| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | proprotein convertase subtilisin/kexin type 9|This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] (NCBI Entrez Gene Database, 255738) |
| External Link | https://ncbi.nlm.nih.gov/gene/255738 |
| Similar Terms | |
| Downloads & Tools |
500 genes differentially expressed following the PCSK9 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PCNA | proliferating cell nuclear antigen | 0.0150237 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0140019 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.0113082 |
| CSTA | cystatin A (stefin A) | 0.0105916 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | 0.010282 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | 0.00996796 |
| ATF3 | activating transcription factor 3 | 0.00988255 |
| MSMB | microseminoprotein, beta- | 0.00962072 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.0095241 |
| KIAA0100 | KIAA0100 | 0.0093609 |
| GALNT3 | polypeptide N-acetylgalactosaminyltransferase 3 | 0.00935994 |
| TLCD3A | TLC domain containing 3A | 0.00928625 |
| INHBA | inhibin, beta A | 0.00914742 |
| KDM5D | lysine (K)-specific demethylase 5D | 0.00884242 |
| MPO | myeloperoxidase | 0.00879835 |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | 0.00877155 |
| TP53I3 | tumor protein p53 inducible protein 3 | 0.00858249 |
| MYO5C | myosin VC | 0.00832894 |
| CCN2 | cellular communication network factor 2 | 0.00826905 |
| TFF1 | trefoil factor 1 | 0.00813997 |
| GNPTAB | N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits | 0.00812928 |
| AREG | amphiregulin | 0.00775501 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 0.00767964 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.00732211 |
| CDS2 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 | 0.00729595 |
| LY75 | lymphocyte antigen 75 | 0.00721601 |
| TUBA1A | tubulin, alpha 1a | 0.00714047 |
| SPON1 | spondin 1, extracellular matrix protein | 0.0071045 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.00710436 |
| TSC22D3 | TSC22 domain family, member 3 | 0.00708282 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.00697762 |
| BPGM | 2,3-bisphosphoglycerate mutase | 0.00695843 |
| DSTN | destrin (actin depolymerizing factor) | 0.00694283 |
| BLNK | B-cell linker | 0.00692668 |
| MGP | matrix Gla protein | 0.00686319 |
| SLC44A4 | solute carrier family 44, member 4 | 0.00685631 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | 0.00683352 |
| CRYBG1 | crystallin beta-gamma domain containing 1 | 0.006805 |
| SCGB1A1 | secretoglobin, family 1A, member 1 (uteroglobin) | 0.0067482 |
| ITM2C | integral membrane protein 2C | 0.0066576 |
| DLST | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) | 0.00659994 |
| ZYX | zyxin | 0.00656587 |
| BCR | breakpoint cluster region | 0.0064869 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | 0.00645394 |
| PANK2 | pantothenate kinase 2 | 0.00643757 |
| NOP56 | NOP56 ribonucleoprotein | 0.00643169 |
| BAMBI | BMP and activin membrane-bound inhibitor | 0.00642173 |
| CENPU | centromere protein U | 0.00640102 |
| AEBP1 | AE binding protein 1 | 0.00637992 |
| FOXG1 | forkhead box G1 | 0.00633904 |
| MZB1 | marginal zone B and B1 cell-specific protein | 0.00631191 |
| IGLL1 | immunoglobulin lambda-like polypeptide 1 | 0.00630563 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 0.00626274 |
| MARCH2 | membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase | 0.00622067 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | 0.00621834 |
| MMP9 | matrix metallopeptidase 9 | 0.00621534 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | 0.00621208 |
| IQCG | IQ motif containing G | 0.0061946 |
| MREG | melanoregulin | 0.00618184 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 0.00616274 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.00615673 |
| INAVA | innate immunity activator | 0.00614768 |
| COL11A1 | collagen, type XI, alpha 1 | 0.00613468 |
| NEBL | nebulette | 0.00613037 |
| HIST1H2AC | histone cluster 1, H2ac | 0.00610761 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | 0.00608315 |
| CSNK2A1 | casein kinase 2, alpha 1 polypeptide | 0.00607598 |
