipase domain containing 6 2.63997
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 2.63997
PYCR1 pyrroline-5-carboxylate reductase 1 2.63997
KCTD14 potassium channel tetramerization domain containing 14 2.59961
EID2B EP300 interacting inhibitor of differentiation 2B 2.57223
CIP2A cellular inhibitor of PP2A 2.51771
NPIPA6 nuclear pore complex interacting protein family, member A6 2.48907
MIA2 melanoma inhibitory activity 2 2.47281
RPL38 ribosomal protein L38 2.46146
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 2.44019
FGF23 fibroblast growth factor 23 2.43587
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.43587
ARLN allregulin 2.35695
CADPS2 Ca++-dependent secretion activator 2 2.35629
BECN1 beclin 1, autophagy related 2.32138
GPX2 glutathione peroxidase 2 2.31199
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) 2.31199
MITD1 MIT, microtubule interacting and transport, domain containing 1 2.31199
EGF epidermal growth factor 2.31199
CROT carnitine O-octanoyltransferase 2.27515
WDR54 WD repeat domain 54 2.26667
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 2.25959
EDC3 enhancer of mRNA decapping 3 2.23956
RAB3C RAB3C, member RAS oncogene family 2.23009
TMEM186 transmembrane protein 186 2.2146
RCC1L RCC1 like 2.20992
SMYD3 SET and MYND domain containing 3 2.20152
CILK1 ciliogenesis associated kinase 1 2.19585
HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 2.19585
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 2.19585
DKK3 dickkopf WNT signaling pathway inhibitor 3 2.19585
NCDN neurochondrin 2.19058
THAP2 THAP domain containing, apoptosis associated protein 2 2.19058
COX17 COX17 cytochrome c oxidase copper chaperone 2.1869
PEBP4 phosphatidylethanolamine-binding protein 4 2.16225
BTF3 basic transcription factor 3 2.1377
ZNF852 zinc finger protein 852 2.13569
TSPAN14 tetraspanin 14 2.11292
CAVIN1 caveolae associated protein 1 2.10963
FPGS folylpolyglutamate synthase 2.10669
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 2.09677
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor 2.09677
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 2.0919
RFK riboflavin kinase 2.07905
TMEM143 transmembrane protein 143 2.06233
PLPP7 phospholipid phosphatase 7 (inactive) 2.06099
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 2.04524
APLP2 amyloid beta (A4) precursor-like protein 2 2.03929
RPL26 ribosomal protein L26 2.03258
WDTC1 WD and tetratricopeptide repeats 1 2.03199
TXN thioredoxin 2.01854
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 2.01729
ZNF839 zinc finger protein 839 2.00709

decreased expression

Symbol Name Standardized Value
TTC21A tetratricopeptide repeat domain 21A -2.77052
CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha -2.77052
GRM6 glutamate receptor, metabotropic 6 -2.77052
LIPT2-AS1 LIPT2 antisense RNA 1 -2.77052
CNTN2 contactin 2 (axonal) -2.77052
TJP3 tight junction protein 3 -2.77052
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) -2.77052
UBE2U ubiquitin-conjugating enzyme E2U (putative) -2.63997
LRG1 leucine-rich alpha-2-glycoprotein 1 -2.63997
C2ORF80 chromosome 2 open reading frame 80 -2.63997
YIPF7 Yip1 domain family, member 7 -2.63997
OVCH1 ovochymase 1 -2.63997
IL18R1 interleukin 18 receptor 1 -2.63997
SPAG6 sperm associated antigen 6 -2.63997
CENPN centromere protein N -2.63997
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 -2.63997
HBA1 hemoglobin, alpha 1 -2.63997
DNAAF19 dynein axonemal assembly factor 19 -2.63997
TBXT T-box transcription factor T -2.63997
UNC93A unc-93 homolog A (C. elegans) -2.63997
