PCED1A Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description PC-esterase domain containing 1A|The protein encoded by this gene is a member of the GDSL/SGNH superfamily. Members of this family are hydrolytic enzymes with esterase and lipase activity and broad substrate specificity. This protein belongs to the Pmr5-Cas1p-esterase subfamily in that it contains the catalytic triad comprised of serine, aspartate and histidine and lacks two conserved regions (glycine after strand S2 and GxND motif). A pseudogene of this gene has been identified on the long arm of chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Sep 2012] (NCBI Entrez Gene Database, 64773)
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Genes

298 genes differentially expressed following the PCED1A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SOST sclerostin 2.70995
SPINK6 serine peptidase inhibitor, Kazal type 6 2.70995
TEX13B testis expressed 13B 2.70995
PDIA2 protein disulfide isomerase family A, member 2 2.70995
EPPIN epididymal peptidase inhibitor 2.70995
PCDHB1 protocadherin beta 1 2.70995
MBLAC1 metallo-beta-lactamase domain containing 1 2.70995
GLYAT glycine-N-acyltransferase 2.70995
CXORF65 chromosome X open reading frame 65 2.70995
CELF3 CUGBP, Elav-like family member 3 2.70995
KLRK1 killer cell lectin-like receptor subfamily K, member 1 2.70995
PDILT protein disulfide isomerase-like, testis expressed 2.70995
COL19A1 collagen, type XIX, alpha 1 2.70995
PLVAP plasmalemma vesicle associated protein 2.70995
CFHR3 complement factor H-related 3 2.70995
CD6 CD6 molecule 2.70995
SOX1 SRY (sex determining region Y)-box 1 2.70995
NPAP1 nuclear pore associated protein 1 2.70995
SCGN secretagogin, EF-hand calcium binding protein 2.70995
PAX8 paired box 8 2.70995
PTH2 parathyroid hormone 2 2.70995
ATOH1 atonal homolog 1 (Drosophila) 2.70995
TAS2R13 taste receptor, type 2, member 13 2.70995
CLEC14A C-type lectin domain family 14, member A 2.70995
CRYAA crystallin, alpha A 2.70995
RTP4 receptor (chemosensory) transporter protein 4 2.70995
SLC10A5 solute carrier family 10, member 5 2.70995
PMCH pro-melanin-concentrating hormone 2.70995
PRSS21 protease, serine, 21 (testisin) 2.70995
BHMT2 betaine--homocysteine S-methyltransferase 2 2.70995
CRYGA crystallin, gamma A 2.70995
PAX2 paired box 2 2.70995
PAX3 paired box 3 2.70995
FNDC7 fibronectin type III domain containing 7 2.70995
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.70995
CXCL2 chemokine (C-X-C motif) ligand 2 2.70995
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.70995
C1ORF146 chromosome 1 open reading frame 146 2.70995
TMEM121 transmembrane protein 121 2.70995
CLDN2 claudin 2 2.70995
MAGEB3 melanoma antigen family B3 2.70995
ANXA10 annexin A10 2.70995
LTO1 LTO1 maturation factor of ABCE1 2.70995
SQOR sulfide quinone oxidoreductase 2.70995
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 2.70995
GBP4 guanylate binding protein 4 2.70995
TGIF2 TGFB-induced factor homeobox 2 2.70995
TAS2R60 taste receptor, type 2, member 60 2.70995
RAX2 retina and anterior neural fold homeobox 2 2.70995
CD300LF CD300 molecule-like family member f 2.70995
DEPP1 DEPP autophagy regulator 1 2.70995
DNAI7 dynein axonemal intermediate chain 7 2.70995
CATSPERT catsper channel auxiliary subunit tau 2.70995
CIMIP2B ciliary microtubule inner protein 2B 2.70995
SPMIP11 sperm microtubule inner protein 11 2.70995
H2BK1 H2B.K variant histone 1 2.70995
GSTT4 glutathione S-transferase theta 4 2.70995
SPDYE9 speedy/RINGO cell cycle regulator family member E9 2.70995
DUSP29 dual specificity phosphatase 29 2.70995
DIPK1C divergent protein kinase domain 1C 2.70995
SPRR2A small proline-rich protein 2A 2.70995
TMEM40 transmembrane protein 40 2.70995
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.70995