| LXN | latexin | 0.00604173 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | 0.00603818 |
| RASA4 | RAS p21 protein activator 4 | 0.00603337 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.00600996 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.00599535 |
| DYRK4 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 | 0.00596653 |
| RANBP9 | RAN binding protein 9 | 0.00596398 |
| TASP1 | taspase, threonine aspartase, 1 | 0.00593023 |
| ACTN1 | actinin, alpha 1 | 0.00591872 |
| DLD | dihydrolipoamide dehydrogenase | 0.00587087 |
| TSPAN1 | tetraspanin 1 | 0.00584868 |
| AKTIP | AKT interacting protein | 0.00584774 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 0.00583992 |
| NME4 | NME/NM23 nucleoside diphosphate kinase 4 | 0.00582318 |
| TSPAN13 | tetraspanin 13 | 0.00579097 |
| TMX4 | thioredoxin-related transmembrane protein 4 | 0.00576226 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | 0.00575306 |
| CEP68 | centrosomal protein 68kDa | 0.0057527 |
| FLT3 | fms-related tyrosine kinase 3 | 0.0057444 |
| MSMO1 | methylsterol monooxygenase 1 | 0.00572921 |
| LIPT1 | lipoyltransferase 1 | 0.00569287 |
| CA12 | carbonic anhydrase XII | 0.00568583 |
| PALLD | palladin, cytoskeletal associated protein | 0.00566474 |
| B4GALT6 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 | 0.00565539 |
| CCT6B | chaperonin containing TCP1, subunit 6B (zeta 2) | 0.00563416 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.00562077 |
| S100A14 | S100 calcium binding protein A14 | 0.0055914 |
| AHCY | adenosylhomocysteinase | 0.00558829 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.00557433 |
| STK26 | serine/threonine protein kinase 26 | 0.00557415 |
| CCND2 | cyclin D2 | 0.00557236 |
| BHLHE41 | basic helix-loop-helix family, member e41 | 0.00557101 |
| MMP3 | matrix metallopeptidase 3 | 0.0055497 |
| SH3YL1 | SH3 and SYLF domain containing 1 | 0.00553638 |
| RHCG | Rh family, C glycoprotein | 0.0055353 |
| ATRN | attractin | 0.00553519 |
| CLEC11A | C-type lectin domain family 11, member A | 0.00551439 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.00550537 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | 0.00548711 |
| MMP10 | matrix metallopeptidase 10 | 0.00548314 |
| IL1RN | interleukin 1 receptor antagonist | 0.00547454 |
| DAXX | death-domain associated protein | 0.00547402 |
| SYBU | syntabulin (syntaxin-interacting) | 0.00547042 |
| SLC4A1 | solute carrier family 4 (anion exchanger), member 1 (Diego blood group) | 0.00546067 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.00545475 |
| FLNA | filamin A, alpha | 0.00544407 |
| REG1A | regenerating islet-derived 1 alpha | 0.00544145 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | 0.00544117 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.00542291 |
| MMP12 | matrix metallopeptidase 12 | 0.00539802 |
| XK | X-linked Kx blood group | 0.00539444 |
| JAG1 | jagged 1 | 0.00538599 |
| HBD | hemoglobin, delta | 0.00538065 |
| SLC15A2 | solute carrier family 15 (oligopeptide transporter), member 2 | 0.00537988 |
| MYB | v-myb avian myeloblastosis viral oncogene homolog | 0.00537891 |
| CLDN8 | claudin 8 | 0.00536189 |
| SIRT3 | sirtuin 3 | 0.00535734 |
| SCRG1 | stimulator of chondrogenesis 1 | 0.00535299 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.00534363 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.00533915 |
| GCA | grancalcin, EF-hand calcium binding protein | 0.00530602 |
| SPOP | speckle-type POZ protein | 0.00529811 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | 0.00529682 |
| TXNDC9 | thioredoxin domain containing 9 | 0.00528062 |
| TRIM22 | tripartite motif containing 22 | 0.00527663 |
| ANXA3 | annexin A3 | 0.00526252 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 0.0052563 |
| STON1 | stonin 1 | 0.00525161 |
| CETN2 | centrin, EF-hand protein, 2 | 0.00524397 |
| CHPT1 | choline phosphotransferase 1 | 0.005232 |
| VWA5A | von Willebrand factor A domain containing 5A | 0.0052218 |
| YBX3 | Y box binding protein 3 | 0.00521538 |
| ZNF185 | zinc finger protein 185 (LIM domain) | 0.00521216 |
| CLTB | clathrin, light chain B | 0.00519393 |
