| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | proprotein convertase subtilisin/kexin type 1|This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene [provided by RefSeq, Jan 2014] (NCBI Entrez Gene Database, 5122) |
| External Link | https://ncbi.nlm.nih.gov/gene/5122 |
| Similar Terms | |
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499 genes differentially expressed following the PCSK1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | 0.0162249 |
| TMEM45A | transmembrane protein 45A | 0.0136514 |
| CP | ceruloplasmin (ferroxidase) | 0.0115803 |
| PXDN | peroxidasin | 0.0113173 |
| SEPP1 | selenoprotein P, plasma, 1 | 0.0113165 |
| ANPEP | alanyl (membrane) aminopeptidase | 0.0105084 |
| POSTN | periostin, osteoblast specific factor | 0.0104379 |
| GNAS | GNAS complex locus | 0.0104233 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.0102389 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0101259 |
| ALB | albumin | 0.0101109 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0100877 |
| C1R | complement component 1, r subcomponent | 0.0100779 |
| MGLL | monoglyceride lipase | 0.00980366 |
| TLCD3A | TLC domain containing 3A | 0.00950625 |
| TAGLN | transgelin | 0.00944952 |
| MT1E | metallothionein 1E | 0.00933501 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.00920864 |
| COL3A1 | collagen, type III, alpha 1 | 0.00915696 |
| FSTL1 | follistatin-like 1 | 0.0089795 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.00892379 |
| MCOLN1 | mucolipin 1 | 0.00887712 |
| TNC | tenascin C | 0.00881908 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0087306 |
| GLS | glutaminase | 0.00856486 |
| GAS1 | growth arrest-specific 1 | 0.00855707 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.00846813 |
| C1S | complement component 1, s subcomponent | 0.00846159 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | 0.00833759 |
| BGN | biglycan | 0.00833009 |
| STEAP3 | STEAP family member 3, metalloreductase | 0.00829085 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.00825388 |
| C3 | complement component 3 | 0.00822642 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.00808679 |
| ATP6V0E2 | ATPase, H+ transporting V0 subunit e2 | 0.00792681 |
| TUBB2B | tubulin, beta 2B class IIb | 0.00785709 |
| SRPX | sushi-repeat containing protein, X-linked | 0.00784167 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.00769443 |
| PMP22 | peripheral myelin protein 22 | 0.00766288 |
| NES | nestin | 0.00762508 |
| METTL7A | methyltransferase like 7A | 0.00762285 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.0076177 |
| SGCE | sarcoglycan, epsilon | 0.00758801 |
| S100A8 | S100 calcium binding protein A8 | 0.0075621 |
| MT1H | metallothionein 1H | 0.00754599 |
| MT1HL1 | metallothionein 1H-like 1 | 0.00747905 |
| FABP1 | fatty acid binding protein 1, liver | 0.00746714 |
| BEX1 | brain expressed, X-linked 1 | 0.00744507 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.00741021 |
| PTBP1 | polypyrimidine tract binding protein 1 | 0.00740907 |
| ICMT | isoprenylcysteine carboxyl methyltransferase | 0.00738575 |
| PCNA | proliferating cell nuclear antigen | 0.00738433 |
| GOLGA8A | golgin A8 family, member A | 0.00736995 |
| MT2A | metallothionein 2A | 0.00736461 |
| MT1G | metallothionein 1G | 0.00736371 |
| NRN1 | neuritin 1 | 0.00736062 |
| COL1A1 | collagen, type I, alpha 1 | 0.00725127 |
| MGP | matrix Gla protein | 0.00723988 |
| THBS2 | thrombospondin 2 | 0.00722844 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | 0.00720542 |
| HMG20B | high mobility group 20B | 0.00718347 |
| TSPAN4 | tetraspanin 4 | 0.00712969 |
| ACADVL | acyl-CoA dehydrogenase, very long chain | 0.00709178 |
| ATP5F1D | ATP synthase F1 subunit delta | 0.00708592 |
| MFAP5 | microfibrillar associated protein 5 | 0.00705643 |
| MXRA5 | matrix-remodelling associated 5 | 0.00700153 |
| PRKD3 | protein kinase D3 | 0.00700107 |
| COL1A2 | collagen, type I, alpha 2 | 0.00698483 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | 0.00689801 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.00687395 |
| HYOU1 | hypoxia up-regulated 1 | 0.00687196 |
