PDGF_PTP1B_KO vs wt_MEF (Mouse) [18515860] Gene Set

Dataset SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Gene Perturbations
Category proteomics
Type gene perturbation
Description gene perturbation identified as [gene perturbation]_[cell line] ([organism]) [[publication PMID]] (SILAC Phosphoproteomics)
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69 proteins differentially phosphorylated following the PDGF_PTP1B_KO vs wt_MEF (Mouse) [18515860] gene perturbation from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Gene Perturbations dataset.

increased phosphorylation

Symbol Name
ABI1 abl-interactor 1
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ARHGAP12 Rho GTPase activating protein 12
ARHGAP35 Rho GTPase activating protein 35
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CTNND1 catenin (cadherin-associated protein), delta 1
CTTN cortactin
DCBLD2 discoidin, CUB and LCCL domain containing 2
DENND2A DENN/MADD domain containing 2A
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
EGFR epidermal growth factor receptor
EPHA4 EPH receptor A4
EPHB3 EPH receptor B3
EPHB4 EPH receptor B4
ERBB2 erb-b2 receptor tyrosine kinase 2
FER fer (fps/fes related) tyrosine kinase
FGFR1 fibroblast growth factor receptor 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB2 GRB2-associated binding protein 2
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GSK3B glycogen synthase kinase 3 beta
INPPL1 inositol polyphosphate phosphatase-like 1
ITSN2 intersectin 2
KIRREL kin of IRRE like (Drosophila)
LAPTM4A lysosomal protein transmembrane 4 alpha
LDLR low density lipoprotein receptor
LPP LIM domain containing preferred translocation partner in lipoma
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK7 mitogen-activated protein kinase 7
MEGF10 multiple EGF-like-domains 10
NCK2 NCK adaptor protein 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
OPHN1 oligophrenin 1
PARD3 par-3 family cell polarity regulator
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PEAK1 pseudopodium-enriched atypical kinase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLCG1 phospholipase C, gamma 1
PRKCD protein kinase C, delta
PTK2 protein tyrosine kinase 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
PXN paxillin
RAB1A RAB1A, member RAS oncogene family
RASA1 RAS p21 protein activator (GTPase activating protein) 1
SGK223 homolog of rat pragma of Rnd2
SH3PXD2A SH3 and PX domains 2A
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
ST5 suppression of tumorigenicity 5
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TJP1 tight junction protein 1
TJP2 tight junction protein 2
TNK2 tyrosine kinase, non-receptor, 2
TNS1 tensin 1
TNS3 tensin 3
UBA1 ubiquitin-like modifier activating enzyme 1
VAV3 vav 3 guanine nucleotide exchange factor
ZDHHC8 zinc finger, DHHC-type containing 8

decreased phosphorylation

Symbol Name
AXL AXL receptor tyrosine kinase
EFNB2 ephrin-B2
EPHB2 EPH receptor B2
GAB1 GRB2-associated binding protein 1
PDGFA platelet-derived growth factor alpha polypeptide
TNS2 tensin 2