| LYZ | lysozyme | 0.00518057 |
| EMP1 | epithelial membrane protein 1 | 0.00514401 |
| OLFM4 | olfactomedin 4 | 0.00514325 |
| SELL | selectin L | 0.00513974 |
| ZNF165 | zinc finger protein 165 | 0.00513773 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | 0.00512773 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.00511436 |
| SMYD2 | SET and MYND domain containing 2 | 0.00511216 |
| EGFL6 | EGF-like-domain, multiple 6 | 0.00510403 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | 0.00510279 |
| MUC2 | mucin 2, oligomeric mucus/gel-forming | 0.00509843 |
| C3ORF52 | chromosome 3 open reading frame 52 | 0.00508863 |
| MLF1 | myeloid leukemia factor 1 | 0.00508349 |
| HSD11B2 | hydroxysteroid (11-beta) dehydrogenase 2 | 0.00508273 |
| BUD31 | BUD31 homolog (S. cerevisiae) | 0.00507532 |
| CLMN | calmin (calponin-like, transmembrane) | 0.00507011 |
| URI1 | URI1, prefoldin-like chaperone | 0.00505263 |
| CD9 | CD9 molecule | 0.00504667 |
| HSPA2 | heat shock 70kDa protein 2 | 0.00504483 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.00503102 |
| CPA3 | carboxypeptidase A3 (mast cell) | 0.00499689 |
| KRT5 | keratin 5, type II | 0.00499627 |
| TADA2A | transcriptional adaptor 2A | 0.00497883 |
| LEFTY1 | left-right determination factor 1 | 0.00496853 |
| RGCC | regulator of cell cycle | 0.0049644 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.00496215 |
| ACKR1 | atypical chemokine receptor 1 (Duffy blood group) | 0.00492137 |
| DNTT | DNA nucleotidylexotransferase | 0.00491992 |
| CLDN10 | claudin 10 | 0.00491707 |
| RAB25 | RAB25, member RAS oncogene family | 0.0049087 |
| MYO5A | myosin VA (heavy chain 12, myoxin) | 0.00490243 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | 0.00489498 |
| FERMT1 | fermitin family member 1 | 0.0048755 |
| KRT13 | keratin 13, type I | 0.00487467 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.00486253 |
| KLHL21 | kelch-like family member 21 | 0.00485629 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | 0.00485545 |
| CLCA4 | chloride channel accessory 4 | 0.00484509 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | 0.00484281 |
| ADIRF | adipogenesis regulatory factor | 0.00483272 |
| UNC119B | unc-119 homolog B (C. elegans) | 0.00482795 |
| KIF2C | kinesin family member 2C | 0.00482537 |
| AGR2 | anterior gradient 2 | 0.00482469 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0048229 |
| AHSP | alpha hemoglobin stabilizing protein | 0.00481471 |
| IDH3B | isocitrate dehydrogenase 3 (NAD+) beta | 0.00480413 |
| BTG2 | BTG family, member 2 | 0.0048034 |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 | 0.00479652 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.00478977 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | 0.00478263 |
| IRF6 | interferon regulatory factor 6 | 0.00477381 |
| ZNF107 | zinc finger protein 107 | 0.00476854 |
| AMZ2 | archaelysin family metallopeptidase 2 | 0.00475576 |
| CHRDL1 | chordin-like 1 | 0.00474544 |
| TNFAIP6 | tumor necrosis factor, alpha-induced protein 6 | 0.00474089 |
| RBM34 | RNA binding motif protein 34 | 0.00472655 |
| LRRC23 | leucine rich repeat containing 23 | 0.00471493 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 0.00470811 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.00470474 |
| GNAS | GNAS complex locus | 0.0047012 |
| TMEM100 | transmembrane protein 100 | 0.00469831 |
| SNRPB2 | small nuclear ribonucleoprotein polypeptide B | 0.00469727 |
| GSPT2 | G1 to S phase transition 2 | 0.00469598 |
| PRRG4 | proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) | 0.00468746 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.00468595 |
| NBEAL2 | neurobeachin-like 2 | 0.00467814 |
| MXRA5 | matrix-remodelling associated 5 | 0.00467721 |
| PTEN | phosphatase and tensin homolog | 0.00466334 |
| CCP110 | centriolar coiled coil protein 110kDa | 0.00465678 |
| HEBP2 | heme binding protein 2 | 0.00463775 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | 0.0046254 |
| AOC1 | amine oxidase, copper containing 1 | 0.00462389 |
| USP46 | ubiquitin specific peptidase 46 | 0.0046102 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.00460014 |