| RBM26 | RNA binding motif protein 26 | 0.00687032 |
| SAA4 | serum amyloid A4, constitutive | 0.0068615 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0068374 |
| MFSD10 | major facilitator superfamily domain containing 10 | 0.00677895 |
| PDGFD | platelet derived growth factor D | 0.00676211 |
| CYP27A1 | cytochrome P450, family 27, subfamily A, polypeptide 1 | 0.00673142 |
| KANK1 | KN motif and ankyrin repeat domains 1 | 0.00671308 |
| CCNF | cyclin F | 0.00671022 |
| MOK | MOK protein kinase | 0.00668366 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.00664289 |
| SULT2A1 | sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 | 0.0066428 |
| MGAT4B | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B | 0.00664279 |
| FCGBP | Fc fragment of IgG binding protein | 0.0066301 |
| ASPH | aspartate beta-hydroxylase | 0.0065984 |
| MST1 | macrophage stimulating 1 | 0.00659737 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 0.00659068 |
| PDLIM2 | PDZ and LIM domain 2 (mystique) | 0.0065905 |
| PXMP2 | peroxisomal membrane protein 2, 22kDa | 0.00656423 |
| PWWP3A | PWWP domain containing 3A, DNA repair factor | 0.00656193 |
| UGT2B17 | UDP glucuronosyltransferase 2 family, polypeptide B17 | 0.00655935 |
| CDO1 | cysteine dioxygenase type 1 | 0.00655338 |
| MCM5 | minichromosome maintenance complex component 5 | 0.00655122 |
| CBS | cystathionine-beta-synthase | 0.00653611 |
| BCHE | butyrylcholinesterase | 0.00652753 |
| ADH1C | alcohol dehydrogenase 1C (class I), gamma polypeptide | 0.00652379 |
| UGT2B28 | UDP glucuronosyltransferase 2 family, polypeptide B28 | 0.00648515 |
| PLAT | plasminogen activator, tissue | 0.00643776 |
| EHD2 | EH-domain containing 2 | 0.00643406 |
| ELN | elastin | 0.0064236 |
| ACTN4 | actinin, alpha 4 | 0.00642168 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.00641944 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | 0.00638258 |
| GRHPR | glyoxylate reductase/hydroxypyruvate reductase | 0.00637797 |
| ITIH3 | inter-alpha-trypsin inhibitor heavy chain 3 | 0.00637088 |
| SLC43A3 | solute carrier family 43, member 3 | 0.00634011 |
| ATP1A1 | ATPase, Na+/K+ transporting, alpha 1 polypeptide | 0.00632761 |
| CPB2 | carboxypeptidase B2 (plasma) | 0.00631209 |
| MMP2 | matrix metallopeptidase 2 | 0.00629966 |
| PITX3 | paired-like homeodomain 3 | 0.00629361 |
| GAL | galanin/GMAP prepropeptide | 0.00628304 |
| MRC2 | mannose receptor, C type 2 | 0.00627265 |
| ALDH4A1 | aldehyde dehydrogenase 4 family, member A1 | 0.00625299 |
| PAX6 | paired box 6 | 0.00623435 |
| LOX | lysyl oxidase | 0.00622593 |
| PON1 | paraoxonase 1 | 0.00620884 |
| SOX11 | SRY (sex determining region Y)-box 11 | 0.00618422 |
| CBFB | core-binding factor, beta subunit | 0.00614748 |
| FAM3C | family with sequence similarity 3, member C | 0.00613236 |
| C4BPA | complement component 4 binding protein, alpha | 0.00612284 |
| SDC3 | syndecan 3 | 0.00611702 |
| MT1X | metallothionein 1X | 0.00610453 |
| GOLGA8H | golgin A8 family, member H | 0.00610081 |
| PLAGL1 | pleiomorphic adenoma gene-like 1 | 0.0060963 |
| MCUB | mitochondrial calcium uniporter dominant negative subunit beta | 0.00609414 |
| LMNB2 | lamin B2 | 0.00609135 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.00607907 |
| GBAP1 | glucosidase, beta, acid pseudogene 1 | 0.00607863 |
| NNMT | nicotinamide N-methyltransferase | 0.00607165 |
| ILVBL | ilvB (bacterial acetolactate synthase)-like | 0.00605233 |
| SDC1 | syndecan 1 | 0.006049 |
| MAEA | macrophage erythroblast attacher | 0.00603583 |
| DGCR8 | DGCR8 microprocessor complex subunit | 0.00602224 |
| MT1F | metallothionein 1F | 0.00601906 |
| CRP | C-reactive protein, pentraxin-related | 0.00599492 |
| IFITM2 | interferon induced transmembrane protein 2 | 0.00598834 |
| CALR | calreticulin | 0.00597936 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | 0.00596944 |
| KIF18B | kinesin family member 18B | 0.00592757 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 0.00590719 |
| DMD | dystrophin | 0.00585732 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.00585478 |
| LUM | lumican | 0.00581939 |
| KRT14 | keratin 14, type I | 0.00580647 |
| DAZAP1 | DAZ associated protein 1 | 0.00579243 |
