PCI-34051 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/24753719
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Genes

199 proteins with high or low expression in PCI-34051 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
AKAP6 A kinase (PRKA) anchor protein 6 1.88
ENO1 enolase 1, (alpha) 1.23
STK33 serine/threonine kinase 33 1.14
OBSL1 obscurin-like 1 0.78
JMJD8 jumonji domain containing 8 0.69
IREB2 iron-responsive element binding protein 2 0.68
COL18A1 collagen, type XVIII, alpha 1 0.53
ZNF561 zinc finger protein 561 0.5
PON3 paraoxonase 3 0.49
ANKRD36C ankyrin repeat domain 36C 0.48
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) 0.48
TPM4 tropomyosin 4 0.46
ZBTB12 zinc finger and BTB domain containing 12 0.46
PIM3 Pim-3 proto-oncogene, serine/threonine kinase 0.46
NET1 neuroepithelial cell transforming 1 0.44
COL12A1 collagen, type XII, alpha 1 0.42
IFT22 intraflagellar transport 22 0.41
CLSTN3 calsyntenin 3 0.41
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.4
TXNL4B thioredoxin-like 4B 0.4
SSH2 slingshot protein phosphatase 2 0.38
FRMPD1 FERM and PDZ domain containing 1 0.38
ITPKB inositol-trisphosphate 3-kinase B 0.38
UBQLN1 ubiquilin 1 0.38
GSTM5 glutathione S-transferase mu 5 0.37
ZNF777 zinc finger protein 777 0.36
TFR2 transferrin receptor 2 0.35
LTO1 LTO1 maturation factor of ABCE1 0.35
KANK3 KN motif and ankyrin repeat domains 3 0.34
SC5D sterol-C5-desaturase 0.33
RNF130 ring finger protein 130 0.33
SARDH sarcosine dehydrogenase 0.33
TULP4 tubby like protein 4 0.33
TEAD3 TEA domain family member 3 0.33
PLIN2 perilipin 2 0.32
EIF5A2 eukaryotic translation initiation factor 5A2 0.32
KMT5B lysine methyltransferase 5B 0.32
NGFR nerve growth factor receptor 0.32
ERICH5 glutamate-rich 5 0.31
MRAS muscle RAS oncogene homolog 0.31
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit 0.31
TPM1 tropomyosin 1 (alpha) 0.31
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 0.31
IGFBP3 insulin-like growth factor binding protein 3 0.3
DOHH deoxyhypusine hydroxylase/monooxygenase 0.3
ACTR8 ARP8 actin-related protein 8 homolog (yeast) 0.29
FRA10AC1 fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 0.29
CPA4 carboxypeptidase A4 0.29
RNF170 ring finger protein 170 0.29
NHSL1 NHS-like 1 0.29
PIM1 Pim-1 proto-oncogene, serine/threonine kinase 0.29
CSNK1G3 casein kinase 1, gamma 3 0.28
MYNN myoneurin 0.28
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 0.28
MSL3P1 male-specific lethal 3 homolog (Drosophila) pseudogene 1 0.28
POMT2 protein-O-mannosyltransferase 2 0.28
OTUD5 OTU deubiquitinase 5 0.27
COL14A1 collagen, type XIV, alpha 1 0.27
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.27
CENPH centromere protein H 0.26
RNF145 ring finger protein 145 0.26
ZNF511 zinc finger protein 511 0.26
TPM2 tropomyosin 2 (beta) 0.26
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.25
RUNDC1 RUN domain containing 1 0.25
SNRK SNF related kinase 0.25
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 0.25
ATXN7L3B ataxin 7-like 3B 0.25
ZNF593 zinc finger protein 593 0.25
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.25
COQ4 coenzyme Q4 0.25
AEN apoptosis enhancing nuclease 0.24
PRKX protein kinase, X-linked 0.24
SP6 Sp6 transcription factor 0.24
TEP1 telomerase-associated protein 1 0.24
C18ORF32 chromosome 18 open reading frame 32 0.24
C17ORF53 chromosome 17 open reading frame 53 0.24
SGMS2 sphingomyelin synthase 2 0.24
RBIS ribosomal biogenesis factor 0.24
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 0.24
FOXO1 forkhead box O1 0.23
KLHL21 kelch-like family member 21 0.23
ZFP30 ZFP30 zinc finger protein 0.23
KIAA1958 KIAA1958 0.23
SUMO2 small ubiquitin-like modifier 2 0.23
EEF2 eukaryotic translation elongation factor 2 0.23
TPST1 tyrosylprotein sulfotransferase 1 0.23
DUSP14 dual specificity phosphatase 14 0.23
NRP1 neuropilin 1 0.23
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.23
MFAP3L microfibrillar-associated protein 3-like 0.23
ETV3 ets variant 3 0.23
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 0.23
GLI2 GLI family zinc finger 2 0.22
ARID3A AT rich interactive domain 3A (BRIGHT-like) 0.22
HOXA9 homeobox A9 0.22
BSDC1 BSD domain containing 1 0.22
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) 0.22
BID BH3 interacting domain death agonist 0.22

