PCK2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description phosphoenolpyruvate carboxykinase 2 (mitochondrial)|This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014] (NCBI Entrez Gene Database, 5106)
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Genes

361 genes differentially expressed following the PCK2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NXPH4 neurexophilin 4 3.05631
SLC37A3 solute carrier family 37, member 3 3.05631
PGR progesterone receptor 3.05631
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 3.05631
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 3.05631
CRHBP corticotropin releasing hormone binding protein 3.05631
PGM5 phosphoglucomutase 5 3.05631
AGXT2 alanine--glyoxylate aminotransferase 2 3.05631
ITGA11 integrin, alpha 11 3.05631
C11ORF86 chromosome 11 open reading frame 86 3.05631
OPRK1 opioid receptor, kappa 1 3.05631
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 3.05631
CCDC116 coiled-coil domain containing 116 3.05631
CLDN2 claudin 2 3.05631
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 3.05631
PLCD4 phospholipase C, delta 4 3.05631
CD300LF CD300 molecule-like family member f 3.05631
ETV7 ets variant 7 3.05631
NLRP14 NLR family, pyrin domain containing 14 3.05631
CPNE8-AS1 CPNE8 antisense RNA 1 3.05631
LHX6 LIM homeobox 6 3.05631
GPRC6A G protein-coupled receptor, class C, group 6, member A 3.05631
FGF4 fibroblast growth factor 4 3.05631
KLLN killin, p53-regulated DNA replication inhibitor 3.05631
MORN5 MORN repeat containing 5 3.05631
PHF24 PHD finger protein 24 3.05631
DHRS2 dehydrogenase/reductase (SDR family) member 2 3.05631
ELOVL3 ELOVL fatty acid elongase 3 3.05631
SCGB3A1 secretoglobin, family 3A, member 1 3.00677
GJB4 gap junction protein, beta 4, 30.3kDa 3.00677
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 3.00677
SLC25A41 solute carrier family 25, member 41 3.00677
CLEC12A C-type lectin domain family 12, member A 3.00677
FAM167B family with sequence similarity 167, member B 3.00677
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 3.00677
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like 3.00677
OIT3 oncoprotein induced transcript 3 3.00677
DUXB double homeobox B 3.00677
GPR151 G protein-coupled receptor 151 3.00677
HEATR9 HEAT repeat containing 9 3.00677
TMEM151A transmembrane protein 151A 3.00677
MAGEA3 melanoma antigen family A3 3.00677
TMEM176A transmembrane protein 176A 3.00677
PAX2 paired box 2 3.00677
SPACA5 sperm acrosome associated 5 3.00677
OPRL1 opiate receptor-like 1 3.00677
TAS2R19 taste receptor, type 2, member 19 3.00677
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 3.00677
MYO1G myosin IG 3.00677
HBZ hemoglobin, zeta 3.00677
TSHZ1 teashirt zinc finger homeobox 1 3.00677
THSD1 thrombospondin, type I, domain containing 1 3.00677
F2 coagulation factor II (thrombin) 3.00677
DLX4 distal-less homeobox 4 3.00677
CRX cone-rod homeobox 3.00677
SMIM5 small integral membrane protein 5 3.00677
C9ORF152 chromosome 9 open reading frame 152 3.00677
ZNF558 zinc finger protein 558 3.00677
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 3.00677
SLC23A3 solute carrier family 23, member 3 3.00677
GIMAP4 GTPase, IMAP family member 4 3.00677
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 3.00677
SHCBP1L SHC SH2-domain binding protein 1-like 3.00677
BMP5 bone morphogenetic protein 5 3.00677
SPMAP2L sperm microtubule associated protein 2 like 3.00677
LY6H lymphocyte antigen 6 complex, locus H 3.00677
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 3.00677
NDP Norrie disease (pseudoglioma) 3.00677