| OSER1 | oxidative stress responsive serine-rich 1 | 0.00459483 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.00459412 |
| NME5 | NME/NM23 family member 5 | 0.0045836 |
| RAB11A | RAB11A, member RAS oncogene family | 0.00458117 |
| TMEM230 | transmembrane protein 230 | 0.00457998 |
| RXYLT1 | ribitol xylosyltransferase 1 | 0.00457054 |
| SEPP1 | selenoprotein P, plasma, 1 | 0.00456671 |
| ZNF184 | zinc finger protein 184 | 0.00456576 |
| EGR1 | early growth response 1 | 0.00455428 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.00454652 |
| ANXA2P2 | annexin A2 pseudogene 2 | 0.00454475 |
| SEPTIN6 | septin 6 | 0.00454197 |
| LY6D | lymphocyte antigen 6 complex, locus D | 0.00450109 |
| FAM46C | family with sequence similarity 46, member C | 0.00449589 |
| PAN2 | PAN2 poly(A) specific ribonuclease subunit | 0.00449382 |
| MNS1 | meiosis-specific nuclear structural 1 | 0.00448925 |
| AREL1 | apoptosis resistant E3 ubiquitin protein ligase 1 | 0.00448787 |
| HSPB1 | heat shock 27kDa protein 1 | 0.00448002 |
| POLI | polymerase (DNA directed) iota | 0.00447758 |
| EAF2 | ELL associated factor 2 | 0.00447437 |
| NADSYN1 | NAD synthetase 1 | 0.00447096 |
| COPS7A | COP9 signalosome subunit 7A | 0.00446804 |
| STK38L | serine/threonine kinase 38 like | 0.00446679 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | 0.00445602 |
| RNFT2 | ring finger protein, transmembrane 2 | 0.00444914 |
| NFIL3 | nuclear factor, interleukin 3 regulated | 0.00444298 |
| TM7SF3 | transmembrane 7 superfamily member 3 | 0.00443856 |
| TYMS | thymidylate synthetase | 0.00443726 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.00443116 |
| PRR5L | proline rich 5 like | 0.00442279 |
| RCAN1 | regulator of calcineurin 1 | 0.00440413 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.00439163 |
| PHF20 | PHD finger protein 20 | 0.00439158 |
| ALDH5A1 | aldehyde dehydrogenase 5 family, member A1 | 0.00439031 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | 0.00438864 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RTN2 | reticulon 2 | -0.0135906 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.0131351 |
| XIC | X chromosome inactivation center | -0.0116921 |
| DLK1 | delta-like 1 homolog (Drosophila) | -0.0114116 |
| RB1 | retinoblastoma 1 | -0.0112423 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0101561 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 | -0.0100342 |
| MEF2C | myocyte enhancer factor 2C | -0.00999058 |
| S100A4 | S100 calcium binding protein A4 | -0.00948486 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.00944265 |
| LUM | lumican | -0.00906838 |
| MYBPC1 | myosin binding protein C, slow type | -0.00893007 |
| REEP1 | receptor accessory protein 1 | -0.00877597 |
| HNMT | histamine N-methyltransferase | -0.00869248 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | -0.00847859 |
| ANPEP | alanyl (membrane) aminopeptidase | -0.00839989 |
| FST | follistatin | -0.00838553 |
| MMP2 | matrix metallopeptidase 2 | -0.00829683 |
| C4BPA | complement component 4 binding protein, alpha | -0.00829662 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.00824243 |
| TWIST1 | twist family bHLH transcription factor 1 | -0.00776626 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.00775638 |
| DCLK1 | doublecortin-like kinase 1 | -0.00775545 |
| C3 | complement component 3 | -0.00754947 |
| MEIS2 | Meis homeobox 2 | -0.00753667 |
| HSPA1A | heat shock 70kDa protein 1A | -0.00747829 |
| MYL1 | myosin, light chain 1, alkali; skeletal, fast | -0.00742351 |
| CDCA4 | cell division cycle associated 4 | -0.00739313 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | -0.00737423 |
| TTN | titin | -0.007349 |
| FBN2 | fibrillin 2 | -0.007263 |
| GPC3 | glypican 3 | -0.00722352 |
| ADCY9 | adenylate cyclase 9 | -0.00720809 |
| HOXA10 | homeobox A10 | -0.00720749 |
| KRT23 | keratin 23, type I | -0.00719687 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | -0.00719603 |
| DPYD | dihydropyrimidine dehydrogenase | -0.00711903 |
| CTSH | cathepsin H | -0.00711144 |
| MEST | mesoderm specific transcript | -0.00708922 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0070795 |