| MOXD1 | monooxygenase, DBH-like 1 | 0.00578506 |
| CDC20 | cell division cycle 20 | 0.00577859 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | 0.0057719 |
| ABCA6 | ATP-binding cassette, sub-family A (ABC1), member 6 | 0.00577153 |
| PLSCR4 | phospholipid scramblase 4 | 0.00577051 |
| ABCB4 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | 0.00576624 |
| SERPINA7 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 | 0.00575286 |
| SOX10 | SRY (sex determining region Y)-box 10 | 0.00574208 |
| COL5A1 | collagen, type V, alpha 1 | 0.00573599 |
| TUBB3 | tubulin, beta 3 class III | 0.00573116 |
| CYP2C9 | cytochrome P450, family 2, subfamily C, polypeptide 9 | 0.00572288 |
| ADORA2B | adenosine A2b receptor | 0.00571977 |
| FBN2 | fibrillin 2 | 0.00571821 |
| SLC46A3 | solute carrier family 46, member 3 | 0.00571165 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.00570745 |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | 0.00570692 |
| AHSG | alpha-2-HS-glycoprotein | 0.00570116 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.00569596 |
| LYVE1 | lymphatic vessel endothelial hyaluronan receptor 1 | 0.00568028 |
| TUBB2A | tubulin, beta 2A class IIa | 0.00565206 |
| PRKCSH | protein kinase C substrate 80K-H | 0.00565113 |
| HMGB1 | high mobility group box 1 | 0.0056475 |
| FXYD5 | FXYD domain containing ion transport regulator 5 | 0.00561474 |
| FBLN2 | fibulin 2 | 0.00560857 |
| PIPOX | pipecolic acid oxidase | 0.00560482 |
| SERPIND1 | serpin peptidase inhibitor, clade D (heparin cofactor), member 1 | 0.00560312 |
| GGA1 | golgi-associated, gamma adaptin ear containing, ARF binding protein 1 | 0.00560194 |
| AOX1 | aldehyde oxidase 1 | 0.00558962 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | 0.00558645 |
| RAB8A | RAB8A, member RAS oncogene family | 0.00558504 |
| TOX | thymocyte selection-associated high mobility group box | 0.0055801 |
| RRBP1 | ribosome binding protein 1 | 0.00557579 |
| C9 | complement component 9 | 0.00557509 |
| SH3BP4 | SH3-domain binding protein 4 | 0.00554827 |
| KRT17 | keratin 17, type I | 0.00554713 |
| ENG | endoglin | 0.00554289 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.00553301 |
| MAB21L2 | mab-21-like 2 (C. elegans) | 0.00551531 |
| APOC2 | apolipoprotein C-II | 0.00551371 |
| DGKZ | diacylglycerol kinase, zeta | 0.0055099 |
| IQGAP2 | IQ motif containing GTPase activating protein 2 | 0.00550473 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | 0.00549945 |
| STK25 | serine/threonine kinase 25 | 0.00549548 |
| TMEM176A | transmembrane protein 176A | 0.00548305 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 0.00547501 |
| ZNF395 | zinc finger protein 395 | 0.00546598 |
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B | 0.00544861 |
| PCOLCE | procollagen C-endopeptidase enhancer | 0.0054454 |
| MCM2 | minichromosome maintenance complex component 2 | 0.00544534 |
| MPDZ | multiple PDZ domain protein | 0.00544261 |
| F9 | coagulation factor IX | 0.00544224 |
| ABHD17A | abhydrolase domain containing 17A | 0.00542335 |
| ELOVL2 | ELOVL fatty acid elongase 2 | 0.00541238 |
| SPINK2 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | 0.00539187 |
| LOXL2 | lysyl oxidase-like 2 | 0.00537326 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.00537239 |
| CD320 | CD320 molecule | 0.00537013 |
| DCHS1 | dachsous cadherin-related 1 | 0.00536936 |
| APOB | apolipoprotein B | 0.00536879 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.00536775 |
| TNIP2 | TNFAIP3 interacting protein 2 | 0.00535015 |
| LEPR | leptin receptor | 0.00534008 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | 0.00531667 |
| ADIPOR2 | adiponectin receptor 2 | 0.00529215 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.00529038 |
| APCS | amyloid P component, serum | 0.00528478 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 0.00528337 |
| LIMA1 | LIM domain and actin binding 1 | 0.00528308 |
| VKORC1 | vitamin K epoxide reductase complex, subunit 1 | 0.00527634 |
| KAZN | kazrin, periplakin interacting protein | 0.0052759 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.00527336 |