C7 complement component 7 -2.63997
CALCA calcitonin-related polypeptide alpha -2.63997
ERVFRD-1 endogenous retrovirus group FRD, member 1 -2.63997
CCDC13 coiled-coil domain containing 13 -2.63997
WEE2 WEE1 homolog 2 (S. pombe) -2.63997
NANOS3 nanos homolog 3 (Drosophila) -2.63997
CIMIP2C ciliary microtubule inner protein 2C -2.63997
WFDC13 WAP four-disulfide core domain 13 -2.63997
CCDC154 coiled-coil domain containing 154 -2.63997
DUSP26 dual specificity phosphatase 26 (putative) -2.63997
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 -2.63997
CD177 CD177 molecule -2.63997
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 -2.63997
PLXNA1 plexin A1 -2.62016
NR1D2 nuclear receptor subfamily 1, group D, member 2 -2.60097
AKAP8 A kinase (PRKA) anchor protein 8 -2.57614
STX17 syntaxin 17 -2.57614
ZNF484 zinc finger protein 484 -2.57223
WTAP Wilms tumor 1 associated protein -2.54942
PCDHGA1 protocadherin gamma subfamily A, 1 -2.53482
TMEM255A transmembrane protein 255A -2.53213
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase -2.51771
ZC2HC1C zinc finger, C2HC-type containing 1C -2.50372
SENP6 SUMO1/sentrin specific peptidase 6 -2.49454
C6ORF141 chromosome 6 open reading frame 141 -2.48917
MEGF6 multiple EGF-like-domains 6 -2.48418
PIGBOS1 PIGB opposite strand 1 -2.44226
SNRK SNF related kinase -2.44012
CARNMT1 carnosine N-methyltransferase 1 -2.39723
H4C8 H4 clustered histone 8 -2.38632
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 -2.38207
TMTC3 transmembrane and tetratricopeptide repeat containing 3 -2.37851
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 -2.36916
POU5F2 POU domain class 5, transcription factor 2 -2.34518
TAS2R20 taste receptor, type 2, member 20 -2.34518
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.33075
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase -2.299
TMEM94 transmembrane protein 94 -2.2883
CLMP CXADR-like membrane protein -2.27969
PTEN phosphatase and tensin homolog -2.27515
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 -2.27515
ZFHX2 zinc finger homeobox 2 -2.25872
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 -2.23956
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) -2.22883
TMEM230 transmembrane protein 230 -2.22647
RUFY1 RUN and FYVE domain containing 1 -2.20992
MRPL58 mitochondrial ribosomal protein L58 -2.20337
GPS2 G protein pathway suppressor 2 -2.19585
DLX4 distal-less homeobox 4 -2.1869
OR56A3 olfactory receptor, family 56, subfamily A, member 3 -2.1869
SMAD4 SMAD family member 4 -2.18589
C17ORF75 chromosome 17 open reading frame 75 -2.16762
MARCHF4 membrane associated ring-CH-type finger 4 -2.16586
SEC24C SEC24 family member C -2.14861
SNCG synuclein, gamma (breast cancer-specific protein 1) -2.14861
PAQR6 progestin and adipoQ receptor family member VI -2.13815
PAQR3 progestin and adipoQ receptor family member III -2.1305
AURKB aurora kinase B -2.12716
PCNT pericentrin -2.11292
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -2.11292
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.09417
SLC51A solute carrier family 51, alpha subunit -2.09366
ACOT8 acyl-CoA thioesterase 8 -2.09366
CCDC158 coiled-coil domain containing 158 -2.07318
PCDHB4 protocadherin beta 4 -2.0672
GPAT3 glycerol-3-phosphate acyltransferase 3 -2.0672
CCNDBP1 cyclin D-type binding-protein 1 -2.0672
RBM12 RNA binding motif protein 12 -2.06438
ZNF318 zinc finger protein 318 -2.05136
VPS9D1 VPS9 domain containing 1 -2.03971
PRODH proline dehydrogenase (oxidase) 1 -2.03652
ZNF687 zinc finger protein 687 -2.03431
PNISR PNN-interacting serine/arginine-rich protein -2.03258