PCYT2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description phosphate cytidylyltransferase 2, ethanolamine|This gene encodes an enzyme that catalyzes the formation of CDP-ethanolamine from CTP and phosphoethanolamine in the Kennedy pathway of phospholipid synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] (NCBI Entrez Gene Database, 5833)
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Genes

333 genes differentially expressed following the PCYT2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SIX1 SIX homeobox 1 3.41208
HES3 hes family bHLH transcription factor 3 3.41208
OSGIN1 oxidative stress induced growth inhibitor 1 3.41208
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like 3.41208
CASP4 caspase 4, apoptosis-related cysteine peptidase 3.41208
SYNPO2L synaptopodin 2-like 3.41208
CCNB3 cyclin B3 3.41208
CCL5 chemokine (C-C motif) ligand 5 3.41208
MUC5B mucin 5B, oligomeric mucus/gel-forming 3.41208
XCL1 chemokine (C motif) ligand 1 3.41208
OLFM4 olfactomedin 4 3.41208
RAX retina and anterior neural fold homeobox 3.41208
PRELP proline/arginine-rich end leucine-rich repeat protein 3.41208
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung) 3.41208
TMPRSS11E transmembrane protease, serine 11E 3.41208
SOX1 SRY (sex determining region Y)-box 1 3.41208
ZACN zinc activated ligand-gated ion channel 3.41208
PARP3 poly (ADP-ribose) polymerase family, member 3 3.41208
NR1H4 nuclear receptor subfamily 1, group H, member 4 3.41208
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 3.41208
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 3.41208
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 3.41208
NCMAP noncompact myelin associated protein 3.41208
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 3.41208
CIITA class II, major histocompatibility complex, transactivator 3.41208
TAS2R10 taste receptor, type 2, member 10 3.41208
PRDM13 PR domain containing 13 3.41208
MYO16 myosin XVI 3.41208
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 3.41208
CSNK2A3 casein kinase 2, alpha 3 polypeptide 3.41208
OIT3 oncoprotein induced transcript 3 3.41208
NCR2 natural cytotoxicity triggering receptor 2 3.41208
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 3.41208
BTBD16 BTB (POZ) domain containing 16 3.41208
SMCO3 single-pass membrane protein with coiled-coil domains 3 3.41208
HBM hemoglobin, mu 3.41208
LRRC61 leucine rich repeat containing 61 3.41208
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 3.41208
FSCN2 fascin actin-bundling protein 2, retinal 3.41208
GMFG glia maturation factor, gamma 3.41208
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) 3.41208
CRIP2 cysteine-rich protein 2 3.41208
NEUROG2 neurogenin 2 3.41208
DPPA3 developmental pluripotency associated 3 3.41208
KIF2B kinesin family member 2B 3.41208
OC90 otoconin 90 3.41208
HIPK4 homeodomain interacting protein kinase 4 3.41208
DSPP dentin sialophosphoprotein 3.41208
SPMAP1 sperm microtubule associated protein 1 3.41208
ALPG alkaline phosphatase, germ cell 3.41208
VSIR V-set immunoregulatory receptor 3.41208
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 3.41208
PCDHGA9 protocadherin gamma subfamily A, 9 3.41208
OTOF otoferlin 3.41208
BGN biglycan 3.41208
RAG1 recombination activating gene 1 3.41208
SAPCD1 suppressor APC domain containing 1 3.41208
TYROBP TYRO protein tyrosine kinase binding protein 3.41208
TRPC7 transient receptor potential cation channel, subfamily C, member 7 3.41208
CCDC198 coiled-coil domain containing 198 3.41208
CLXN calaxin 3.41208
THSD8 thrombospondin type 1 domain containing 8 3.41208
PPIAL4H peptidylprolyl isomerase A like 4H 3.41208
DEFB109B defensin beta 109B 3.41208
LOC124906010 uncharacterized LOC124906010 3.41208
H3C13 H3 clustered histone 13 3.41208
TEX13D TEX13 family member D 3.41208
SEPTIN12 septin 12 3.41208
H2BW2 H2B.W histone 2 3.41208
DIPK1C divergent protein kinase domain 1C 3.41208
CFAP119 cilia and flagella associated protein 119 3.41208
CXCL13 chemokine (C-X-C motif) ligand 13 3.41208
SIM1 single-minded family bHLH transcription factor 1 3.41208
DAO D-amino-acid oxidase 3.41208
VSX2 visual system homeobox 2 3.41208
CHRD chordin 3.41208
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 3.41208
