PDGFRB Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description platelet-derived growth factor receptor, beta polypeptide|This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5159)
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Genes

306 genes differentially expressed following the PDGFRB gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 2.88183
GDA guanine deaminase 2.88183
LAT linker for activation of T cells 2.88183
SCGN secretagogin, EF-hand calcium binding protein 2.88183
ADGRF5 adhesion G protein-coupled receptor F5 2.88183
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like 2.88183
CRHR1 corticotropin releasing hormone receptor 1 2.88183
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.88183
OSTN osteocrin 2.88183
HRH1 histamine receptor H1 2.88183
TLR5 toll-like receptor 5 2.88183
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 2.88183
SNX31 sorting nexin 31 2.88183
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 2.88183
PRELP proline/arginine-rich end leucine-rich repeat protein 2.88183
RIPPLY2 ripply transcriptional repressor 2 2.88183
ZSCAN22 zinc finger and SCAN domain containing 22 2.88183
TMEM86A transmembrane protein 86A 2.88183
NKD2 naked cuticle homolog 2 (Drosophila) 2.88183
PCDHAC1 protocadherin alpha subfamily C, 1 2.88183
DNAAF19 dynein axonemal assembly factor 19 2.88183
CPLX1 complexin 1 2.88183
LGALS2 lectin, galactoside-binding, soluble, 2 2.88183
EBF4 early B-cell factor 4 2.88183
SEMG1 semenogelin I 2.88183
IRX4 iroquois homeobox 4 2.88183
WEE2 WEE1 homolog 2 (S. pombe) 2.88183
APOA1 apolipoprotein A-I 2.88183
GLUD2 glutamate dehydrogenase 2 2.81725
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.81725
HRH4 histamine receptor H4 2.81725
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 2.81725
CD6 CD6 molecule 2.81725
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 2.81725
SCN2B sodium channel, voltage gated, type II beta subunit 2.81725
MYBPHL myosin binding protein H-like 2.81725
CEMP1 cementum protein 1 2.81725
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 2.81725
C1ORF146 chromosome 1 open reading frame 146 2.81725
OR1L8 olfactory receptor, family 1, subfamily L, member 8 2.81725
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 2.81725
MAGED4 melanoma antigen family D4 2.81725
SPDYE11 speedy/RINGO cell cycle regulator family member E11 2.81725
PARD6A par-6 family cell polarity regulator alpha 2.81725
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 2.81725
ETV2 ets variant 2 2.81725
TNIP3 TNFAIP3 interacting protein 3 2.81725
ALPK2 alpha-kinase 2 2.81725
TAL2 T-cell acute lymphocytic leukemia 2 2.81725
GJB1 gap junction protein, beta 1, 32kDa 2.81725
LRRC52 leucine rich repeat containing 52 2.81725
PAX6 paired box 6 2.81725
ARHGAP36 Rho GTPase activating protein 36 2.81725
LRG1 leucine-rich alpha-2-glycoprotein 1 2.81725
ASB18 ankyrin repeat and SOCS box containing 18 2.81725
C19ORF67 chromosome 19 open reading frame 67 2.81725
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.81725
SPACA5 sperm acrosome associated 5 2.81725
SPMIP11 sperm microtubule inner protein 11 2.81725
CCN3 cellular communication network factor 3 2.81725
H3-5 H3.5 histone 2.81725
H2BC1 H2B clustered histone 1 2.81725
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.81725
CAPN9 calpain 9 2.81725
C6ORF141 chromosome 6 open reading frame 141 2.81725
PLCZ1 phospholipase C, zeta 1 2.81725
SMPX small muscle protein, X-linked 2.81725
CCDC187 coiled-coil domain containing 187 2.81725
CGB3 chorionic gonadotropin subunit beta 3 2.81725
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.81725
CIROZ ciliated left-right organizer protein containing ZP-N domains 2.81725
OR56B2 olfactory receptor family 56 subfamily B member 2 2.81725
MINDY4B MINDY family member 4B 2.81725
