PCNA Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description proliferating cell nuclear antigen|The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5111)
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Genes

354 genes differentially expressed following the PCNA gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PRRT4 proline-rich transmembrane protein 4 3.43415
GJD4 gap junction protein, delta 4, 40.1kDa 3.43415
S100A1 S100 calcium binding protein A1 3.43415
CRYGN crystallin, gamma N 3.43415
GJD2 gap junction protein, delta 2, 36kDa 3.43415
CDKN2A cyclin-dependent kinase inhibitor 2A 3.43415
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 3.43415
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 3.43415
LVRN laeverin 3.43415
PGA5 pepsinogen 5, group I (pepsinogen A) 3.43415
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 3.43415
PPIAL4G peptidylprolyl isomerase A (cyclophilin A)-like 4G 3.43415
UBE2U ubiquitin-conjugating enzyme E2U (putative) 3.43415
FGFR3 fibroblast growth factor receptor 3 3.43415
PTGER3 prostaglandin E receptor 3 (subtype EP3) 3.43415
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 3.43415
MROH2B maestro heat-like repeat family member 2B 3.43415
C1QTNF2 C1q and tumor necrosis factor related protein 2 3.43415
UBA7 ubiquitin-like modifier activating enzyme 7 3.43415
SPNS2 spinster homolog 2 (Drosophila) 3.43415
GPR183 G protein-coupled receptor 183 3.43415
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 3.43415
TMEM132C transmembrane protein 132C 3.43415
SPAG8 sperm associated antigen 8 3.43415
CSF3 colony stimulating factor 3 (granulocyte) 3.43415
NPC1L1 NPC1-like 1 3.43415
KL klotho 3.43415
KIF19 kinesin family member 19 3.43415
TMEM81 transmembrane protein 81 3.43415
GATA3 GATA binding protein 3 3.43415
TNMD tenomodulin 3.43415
RP1 retinitis pigmentosa 1 (autosomal dominant) 3.43415
PAX7 paired box 7 3.43415
PSD4 pleckstrin and Sec7 domain containing 4 3.43415
CD22 CD22 molecule 3.43415
ARSH arylsulfatase family, member H 3.43415
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 3.43415
LEP leptin 3.43415
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 3.43415
ERAP2 endoplasmic reticulum aminopeptidase 2 3.43415
FGF9 fibroblast growth factor 9 3.43415
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 3.43415
PRSS27 protease, serine 27 3.43415
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 3.43415
MMP10 matrix metallopeptidase 10 3.43415
TPTE transmembrane phosphatase with tensin homology 3.43415
FOXD1 forkhead box D1 3.43415
MAGEB16 melanoma antigen family B16 3.43415
CELF6 CUGBP, Elav-like family member 6 3.43415
PCDHB12 protocadherin beta 12 3.43415
TRIM17 tripartite motif containing 17 3.43415
MAGEA2 melanoma antigen family A2 3.43415
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 3.43415
C1ORF87 chromosome 1 open reading frame 87 3.43415
GFRA3 GDNF family receptor alpha 3 3.43415
EPPIN epididymal peptidase inhibitor 3.43415
PCDHB14 protocadherin beta 14 3.43415
NKAPL NFKB activating protein-like 3.43415
CAPN14 calpain 14 3.43415
RLBP1 retinaldehyde binding protein 1 3.43415
LOC107986837 uncharacterized LOC107986837 3.43415
ZNF597 zinc finger protein 597 3.43415
TAS2R5 taste receptor, type 2, member 5 3.43415
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.43415
GPR75 G protein-coupled receptor 75 3.43415
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 3.43415
