PDGFRB Gene Set

Dataset Kinase Library Tyrosine Kinome Atlas
Category proteomics
Type kinase
Description platelet-derived growth factor receptor, beta polypeptide|This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5159)
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100 substrates of the kinase PDGFRB from the Kinase Library Tyrosine Kinome Atlas dataset.

Symbol Name Standardized Value
FCHO1 FCH domain only 1 99.98
ATXN1 ataxin 1 99.89
EIF3I eukaryotic translation initiation factor 3, subunit I 99.85
SHROOM1 shroom family member 1 99.78
SEC14L2 SEC14-like 2 (S. cerevisiae) 99.76
SEC14L3 SEC14-like 3 (S. cerevisiae) 99.76
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa 99.69
FKBP5 FK506 binding protein 5 99.65
EIF1 eukaryotic translation initiation factor 1 99.63
EIF1B eukaryotic translation initiation factor 1B 99.63
THRB thyroid hormone receptor, beta 99.54
FZD2 frizzled class receptor 2 99.54
ITSN1 intersectin 1 (SH3 domain protein) 99.52
SH2D3C SH2 domain containing 3C 99.5
CNOT9 CCR4-NOT transcription complex subunit 9 99.45
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 99.32
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 99.26
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 99.21
MYL12B myosin, light chain 12B, regulatory 99.1
DLG3 discs, large homolog 3 (Drosophila) 98.985
TRPV2 transient receptor potential cation channel, subfamily V, member 2 98.77
EGR1 early growth response 1 98.75
USP31 ubiquitin specific peptidase 31 98.73
WWP2 WW domain containing E3 ubiquitin protein ligase 2 98.71
ARHGAP30 Rho GTPase activating protein 30 98.66
TRIOBP TRIO and F-actin binding protein 98.54
SIPA1L1 signal-induced proliferation-associated 1 like 1 98.53
CHAF1B chromatin assembly factor 1, subunit B (p60) 98.51
GRAMD4 GRAM domain containing 4 98.49
TPRN taperin 98.43
PLPPR4 phospholipid phosphatase related 4 98.38
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 98.32
ESYT2 extended synaptotagmin-like protein 2 98.2
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 98.1
RASA3 RAS p21 protein activator 3 98.09
SH2D1B SH2 domain containing 1B 98.07
PTBP3 polypyrimidine tract binding protein 3 98.03
TERB1 telomere repeat binding bouquet formation protein 1 97.94
DLG2 discs, large homolog 2 (Drosophila) 97.88
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A 97.72
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 97.61
PM20D2 peptidase M20 domain containing 2 97.59
HYAL2 hyaluronoglucosaminidase 2 97.5
PRUNE2 prune homolog 2 (Drosophila) 97.5
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 97.48
CLDN4 claudin 4 97.46
RPL8 ribosomal protein L8 97.35
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 97.22
FPR2 formyl peptide receptor 2 97.2
ALOX5 arachidonate 5-lipoxygenase 97.18
GIMAP4 GTPase, IMAP family member 4 97.16
IL7R interleukin 7 receptor 97.16
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 97.09
RFTN1 raftlin, lipid raft linker 1 97.05
AKAP9 A kinase (PRKA) anchor protein 9 97.02
SNU13 small nuclear ribonucleoprotein 13 96.98
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 96.91
IRS4 insulin receptor substrate 4 96.815
CUL3 cullin 3 96.81
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 96.8
LHX3 LIM homeobox 3 96.76
SLC39A3 solute carrier family 39 (zinc transporter), member 3 96.69
KLHDC3 kelch domain containing 3 96.65
KAT2A K(lysine) acetyltransferase 2A 96.63
NOP56 NOP56 ribonucleoprotein 96.61
CHRM2 cholinergic receptor, muscarinic 2 96.59
TGOLN2 trans-golgi network protein 2 96.56
CORO1C coronin, actin binding protein, 1C 96.54
TCF25 transcription factor 25 (basic helix-loop-helix) 96.39
EML4 echinoderm microtubule associated protein like 4 96.35
STARD13 StAR-related lipid transfer (START) domain containing 13 96.32
KIF20A kinesin family member 20A 96.11
CMKLR1 chemerin chemokine-like receptor 1 96.06
SOCS6 suppressor of cytokine signaling 6 96.06
MREG melanoregulin 95.93
CEP170B centrosomal protein 170B 95.91
TLK1 tousled-like kinase 1 95.89
CLDN1 claudin 1 95.8
MCC mutated in colorectal cancers 95.77
ERCC6L excision repair cross-complementation group 6-like 95.74
MIS18BP1 MIS18 binding protein 1 95.73
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa 95.69
NDC80 NDC80 kinetochore complex component 95.64
PA2G4 proliferation-associated 2G4, 38kDa 95.64
MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) 95.58
RAD52 RAD52 homolog (S. cerevisiae) 95.58
CD3D CD3d molecule, delta (CD3-TCR complex) 95.515
ZCCHC3 zinc finger, CCHC domain containing 3 95.49
NIPSNAP1 nipsnap homolog 1 (C. elegans) 95.455
HCST hematopoietic cell signal transducer 95.38
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 95.36
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 95.32
GSDMD gasdermin D 95.21
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 95.21
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 95.1
TWSG1 twisted gastrulation BMP signaling modulator 1 95.08
MUC16 mucin 16, cell surface associated 95.07
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 95.05
TRPC6 transient receptor potential cation channel, subfamily C, member 6 95.01
C12ORF75 chromosome 12 open reading frame 75 94.97