HNF1A HNF1 homeobox A 3.00677
LOC107986837 uncharacterized LOC107986837 3.00677
WDR93 WD repeat domain 93 3.00677
PCDHGC4 protocadherin gamma subfamily C, 4 3.00677
ASIC3 acid sensing (proton gated) ion channel 3 3.00677
NPIPB7 nuclear pore complex interacting protein family, member B7 3.00677
LRRC72 leucine rich repeat containing 72 3.00677
MYEOV myeloma overexpressed 3.00677
TMEM40 transmembrane protein 40 3.00677
CFAP97D2 CFAP97 domain containing 2 3.00677
H3C13 H3 clustered histone 13 3.00677
MEIOSIN meiosis initiator 3.00677
H2AC1 H2A clustered histone 1 3.00677
MINAR1 membrane integral NOTCH2 associated receptor 1 3.00677
MAB21L4 mab-21 like 4 3.00677
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.00677
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 3.00677
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 3.00677
OR1C1 olfactory receptor, family 1, subfamily C, member 1 3.00677
FRK fyn-related Src family tyrosine kinase 3.00677
FGFBP1 fibroblast growth factor binding protein 1 3.00677
PGA5 pepsinogen 5, group I (pepsinogen A) 3.00677
NKX3-2 NK3 homeobox 2 3.00677
FRMD7 FERM domain containing 7 3.00677
FPR2 formyl peptide receptor 2 3.00677
SPDYC speedy/RINGO cell cycle regulator family member C 3.00677
HBA2 hemoglobin, alpha 2 3.00677
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 3.00677
KLHL34 kelch-like family member 34 3.00677
FOXL1 forkhead box L1 3.00677
GPR75 G protein-coupled receptor 75 3.00677
SIX2 SIX homeobox 2 3.00677
ISM2 isthmin 2 3.00677
CCDC13 coiled-coil domain containing 13 3.00677
PLD4 phospholipase D family, member 4 3.00677
EXOC3L1 exocyst complex component 3-like 1 3.00677
EXOC3L4 exocyst complex component 3-like 4 3.00677
C1QL2 complement component 1, q subcomponent-like 2 3.00677
AWAT2 acyl-CoA wax alcohol acyltransferase 2 3.00677
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 3.00677
AMHR2 anti-Mullerian hormone receptor, type II 3.00677
CD79B CD79b molecule, immunoglobulin-associated beta 3.00677
ERVFRD-1 endogenous retrovirus group FRD, member 1 3.00677
CLDN9 claudin 9 3.00677
SIX6 SIX homeobox 6 3.00677
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 3.00677
RORC RAR-related orphan receptor C 3.00677
PRM1 protamine 1 3.00677
ADAM7 ADAM metallopeptidase domain 7 3.00677
SERINC4 serine incorporator 4 3.00677
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 3.00677
CGB7 chorionic gonadotropin, beta polypeptide 7 3.00677
DRD5 dopamine receptor D5 3.00677
RRH retinal pigment epithelium-derived rhodopsin homolog 3.00677
ISL2 ISL LIM homeobox 2 3.00677
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 3.00677
ZFP92 ZFP92 zinc finger protein 3.00677
ANKRD61 ankyrin repeat domain 61 3.00677
GCOM1 GRINL1A complex locus 1 3.00677
CIDEA cell death-inducing DFFA-like effector a 3.00677
CIDEC cell death-inducing DFFA-like effector c 3.00677
PHOSPHO1 phosphatase, orphan 1 3.00677
GP1BB glycoprotein Ib (platelet), beta polypeptide 3.00677
MYF6 myogenic factor 6 (herculin) 3.00677
AKR1B15 aldo-keto reductase family 1, member B15 3.00677
ZSCAN4 zinc finger and SCAN domain containing 4 3.00677
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 3.00677
RGSL1 regulator of G-protein signaling like 1 3.00677
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 3.00677
SST somatostatin 3.00677
TSPAN8 tetraspanin 8 3.00677
CLUL1 clusterin-like 1 (retinal) 3.00677
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 3.00677
PLA2G2C phospholipase A2, group IIC 3.00677
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 3.00677
ESPNL espin-like 3.00677