CD96 CD96 molecule 3.43415
ZNF469 zinc finger protein 469 3.43415
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 3.43415
ECEL1 endothelin converting enzyme-like 1 3.43415
LRG1 leucine-rich alpha-2-glycoprotein 1 3.43415
AKR1C1 aldo-keto reductase family 1, member C1 3.43415
SSTR3 somatostatin receptor 3 3.43415
TFEC transcription factor EC 3.43415
DIRAS2 DIRAS family, GTP-binding RAS-like 2 3.43415
TAL2 T-cell acute lymphocytic leukemia 2 3.43415
LYNX1 Ly6/neurotoxin 1 3.43415
C11ORF86 chromosome 11 open reading frame 86 3.43415
CA1 carbonic anhydrase I 3.43415
OLIG3 oligodendrocyte transcription factor 3 3.43415
IL4 interleukin 4 3.43415
GOLGA7B golgin A7 family, member B 3.43415
NOD2 nucleotide-binding oligomerization domain containing 2 3.43415
MYBPC3 myosin binding protein C, cardiac 3.43415
UMOD uromodulin 3.43415
SGPP2 sphingosine-1-phosphate phosphatase 2 3.43415
ELSPBP1 epididymal sperm binding protein 1 3.43415
OR2A14 olfactory receptor, family 2, subfamily A, member 14 3.43415
LMO1 LIM domain only 1 (rhombotin 1) 3.43415
PDE7B phosphodiesterase 7B 3.43415
RFPL2 ret finger protein-like 2 3.43415
TNS2 tensin 2 3.43415
KLF1 Kruppel-like factor 1 (erythroid) 3.43415
FAM209B family with sequence similarity 209, member B 3.43415
ALOXE3 arachidonate lipoxygenase 3 3.43415
TBATA thymus, brain and testes associated 3.43415
ZNF843 zinc finger protein 843 3.43415
KLK6 kallikrein-related peptidase 6 3.43415
KLK4 kallikrein-related peptidase 4 3.43415
H1-8 H1.8 linker histone 3.43415
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 3.43415
HK3 hexokinase 3 (white cell) 3.43415
TBXA2R thromboxane A2 receptor 3.43415
FAM209A family with sequence similarity 209, member A 3.43415
TRIM55 tripartite motif containing 55 3.43415
KASH5 KASH domain containing 5 3.43415
CABCOCO1 ciliary associated calcium binding coiled-coil 1 3.43415
CAMK2B calcium/calmodulin-dependent protein kinase II beta 3.43415
CCDC190 coiled-coil domain containing 190 3.43415
DEFB131B defensin beta 131B 3.43415
PAGE4 P antigen family, member 4 (prostate associated) 3.43415
CLEC4C C-type lectin domain family 4, member C 3.43415
HUS1B HUS1 checkpoint homolog b (S. pombe) 3.43415
ITPRID1 ITPR interacting domain containing 1 3.43415
MEIOSIN meiosis initiator 3.43415
PRR35 proline rich 35 3.43415
SLN sarcolipin 3.43415
PAQR9 progestin and adipoQ receptor family member IX 3.43415
GPRC6A G protein-coupled receptor, class C, group 6, member A 3.43415
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 3.43415
CIMAP2 ciliary microtubule associated protein 2 3.43415
SPMAP1 sperm microtubule associated protein 1 3.43415
CXORF58 chromosome X open reading frame 58 3.43415
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 3.43415
GOLGA8M golgin A8 family, member M 3.43415
CFH complement factor H 3.43415
LOC124902436 talanin 3.43415
MOS v-mos Moloney murine sarcoma viral oncogene homolog 3.43415
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 3.43415
H4C14 H4 clustered histone 14 3.43415
RBM24 RNA binding motif protein 24 3.43415
SMIM45 small integral membrane protein 45 3.43415
DLX3 distal-less homeobox 3 3.43415
INSYN1 inhibitory synaptic factor 1 3.43415
CTSO cathepsin O 3.43415
ATP10B ATPase, class V, type 10B 3.43415
RGS4 regulator of G-protein signaling 4 3.43415
UPK1A uroplakin 1A 3.43415
BDKRB1 bradykinin receptor B1 3.43415
AMER3 APC membrane recruitment protein 3 3.43415
NUTM2B NUT family member 2B 3.43415