NXPE1 neurexophilin and PC-esterase domain family, member 1 3.41208
TUBA3D tubulin, alpha 3d 3.41208
TUBA3C tubulin, alpha 3c 3.41208
CATSPERT catsper channel auxiliary subunit tau 3.41208
IL36G interleukin 36, gamma 3.41208
FPR1 formyl peptide receptor 1 3.41208
PSAPL1 prosaposin-like 1 (gene/pseudogene) 3.41208
LIX1 Lix1 homolog (chicken) 3.41208
PCP4L1 Purkinje cell protein 4 like 1 3.41208
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 3.41208
PRDM7 PR domain containing 7 3.41208
ASIC3 acid sensing (proton gated) ion channel 3 3.41208
GDF6 growth differentiation factor 6 3.41208
GLIPR1L2 GLI pathogenesis-related 1 like 2 3.41208
S100G S100 calcium binding protein G 3.41208
CCR8 chemokine (C-C motif) receptor 8 3.41208
CCR4 chemokine (C-C motif) receptor 4 3.41208
HSPB6 heat shock protein, alpha-crystallin-related, B6 3.41208
RAET1G retinoic acid early transcript 1G 3.41208
CPZ carboxypeptidase Z 3.41208
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 3.41208
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 3.41208
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 3.41208
CBX8 chromobox homolog 8 3.41208
IL36R interleukin 36 receptor 3.41208
EMP1 epithelial membrane protein 1 3.41208
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 3.41208
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 3.41208
VWA7 von Willebrand factor A domain containing 7 3.41208
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 3.41208
GOLGA6C golgin A6 family, member C 3.41208
MKRN3 makorin ring finger protein 3 3.41208
DRD2 dopamine receptor D2 3.41208
FNDC9 fibronectin type III domain containing 9 3.41208
LRRC43 leucine rich repeat containing 43 3.41208
ARHGAP20 Rho GTPase activating protein 20 3.41208
LCT lactase 3.41208
CDC20B cell division cycle 20B 3.41208
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 3.41208
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 3.41208
CLRN2 clarin 2 3.41208
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 3.41208
RHCG Rh family, C glycoprotein 3.41208
IL19 interleukin 19 3.41208
PCDHA13 protocadherin alpha 13 3.41208
CXORF58 chromosome X open reading frame 58 3.41208
EOMES eomesodermin 3.41208
NPY2R neuropeptide Y receptor Y2 3.41208
TMEM255A transmembrane protein 255A 3.41208
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 3.41208
GJC2 gap junction protein, gamma 2, 47kDa 3.41208
GOLGA8T golgin A8 family, member T 3.41208
CCDC178 coiled-coil domain containing 178 3.41208
LRRC24 leucine rich repeat containing 24 3.41208
CFP complement factor properdin 3.41208
PCDH20 protocadherin 20 3.41208
DDI1 DNA-damage inducible 1 homolog 1 (S. cerevisiae) 3.41208
SPATA9 spermatogenesis associated 9 3.41208
CRYBA1 crystallin, beta A1 3.41208
SCUBE2 signal peptide, CUB domain, EGF-like 2 3.41208
SCNN1D sodium channel, non voltage gated 1 delta subunit 3.41208
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 3.41208
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 3.41208
ATP10B ATPase, class V, type 10B 3.41208
CDH22 cadherin 22, type 2 3.41208
LGALS14 lectin, galactoside-binding, soluble, 14 3.41208
PCDHAC1 protocadherin alpha subfamily C, 1 3.41208
PCDHGB5 protocadherin gamma subfamily B, 5 3.41208
LST1 leukocyte specific transcript 1 3.41208
NLRP6 NLR family, pyrin domain containing 6 3.41208
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 3.41208
FOXG1 forkhead box G1 3.41208
ACSM1 acyl-CoA synthetase medium-chain family member 1 3.41208
ECM1 extracellular matrix protein 1 3.41208
TAS2R43 taste receptor, type 2, member 43 3.41208
ACKR2 atypical chemokine receptor 2 3.41208
ERP27 endoplasmic reticulum protein 27 3.41208
FOXP3 forkhead box P3 3.41208
TUBAL3 tubulin, alpha-like 3 3.41208
CGA glycoprotein hormones, alpha polypeptide 3.41208
NUTM2F NUT family member 2F 3.41208
DMTN dematin actin binding protein 3.41208
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 3.41208
PDCD1 programmed cell death 1 3.41208
PRSS55 protease, serine, 55 3.41208
NEUROD2 neuronal differentiation 2 3.41208
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 3.41208
PRSS57 protease, serine, 57 3.41208
NEUROD1 neuronal differentiation 1 3.41208
TBC1D28 TBC1 domain family, member 28 3.41208