TBKBP1 TBK1 binding protein 1 3.00677
PCSK1 proprotein convertase subtilisin/kexin type 1 3.00677
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 3.00677
BCL2A1 BCL2-related protein A1 3.00677
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 3.00677
LDLRAD2 low density lipoprotein receptor class A domain containing 2 3.00677
NKX6-2 NK6 homeobox 2 3.00677
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 3.00677
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 3.00677
PLA2G12B phospholipase A2, group XIIB 3.00677
ZIM2 zinc finger, imprinted 2 3.00677
CTSW cathepsin W 3.00677
DND1 DND microRNA-mediated repression inhibitor 1 3.00677
SLC38A3 solute carrier family 38, member 3 3.00677
CTRB1 chymotrypsinogen B1 3.00677
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 3.00677
LGALS12 lectin, galactoside-binding, soluble, 12 3.00677
ITGA8 integrin, alpha 8 3.00677
MYBPH myosin binding protein H 3.00677
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 3.00677
ITPKA inositol-trisphosphate 3-kinase A 3.00677
AOC1 amine oxidase, copper containing 1 3.00677
TGM6 transglutaminase 6 3.00677
IL17B interleukin 17B 3.00677
DEFB105A defensin, beta 105A 3.00677
TGM3 transglutaminase 3 3.00677
GLT6D1 glycosyltransferase 6 domain containing 1 3.00677
IL32 interleukin 32 3.00677
POTEI POTE ankyrin domain family, member I 3.00677
PXT1 peroxisomal, testis specific 1 3.00677
TAS2R46 taste receptor, type 2, member 46 3.00677
CALML6 calmodulin-like 6 3.00677
GREM1 gremlin 1, DAN family BMP antagonist 3.00677
FAM9C family with sequence similarity 9, member C 3.00677
RAMP3 receptor (G protein-coupled) activity modifying protein 3 3.00677
DMTN dematin actin binding protein 3.00677
OR14A16 olfactory receptor, family 14, subfamily A, member 16 3.00677
TMEM88 transmembrane protein 88 3.00677
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 3.00677
TEX38 testis expressed 38 3.00677
TGM1 transglutaminase 1 3.00677
PSD2 pleckstrin and Sec7 domain containing 2 3.00677
TMCC2 transmembrane and coiled-coil domain family 2 2.98204
SCN3B sodium channel, voltage gated, type III beta subunit 2.93842
SYCP3 synaptonemal complex protein 3 2.93842
C13ORF42 chromosome 13 open reading frame 42 2.90503
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) 2.7836
SUSD5 sushi domain containing 5 2.7301
PCTP phosphatidylcholine transfer protein 2.7301
ZC3H3 zinc finger CCCH-type containing 3 2.66282
ITGB5 integrin, beta 5 2.64966
MTRF1L mitochondrial translational release factor 1-like 2.6374
MITF microphthalmia-associated transcription factor 2.57331
WDR72 WD repeat domain 72 2.57331
OSTN osteocrin 2.57331
CEP63 centrosomal protein 63kDa 2.55625
C1GALT1C1 C1GALT1-specific chaperone 1 2.53729
VPS26C VPS26 endosomal protein sorting factor C 2.53698
ELOB elongin B 2.50121
SETDB2 SET domain, bifurcated 2 2.48236
CPHXL2 cytoplasmic polyadenylated homeobox like 2 2.46237
TGFB1 transforming growth factor, beta 1 2.44293
CNPPD1 cyclin Pas1/PHO80 domain containing 1 2.43742
FEM1C fem-1 homolog c (C. elegans) 2.42742
DZIP3 DAZ interacting zinc finger protein 3 2.42742
H2AC7 H2A clustered histone 7 2.41791
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 2.40815
PRAP1 proline-rich acidic protein 1 2.40572
ERVW-1 endogenous retrovirus group W, member 1 2.40572
BHLHE40 basic helix-loop-helix family, member e40 2.40572
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 2.39363
INVS inversin 2.33343
AP2B1 adaptor-related protein complex 2, beta 1 subunit 2.31626
SUZ12 SUZ12 polycomb repressive complex 2 subunit 2.28531
