| Dataset | Pathway Commons Protein-Protein Interactions |
| Category | physical interactions |
| Type | interacting protein |
| Description | protocadherin alpha 4|This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 56144) |
| External Link | http://www.ncbi.nlm.nih.gov/gene/56144 |
| Similar Terms | |
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28 interacting proteins for PCDHA4 from the Pathway Commons Protein-Protein Interactions dataset.
| Symbol | Name |
|---|---|
| APLP1 | amyloid beta (A4) precursor-like protein 1 |
| C14ORF1 | chromosome 14 open reading frame 1 |
| CCDC90B | coiled-coil domain containing 90B |
| CSNK2A1 | casein kinase 2, alpha 1 polypeptide |
| CSNK2A2 | casein kinase 2, alpha prime polypeptide |
| CSNK2B | casein kinase 2, beta polypeptide |
| CTNND1 | catenin (cadherin-associated protein), delta 1 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 |
| EGFR | epidermal growth factor receptor |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 |
| FER | fer (fps/fes related) tyrosine kinase |
| FYN | FYN proto-oncogene, Src family tyrosine kinase |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase |
| GDF9 | growth differentiation factor 9 |
| IGSF21 | immunoglobin superfamily, member 21 |
| LRIF1 | ligand dependent nuclear receptor interacting factor 1 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 |
| RBM48 | RNA binding motif protein 48 |
| RELN | reelin |
| RIF1 | replication timing regulatory factor 1 |
| SETDB1 | SET domain, bifurcated 1 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) |
| TP53 | tumor protein p53 |
| UNC119 | unc-119 homolog (C. elegans) |
