PCSK7 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description proprotein convertase subtilisin/kexin type 7|This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes and plays a role in the regulation of iron metabolism. A t(11;14)(q23;q32) chromosome translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq, Feb 2014] (NCBI Entrez Gene Database, 9159)
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Genes

292 genes differentially expressed following the PCSK7 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 3.31487
GJB3 gap junction protein, beta 3, 31kDa 3.31487
AADACL3 arylacetamide deacetylase-like 3 3.31487
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit 3.31487
SSTR4 somatostatin receptor 4 3.31487
MFAP4 microfibrillar-associated protein 4 3.31487
GIMAP4 GTPase, IMAP family member 4 3.31487
CA6 carbonic anhydrase VI 3.31487
BAAT bile acid CoA:amino acid N-acyltransferase 3.31487
OR2AG2 olfactory receptor, family 2, subfamily AG, member 2 3.31487
AZGP1 alpha-2-glycoprotein 1, zinc-binding 3.31487
NOD2 nucleotide-binding oligomerization domain containing 2 3.31487
ASB15 ankyrin repeat and SOCS box containing 15 3.31487
SLC46A2 solute carrier family 46, member 2 3.31487
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 3.31487
OR52A5 olfactory receptor, family 52, subfamily A, member 5 3.31487
PRICKLE4 prickle homolog 4 (Drosophila) 3.31487
CABP4 calcium binding protein 4 3.31487
CD163 CD163 molecule 3.31487
PNMA5 paraneoplastic Ma antigen family member 5 3.31487
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 3.31487
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 3.31487
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 3.31487
HES2 hes family bHLH transcription factor 2 3.31487
NWD2 NACHT and WD repeat domain containing 2 3.31487
RBP4 retinol binding protein 4, plasma 3.31487
CD226 CD226 molecule 3.31487
ICAM2 intercellular adhesion molecule 2 3.31487
MAGEC3 melanoma antigen family C3 3.31487
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 3.31487
ZNF396 zinc finger protein 396 3.31487
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 3.31487
HMX3 H6 family homeobox 3 3.31487
SP6 Sp6 transcription factor 3.31487
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 3.31487
S100A1 S100 calcium binding protein A1 3.31487
OR5V1 olfactory receptor, family 5, subfamily V, member 1 3.31487
GNRHR gonadotropin-releasing hormone receptor 3.31487
OXT oxytocin/neurophysin I prepropeptide 3.31487
MPL MPL proto-oncogene, thrombopoietin receptor 3.31487
TMC2 transmembrane channel-like 2 3.31487
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 3.31487
SOX30 SRY (sex determining region Y)-box 30 3.31487
SPATA31F3 SPATA31 subfamily F member 3 3.31487
TMEM271 transmembrane protein 271 3.31487
GPR35 G protein-coupled receptor 35 3.31487
CXCL13 chemokine (C-X-C motif) ligand 13 3.31487
RD3 retinal degeneration 3 3.31487
C9ORF43 chromosome 9 open reading frame 43 3.31487
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 3.31487
NEURL3 neuralized E3 ubiquitin protein ligase 3 3.31487
OR1C1 olfactory receptor, family 1, subfamily C, member 1 3.31487
PLAAT4 phospholipase A and acyltransferase 4 3.31487
MINAR2 membrane integral NOTCH2 associated receptor 2 3.31487
RNF227 ring finger protein 227 3.31487
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 3.31487
LIPT2-AS1 LIPT2 antisense RNA 1 3.31487
DEFB109B defensin beta 109B 3.31487
SPMIP3 sperm microtubule inner protein 3 3.31487
H2BK1 H2B.K variant histone 1 3.31487
TMEM238L transmembrane protein 238 like 3.31487
HOATZ HOATZ cilia and flagella associated protein 3.31487
TERB1 telomere repeat binding bouquet formation protein 1 3.31487