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 2.2805
GFRA2 GDNF family receptor alpha 2 2.26085
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 2.24568
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 2.23552
RIMS1 regulating synaptic membrane exocytosis 1 2.22942
GNPAT glyceronephosphate O-acyltransferase 2.2228
COL4A1 collagen, type IV, alpha 1 2.22115
SMIM30 small integral membrane protein 30 2.21971
DMAC2 distal membrane arm assembly component 2 2.21971
AAR2 AAR2 splicing factor homolog (S. cerevisiae) 2.20215
RPS19BP1 ribosomal protein S19 binding protein 1 2.20215
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 2.2016
ADRA2B adrenoceptor alpha 2B 2.18245
SEC24D SEC24 family member D 2.15925
ARFGEF3 ARFGEF family member 3 2.14342
PDPK1 3-phosphoinositide dependent protein kinase 1 2.12895
CEL carboxyl ester lipase 2.12895
MFF mitochondrial fission factor 2.1151
AOAH acyloxyacyl hydrolase (neutrophil) 2.10429
CCN1 cellular communication network factor 1 2.10028
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) 2.10028
DCAF8 DDB1 and CUL4 associated factor 8 2.10028
ELOVL1 ELOVL fatty acid elongase 1 2.09783
QTGAL queuosine-tRNA galactosyltransferase 2.08877
GJD3 gap junction protein, delta 3, 31.9kDa 2.07981
ELAC1 elaC ribonuclease Z 1 2.0749
ZBED3 zinc finger, BED-type containing 3 2.06801
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 2.06046
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 2.05295
CLEC2L C-type lectin domain family 2, member L 2.04871
ZFYVE16 zinc finger, FYVE domain containing 16 2.01663
STYXL1 serine/threonine/tyrosine interacting-like 1 2.0055
PTK2B protein tyrosine kinase 2 beta 2.0055

decreased expression

Symbol Name Standardized Value
PCDHB3 protocadherin beta 3 -3.05631
LRRIQ1 leucine-rich repeats and IQ motif containing 1 -3.02882
SPDYE21 speedy/RINGO cell cycle regulator family member E21 -3.00677
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 -3.00677
SYNDIG1L synapse differentiation inducing 1-like -3.00677
STYK1 serine/threonine/tyrosine kinase 1 -3.00677
UBXN10 UBX domain protein 10 -3.00677
APAF1 apoptotic peptidase activating factor 1 -3.00677
P3H2 prolyl 3-hydroxylase 2 -3.00677
ASIC1 acid sensing (proton gated) ion channel 1 -3.00677
CSPG4 chondroitin sulfate proteoglycan 4 -3.00677
PCDH12 protocadherin 12 -3.00677
AKT2 v-akt murine thymoma viral oncogene homolog 2 -2.95973
FBXO33 F-box protein 33 -2.92582
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta -2.80725
SYCE3 synaptonemal complex central element protein 3 -2.7836
SUSD2 sushi domain containing 2 -2.7836
BIRC3 baculoviral IAP repeat containing 3 -2.7836
GMFG glia maturation factor, gamma -2.7836
KCNIP3 Kv channel interacting protein 3, calsenilin -2.7836
LCN10 lipocalin 10 -2.7836
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) -2.7836
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -2.7836
MYO16 myosin XVI -2.7836
CRYGN crystallin, gamma N -2.7836
VENTX VENT homeobox -2.7836
SSTR5 somatostatin receptor 5 -2.7836
GDF6 growth differentiation factor 6 -2.7836
LEF1 lymphoid enhancer-binding factor 1 -2.7836
SCRT2 scratch family zinc finger 2 -2.7836
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -2.7836
TAFA3 TAFA chemokine like family member 3 -2.7836
SOX21 SRY (sex determining region Y)-box 21 -2.7836
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 -2.7836
TMPRSS11A transmembrane protease, serine 11A -2.7836
RAX retina and anterior neural fold homeobox -2.7836
PDYN prodynorphin -2.7836
NOD2 nucleotide-binding oligomerization domain containing 2 -2.7836