CREB3L3 cAMP responsive element binding protein 3-like 3 2.70995
TBX3 T-box 3 2.70995
LRTM3 leucine rich repeat transmembrane protein 3 2.70995
GDF10 growth differentiation factor 10 2.70995
TLR4 toll-like receptor 4 2.70995
TLR7 toll-like receptor 7 2.70995
UROC1 urocanate hydratase 1 2.70995
CCR9 chemokine (C-C motif) receptor 9 2.70995
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 2.70995
BDKRB1 bradykinin receptor B1 2.70995
GCSAM germinal center-associated, signaling and motility 2.70995
GATA2 GATA binding protein 2 2.70995
ZG16B zymogen granule protein 16B 2.70995
ACE2 angiotensin I converting enzyme 2 2.70995
GDF9 growth differentiation factor 9 2.70995
GPR83 G protein-coupled receptor 83 2.70995
DDTL D-dopachrome tautomerase-like 2.70995
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 2.70995
OR5A1 olfactory receptor, family 5, subfamily A, member 1 2.70995
TG thyroglobulin 2.70995
C17ORF99 chromosome 17 open reading frame 99 2.70995
CGB7 chorionic gonadotropin, beta polypeptide 7 2.70995
NPBWR1 neuropeptides B/W receptor 1 2.70995
NPFFR1 neuropeptide FF receptor 1 2.70995
WFDC9 WAP four-disulfide core domain 9 2.70995
KLF2 Kruppel-like factor 2 2.70995
S100Z S100 calcium binding protein Z 2.70995
CRYBB2 crystallin, beta B2 2.70995
AQP6 aquaporin 6, kidney specific 2.70995
GPR12 G protein-coupled receptor 12 2.70995
CST7 cystatin F (leukocystatin) 2.70995
CSTA cystatin A (stefin A) 2.70995
AMIGO1 adhesion molecule with Ig-like domain 1 2.70995
CCL19 chemokine (C-C motif) ligand 19 2.70995
MR1 major histocompatibility complex, class I-related 2.70995
SPATA9 spermatogenesis associated 9 2.70995
LRRC15 leucine rich repeat containing 15 2.70995
OR2T8 olfactory receptor, family 2, subfamily T, member 8 2.70995
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.70995
NPY2R neuropeptide Y receptor Y2 2.70995
LRRN4 leucine rich repeat neuronal 4 2.70995
OPALIN oligodendrocytic myelin paranodal and inner loop protein 2.70995
PCDH20 protocadherin 20 2.70995
GDI1 GDP dissociation inhibitor 1 2.70995
FOXF2 forkhead box F2 2.70995
OR13G1 olfactory receptor, family 13, subfamily G, member 1 2.70995
CSF1R colony stimulating factor 1 receptor 2.70995
DCN decorin 2.70995
QRFP pyroglutamylated RFamide peptide 2.70995
CD27 CD27 molecule 2.70995
IL25 interleukin 25 2.70995
CTRB1 chymotrypsinogen B1 2.70995
ZC3H12D zinc finger CCCH-type containing 12D 2.70995
APLNR apelin receptor 2.70995
SOWAHA sosondowah ankyrin repeat domain family member A 2.70995
TOPAZ1 testis and ovary specific PAZ domain containing 1 2.70995
IGFL3 IGF-like family member 3 2.70995
KIF4B kinesin family member 4B 2.70995
ANXA1 annexin A1 2.70995
PADI4 peptidyl arginine deiminase, type IV 2.70995
AGR2 anterior gradient 2 2.70995
C5AR2 complement component 5a receptor 2 2.70995
TEX35 testis expressed 35 2.70995
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.70995
PLGLB2 plasminogen-like B2 2.70995
ITPKA inositol-trisphosphate 3-kinase A 2.70995
CHRM4 cholinergic receptor, muscarinic 4 2.70995
TSPAN32 tetraspanin 32 2.70995
MBOAT4 membrane bound O-acyltransferase domain containing 4 2.70995
ONECUT3 one cut homeobox 3 2.70995
ICAM2 intercellular adhesion molecule 2 2.70995
MYOZ2 myozenin 2 2.70995
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 2.70995
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 2.70995
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.70995
PDAP1 PDGFA associated protein 1 2.7008
GLIPR1 GLI pathogenesis-related 1 2.64019
PRTN3 proteinase 3 2.64019
NOPCHAP1 NOP protein chaperone 1 2.63913
STAG1 stromal antigen 1 2.63295
PHLDA1 pleckstrin homology-like domain, family A, member 1 2.63295
GPR176 G protein-coupled receptor 176 2.63295
MON2 MON2 homolog (S. cerevisiae) 2.58853