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 3.33486
GHR growth hormone receptor 3.30955
DKK2 dickkopf WNT signaling pathway inhibitor 2 3.30955
FGF2 fibroblast growth factor 2 (basic) 3.19061
SCAMP5 secretory carrier membrane protein 5 3.13067
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 2.96962
WDR36 WD repeat domain 36 2.88487
IFITM3 interferon induced transmembrane protein 3 2.87572
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 2.8722
COPE coatomer protein complex, subunit epsilon 2.83167
DNHD1 dynein heavy chain domain 1 2.79318
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 2.7878
KCTD2 potassium channel tetramerization domain containing 2 2.7797
NOCT nocturnin 2.7258
CHDH choline dehydrogenase 2.63172
SOX3 SRY (sex determining region Y)-box 3 2.60397
RPL39L ribosomal protein L39-like 2.54917
ARID4B AT rich interactive domain 4B (RBP1-like) 2.54825
GK glycerol kinase 2.54825
PDLIM3 PDZ and LIM domain 3 2.52945
SCML2 sex comb on midleg-like 2 (Drosophila) 2.50458
PZP pregnancy-zone protein 2.42912
RUMY3 RUMY family member 3 2.42175
CRHR1 corticotropin releasing hormone receptor 1 2.41297
CCNK cyclin K 2.38576
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.36325
IFT57 intraflagellar transport 57 2.36035
OGG1 8-oxoguanine DNA glycosylase 2.36035
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 2.35944
ZNF33B zinc finger protein 33B 2.33652
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 2.3226
STK11IP serine/threonine kinase 11 interacting protein 2.27221
SAV1 salvador family WW domain containing protein 1 2.26777
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 2.25127
GPX2 glutathione peroxidase 2 2.25127
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma 2.25127
CTIF CBP80/20-dependent translation initiation factor 2.21509
POLM polymerase (DNA directed), mu 2.18903
CDK7 cyclin-dependent kinase 7 2.1671
ZDHHC20 zinc finger, DHHC-type containing 20 2.1671
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 2.1671
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 2.1671
SCOC short coiled-coil protein 2.1671
IARS1 isoleucyl-tRNA synthetase 1 2.15818
SLC25A51 solute carrier family 25, member 51 2.15058
AFAP1L2 actin filament associated protein 1-like 2 2.14775
ZFP69 ZFP69 zinc finger protein 2.14619
FMNL3 formin-like 3 2.1215
TECPR1 tectonin beta-propeller repeat containing 1 2.10267
MANBA mannosidase, beta A, lysosomal 2.09859
PCCA propionyl CoA carboxylase, alpha polypeptide 2.08516
CFAP70 cilia and flagella associated protein 70 2.06165
GLTP glycolipid transfer protein 2.05201
LUC7L2 LUC7-like 2 (S. cerevisiae) 2.0508
CDO1 cysteine dioxygenase type 1 2.04301
RET ret proto-oncogene 2.02872
ZNF219 zinc finger protein 219 2.02368
BOD1 biorientation of chromosomes in cell division 1 2.02368
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 2.02262
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2.01716
MIPOL1 mirror-image polydactyly 1 2.01605
PBRM1 polybromo 1 2.01605
ZDHHC9 zinc finger, DHHC-type containing 9 2.01408
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.01408
FAM227B family with sequence similarity 227, member B 2.01408
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) 2.00597

decreased expression

Symbol Name Standardized Value
CHRNG cholinergic receptor, nicotinic, gamma (muscle) -3.41208
GMPR guanosine monophosphate reductase -3.41208
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 -3.41208
CHAD chondroadherin -3.41208
NOS2 nitric oxide synthase 2, inducible -3.41208
CARD6 caspase recruitment domain family, member 6 -3.41208
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 -3.41208
LGSN lengsin, lens protein with glutamine synthetase domain -3.41208
ACSL5 acyl-CoA synthetase long-chain family member 5 -3.41208
GUCY2D guanylate cyclase 2D, membrane (retina-specific) -3.41208
NPNT nephronectin -3.41208
HGD homogentisate 1,2-dioxygenase -3.41208
PKD1L1 polycystic kidney disease 1 like 1 -3.41208
SACK1E scaffolding CK1 anchoring protein E -3.41208
ADAMTSL5 ADAMTS-like 5 -3.41208
CCDC144A coiled-coil domain containing 144A -3.41208
PTPRQ protein tyrosine phosphatase, receptor type, Q -3.41208
PGBD4 piggyBac transposable element derived 4 -3.41208