| MYBPC2 | myosin binding protein C, fast type | -0.00705664 |
| WNT5A | wingless-type MMTV integration site family, member 5A | -0.00705545 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.00700961 |
| TNNC2 | troponin C type 2 (fast) | -0.00700193 |
| TNNI2 | troponin I type 2 (skeletal, fast) | -0.00697794 |
| CGA | glycoprotein hormones, alpha polypeptide | -0.00697411 |
| TPBG | trophoblast glycoprotein | -0.00694191 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.00692937 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.00688805 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0067568 |
| IRS1 | insulin receptor substrate 1 | -0.00674879 |
| FBP1 | fructose-1,6-bisphosphatase 1 | -0.0067456 |
| SMC1A | structural maintenance of chromosomes 1A | -0.00673541 |
| SNAI2 | snail family zinc finger 2 | -0.00671379 |
| DIPK1A | divergent protein kinase domain 1A | -0.00661187 |
| TDO2 | tryptophan 2,3-dioxygenase | -0.00660973 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | -0.00659573 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.00659204 |
| MET | MET proto-oncogene, receptor tyrosine kinase | -0.00652645 |
| NAV2 | neuron navigator 2 | -0.00649946 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | -0.00648081 |
| TMSB15A | thymosin beta 15a | -0.00645312 |
| CKM | creatine kinase, muscle | -0.00638594 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.00635037 |
| NRCAM | neuronal cell adhesion molecule | -0.00631494 |
| MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog | -0.00630471 |
| EIF1AX | eukaryotic translation initiation factor 1A, X-linked | -0.00629009 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.00627914 |
| HABP2 | hyaluronan binding protein 2 | -0.00625067 |
| ACO2 | aconitase 2, mitochondrial | -0.00623922 |
| LAPTM4B | lysosomal protein transmembrane 4 beta | -0.00622468 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | -0.00619766 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.00612861 |
| TYMP | thymidine phosphorylase | -0.00610379 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | -0.00610177 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | -0.00610116 |
| PLPP3 | phospholipid phosphatase 3 | -0.00607694 |
| DYNLL1 | dynein, light chain, LC8-type 1 | -0.00602132 |
| KCNJ2 | potassium channel, inwardly rectifying subfamily J, member 2 | -0.00599181 |
| TNNC1 | troponin C type 1 (slow) | -0.00598817 |
| DLX5 | distal-less homeobox 5 | -0.00596458 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | -0.00595239 |
| KLHL41 | kelch-like family member 41 | -0.00594041 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.00590555 |
| TNNI1 | troponin I type 1 (skeletal, slow) | -0.00586084 |
| HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) | -0.00583944 |
| NPM3 | nucleophosmin/nucleoplasmin 3 | -0.00583582 |
| CCNL2 | cyclin L2 | -0.00580778 |
| CHST1 | carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 | -0.00577499 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | -0.00576568 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | -0.00576152 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -0.00576137 |
| GABRE | gamma-aminobutyric acid (GABA) A receptor, epsilon | -0.00574305 |
| SNX7 | sorting nexin 7 | -0.00573225 |
| SHOX2 | short stature homeobox 2 | -0.00570272 |
| SERPIND1 | serpin peptidase inhibitor, clade D (heparin cofactor), member 1 | -0.00568835 |
| MFSD10 | major facilitator superfamily domain containing 10 | -0.00566047 |
| APOC3 | apolipoprotein C-III | -0.0056559 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -0.00564912 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.00562365 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | -0.0056193 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | -0.00561388 |
| NELL1 | NEL-like 1 (chicken) | -0.00561299 |
| MYL2 | myosin, light chain 2, regulatory, cardiac, slow | -0.005601 |
| AURKB | aurora kinase B | -0.00558059 |
| CD164 | CD164 molecule, sialomucin | -0.005476 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | -0.00547502 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.00547187 |