PLGLB1 plasminogen-like B1 3.43415
MAEL maelstrom spermatogenic transposon silencer 3.43415
PRAM1 PML-RARA regulated adaptor molecule 1 3.43415
DBX2 developing brain homeobox 2 3.43415
SHOX short stature homeobox 3.43415
KPNA7 karyopherin alpha 7 (importin alpha 8) 3.43415
SMYD1 SET and MYND domain containing 1 3.43415
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 3.43415
LAMP3 lysosomal-associated membrane protein 3 3.43415
TMEM40 transmembrane protein 40 3.43415
ADAM29 ADAM metallopeptidase domain 29 3.43415
SDSL serine dehydratase-like 3.43415
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 3.43415
NELL1 NEL-like 1 (chicken) 3.43415
LYZL2 lysozyme-like 2 3.43415
RNF148 ring finger protein 148 3.43415
RTN4RL1 reticulon 4 receptor-like 1 3.43415
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 3.43415
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 3.43415
SMPX small muscle protein, X-linked 3.43415
MYOCOS myocilin opposite strand 3.43415
CSTA cystatin A (stefin A) 3.43415
BTNL2 butyrophilin-like 2 3.43415
CLDN34 claudin 34 3.43415
CTAGE9 CTAGE family, member 9 3.43415
ZNF703 zinc finger protein 703 3.43415
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 3.43415
CCN6 cellular communication network factor 6 3.43415
C2ORF66 chromosome 2 open reading frame 66 3.43415
NIM1K NIM1 serine/threonine protein kinase 3.43415
RSAD2 radical S-adenosyl methionine domain containing 2 3.43415
MYZAP myocardial zonula adherens protein 3.43415
NPPA natriuretic peptide A 3.43415
SV2B synaptic vesicle glycoprotein 2B 3.43415
BNC1 basonuclin 1 3.43415
BGN biglycan 3.43415
DST dystonin 3.42514
TENM4 teneurin transmembrane protein 4 3.42042
FBXO6 F-box protein 6 3.42042
CREB3L2 cAMP responsive element binding protein 3-like 2 3.39668
ADRA1A adrenoceptor alpha 1A 3.36026
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 3.36026
C1ORF146 chromosome 1 open reading frame 146 3.26219
SPC24 SPC24, NDC80 kinetochore complex component 3.22968
TBP TATA box binding protein 3.10231
POU3F4 POU class 3 homeobox 4 3.09722
BRWD1 bromodomain and WD repeat domain containing 1 3.06046
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 2.89379
CCR5AS CCR5 antisense RNA 2.84737
SFT2D1 SFT2 domain containing 1 2.84717
LMTK1 lemur tail kinase 1 2.84269
LARS2 leucyl-tRNA synthetase 2, mitochondrial 2.77786
ATG9B autophagy related 9B 2.72197
TMEM190 transmembrane protein 190 2.72197
WNK4 WNK lysine deficient protein kinase 4 2.72197
KIF21A kinesin family member 21A 2.69302
EPB41L3 erythrocyte membrane protein band 4.1-like 3 2.63459
USP9X ubiquitin specific peptidase 9, X-linked 2.56221
AP1B1 adaptor-related protein complex 1, beta 1 subunit 2.54668
LRRC40 leucine rich repeat containing 40 2.54496
HINT3 histidine triad nucleotide binding protein 3 2.54006
DYDC1 DPY30 domain containing 1 2.48425
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) 2.46661
ANKMY1 ankyrin repeat and MYND domain containing 1 2.44678
ZC3H14 zinc finger CCCH-type containing 14 2.43807
MASP2 mannan-binding lectin serine peptidase 2 2.38204
ANXA9 annexin A9 2.38204
CD36 CD36 molecule (thrombospondin receptor) 2.38204
CEL carboxyl ester lipase 2.38204
CD164L2 CD164 sialomucin-like 2 2.38204
VWA5B1 von Willebrand factor A domain containing 5B1 2.38204
ZNF221 zinc finger protein 221 2.38204
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 2.38204
KCNK13 potassium channel, two pore domain subfamily K, member 13 2.35793