ASB4 ankyrin repeat and SOCS box containing 4 3.31487
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 3.31487
DLK2 delta-like 2 homolog (Drosophila) 3.31487
MAG myelin associated glycoprotein 3.31487
CHRD chordin 3.31487
C1ORF87 chromosome 1 open reading frame 87 3.31487
SPATA31G1 SPATA31 subfamily G member 1 3.31487
ERAS ES cell expressed Ras 3.31487
NRN1 neuritin 1 3.31487
COL19A1 collagen, type XIX, alpha 1 3.31487
ZNF285 zinc finger protein 285 3.31487
CLIP4 CAP-GLY domain containing linker protein family, member 4 3.31487
OR8D4 olfactory receptor, family 8, subfamily D, member 4 3.31487
C10ORF67 chromosome 10 open reading frame 67 3.31487
LRRC73 leucine rich repeat containing 73 3.31487
FMR1NB fragile X mental retardation 1 neighbor 3.31487
PGLYRP4 peptidoglycan recognition protein 4 3.31487
CDSN corneodesmosin 3.31487
FAM186A family with sequence similarity 186, member A 3.31487
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 3.31487
AWAT1 acyl-CoA wax alcohol acyltransferase 1 3.31487
UROC1 urocanate hydratase 1 3.31487
CFAP74 cilia and flagella associated protein 74 3.31487
PRPH2 peripherin 2 (retinal degeneration, slow) 3.31487
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 3.31487
ZNF541 zinc finger protein 541 3.31487
GP5 glycoprotein V (platelet) 3.31487
DDI1 DNA-damage inducible 1 homolog 1 (S. cerevisiae) 3.31487
LRTM2 leucine-rich repeats and transmembrane domains 2 3.31487
C18ORF63 chromosome 18 open reading frame 63 3.31487
CCNI2 cyclin I family, member 2 3.31487
OPRK1 opioid receptor, kappa 1 3.31487
C20ORF144 chromosome 20 open reading frame 144 3.31487
ERICH6 glutamate-rich 6 3.31487
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 3.31487
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 3.31487
KCNK3 potassium channel, two pore domain subfamily K, member 3 3.31487
NKX6-1 NK6 homeobox 1 3.31487
TMEM132D transmembrane protein 132D 3.31487
CST1 cystatin SN 3.31487
CST9 cystatin 9 (testatin) 3.31487
CLRN1 clarin 1 3.31487
ZNF750 zinc finger protein 750 3.31487
TF transferrin 3.31487
TAPBPL TAP binding protein-like 3.31487
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.31487
VSTM1 V-set and transmembrane domain containing 1 3.31487
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.31487
SAMD5 sterile alpha motif domain containing 5 3.31487
EGR2 early growth response 2 3.31487
ISL2 ISL LIM homeobox 2 3.31487
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 3.31487
PAGE2 P antigen family, member 2 (prostate associated) 3.31487
HKDC1 hexokinase domain containing 1 3.31487
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 3.31487
TDRD10 tudor domain containing 10 3.31487
TBC1D10C TBC1 domain family, member 10C 3.31487
FNDC9 fibronectin type III domain containing 9 3.31487
FNDC1 fibronectin type III domain containing 1 3.31487
MMP13 matrix metallopeptidase 13 3.31487
CCNA1 cyclin A1 3.31487
ACKR3 atypical chemokine receptor 3 3.31487
AMER3 APC membrane recruitment protein 3 3.31487
GH1 growth hormone 1 3.31487
SFTA2 surfactant associated 2 3.31487
CD8A CD8a molecule 3.31487
DMRTC1 DMRT-like family C1 3.31487
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 3.31487
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 3.31487
TMEM156 transmembrane protein 156 3.31487
XCR1 chemokine (C motif) receptor 1 3.31487
PADI3 peptidyl arginine deiminase, type III 3.31487
LRRC23 leucine rich repeat containing 23 3.31487
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 3.31487
SUN3 Sad1 and UNC84 domain containing 3 3.31487
WNT10A wingless-type MMTV integration site family, member 10A 3.31487
ZMYND12 zinc finger, MYND-type containing 12 3.31487
IL26 interleukin 26 3.31487
MORC1 MORC family CW-type zinc finger 1 3.31487