IQCN IQ motif containing N 2.81725
MAJIN membrane anchored junction protein 2.81725
DNAAF6 dynein axonemal assembly factor 6 2.81725
FNDC11 fibronectin type III domain containing 11 2.81725
DUSP29 dual specificity phosphatase 29 2.81725
IGSF22 immunoglobulin superfamily, member 22 2.81725
TUBA4B tubulin, alpha 4b 2.81725
PRG4 proteoglycan 4 2.81725
CD48 CD48 molecule 2.81725
THPO thrombopoietin 2.81725
PCDHB10 protocadherin beta 10 2.81725
KLHL33 kelch-like family member 33 2.81725
HHEX hematopoietically expressed homeobox 2.81725
HNF4A hepatocyte nuclear factor 4, alpha 2.81725
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.81725
TSSK4 testis-specific serine kinase 4 2.81725
SCN10A sodium channel, voltage gated, type X alpha subunit 2.81725
LYSMD2 LysM, putative peptidoglycan-binding, domain containing 2 2.81725
TMEM236 transmembrane protein 236 2.81725
FOXD4L5 forkhead box D4-like 5 2.81725
SAMD11 sterile alpha motif domain containing 11 2.81725
UTS2 urotensin 2 2.81725
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.81725
S100B S100 calcium binding protein B 2.81725
S100G S100 calcium binding protein G 2.81725
EXOC3L1 exocyst complex component 3-like 1 2.81725
PRRT4 proline-rich transmembrane protein 4 2.81725
GJA5 gap junction protein, alpha 5, 40kDa 2.81725
PLA2G4D phospholipase A2, group IVD (cytosolic) 2.81725
CXCR2 chemokine (C-X-C motif) receptor 2 2.81725
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 2.81725
GOLGA6B golgin A6 family, member B 2.81725
WFDC9 WAP four-disulfide core domain 9 2.81725
ADAM7 ADAM metallopeptidase domain 7 2.81725
HKDC1 hexokinase domain containing 1 2.81725
APOC2 apolipoprotein C-II 2.81725
MAB21L2 mab-21-like 2 (C. elegans) 2.81725
FAM209A family with sequence similarity 209, member A 2.81725
MPLKIP M-phase specific PLK1 interacting protein 2.81725
C11ORF96 chromosome 11 open reading frame 96 2.81725
PHOSPHO1 phosphatase, orphan 1 2.81725
LRRC36 leucine rich repeat containing 36 2.81725
FNDC9 fibronectin type III domain containing 9 2.81725
APLNR apelin receptor 2.81725
TTLL10 tubulin tyrosine ligase-like family member 10 2.81725
GOLGA6C golgin A6 family, member C 2.81725
OPRK1 opioid receptor, kappa 1 2.81725
CERKL ceramide kinase-like 2.81725
OTC ornithine carbamoyltransferase 2.81725
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 2.81725
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 2.81725
UBXN10 UBX domain protein 10 2.81725
SLC22A31 solute carrier family 22, member 31 2.81725
CLEC4A C-type lectin domain family 4, member A 2.81725
LOXHD1 lipoxygenase homology domains 1 2.81725
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 2.81725
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.81725
CCNA1 cyclin A1 2.81725
GBX2 gastrulation brain homeobox 2 2.81725
TEX29 testis expressed 29 2.81725
DAW1 dynein assembly factor with WDR repeat domains 1 2.81725
VWF von Willebrand factor 2.81725
PRSS38 protease, serine, 38 2.81725
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 2.81725
C2CD4D C2 calcium-dependent domain containing 4D 2.81725
LRRK2 leucine-rich repeat kinase 2 2.81725
EGR2 early growth response 2 2.81725
KLK5 kallikrein-related peptidase 5 2.81725
UTS2B urotensin 2B 2.81725
ACSBG2 acyl-CoA synthetase bubblegum family member 2 2.81725
WNK3 WNK lysine deficient protein kinase 3 2.81725
ART3 ADP-ribosyltransferase 3 2.81725
HSPB2 heat shock 27kDa protein 2 2.81725
MMP12 matrix metallopeptidase 12 2.81725
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 2.81725
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 2.81725
SNTN sentan, cilia apical structure protein 2.81725
BIN2 bridging integrator 2 2.81725
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.81725
GRM6 glutamate receptor, metabotropic 6 2.81725
DSPP dentin sialophosphoprotein 2.81725