| COL11A1 | collagen, type XI, alpha 1 | 0.00526813 |
| SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | 0.00526735 |
| DHFR | dihydrofolate reductase | 0.00526605 |
| TLN1 | talin 1 | 0.00525649 |
| TBC1D16 | TBC1 domain family, member 16 | 0.00524143 |
| PUF60 | poly-U binding splicing factor 60KDa | 0.00522104 |
| NOP2 | NOP2 nucleolar protein | 0.00521423 |
| KPNA6 | karyopherin alpha 6 (importin alpha 7) | 0.00520684 |
| SLC35G2 | solute carrier family 35, member G2 | 0.00519344 |
| TSPO | translocator protein (18kDa) | 0.00518163 |
| OXTR | oxytocin receptor | 0.00518082 |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | 0.00518028 |
| TMEM176B | transmembrane protein 176B | 0.00517669 |
| OLFM4 | olfactomedin 4 | 0.00517467 |
| TFR2 | transferrin receptor 2 | 0.00516002 |
| NSD2 | nuclear receptor binding SET domain protein 2 | 0.00515011 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | 0.00514978 |
| KHSRP | KH-type splicing regulatory protein | 0.00513604 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | 0.00513567 |
| CTPS1 | CTP synthase 1 | 0.00511032 |
| DKK2 | dickkopf WNT signaling pathway inhibitor 2 | 0.0051058 |
| TRAF5 | TNF receptor-associated factor 5 | 0.00510459 |
| MFGE8 | milk fat globule-EGF factor 8 protein | 0.00510246 |
| MELK | maternal embryonic leucine zipper kinase | 0.00509495 |
| LOC283683 | uncharacterized LOC283683 | 0.00508998 |
| FOXM1 | forkhead box M1 | 0.00508334 |
| ACP2 | acid phosphatase 2, lysosomal | 0.00507299 |
| CYP2A6 | cytochrome P450, family 2, subfamily A, polypeptide 6 | 0.00507134 |
| KRT23 | keratin 23, type I | 0.00506819 |
| PMM2 | phosphomannomutase 2 | 0.00505912 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | 0.00505653 |
| RGN | regucalcin | 0.00505037 |
| WT1 | Wilms tumor 1 | 0.00504193 |
| FABP4 | fatty acid binding protein 4, adipocyte | 0.00503252 |
| Symbol | Name | Standardized Value |
|---|---|---|
| S100P | S100 calcium binding protein P | -0.0193727 |
| MSMB | microseminoprotein, beta- | -0.0146787 |
| EPCAM | epithelial cell adhesion molecule | -0.0137934 |
| CHP1 | calcineurin-like EF-hand protein 1 | -0.0132212 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0119643 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | -0.0118239 |
| NEBL | nebulette | -0.0112955 |
| ACP3 | acid phosphatase 3 | -0.0111743 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0110891 |
| MAP7 | microtubule-associated protein 7 | -0.0109165 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -0.0107242 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | -0.0105883 |
| SORD | sorbitol dehydrogenase | -0.0105436 |
| AGR2 | anterior gradient 2 | -0.0102835 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | -0.0102567 |
| OSR2 | odd-skipped related transciption factor 2 | -0.0101628 |
| ESRP1 | epithelial splicing regulatory protein 1 | -0.0099376 |
| GALC | galactosylceramidase | -0.00983728 |
| VEGFA | vascular endothelial growth factor A | -0.00967867 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | -0.00960608 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | -0.00943866 |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | -0.00943001 |
| LPAR6 | lysophosphatidic acid receptor 6 | -0.00940805 |
| ACOT9 | acyl-CoA thioesterase 9 | -0.00937502 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | -0.00935617 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.00920147 |
| HSPA1A | heat shock 70kDa protein 1A | -0.00900027 |
| HIST1H2BD | histone cluster 1, H2bd | -0.00894622 |
| HIST1H2AE | histone cluster 1, H2ae | -0.00891826 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.00878262 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.00877813 |
| NEFH | neurofilament, heavy polypeptide | -0.00874146 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | -0.00861797 |
| KLHL24 | kelch-like family member 24 | -0.00853785 |
| ATF3 | activating transcription factor 3 | -0.00852958 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | -0.00852246 |
| VAMP8 | vesicle-associated membrane protein 8 | -0.00851292 |
| HIST1H2AC | histone cluster 1, H2ac | -0.00848865 |