ZMYND10 zinc finger, MYND-type containing 10 3.31487
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 3.31487
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 3.31487
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 3.31487
RORC RAR-related orphan receptor C 3.31487
SUMO4 small ubiquitin-like modifier 4 3.16314
PCSK1 proprotein convertase subtilisin/kexin type 1 3.16314
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 3.16314
NUSAP1 nucleolar and spindle associated protein 1 3.07773
TECPR2 tectonin beta-propeller repeat containing 2 2.99216
YPEL5 yippee-like 5 (Drosophila) 2.96139
CBR4 carbonyl reductase 4 2.82075
PLPP5 phospholipid phosphatase 5 2.69513
SACK1H scaffolding CK1 anchoring protein H 2.66192
IST1 increased sodium tolerance 1 homolog (yeast) 2.65544
ASB18 ankyrin repeat and SOCS box containing 18 2.62105
ADGRE2 adhesion G protein-coupled receptor E2 2.53054
NFIB nuclear factor I/B 2.5172
ENTREP1 endosomal transmembrane epsin interactor 1 2.50135
ATAD1 ATPase family, AAA domain containing 1 2.49615
MAP9 microtubule-associated protein 9 2.49564
GCC1 GRIP and coiled-coil domain containing 1 2.4693
ANO4 anoctamin 4 2.37916
GPR68 G protein-coupled receptor 68 2.36861
ZFP28 ZFP28 zinc finger protein 2.36861
ACSM1 acyl-CoA synthetase medium-chain family member 1 2.36861
NSG1 neuron specific gene family member 1 2.32628
ANKRD35 ankyrin repeat domain 35 2.32628
PAXBP1 PAX3 and PAX7 binding protein 1 2.3245
KLHL5 kelch-like family member 5 2.32359
IQCC IQ motif containing C 2.31565
ACP4 acid phosphatase 4 2.31565
PXYLP1 2-phosphoxylose phosphatase 1 2.30535
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 2.30535
GPR22 G protein-coupled receptor 22 2.30067
SEMG1 semenogelin I 2.30067
ITGB1BP1 integrin beta 1 binding protein 1 2.30056
TMEM177 transmembrane protein 177 2.28702
JRKL JRK-like 2.28153
CDK16 cyclin-dependent kinase 16 2.2598
ACAD10 acyl-CoA dehydrogenase family, member 10 2.2339
SVBP small vasohibin binding protein 2.20826
ZNF135 zinc finger protein 135 2.20229
ACACB acetyl-CoA carboxylase beta 2.19616
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 2.19479
ALKAL2 ALK and LTK ligand 2 2.18839
BRAF B-Raf proto-oncogene, serine/threonine kinase 2.15762
ELMOD1 ELMO/CED-12 domain containing 1 2.15117
EPN3 epsin 3 2.15117
SNPH syntaphilin 2.15117
CFAP95 cilia and flagella associated protein 95 2.14064
NGB neuroglobin 2.13785
ABITRAM actin binding transcription modulator 2.13107
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 2.08889
DDAH2 dimethylarginine dimethylaminohydrolase 2 2.08625
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 2.08322
TSHZ2 teashirt zinc finger homeobox 2 2.07023
ZNF324 zinc finger protein 324 2.05902
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 2.05902
NFIA nuclear factor I/A 2.04979
DPH3 diphthamide biosynthesis 3 2.04926
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 2.03981

decreased expression

Symbol Name Standardized Value
FYB2 FYN binding protein 2 -3.31487
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit -3.31487
LIN37 lin-37 DREAM MuvB core complex component -3.31487
SLC30A3 solute carrier family 30 (zinc transporter), member 3 -3.31487
TRPV3 transient receptor potential cation channel, subfamily V, member 3 -3.31487
ATXN7L2 ataxin 7-like 2 -3.31487
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) -3.31487
BTBD19 BTB (POZ) domain containing 19 -3.31487
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) -3.31487
LKAAEAR1 LKAAEAR motif containing 1 -3.31487
DNAH1 dynein, axonemal, heavy chain 1 -3.31487
ADRA1A adrenoceptor alpha 1A -3.31487
COL20A1 collagen, type XX, alpha 1 -3.31487
AKAP3 A kinase (PRKA) anchor protein 3 -3.31487