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 2.47502
EGLN3 egl-9 family hypoxia-inducible factor 3 2.46126
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 2.42597
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.4187
PAOX polyamine oxidase (exo-N4-amino) 2.38586
RPL17 ribosomal protein L17 2.38196
CPNE7 copine VII 2.37316
RSRP1 arginine/serine-rich protein 1 2.34743
SCHIP1 schwannomin interacting protein 1 2.33646
SAMHD1 SAM domain and HD domain 1 2.32368
SIN3A SIN3 transcription regulator family member A 2.31331
CNGB3 cyclic nucleotide gated channel beta 3 2.30577
KCNK17 potassium channel, two pore domain subfamily K, member 17 2.29058
MAT2B methionine adenosyltransferase II, beta 2.28824
DDIT4 DNA-damage-inducible transcript 4 2.28631
ADGRL4 adhesion G protein-coupled receptor L4 2.28631
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 2.28631
TAFA1 TAFA chemokine like family member 1 2.28115
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa 2.28115
C1QTNF1 C1q and tumor necrosis factor related protein 1 2.27099
EDN1 endothelin 1 2.27099
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 2.25627
CHMP4A charged multivesicular body protein 4A 2.25557
TM2D2 TM2 domain containing 2 2.2484
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 2.24457
DMBX1 diencephalon/mesencephalon homeobox 1 2.24068
RNF215 ring finger protein 215 2.24068
HAUS6 HAUS augmin-like complex, subunit 6 2.24068
ZNF660 zinc finger protein 660 2.22515
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like 2.18595
ZFPM2 zinc finger protein, FOG family member 2 2.1657
ADCY8 adenylate cyclase 8 (brain) 2.14659
RSL24D1 ribosomal L24 domain containing 1 2.1419
RAD23B RAD23 homolog B (S. cerevisiae) 2.13371
TDRP testis development related protein 2.12163
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.12092
PLBD1 phospholipase B domain containing 1 2.11336
CCSER2 coiled-coil serine-rich protein 2 2.11336
FMO5 flavin containing monooxygenase 5 2.11153
C1QTNF6 C1q and tumor necrosis factor related protein 6 2.11079
LIPG lipase, endothelial 2.10747
ELMOD2 ELMO/CED-12 domain containing 2 2.08179
C11ORF52 chromosome 11 open reading frame 52 2.04284
ANKFY1 ankyrin repeat and FYVE domain containing 1 2.03323
PNMA8C PNMA family member 8C 2.03323
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 2.01848
TEX15 testis expressed 15 2.01827

decreased expression

Symbol Name Standardized Value
PCDHA6 protocadherin alpha 6 -2.70995
RUSC1 RUN and SH3 domain containing 1 -2.70995
ITLN2 intelectin 2 -2.70995
NARF nuclear prelamin A recognition factor -2.70995
HLA-DMB major histocompatibility complex, class II, DM beta -2.70995
LSM11 LSM11, U7 small nuclear RNA associated -2.70995
GBX2 gastrulation brain homeobox 2 -2.70995
DCLK3 doublecortin-like kinase 3 -2.70995
FGF22 fibroblast growth factor 22 -2.70995
ZNF222 zinc finger protein 222 -2.70995
MYO18B myosin XVIIIB -2.70995
NCOA6 nuclear receptor coactivator 6 -2.64019
NECTIN1 nectin cell adhesion molecule 1 -2.63913
PCDHA5 protocadherin alpha 5 -2.63295
FOXC1 forkhead box C1 -2.63295
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -2.63295
OR14A16 olfactory receptor, family 14, subfamily A, member 16 -2.63295
SLCO1C1 solute carrier organic anion transporter family, member 1C1 -2.63295
GJB3 gap junction protein, beta 3, 31kDa -2.63295
NXPH3 neurexophilin 3 -2.63295
FOXJ1 forkhead box J1 -2.63295
ADH6 alcohol dehydrogenase 6 (class V) -2.63295
HES2 hes family bHLH transcription factor 2 -2.63295
EGFR epidermal growth factor receptor -2.63295
RAB7B RAB7B, member RAS oncogene family -2.63295
TNMD tenomodulin -2.63295
NHLH1 nescient helix loop helix 1 -2.63295
MYZAP myocardial zonula adherens protein -2.63295
PLA2G2C phospholipase A2, group IIC -2.63295
MAJIN membrane anchored junction protein -2.63295