| EGR1 | early growth response 1 | -0.00844917 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | -0.00839374 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.00834121 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.00832317 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -0.00832241 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | -0.00822722 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.00815982 |
| PCP4 | Purkinje cell protein 4 | -0.00811331 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | -0.0080877 |
| UBFD1 | ubiquitin family domain containing 1 | -0.00805063 |
| HTATIP2 | HIV-1 Tat interactive protein 2, 30kDa | -0.00804807 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.00803216 |
| TNNT1 | troponin T type 1 (skeletal, slow) | -0.00796058 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.00795107 |
| FYB1 | FYN binding protein 1 | -0.0079417 |
| TPD52L1 | tumor protein D52-like 1 | -0.00784742 |
| GALNT3 | polypeptide N-acetylgalactosaminyltransferase 3 | -0.00779028 |
| CCNB1IP1 | cyclin B1 interacting protein 1, E3 ubiquitin protein ligase | -0.00771895 |
| ADIRF | adipogenesis regulatory factor | -0.00769731 |
| TSPAN1 | tetraspanin 1 | -0.00769226 |
| MX1 | MX dynamin-like GTPase 1 | -0.00765449 |
| CYTIP | cytohesin 1 interacting protein | -0.00765433 |
| OPN3 | opsin 3 | -0.00758559 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.00755358 |
| TBX3 | T-box 3 | -0.0074744 |
| COG7 | component of oligomeric golgi complex 7 | -0.00741639 |
| ZNF652 | zinc finger protein 652 | -0.00738427 |
| SVIL | supervillin | -0.00733603 |
| RIN2 | Ras and Rab interactor 2 | -0.00731047 |
| GAB2 | GRB2-associated binding protein 2 | -0.00728875 |
| DMAC2L | distal membrane arm assembly component 2 like | -0.00722029 |
| GALNT12 | polypeptide N-acetylgalactosaminyltransferase 12 | -0.00721088 |
| FOSL2 | FOS-like antigen 2 | -0.00719833 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | -0.007168 |
| MNDA | myeloid cell nuclear differentiation antigen | -0.00715092 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | -0.00712833 |
| EAPP | E2F-associated phosphoprotein | -0.007128 |
| EVI2A | ecotropic viral integration site 2A | -0.0070924 |
| KCNJ15 | potassium channel, inwardly rectifying subfamily J, member 15 | -0.0070811 |
| C3ORF52 | chromosome 3 open reading frame 52 | -0.00703723 |
| MLPH | melanophilin | -0.0069967 |
| TFF1 | trefoil factor 1 | -0.00699101 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.00698954 |
| AOC1 | amine oxidase, copper containing 1 | -0.00695629 |
| FLRT3 | fibronectin leucine rich transmembrane protein 3 | -0.00695392 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.00690873 |
| HSPB8 | heat shock 22kDa protein 8 | -0.00688988 |
| KLK11 | kallikrein-related peptidase 11 | -0.00685788 |
| HSPA2 | heat shock 70kDa protein 2 | -0.00684615 |
| SHTN1 | shootin 1 | -0.00681453 |
| TSPAN8 | tetraspanin 8 | -0.00678688 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | -0.00677994 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.00676056 |
| DNAJA2 | DnaJ (Hsp40) homolog, subfamily A, member 2 | -0.00671682 |
| CHKB | choline kinase beta | -0.00671565 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.00669336 |
| S100A12 | S100 calcium binding protein A12 | -0.00668919 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | -0.00668524 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0066455 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.00661456 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | -0.00659681 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.00655435 |
| KLK2 | kallikrein-related peptidase 2 | -0.00654458 |
| CNPY3 | canopy FGF signaling regulator 3 | -0.00648918 |
| CYBB | cytochrome b-245, beta polypeptide | -0.00647681 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.00646516 |
| FGF13 | fibroblast growth factor 13 | -0.0064282 |
| RGCC | regulator of cell cycle | -0.00642793 |
| CETN2 | centrin, EF-hand protein, 2 | -0.00642515 |
| MYLIP | myosin regulatory light chain interacting protein | -0.00641671 |
| ANXA3 | annexin A3 | -0.00641663 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.00640518 |