CPHXL cytoplasmic polyadenylated homeobox like -3.31487
RPL28 ribosomal protein L28 -3.31487
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 -3.31487
C4ORF50 chromosome 4 open reading frame 50 -3.31487
COX8C cytochrome c oxidase subunit VIIIC -3.31487
ARMC12 armadillo repeat containing 12 -3.31487
MPPED1 metallophosphoesterase domain containing 1 -3.31487
CNTFR ciliary neurotrophic factor receptor -3.31487
CCR6 chemokine (C-C motif) receptor 6 -3.31487
TMIE transmembrane inner ear -3.31487
LOC124902694 uncharacterized LOC124902694 -3.31487
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 -3.31487
NTSR1 neurotensin receptor 1 (high affinity) -3.31487
CBX8 chromobox homolog 8 -3.31487
SCARF1 scavenger receptor class F, member 1 -3.31487
ADGRD1 adhesion G protein-coupled receptor D1 -3.31487
CLUL1 clusterin-like 1 (retinal) -3.31487
GPRC6A G protein-coupled receptor, class C, group 6, member A -3.31487
SHANK1 SH3 and multiple ankyrin repeat domains 1 -3.31487
GSDMA gasdermin A -3.31487
APOL6 apolipoprotein L, 6 -3.31487
CCDC177 coiled-coil domain containing 177 -3.31487
MAN2B2 mannosidase, alpha, class 2B, member 2 -3.31487
RPS16 ribosomal protein S16 -3.22215
SAMD14 sterile alpha motif domain containing 14 -3.00263
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -2.91586
RUMY1 regulator of UNG2 and MKLN1 interacting yippee protein 1 -2.83826
PANK1 pantothenate kinase 1 -2.79143
HSPD1 heat shock 60kDa protein 1 (chaperonin) -2.76951
CCDC150 coiled-coil domain containing 150 -2.75903
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -2.72853
COX7C cytochrome c oxidase subunit VIIc -2.70835
PIF1 PIF1 5'-to-3' DNA helicase -2.67164
NUB1 negative regulator of ubiquitin-like proteins 1 -2.64112
COQ4 coenzyme Q4 -2.6331
VRK2 vaccinia related kinase 2 -2.58924
CHML choroideremia-like (Rab escort protein 2) -2.50135
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) -2.49615
H2AC20 H2A clustered histone 20 -2.48475
EXTL2 exostosin-like glycosyltransferase 2 -2.40612
TMEM127 transmembrane protein 127 -2.37111
UQCRB ubiquinol-cytochrome c reductase binding protein -2.36626
GMPPA GDP-mannose pyrophosphorylase A -2.34971
RAD23A RAD23 homolog A (S. cerevisiae) -2.34846
IL32 interleukin 32 -2.34846
BMP8B bone morphogenetic protein 8b -2.34846
CSF1 colony stimulating factor 1 (macrophage) -2.34846
JHY junctional cadherin complex regulator -2.32707
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.32628
C16ORF54 chromosome 16 open reading frame 54 -2.31565
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -2.29017
DIAPH3 diaphanous-related formin 3 -2.26153
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 -2.24893
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 -2.24893
USP35 ubiquitin specific peptidase 35 -2.24893
TUBA1B tubulin, alpha 1b -2.23505
ADGRG5 adhesion G protein-coupled receptor G5 -2.1853
CCNE2 cyclin E2 -2.17002
CISD1 CDGSH iron sulfur domain 1 -2.16002
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -2.15181
MRPS18B mitochondrial ribosomal protein S18B -2.15117
KRT18 keratin 18, type I -2.11289
CCT7 chaperonin containing TCP1, subunit 7 (eta) -2.11132
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 -2.09536
CHAMP1 chromosome alignment maintaining phosphoprotein 1 -2.08889
LAT2 linker for activation of T cells family, member 2 -2.08591
RPL24 ribosomal protein L24 -2.07114
SRI sorcin -2.07016
ZNF426 zinc finger protein 426 -2.06653
FOXRED1 FAD-dependent oxidoreductase domain containing 1 -2.04926
ERP29 endoplasmic reticulum protein 29 -2.04318
SLC16A12 solute carrier family 16, member 12 -2.01905
RHOQ ras homolog family member Q -2.00593
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -2.00443