C2ORF80 chromosome 2 open reading frame 80 -2.63295
AANAT aralkylamine N-acetyltransferase -2.63295
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C -2.63295
HBG2 hemoglobin, gamma G -2.63295
CCDC70 coiled-coil domain containing 70 -2.63295
C16ORF78 chromosome 16 open reading frame 78 -2.63295
BTG4 B-cell translocation gene 4 -2.63295
PNLIPRP2 pancreatic lipase-related protein 2 -2.63295
TSLP thymic stromal lymphopoietin -2.63295
KLHL6 kelch-like family member 6 -2.63295
SEZ6L seizure related 6 homolog (mouse)-like -2.63295
CNTF ciliary neurotrophic factor -2.63295
ACP4 acid phosphatase 4 -2.63295
PNMA8B PNMA family member 8B -2.63295
PGGT1B protein geranylgeranyltransferase type I, beta subunit -2.60093
TRIO trio Rho guanine nucleotide exchange factor -2.55638
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 -2.55286
APAF1 apoptotic peptidase activating factor 1 -2.55231
LCMT1 leucine carboxyl methyltransferase 1 -2.54159
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -2.54159
CENPU centromere protein U -2.53109
RBM34 RNA binding motif protein 34 -2.52072
SOX15 SRY (sex determining region Y)-box 15 -2.51473
E2F8 E2F transcription factor 8 -2.50231
OR56A1 olfactory receptor, family 56, subfamily A, member 1 -2.49089
FKBPL FK506 binding protein like -2.49089
TSPAN9 tetraspanin 9 -2.48747
TMC3 transmembrane channel-like 3 -2.45238
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 -2.45238
CCDC124 coiled-coil domain containing 124 -2.42728
LYRM2 LYR motif containing 2 -2.42178
MGARP mitochondria-localized glutamic acid-rich protein -2.40824
TMEM67 transmembrane protein 67 -2.40817
S100A6 S100 calcium binding protein A6 -2.36777
DHRS2 dehydrogenase/reductase (SDR family) member 2 -2.36657
TM9SF1 transmembrane 9 superfamily member 1 -2.36554
FASTKD1 FAST kinase domains 1 -2.36531
COLEC11 collectin sub-family member 11 -2.3612
MME membrane metallo-endopeptidase -2.35837
INF2 inverted formin, FH2 and WH2 domain containing -2.34047
COQ10B coenzyme Q10 homolog B (S. cerevisiae) -2.30577
BRAT1 BRCA1-associated ATM activator 1 -2.29282
COPS5 COP9 signalosome subunit 5 -2.2925
RRM2 ribonucleotide reductase M2 -2.2899
CRYGD crystallin, gamma D -2.28115
CDCA2 cell division cycle associated 2 -2.28115
SBNO1 strawberry notch homolog 1 (Drosophila) -2.2707
ANTXR2 anthrax toxin receptor 2 -2.25954
PARN poly(A)-specific ribonuclease -2.2484
FZD2 frizzled class receptor 2 -2.24068
MATN1 matrilin 1, cartilage matrix protein -2.23833
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -2.22393
SLC26A5 solute carrier family 26 (anion exchanger), member 5 -2.20824
RPL39L ribosomal protein L39-like -2.17453
FAM24B family with sequence similarity 24, member B -2.16199
FAXC failed axon connections homolog (Drosophila) -2.14659
SPDYE21 speedy/RINGO cell cycle regulator family member E21 -2.1419
SKA1 spindle and kinetochore associated complex subunit 1 -2.14107
PNMA6A paraneoplastic Ma antigen family member 6A -2.13468
DNAI2 dynein, axonemal, intermediate chain 2 -2.13468
OR52A1 olfactory receptor, family 52, subfamily A, member 1 -2.12864
ZMYND15 zinc finger, MYND-type containing 15 -2.11153
IRF2 interferon regulatory factor 2 -2.11153
LAMA4 laminin, alpha 4 -2.11153
WDR76 WD repeat domain 76 -2.11079
SYT17 synaptotagmin XVII -2.11079
KEL Kell blood group, metallo-endopeptidase -2.10936
TMTC4 transmembrane and tetratricopeptide repeat containing 4 -2.08179
NAXE NAD(P)HX epimerase -2.05965
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -2.05965
MED23 mediator complex subunit 23 -2.05292
CPEB1 cytoplasmic polyadenylation element binding protein 1 -2.04856
HEMK2 HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine -2.03848
ORC4 origin recognition complex, subunit 4 -2.01848
SEPTIN9 septin 9 -2.00521