| SLC47A1 | solute carrier family 47 (multidrug and toxin extrusion), member 1 | -0.00546792 |
| ATP6V0A1 | ATPase, H+ transporting, lysosomal V0 subunit a1 | -0.0054589 |
| NECTIN3 | nectin cell adhesion molecule 3 | -0.00545238 |
| MYOF | myoferlin | -0.00545214 |
| PRSS21 | protease, serine, 21 (testisin) | -0.0054373 |
| MB | myoglobin | -0.00543724 |
| DMD | dystrophin | -0.00538872 |
| PRAME | preferentially expressed antigen in melanoma | -0.00538447 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.00537475 |
| RDX | radixin | -0.00536497 |
| CLEC2B | C-type lectin domain family 2, member B | -0.0053579 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.00534678 |
| BIN1 | bridging integrator 1 | -0.00534296 |
| NCAM1 | neural cell adhesion molecule 1 | -0.00532585 |
| FZD10 | frizzled class receptor 10 | -0.00532206 |
| MYOT | myotilin | -0.00527644 |
| OSMR | oncostatin M receptor | -0.0052646 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0052586 |
| LOXL2 | lysyl oxidase-like 2 | -0.00525101 |
| HAMP | hepcidin antimicrobial peptide | -0.00525034 |
| GGTLC1 | gamma-glutamyltransferase light chain 1 | -0.00524395 |
| ACADVL | acyl-CoA dehydrogenase, very long chain | -0.0052375 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.00523678 |
| CBS | cystathionine-beta-synthase | -0.00522969 |
| FRS2 | fibroblast growth factor receptor substrate 2 | -0.00522251 |
| COLEC12 | collectin sub-family member 12 | -0.0052169 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | -0.00521051 |
| MTRR | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | -0.0051456 |
| TGOLN2 | trans-golgi network protein 2 | -0.00513889 |
| VSIG4 | V-set and immunoglobulin domain containing 4 | -0.00512048 |
| LOX | lysyl oxidase | -0.00511391 |
| CD14 | CD14 molecule | -0.00509333 |
| ABCB4 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | -0.00509166 |
| CPM | carboxypeptidase M | -0.00508405 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.00506745 |
| MYLPF | myosin light chain, phosphorylatable, fast skeletal muscle | -0.00505969 |
| NNMT | nicotinamide N-methyltransferase | -0.00505916 |
| ZIC1 | Zic family member 1 | -0.0050591 |
| CYP2A6 | cytochrome P450, family 2, subfamily A, polypeptide 6 | -0.00504064 |
| NID1 | nidogen 1 | -0.00503726 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.00502839 |
| CSF1R | colony stimulating factor 1 receptor | -0.00502356 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | -0.00501736 |
| ACP2 | acid phosphatase 2, lysosomal | -0.00499925 |
| HDAC1 | histone deacetylase 1 | -0.00499147 |
| ERBIN | erbb2 interacting protein | -0.00498833 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | -0.00498784 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | -0.00497669 |
| COL4A5 | collagen, type IV, alpha 5 | -0.00497395 |
| CADM1 | cell adhesion molecule 1 | -0.00496997 |
| PMP22 | peripheral myelin protein 22 | -0.00496941 |
| PLEKHM1 | pleckstrin homology domain containing, family M (with RUN domain) member 1 | -0.00496418 |
| AHR | aryl hydrocarbon receptor | -0.00495895 |
| TMEM176B | transmembrane protein 176B | -0.00495608 |
| BST2 | bone marrow stromal cell antigen 2 | -0.00495402 |
| CCL8 | chemokine (C-C motif) ligand 8 | -0.00495375 |
| SUB1 | SUB1 homolog (S. cerevisiae) | -0.00494871 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | -0.00494839 |
| VEGFC | vascular endothelial growth factor C | -0.00494521 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0049354 |
| GGCX | gamma-glutamyl carboxylase | -0.00493367 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | -0.00491534 |
| CBX1 | chromobox homolog 1 | -0.00488765 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | -0.00487919 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | -0.00486774 |
| ALB | albumin | -0.00486424 |
| SCUBE2 | signal peptide, CUB domain, EGF-like 2 | -0.00486423 |
| C9 | complement component 9 | -0.00486358 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | -0.00485835 |
| NIT1 | nitrilase 1 | -0.00485732 |
| PDP1 | pyruvate dehyrogenase phosphatase catalytic subunit 1 | -0.00483274 |
