PDK1 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description pyruvate dehydrogenase kinase, isozyme 1|Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013] (NCBI Entrez Gene Database, 5163)
External Link http://www.ncbi.nlm.nih.gov/gene/5163
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Genes

2 substrates of the kinase PDK1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2