PDGFRA Gene Set

Dataset Kinase Library Tyrosine Kinome Atlas
Category proteomics
Type kinase
Description platelet-derived growth factor receptor, alpha polypeptide|This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012] (NCBI Entrez Gene Database, 5156)
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100 substrates of the kinase PDGFRA from the Kinase Library Tyrosine Kinome Atlas dataset.

Symbol Name Standardized Value
SEC14L3 SEC14-like 3 (S. cerevisiae) 99.98
SEC14L2 SEC14-like 2 (S. cerevisiae) 99.98
SHROOM1 shroom family member 1 99.93
EIF3I eukaryotic translation initiation factor 3, subunit I 99.83
MRPS27 mitochondrial ribosomal protein S27 99.74
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 99.71
ITSN1 intersectin 1 (SH3 domain protein) 99.67
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 99.61
PRUNE2 prune homolog 2 (Drosophila) 99.58
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 99.43
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 99.41
EIF1B eukaryotic translation initiation factor 1B 99.39
EIF1 eukaryotic translation initiation factor 1 99.39
FPR2 formyl peptide receptor 2 99.39
USP31 ubiquitin specific peptidase 31 99.23
THRB thyroid hormone receptor, beta 99.17
DLG3 discs, large homolog 3 (Drosophila) 99.14
FDFT1 farnesyl-diphosphate farnesyltransferase 1 99.13
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 99.02
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 99.01
MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) 98.99
EGR1 early growth response 1 98.97
PHLDB3 pleckstrin homology-like domain, family B, member 3 98.93
WWP2 WW domain containing E3 ubiquitin protein ligase 2 98.9
ATXN1 ataxin 1 98.82
LHX3 LIM homeobox 3 98.82
FCHO1 FCH domain only 1 98.73
CHAF1B chromatin assembly factor 1, subunit B (p60) 98.71
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 98.64
RUSC2 RUN and SH3 domain containing 2 98.55
PLPPR4 phospholipid phosphatase related 4 98.53
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa 98.47
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 98.42
CNOT9 CCR4-NOT transcription complex subunit 9 98.38
DLG2 discs, large homolog 2 (Drosophila) 98.36
SEC14L1 SEC14-like 1 (S. cerevisiae) 98.32
SPATS2L spermatogenesis associated, serine-rich 2-like 98.2
MREG melanoregulin 98.18
CMKLR1 chemerin chemokine-like receptor 1 98.09
FBXO11 F-box protein 11 98.05
ARHGAP30 Rho GTPase activating protein 30 97.97
ZNF579 zinc finger protein 579 97.94
CEP170B centrosomal protein 170B 97.86
WWC1 WW and C2 domain containing 1 97.85
PADI2 peptidyl arginine deiminase, type II 97.83
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 97.74
GRAMD4 GRAM domain containing 4 97.66
PTBP3 polypyrimidine tract binding protein 3 97.64
FKBP10 FK506 binding protein 10, 65 kDa 97.62
ESYT2 extended synaptotagmin-like protein 2 97.59
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 97.57
FZD2 frizzled class receptor 2 97.5
FKBP5 FK506 binding protein 5 97.46
EML4 echinoderm microtubule associated protein like 4 97.44
LURAP1L leucine rich adaptor protein 1-like 97.4
BDKRB2 bradykinin receptor B2 97.39
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 97.37
SNU13 small nuclear ribonucleoprotein 13 97.35
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 97.33
STRBP spermatid perinuclear RNA binding protein 97.33
TERB1 telomere repeat binding bouquet formation protein 1 97.31
PHB2 prohibitin 2 97.25
TRPV2 transient receptor potential cation channel, subfamily V, member 2 97.2
SPANXN2 SPANX family, member N2 97.15
KLHDC3 kelch domain containing 3 97.13
NOX5 NADPH oxidase, EF-hand calcium binding domain 5 97.045
SMG8 SMG8 nonsense mediated mRNA decay factor 96.98
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 96.94
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 96.81
TCF25 transcription factor 25 (basic helix-loop-helix) 96.8
MYL12B myosin, light chain 12B, regulatory 96.78
PM20D2 peptidase M20 domain containing 2 96.72
STARD13 StAR-related lipid transfer (START) domain containing 13 96.7
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 96.67
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 96.67
RASGRP4 RAS guanyl releasing protein 4 96.63
RERE arginine-glutamic acid dipeptide (RE) repeats 96.46
TPRN taperin 96.39
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa 96.37
UMPS uridine monophosphate synthetase 96.34
ZBED6 zinc finger, BED-type containing 6 96.32
RASAL2 RAS protein activator like 2 96.3
DDIAS DNA damage-induced apoptosis suppressor 96.19
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 96.17
TRIM25 tripartite motif containing 25 96.13
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 96.11
HPSE heparanase 96.08
TLK1 tousled-like kinase 1 96.02
DCTN4 dynactin 4 (p62) 95.91
NOL10 nucleolar protein 10 95.89
ALOX5 arachidonate 5-lipoxygenase 95.82
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 95.8
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 95.69
NPHP1 nephronophthisis 1 (juvenile) 95.64
NAXE NAD(P)HX epimerase 95.6
AKAP9 A kinase (PRKA) anchor protein 9 95.56
DENND1A DENN/MADD domain containing 1A 95.54
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 95.53
TET2 tet methylcytosine dioxygenase 2 95.51
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 95.43