low expression

Symbol Name Standardized Value
ZNF555 zinc finger protein 555 -1.43
ARHGAP44 Rho GTPase activating protein 44 -1.4
NTHL1 nth endonuclease III-like 1 (E. coli) -1.15
MUTYH mutY homolog -0.95
SPTA1 spectrin, alpha, erythrocytic 1 -0.78
FAM241B family with sequence similarity 241 member B -0.78
ARL4A ADP-ribosylation factor-like 4A -0.7
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 -0.7
PPAT phosphoribosyl pyrophosphate amidotransferase -0.63
DDX12P DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12, pseudogene -0.62
ALDOA aldolase A, fructose-bisphosphate -0.61
KMT2B lysine (K)-specific methyltransferase 2B -0.6
TVP23C trans-golgi network vesicle protein 23 homolog C (S. cerevisiae) -0.57
CISD1 CDGSH iron sulfur domain 1 -0.55
CIAO3 cytosolic iron-sulfur assembly component 3 -0.53
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 -0.52
ZNF114 zinc finger protein 114 -0.5
C8ORF37 chromosome 8 open reading frame 37 -0.49
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 -0.48
ZBED6 zinc finger, BED-type containing 6 -0.48
CDCA4 cell division cycle associated 4 -0.48
ELP3 elongator acetyltransferase complex subunit 3 -0.47
LAMA3 laminin, alpha 3 -0.47
HSPG2 heparan sulfate proteoglycan 2 -0.46
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) -0.46
CFAP47 cilia and flagella associated protein 47 -0.45
ERCC6 excision repair cross-complementation group 6 -0.45
UNC93B1 unc-93 homolog B1 (C. elegans) -0.44
BAIAP3 BAI1-associated protein 3 -0.43
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.43
GPATCH4 G patch domain containing 4 -0.42
FRS2 fibroblast growth factor receptor substrate 2 -0.42
TMEM231 transmembrane protein 231 -0.42
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 -0.42
TACSTD2 tumor-associated calcium signal transducer 2 -0.4
BBS10 Bardet-Biedl syndrome 10 -0.4
SLC25A39 solute carrier family 25, member 39 -0.4
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -0.4
GATD1 glutamine amidotransferase class 1 domain containing 1 -0.39
KRT222 keratin 222, type II -0.39
METTL17 methyltransferase like 17 -0.39
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C -0.39
ZNF664 zinc finger protein 664 -0.38
FTH1 ferritin, heavy polypeptide 1 -0.38
CLK2 CDC-like kinase 2 -0.38
TMPPE transmembrane protein with metallophosphoesterase domain -0.38
DPH1 diphthamide biosynthesis 1 -0.38
BAG1 BCL2-associated athanogene -0.38
EMB embigin -0.37
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.37
NR1D2 nuclear receptor subfamily 1, group D, member 2 -0.37
HYLS1 hydrolethalus syndrome 1 -0.37
SARS seryl-tRNA synthetase -0.36
LIME1 Lck interacting transmembrane adaptor 1 -0.36
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -0.36
NPHP3 nephronophthisis 3 (adolescent) -0.36
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like -0.36
ARHGEF39 Rho guanine nucleotide exchange factor (GEF) 39 -0.35
TCEA3 transcription elongation factor A (SII), 3 -0.35
GIGYF1 GRB10 interacting GYF protein 1 -0.35
ZC3H12C zinc finger CCCH-type containing 12C -0.35
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle -0.35
RTEL1 regulator of telomere elongation helicase 1 -0.35
METTL25 methyltransferase like 25 -0.34
H1-4 H1.4 linker histone, cluster member -0.34
NCOR1 nuclear receptor corepressor 1 -0.34
GRAMD2B GRAM domain containing 2B -0.34
PCTP phosphatidylcholine transfer protein -0.33
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like -0.33
METTL26 methyltransferase like 26 -0.33
ALOXE3 arachidonate lipoxygenase 3 -0.33
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -0.33
ACSM3 acyl-CoA synthetase medium-chain family member 3 -0.33
SYBU syntabulin (syntaxin-interacting) -0.33
BLOC1S4 biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino -0.32
KDM4D lysine (K)-specific demethylase 4D -0.32
TRIB3 tribbles pseudokinase 3 -0.32
FADS1 fatty acid desaturase 1 -0.32
ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) -0.32
TTC38 tetratricopeptide repeat domain 38 -0.31
SYTL1 synaptotagmin-like 1 -0.31
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.31
POLD2 polymerase (DNA directed), delta 2, accessory subunit -0.31
TMEM186 transmembrane protein 186 -0.31
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 -0.31
CCDC158 coiled-coil domain containing 158 -0.31
SCAND1 SCAN domain containing 1 -0.31
ZNF195 zinc finger protein 195 -0.31
CCN2 cellular communication network factor 2 -0.3
FECH ferrochelatase -0.3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.3
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.3
DCLRE1A DNA cross-link repair 1A -0.3
ALAS1 5'-aminolevulinate synthase 1 -0.3
CDK18 cyclin-dependent kinase 18 -0.29
LMO4 LIM domain only 4 -0.29
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme -0.29
WDFY2 WD repeat and FYVE domain containing 2 -0.29
CYB5D2 cytochrome b5 domain containing 2 -0.28
CISD2 CDGSH iron sulfur domain 2 -0.28