LRRC4 leucine rich repeat containing 4 2.35793
PNPLA8 patatin-like phospholipase domain containing 8 2.35793
TBC1D13 TBC1 domain family, member 13 2.35663
ACRV1 acrosomal vesicle protein 1 2.33511
MINDY4 MINDY lysine 48 deubiquitinase 4 2.33136
PRKD1 protein kinase D1 2.31856
GPHA2 glycoprotein hormone alpha 2 2.27343
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 2.27343
ATXN7L3B ataxin 7-like 3B 2.2427
ISOC2 isochorismatase domain containing 2 2.18491
MRPS21 mitochondrial ribosomal protein S21 2.18491
MMP24 matrix metallopeptidase 24 (membrane-inserted) 2.18491
ZCCHC10 zinc finger, CCHC domain containing 10 2.1816
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.17471
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 2.16223
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 2.15166
ERLIN2 ER lipid raft associated 2 2.14775
MTPAP mitochondrial poly(A) polymerase 2.14775
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 2.13596
EPPK1 epiplakin 1 2.13395
ZDHHC6 zinc finger, DHHC-type containing 6 2.12115
PLCB4 phospholipase C, beta 4 2.11151
WASHC2C WASH complex subunit 2C 2.11151
DAXX death-domain associated protein 2.10589
AFF2 AF4/FMR2 family, member 2 2.09416
NADSYN1 NAD synthetase 1 2.08471
NCAPG2 non-SMC condensin II complex, subunit G2 2.06744
FAM86B1 family with sequence similarity 86, member B1 2.05428
VGF VGF nerve growth factor inducible 2.0504
TAGLN2 transgelin 2 2.0407
KIF5C kinesin family member 5C 2.03589
CREBL2 cAMP responsive element binding protein-like 2 2.03589
MDH1 malate dehydrogenase 1, NAD (soluble) 2.01218

decreased expression

Symbol Name Standardized Value
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 -3.43415
TMPRSS9 transmembrane protease, serine 9 -3.43415
SLFN5 schlafen family member 5 -3.43415
CACNG5 calcium channel, voltage-dependent, gamma subunit 5 -3.43415
NUTM1 NUT midline carcinoma, family member 1 -3.43415
MOGAT1 monoacylglycerol O-acyltransferase 1 -3.43415
TEPSIN TEPSIN adaptor related protein complex 4 accessory protein -3.43415
UNC5A unc-5 homolog A (C. elegans) -3.43415
ZNF404 zinc finger protein 404 -3.43415
PCDHA6 protocadherin alpha 6 -3.42042
TMEM233 transmembrane protein 233 -3.42042
BATF2 basic leucine zipper transcription factor, ATF-like 2 -3.42042
ADAM21 ADAM metallopeptidase domain 21 -3.42042
WDR72 WD repeat domain 72 -3.42042
NTNG2 netrin G2 -3.42042
C19ORF38 chromosome 19 open reading frame 38 -3.42042
AZU1 azurocidin 1 -3.42042
PRCD progressive rod-cone degeneration -3.42042
PCDH8 protocadherin 8 -3.42042
NLRP10 NLR family, pyrin domain containing 10 -3.42042
FSCN3 fascin actin-bundling protein 3, testicular -3.42042
KDM6B lysine (K)-specific demethylase 6B -3.42042
RGPD6 RANBP2-like and GRIP domain containing 6 -3.42042
MTTP microsomal triglyceride transfer protein -3.42042
UNC13C unc-13 homolog C (C. elegans) -3.42042
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 -3.42042
OSTN osteocrin -3.42042
EPOP elongin BC and polycomb repressive complex 2 associated protein -3.42042
TRHR thyrotropin-releasing hormone receptor -3.42042
CRTAC1 cartilage acidic protein 1 -3.42042
MUSTN1 musculoskeletal, embryonic nuclear protein 1 -3.42042
LOC114841035 uncharacterized LOC114841035 -3.42042
SOWAHD sosondowah ankyrin repeat domain family member D -3.42042
B9D2 B9 protein domain 2 -3.42042
NPM2 nucleophosmin/nucleoplasmin 2 -3.42042
SPATS1 spermatogenesis associated, serine-rich 1 -3.42042