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 2.81725
TEX35 testis expressed 35 2.81725
GJA10 gap junction protein, alpha 10, 62kDa 2.81725
IL23R interleukin 23 receptor 2.81725
WFDC13 WAP four-disulfide core domain 13 2.81725
ADRA1B adrenoceptor alpha 1B 2.81725
FOXG1 forkhead box G1 2.81725
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 2.81725
ANXA1 annexin A1 2.81725
FGF6 fibroblast growth factor 6 2.81725
FOXP3 forkhead box P3 2.81725
SLC30A10 solute carrier family 30, member 10 2.81725
DAND5 DAN domain family member 5, BMP antagonist 2.81725
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 2.81725
SP100 SP100 nuclear antigen 2.81725
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.81725
ELANE elastase, neutrophil expressed 2.81725
KCNU1 potassium channel, subfamily U, member 1 2.81725
ZBED6 zinc finger, BED-type containing 6 2.81725
ROM1 retinal outer segment membrane protein 1 2.81725
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.81725
RNF224 ring finger protein 224 2.81725
UBASH3A ubiquitin associated and SH3 domain containing A 2.81725
UNC119B unc-119 homolog B (C. elegans) 2.69349
ANKZF1 ankyrin repeat and zinc finger domain containing 1 2.68617
TRIM54 tripartite motif containing 54 2.67778
ATXN7L2 ataxin 7-like 2 2.67778
LYNX1 Ly6/neurotoxin 1 2.67778
REM2 RAS (RAD and GEM)-like GTP binding 2 2.67778
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 2.67403
CHD9 chromodomain helicase DNA binding protein 9 2.66473
EPS8 epidermal growth factor receptor pathway substrate 8 2.59546
SYNE2 spectrin repeat containing, nuclear envelope 2 2.5813
COL4A1 collagen, type IV, alpha 1 2.54786
SLC38A12 solute carrier family 38 member 12 2.5009
HELLS helicase, lymphoid-specific 2.49741
TOR1AIP2 torsin A interacting protein 2 2.473
TBX22 T-box 22 2.39749
KLHL22 kelch-like family member 22 2.34245
GRWD1 glutamate-rich WD repeat containing 1 2.31147
NLE1 notchless homolog 1 (Drosophila) 2.30433
SERINC1 serine incorporator 1 2.28624
SLC39A8 solute carrier family 39 (zinc transporter), member 8 2.26403
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 2.2552
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 2.20538
RNF150 ring finger protein 150 2.20456
CIT citron rho-interacting serine/threonine kinase 2.1996
VTI1A vesicle transport through interaction with t-SNAREs 1A 2.15851
SCRN1 secernin 1 2.15513
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase 2.15361
RORB RAR-related orphan receptor B 2.1488
SHISAL2A shisa like 2A 2.1488
FGR FGR proto-oncogene, Src family tyrosine kinase 2.13704
TMA16 translation machinery associated 16 homolog (S. cerevisiae) 2.10218
CFAP43 cilia and flagella associated protein 43 2.08345
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 2.07726
GRIK4 glutamate receptor, ionotropic, kainate 4 2.0467
TSPYL1 TSPY-like 1 2.0438
BZW2 basic leucine zipper and W2 domains 2 2.03229
RFTN2 raftlin family member 2 2.02876

decreased expression

Symbol Name Standardized Value
VSTM2L V-set and transmembrane domain containing 2 like -2.88183
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 -2.88183
BMP2 bone morphogenetic protein 2 -2.88183
KLRB1 killer cell lectin-like receptor subfamily B, member 1 -2.88183
PPM1J protein phosphatase, Mg2+/Mn2+ dependent, 1J -2.82719
ACTB actin, beta -2.82719
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) -2.81725
F2 coagulation factor II (thrombin) -2.81725
CDKN2A cyclin-dependent kinase inhibitor 2A -2.81725
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 -2.81725
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) -2.81725
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) -2.81725
SAXO2 stabilizer of axonemal microtubules 2 -2.81725
FANCD2OS FANCD2 opposite strand -2.81725
KIF19 kinesin family member 19 -2.81725
CLCNKB chloride channel, voltage-sensitive Kb -2.81725