| PLN | phospholamban | -0.0063765 |
| TMC5 | transmembrane channel-like 5 | -0.00637373 |
| CLIC3 | chloride intracellular channel 3 | -0.0063541 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.00634207 |
| ADPRM | ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent | -0.00631786 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | -0.00631431 |
| MITF | microphthalmia-associated transcription factor | -0.00628869 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | -0.00627862 |
| LBH | limb bud and heart development | -0.00627654 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | -0.00626256 |
| CLEC4A | C-type lectin domain family 4, member A | -0.00625068 |
| FRMD4B | FERM domain containing 4B | -0.00624678 |
| EDNRA | endothelin receptor type A | -0.00620551 |
| PIR | pirin (iron-binding nuclear protein) | -0.00619925 |
| RCBTB2 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 | -0.00618281 |
| PSAP | prosaposin | -0.00615042 |
| SKAP2 | src kinase associated phosphoprotein 2 | -0.00614436 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.00612051 |
| ZNF165 | zinc finger protein 165 | -0.00611972 |
| ARHGAP6 | Rho GTPase activating protein 6 | -0.00609329 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -0.00608374 |
| THBD | thrombomodulin | -0.00606504 |
| KLK3 | kallikrein-related peptidase 3 | -0.0060486 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.00602135 |
| CDS1 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 | -0.00602034 |
| SLC39A4 | solute carrier family 39 (zinc transporter), member 4 | -0.00601672 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.00599782 |
| IL7R | interleukin 7 receptor | -0.00599415 |
| STX3 | syntaxin 3 | -0.00597645 |
| OGFRL1 | opioid growth factor receptor-like 1 | -0.00597328 |
| ENTPD1 | ectonucleoside triphosphate diphosphohydrolase 1 | -0.00597222 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | -0.00594235 |
| ATP6V1C1 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 | -0.00593174 |
| YPEL5 | yippee-like 5 (Drosophila) | -0.00592172 |
| NMD3 | NMD3 ribosome export adaptor | -0.00592121 |
| CST7 | cystatin F (leukocystatin) | -0.00592096 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.00591792 |
| MYRF | myelin regulatory factor | -0.00591393 |
| MME | membrane metallo-endopeptidase | -0.00589889 |
| HIST1H2BH | histone cluster 1, H2bh | -0.00589252 |
| KLK10 | kallikrein-related peptidase 10 | -0.0058914 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | -0.00586944 |
| PRRG4 | proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) | -0.00584403 |
| SLC44A4 | solute carrier family 44, member 4 | -0.00583541 |
| NMRK1 | nicotinamide riboside kinase 1 | -0.00583102 |
| KYNU | kynureninase | -0.00583034 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.00582926 |
| TSPAN31 | tetraspanin 31 | -0.00581856 |
| RHOB | ras homolog family member B | -0.00581771 |
| PYCARD | PYD and CARD domain containing | -0.00581457 |
| ADM | adrenomedullin | -0.00578178 |
| STXBP6 | syntaxin binding protein 6 (amisyn) | -0.00576008 |
| COPS2 | COP9 signalosome subunit 2 | -0.00576001 |
| SH3BGR | SH3 domain binding glutamate-rich protein | -0.00575597 |
| CD86 | CD86 molecule | -0.00575497 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0057545 |
| JAK2 | Janus kinase 2 | -0.00574304 |
| TSLIG2 | tRNA splicing ligase complex subunit 2 | -0.00572957 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.00572048 |
| MAPK1 | mitogen-activated protein kinase 1 | -0.00567968 |
| EHF | ets homologous factor | -0.00566152 |
| RIT1 | Ras-like without CAAX 1 | -0.00565194 |
| CD93 | CD93 molecule | -0.00564592 |
| MSRB2 | methionine sulfoxide reductase B2 | -0.005642 |
| OSER1 | oxidative stress responsive serine-rich 1 | -0.00563582 |
| PIGA | phosphatidylinositol glycan anchor biosynthesis, class A | -0.00563253 |
| CLNS1A | chloride channel, nucleotide-sensitive, 1A | -0.00562878 |
| SH3YL1 | SH3 and SYLF domain containing 1 | -0.00562737 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.00562617 |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | -0.00562374 |