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) -3.42042
MEIS1 Meis homeobox 1 -3.42042
C6ORF163 chromosome 6 open reading frame 163 -3.42042
ZNF446 zinc finger protein 446 -3.42042
PADI3 peptidyl arginine deiminase, type III -3.42042
NXNL2 nucleoredoxin-like 2 -3.37657
PELI3 pellino E3 ubiquitin protein ligase family member 3 -3.36026
AMOT angiomotin -3.36026
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) -3.34747
MMP25 matrix metallopeptidase 25 -3.26219
HIP1R huntingtin interacting protein 1 related -3.05599
CDK9 cyclin-dependent kinase 9 -2.77786
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -2.73807
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 -2.70229
FRMD4A FERM domain containing 4A -2.65661
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -2.63459
RNF115 ring finger protein 115 -2.62825
OGFRL1 opioid growth factor receptor-like 1 -2.57924
ZNF830 zinc finger protein 830 -2.56707
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 -2.55447
SCNN1A sodium channel, non voltage gated 1 alpha subunit -2.54341
SRSF9 serine/arginine-rich splicing factor 9 -2.53312
SPDYE17 speedy/RINGO cell cycle regulator family member E17 -2.53042
ZNF408 zinc finger protein 408 -2.51442
LAP3 leucine aminopeptidase 3 -2.47946
MCOLN3 mucolipin 3 -2.43922
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) -2.43293
ZW10 zw10 kinetochore protein -2.42622
A4GALT alpha 1,4-galactosyltransferase -2.37858
VWC2 von Willebrand factor C domain containing 2 -2.37858
UBQLN2 ubiquilin 2 -2.37858
CIART circadian associated repressor of transcription -2.37858
IL6R interleukin 6 receptor -2.37858
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 -2.37858
OSBPL7 oxysterol binding protein-like 7 -2.37166
SHANK3 SH3 and multiple ankyrin repeat domains 3 -2.36361
RRM1 ribonucleotide reductase M1 -2.35793
ZSCAN31 zinc finger and SCAN domain containing 31 -2.30677
NIBAN3 niban apoptosis regulator 3 -2.30677
STAB2 stabilin 2 -2.30677
CAPNS1 calpain, small subunit 1 -2.3023
HSD11B1L hydroxysteroid (11-beta) dehydrogenase 1-like -2.27343
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B -2.2384
MTF1 metal-regulatory transcription factor 1 -2.22871
CA12 carbonic anhydrase XII -2.22673
LAPTM4B lysosomal protein transmembrane 4 beta -2.19794
DIXDC1 DIX domain containing 1 -2.18491
FBXO33 F-box protein 33 -2.18491
SMC2 structural maintenance of chromosomes 2 -2.16986
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase -2.1507
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.1507
RPIA ribose 5-phosphate isomerase A -2.14384
ZNF627 zinc finger protein 627 -2.14384
CCT8 chaperonin containing TCP1, subunit 8 (theta) -2.13896
TTYH1 tweety family member 1 -2.12993
RILP Rab interacting lysosomal protein -2.12013
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4 -2.11151
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.10826
CCDC51 coiled-coil domain containing 51 -2.10589
GPR137 G protein-coupled receptor 137 -2.1001
CFDP1 craniofacial development protein 1 -2.09027
HACL1 2-hydroxyacyl-CoA lyase 1 -2.09027
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -2.08962
TSPAN17 tetraspanin 17 -2.08452
SYT9 synaptotagmin IX -2.07449
VDAC3 voltage-dependent anion channel 3 -2.06744
ANKRD36 ankyrin repeat domain 36 -2.02156
GRM8 glutamate receptor, metabotropic 8 -2.0179
KRABD2 KRAB domain containing 2 -2.01218
TOR1AIP1 torsin A interacting protein 1 -2.00857