CACNB3 calcium channel, voltage-dependent, beta 3 subunit -2.81725
OSGIN1 oxidative stress induced growth inhibitor 1 -2.81725
TBC1D31 TBC1 domain family, member 31 -2.81725
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 -2.81725
C3 complement component 3 -2.81725
RBM46 RNA binding motif protein 46 -2.81725
ARHGEF33 Rho guanine nucleotide exchange factor (GEF) 33 -2.81725
AKR1D1 aldo-keto reductase family 1, member D1 -2.81725
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 -2.81725
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -2.81725
MALL mal, T-cell differentiation protein-like -2.81725
PNMA8C PNMA family member 8C -2.81725
ZNF491 zinc finger protein 491 -2.81725
IZUMO3 IZUMO family member 3 -2.81725
BSND barttin CLCNK-type chloride channel accessory beta subunit -2.81725
LOC124903233 uncharacterized LOC124903233 -2.81725
SLITRK5 SLIT and NTRK-like family, member 5 -2.81725
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 -2.81725
IFI35 interferon-induced protein 35 -2.81725
CREG2 cellular repressor of E1A-stimulated genes 2 -2.81725
SPATA6 spermatogenesis associated 6 -2.81725
INHA inhibin, alpha -2.81725
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 -2.81725
MKRN2OS MKRN2 opposite strand -2.81725
CLEC18B C-type lectin domain family 18, member B -2.81725
PLD6 phospholipase D family, member 6 -2.81725
ADM5 adrenomedullin 5 (putative) -2.81725
CXCR6 chemokine (C-X-C motif) receptor 6 -2.81725
PODXL podocalyxin-like -2.81545
DNAJC18 DnaJ (Hsp40) homolog, subfamily C, member 18 -2.67121
ADGRB1 adhesion G protein-coupled receptor B1 -2.66473
LONP1 lon peptidase 1, mitochondrial -2.66473
SRD5A3 steroid 5 alpha-reductase 3 -2.53248
LRRC45 leucine rich repeat containing 45 -2.52564
PGPEP1 pyroglutamyl-peptidase I -2.48345
ERGIC2 ERGIC and golgi 2 -2.47802
DISP2 dispatched homolog 2 (Drosophila) -2.45405
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 -2.45341
ZNF469 zinc finger protein 469 -2.4118
RTCA RNA 3'-terminal phosphate cyclase -2.36068
STAC3 SH3 and cysteine rich domain 3 -2.35828
CEP85 centrosomal protein 85kDa -2.32767
TGFB1I1 transforming growth factor beta 1 induced transcript 1 -2.32151
INPP5J inositol polyphosphate-5-phosphatase J -2.32107
ZNF408 zinc finger protein 408 -2.31396
CCT4 chaperonin containing TCP1, subunit 4 (delta) -2.31378
EIF6 eukaryotic translation initiation factor 6 -2.31274
TRPM4 transient receptor potential cation channel, subfamily M, member 4 -2.30122
PSKH1 protein serine kinase H1 -2.29724
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 -2.29555
NR2C1 nuclear receptor subfamily 2, group C, member 1 -2.28624
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 -2.2662
RNF10 ring finger protein 10 -2.25148
ESRRG estrogen-related receptor gamma -2.23136
NCOA6 nuclear receptor coactivator 6 -2.22592
FGD3 FYVE, RhoGEF and PH domain containing 3 -2.20673
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) -2.20596
QRICH2 glutamine rich 2 -2.20596
LRRC39 leucine rich repeat containing 39 -2.20596
PHACTR4 phosphatase and actin regulator 4 -2.20456
ZNF891 zinc finger protein 891 -2.19354
TSKU tsukushi, small leucine rich proteoglycan -2.15851
RAB35 RAB35, member RAS oncogene family -2.15513
NRK Nik related kinase -2.15403
CDT1 chromatin licensing and DNA replication factor 1 -2.10548
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 -2.09108
ZBTB5 zinc finger and BTB domain containing 5 -2.0535
ZNF500 zinc finger protein 500 -2.0535
CTNND2 catenin (cadherin-associated protein), delta 2 -2.0438
NTN1 netrin 1 -2.03376
CLMP CXADR-like membrane protein -2.03376
PRPF6 pre-mRNA processing factor 6 -2.03376
GAA glucosidase, alpha; acid -2.02876
EHD4 EH-domain containing 4 -2.02876
GET3 guided entry of tail-anchored proteins factor 3, ATPase -2.02876
FTCD formimidoyltransferase cyclodeaminase -2.00578