PDCD1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description programmed cell death 1|This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5133)
External Link http://www.ncbi.nlm.nih.gov/gene/5133
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Genes

55 interacting proteins for PDCD1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AGO1 argonaute RISC catalytic component 1
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
CD247 CD247 molecule
CD274 CD274 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD4 CD4 molecule
CSK c-src tyrosine kinase
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DICER1 dicer 1, ribonuclease type III
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB3 major histocompatibility complex, class II, DR beta 3
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HLA-DRB5 major histocompatibility complex, class II, DR beta 5
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IPO9 importin 9
LCK LCK proto-oncogene, Src family tyrosine kinase
PDCD1LG2 programmed cell death 1 ligand 2
PRMT5 protein arginine methyltransferase 5
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RPL23 ribosomal protein L23
RPL38 ribosomal protein L38
RPS27L ribosomal protein S27-like
RPS3 ribosomal protein S3
RUVBL2 RuvB-like AAA ATPase 2
SART3 squamous cell carcinoma antigen recognized by T cells 3
SIRT1 sirtuin 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SOCS1 suppressor of cytokine signaling 1
SSR1 signal sequence receptor, alpha
TARBP2 TAR (HIV-1) RNA binding protein 2
TMEM33 transmembrane protein 33
TRA T cell receptor alpha locus
TRAC T cell receptor alpha constant
TRB T cell receptor beta locus
TRBC1 T cell receptor beta constant 1
TRBV12-3 T cell receptor beta variable 12-3
WDR77 WD repeat domain 77