IRF8 interferon regulatory factor 8 -3.41208
RAB40A RAB40A, member RAS oncogene family -3.41208
TRIM54 tripartite motif containing 54 -3.41208
SPMIP8 sperm microtubule inner protein 8 -3.41208
PIERCE2 piercer of microtubule wall 2 -3.41208
MAP10 microtubule-associated protein 10 -3.41208
PLA2G5 phospholipase A2, group V -3.41208
IFT70A intraflagellar transport 70A -3.41208
LINC02762 long intergenic non-protein coding RNA 2762 -3.41208
SBSPON somatomedin B and thrombospondin, type 1 domain containing -3.41208
CLEC4G C-type lectin domain family 4, member G -3.41208
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) -3.41208
MYOCOS myocilin opposite strand -3.41208
MCHR1 melanin-concentrating hormone receptor 1 -3.41208
ZNF773 zinc finger protein 773 -3.37824
TMEM200B transmembrane protein 200B -3.37824
TULP2 tubby like protein 2 -3.34497
CREB3L2 cAMP responsive element binding protein 3-like 2 -3.31149
C1QTNF6 C1q and tumor necrosis factor related protein 6 -3.18354
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 -3.06005
DHRS4 dehydrogenase/reductase (SDR family) member 4 -3.00878
RAB28 RAB28, member RAS oncogene family -2.96411
ZNF502 zinc finger protein 502 -2.95959
SIRAL2 SIR2 antiphage like 2 -2.95959
NAGS N-acetylglutamate synthase -2.95959
ZMYM3 zinc finger, MYM-type 3 -2.93454
DENND2D DENN/MADD domain containing 2D -2.91222
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -2.88829
IGSF21 immunoglobin superfamily, member 21 -2.81614
RUFY2 RUN and FYVE domain containing 2 -2.79607
COMMD1 copper metabolism (Murr1) domain containing 1 -2.73503
TP53I11 tumor protein p53 inducible protein 11 -2.56072
SLC25A46 solute carrier family 25, member 46 -2.53798
MAP3K6 mitogen-activated protein kinase kinase kinase 6 -2.46495
PLAC1 placenta-specific 1 -2.46495
SHISAL2A shisa like 2A -2.46495
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21 -2.45173
HELZ2 helicase with zinc finger 2, transcriptional coactivator -2.44681
TATDN1 TatD DNase domain containing 1 -2.44611
JAG2 jagged 2 -2.41297
COL15A1 collagen, type XV, alpha 1 -2.41297
GSTM2 glutathione S-transferase mu 2 (muscle) -2.41297
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) -2.41297
RAP2B RAP2B, member of RAS oncogene family -2.4015
BRD3 bromodomain containing 3 -2.34318
CRELD1 cysteine-rich with EGF-like domains 1 -2.33732
DCTN1 dynactin 1 -2.31755
TNNI3K TNNI3 interacting kinase -2.30771
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 -2.30771
TSPAN3 tetraspanin 3 -2.29626
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -2.29534
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.26235
BSN bassoon presynaptic cytomatrix protein -2.26037
NAE1 NEDD8 activating enzyme E1 subunit 1 -2.20224
RBMS3 RNA binding motif, single stranded interacting protein 3 -2.17842
RAD17 RAD17 homolog (S. pombe) -2.17118
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 -2.1671
TMEM255B transmembrane protein 255B -2.1671
LCMT2 leucine carboxyl methyltransferase 2 -2.15457
DRC11 dynein regulatory complex subunit 11 -2.15272
LAMA3 laminin, alpha 3 -2.15169
MED15 mediator complex subunit 15 -2.14299
SARNP SAP domain containing ribonucleoprotein -2.12422
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 -2.11905
PDIA3 protein disulfide isomerase family A, member 3 -2.09859
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 -2.09859
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -2.0975
ZNF514 zinc finger protein 514 -2.09684
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1 -2.07758
NCAPG2 non-SMC condensin II complex, subunit G2 -2.06949
TMED7 transmembrane emp24 protein transport domain containing 7 -2.0648
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 -2.0648
NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 -2.06005
TSPYL4 TSPY-like 4 -2.04976
XPA xeroderma pigmentosum, complementation group A -2.04748
LRP10 low density lipoprotein receptor-related protein 10 -2.03592
PSAT1 phosphoserine aminotransferase 1 -2.03222
PGBD2 piggyBac transposable element derived 2 -2.02368
CENPF centromere protein F, 350/400kDa -2.02368
WAC WW domain containing adaptor with coiled-coil -2.01897
RING1 ring finger protein 1 -2.01408
CPNE4 copine IV -2.00597