DRICH1 aspartate-rich 1 -2.7836
PAX5 paired box 5 -2.7836
C6ORF58 chromosome 6 open reading frame 58 -2.7836
TMPRSS6 transmembrane protease, serine 6 -2.7836
RUFY4 RUN and FYVE domain containing 4 -2.7836
LRRC38 leucine rich repeat containing 38 -2.7836
GAGE10 G antigen 10 -2.7836
ZNF536 zinc finger protein 536 -2.7836
EPHA5 EPH receptor A5 -2.7836
PRSS53 protease, serine, 53 -2.7836
TTC16 tetratricopeptide repeat domain 16 -2.7836
LRRC32 leucine rich repeat containing 32 -2.7836
COL11A2 collagen, type XI, alpha 2 -2.7836
DAPL1 death associated protein-like 1 -2.7836
DPRX divergent-paired related homeobox -2.7836
OR52N2 olfactory receptor, family 52, subfamily N, member 2 -2.7836
PCDH20 protocadherin 20 -2.7836
PLPP6 phospholipid phosphatase 6 -2.76033
CSRNP2 cysteine-serine-rich nuclear protein 2 -2.69869
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 -2.64966
LYG1 lysozyme G-like 1 -2.64966
DGKQ diacylglycerol kinase, theta 110kDa -2.64966
GPHA2 glycoprotein hormone alpha 2 -2.64966
FRS3 fibroblast growth factor receptor substrate 3 -2.62132
CR1 complement component (3b/4b) receptor 1 (Knops blood group) -2.62132
TRIM56 tripartite motif containing 56 -2.61751
SIN3A SIN3 transcription regulator family member A -2.6057
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 -2.58952
MAP2K5 mitogen-activated protein kinase kinase 5 -2.57699
QSOX1 quiescin Q6 sulfhydryl oxidase 1 -2.57331
S100A11 S100 calcium binding protein A11 -2.5729
TMEM242 transmembrane protein 242 -2.5729
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2 -2.55314
CLCN3 chloride channel, voltage-sensitive 3 -2.53729
STK32C serine/threonine kinase 32C -2.53698
EIF4A2 eukaryotic translation initiation factor 4A2 -2.5211
APTX aprataxin -2.50121
ZNF639 zinc finger protein 639 -2.49418
FAM234A family with sequence similarity 234 member A -2.41791
FKBP5 FK506 binding protein 5 -2.41791
MARCHF10 membrane associated ring-CH-type finger 10 -2.4171
CD151 CD151 molecule (Raph blood group) -2.40655
BEX3 brain expressed X-linked 3 -2.40572
GRTP1 growth hormone regulated TBC protein 1 -2.37029
PTPRS protein tyrosine phosphatase, receptor type, S -2.36787
FAM161A family with sequence similarity 161, member A -2.34549
C16ORF96 chromosome 16 open reading frame 96 -2.34549
SCAF4 SR-related CTD-associated factor 4 -2.34549
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) -2.34418
CEP95 centrosomal protein 95kDa -2.31307
SIRPA signal-regulatory protein alpha -2.29892
C6ORF120 chromosome 6 open reading frame 120 -2.27056
PLCB4 phospholipase C, beta 4 -2.26871
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -2.26871
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) -2.2544
TTC7B tetratricopeptide repeat domain 7B -2.24594
MAP2K2 mitogen-activated protein kinase kinase 2 -2.23939
L3MBTL1 l(3)mbt-like 1 (Drosophila) -2.20215
FAM216A family with sequence similarity 216, member A -2.17126
CNR1 cannabinoid receptor 1 (brain) -2.13544
CASR calcium-sensing receptor -2.09748
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma -2.08824
GPI glucose-6-phosphate isomerase -2.0857
HPS3 Hermansky-Pudlak syndrome 3 -2.08191
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.06717
ARPC5L actin related protein 2/3 complex, subunit 5-like -2.05063
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -2.05038
PRPF38B pre-mRNA processing factor 38B -2.03081
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase -2.0302
SCN11A sodium channel, voltage gated, type XI alpha subunit -2.01671
XPO6 exportin 6 -2.01486
GTSE1 G-2 and S-phase expressed 1 -2.01382