| ABHD4 | abhydrolase domain containing 4 | -0.00562128 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.00561898 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.00561435 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | -0.00561116 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | -0.00560842 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.00560722 |
| PREPL | prolyl endopeptidase-like | -0.00560441 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | -0.00560302 |
| IGBP1 | immunoglobulin (CD79A) binding protein 1 | -0.00560228 |
| AVPI1 | arginine vasopressin-induced 1 | -0.00558331 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.00558231 |
| ZNF277 | zinc finger protein 277 | -0.00557712 |
| DAZAP2 | DAZ associated protein 2 | -0.00557686 |
| TMEM260 | transmembrane protein 260 | -0.00555711 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.00555426 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | -0.00554073 |
| RIOK3 | RIO kinase 3 | -0.00553496 |
| ABHD5 | abhydrolase domain containing 5 | -0.00553138 |
| ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | -0.00552638 |
| PAGE4 | P antigen family, member 4 (prostate associated) | -0.00551861 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.00550545 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.00549452 |
| INHBB | inhibin, beta B | -0.00549036 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | -0.00547908 |
| MRS2 | MRS2 magnesium transporter | -0.0054744 |
| SERINC5 | serine incorporator 5 | -0.00547388 |
| PDP1 | pyruvate dehyrogenase phosphatase catalytic subunit 1 | -0.00547112 |
| NPR3 | natriuretic peptide receptor 3 | -0.00546581 |
| EPHA4 | EPH receptor A4 | -0.0054607 |
| IL1RN | interleukin 1 receptor antagonist | -0.00545048 |
| S100A14 | S100 calcium binding protein A14 | -0.00545028 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.00544295 |
| SFRP4 | secreted frizzled-related protein 4 | -0.00543582 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.00543195 |
| POLR2J2 | polymerase (RNA) II (DNA directed) polypeptide J2 | -0.00541923 |
| MYCL | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog | -0.0054192 |
| TJP2 | tight junction protein 2 | -0.00541689 |
| SCUBE2 | signal peptide, CUB domain, EGF-like 2 | -0.00541663 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.00541264 |
| TUFT1 | tuftelin 1 | -0.00540575 |
| TBX2 | T-box 2 | -0.0053993 |
| BTG2 | BTG family, member 2 | -0.00539559 |
| NEU1 | sialidase 1 (lysosomal sialidase) | -0.00539378 |
| ATP5MJ | ATP synthase membrane subunit j | -0.00539136 |
| IL18 | interleukin 18 | -0.00538947 |
| RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) | -0.00538466 |
| PSMA6 | proteasome (prosome, macropain) subunit, alpha type, 6 | -0.0053801 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.00537318 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | -0.00537305 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.00537144 |
| POLE3 | polymerase (DNA directed), epsilon 3, accessory subunit | -0.00536981 |
| CST1 | cystatin SN | -0.00536959 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.00536456 |
| ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) | -0.00535514 |
| BACH1 | BTB and CNC homology 1, basic leucine zipper transcription factor 1 | -0.00534686 |
| CHMP4A | charged multivesicular body protein 4A | -0.00534186 |
| TXNIP | thioredoxin interacting protein | -0.00532525 |
| MBOAT7 | membrane bound O-acyltransferase domain containing 7 | -0.00532436 |
| NPIPB3 | nuclear pore complex interacting protein family, member B3 | -0.00532292 |
| GNS | glucosamine (N-acetyl)-6-sulfatase | -0.00532227 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.00532177 |
| GLUL | glutamate-ammonia ligase | -0.00532149 |
| DIO2 | deiodinase, iodothyronine, type II | -0.00531966 |
| WASHC3 | WASH complex subunit 3 | -0.0053137 |
| TMEM159 | transmembrane protein 159 | -0.00530726 |
| ATP6V1G1 | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 | -0.00530074 |
| ENTPD3 | ectonucleoside triphosphate diphosphohydrolase 3 | -0.00530058 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.00529077 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -0.00528906 |