| PDZRN3 | PDZ domain containing ring finger 3 | -0.00481821 |
| IL17B | interleukin 17B | -0.00477987 |
| TBX3 | T-box 3 | -0.00477644 |
| MCCC2 | methylcrotonoyl-CoA carboxylase 2 (beta) | -0.0047704 |
| MKNK1 | MAP kinase interacting serine/threonine kinase 1 | -0.00474338 |
| HMG20B | high mobility group 20B | -0.00474035 |
| GPR37 | G protein-coupled receptor 37 (endothelin receptor type B-like) | -0.00473119 |
| CRP | C-reactive protein, pentraxin-related | -0.00473075 |
| SDHAP1 | succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 1 | -0.00472716 |
| PLAT | plasminogen activator, tissue | -0.00472181 |
| MOK | MOK protein kinase | -0.00471922 |
| HOXB2 | homeobox B2 | -0.00471676 |
| OPHN1 | oligophrenin 1 | -0.0047151 |
| BMI1 | BMI1 proto-oncogene, polycomb ring finger | -0.00470825 |
| MFAP2 | microfibrillar-associated protein 2 | -0.0046987 |
| CD36 | CD36 molecule (thrombospondin receptor) | -0.00469303 |
| BSG | basigin (Ok blood group) | -0.00468269 |
| DOCK9 | dedicator of cytokinesis 9 | -0.00466429 |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) | -0.00466014 |
| ISL1 | ISL LIM homeobox 1 | -0.00465794 |
| SFTPB | surfactant protein B | -0.00465105 |
| PUDP | pseudouridine 5'-phosphatase | -0.00464839 |
| PDE4DIP | phosphodiesterase 4D interacting protein | -0.00464658 |
| GGT1 | gamma-glutamyltransferase 1 | -0.00464536 |
| SDHA | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | -0.00464012 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0046395 |
| NAV3 | neuron navigator 3 | -0.00463517 |
| RGS16 | regulator of G-protein signaling 16 | -0.00463266 |
| RNF167 | ring finger protein 167 | -0.00461936 |
| CYP2B6 | cytochrome P450, family 2, subfamily B, polypeptide 6 | -0.00461211 |
| SCARB2 | scavenger receptor class B, member 2 | -0.00461038 |
| KRT17 | keratin 17, type I | -0.00460995 |
| RNPS1 | RNA binding protein S1, serine-rich domain | -0.00459948 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | -0.00458851 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.00458816 |
| COL3A1 | collagen, type III, alpha 1 | -0.00458349 |
| ENO3 | enolase 3 (beta, muscle) | -0.00458179 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.00457829 |
| CHP1 | calcineurin-like EF-hand protein 1 | -0.0045754 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.00457366 |
| TENM3 | teneurin transmembrane protein 3 | -0.00457154 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.00457072 |
| C2 | complement component 2 | -0.00455606 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.00455342 |
| ITM2B | integral membrane protein 2B | -0.00454322 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.00454256 |
| MYOZ2 | myozenin 2 | -0.00454135 |
| ADGRF5 | adhesion G protein-coupled receptor F5 | -0.00453748 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0045365 |
| RXRA | retinoid X receptor, alpha | -0.00452967 |
| C3AR1 | complement component 3a receptor 1 | -0.00452689 |
| CPS1 | carbamoyl-phosphate synthase 1, mitochondrial | -0.0045198 |
| HHEX | hematopoietically expressed homeobox | -0.00451621 |
| APOB | apolipoprotein B | -0.00451258 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | -0.00451024 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | -0.004508 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | -0.00450391 |
| ACTA1 | actin, alpha 1, skeletal muscle | -0.00450343 |
| CD302 | CD302 molecule | -0.00449551 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | -0.00448321 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.00447838 |
| MOXD1 | monooxygenase, DBH-like 1 | -0.00447767 |
| TSPAN4 | tetraspanin 4 | -0.00446788 |
| TGFB1 | transforming growth factor, beta 1 | -0.00446702 |
| RGL1 | ral guanine nucleotide dissociation stimulator-like 1 | -0.00446591 |
| ANXA1 | annexin A1 | -0.00446424 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | -0.00445663 |
| EPHX1 | epoxide hydrolase 1, microsomal (xenobiotic) | -0.00445431 |
| TMED5 | transmembrane emp24 protein transport domain containing 5 | -0.00445174 |
| FOXF1 | forkhead box F1 | -0.00444824 |
| TPM3 | tropomyosin 3 | -0.00443795 |
