PDK1_knockout_265_GSE42187 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Kinase Perturbations
Category transcriptomics
Type kinase perturbation
Description kinase perturbation identified as [kinase gene symbol]_[perturbation]_[perturbation ID]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE42187
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Genes

600 genes differentially expressed following the PDK1_knockout_265_GSE42187 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

increased expression

Symbol Name Standardized Value
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 4.68638
LIPT2 lipoyl(octanoyl) transferase 2 (putative) 4.03205
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.89533
MAX MYC associated factor X 3.5503
BFAR bifunctional apoptosis regulator 3.226
ARL14EP ADP-ribosylation factor-like 14 effector protein 3.18931
BTG1 B-cell translocation gene 1, anti-proliferative 2.92935
SYF2 SYF2 pre-mRNA-splicing factor 2.84912
C19ORF71 chromosome 19 open reading frame 71 2.83894
MAPT microtubule-associated protein tau 2.79024
PI4K2B phosphatidylinositol 4-kinase type 2 beta 2.72177
KDM6A lysine (K)-specific demethylase 6A 2.70847
RABAC1 Rab acceptor 1 (prenylated) 2.69904
WBP4 WW domain binding protein 4 2.65729
SLC38A2 solute carrier family 38, member 2 2.61795
HOXA13 homeobox A13 2.59153
FAM65B family with sequence similarity 65, member B 2.56865
RPAP2 RNA polymerase II associated protein 2 2.52832
PITX1 paired-like homeodomain 1 2.51691
PIM2 Pim-2 proto-oncogene, serine/threonine kinase 2.51138
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 2.50402
BCLAF1 BCL2-associated transcription factor 1 2.48038
AP3S2 adaptor-related protein complex 3, sigma 2 subunit 2.45535
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 2.45259
RYK receptor-like tyrosine kinase 2.43757
NECAP1 NECAP endocytosis associated 1 2.41454
CLEC4A C-type lectin domain family 4, member A 2.40086
PHF1 PHD finger protein 1 2.38966
UBE2G1 ubiquitin-conjugating enzyme E2G 1 2.3869
SOCS6 suppressor of cytokine signaling 6 2.36673
BTG3 BTG family, member 3 2.3608
RAB34 RAB34, member RAS oncogene family 2.35613
IMPAD1 inositol monophosphatase domain containing 1 2.35121
IGF1R insulin-like growth factor 1 receptor 2.34571
YPEL3 yippee-like 3 (Drosophila) 2.3367
OR5D16 olfactory receptor, family 5, subfamily D, member 16 2.30284
DGUOK deoxyguanosine kinase 2.30106
HIGD2A HIG1 hypoxia inducible domain family, member 2A 2.29829
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.29749
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G 2.2675
LZTS2 leucine zipper, putative tumor suppressor 2 2.26259
HPSE2 heparanase 2 (inactive) 2.26018
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 2.25052
CAPZB capping protein (actin filament) muscle Z-line, beta 2.2481
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 2.23507
PHB prohibitin 2.2347
ABI1 abl-interactor 1 2.2222
DCAF5 DDB1 and CUL4 associated factor 5 2.22148
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 2.21572
SEC23B Sec23 homolog B (S. cerevisiae) 2.19808
SLC39A13 solute carrier family 39 (zinc transporter), member 13 2.19671
TIGD2 tigger transposable element derived 2 2.18634
CARHSP1 calcium regulated heat stable protein 1, 24kDa 2.18555
GABARAP GABA(A) receptor-associated protein 2.1725
OXR1 oxidation resistance 1 2.15748
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12 2.14532
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 2.14055
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa 2.1366
RBM12B RNA binding motif protein 12B 2.10994
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 2.10928
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.09641
RPL9 ribosomal protein L9 2.09612
RRAS related RAS viral (r-ras) oncogene homolog 2.07876
ABHD16A abhydrolase domain containing 16A 2.05932
TRAPPC3 trafficking protein particle complex 3 2.05317
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 2.04257
KIAA1324 KIAA1324 2.04007
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 2.03568
TRIM17 tripartite motif containing 17 2.03352
OR5M11 olfactory receptor, family 5, subfamily M, member 11 2.02953
LAMP2 lysosomal-associated membrane protein 2 2.02655
FOXJ3 forkhead box J3 2.01262
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 2.00882
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 2.00122
JADE1 jade family PHD finger 1 1.99924
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 1.99904
VIMP VCP-interacting membrane selenoprotein 1.98058
DCAF10 DDB1 and CUL4 associated factor 10 1.94919
SDF2 stromal cell-derived factor 2 1.94485
RPL35 ribosomal protein L35 1.9445
MED6 mediator complex subunit 6 1.93977
GNPTG N-acetylglucosamine-1-phosphate transferase, gamma subunit 1.93733
VCAM1 vascular cell adhesion molecule 1 1.93453
IGSF1 immunoglobulin superfamily, member 1 1.93423
MFSD1 major facilitator superfamily domain containing 1 1.93205
LY75 lymphocyte antigen 75 1.93191
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 1.92808
KIAA1324L KIAA1324-like 1.92439
SERINC1 serine incorporator 1 1.9234
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 1.92308
RNF11 ring finger protein 11 1.91801
ELF1 E74-like factor 1 (ets domain transcription factor) 1.91576
TBP TATA box binding protein 1.90251
GINM1 glycoprotein integral membrane 1 1.89954
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 1.89752
KLHL32 kelch-like family member 32 1.87574
IRAK2 interleukin-1 receptor-associated kinase 2 1.87436
STX5 syntaxin 5 1.86316
GRSF1 G-rich RNA sequence binding factor 1 1.85773
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 1.85726
MATR3 matrin 3 1.85103
HACD1 3-hydroxyacyl-CoA dehydratase 1 1.84772
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 1.84714
NUPL1 nucleoporin like 1 1.8468
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 1.83385
GK5 glycerol kinase 5 (putative) 1.83311
MTPN myotrophin 1.82746
PIGO phosphatidylinositol glycan anchor biosynthesis, class O 1.82446
TLE3 transducin-like enhancer of split 3 1.8179
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 1.8173
CLK2 CDC-like kinase 2 1.81249
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 1.8106
OR52E2 olfactory receptor, family 52, subfamily E, member 2 1.81033
ZFX zinc finger protein, X-linked 1.80814
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 1.79889
IRS1 insulin receptor substrate 1 1.79027
DSTYK dual serine/threonine and tyrosine protein kinase 1.78565
TAZ tafazzin 1.77701
SRRM4 serine/arginine repetitive matrix 4 1.77074
RUNX2 runt-related transcription factor 2 1.76862
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 1.76745
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 1.76616
CCDC150 coiled-coil domain containing 150 1.76552
DACH1 dachshund family transcription factor 1 1.76256
FBXO34 F-box protein 34 1.7593
EFNA5 ephrin-A5 1.75918
TMEM59 transmembrane protein 59 1.75798
SNAP47 synaptosomal-associated protein, 47kDa 1.75368
ARSA arylsulfatase A 1.75074
BTBD3 BTB (POZ) domain containing 3 1.74747
TMX3 thioredoxin-related transmembrane protein 3 1.74552
BPIFA3 BPI fold containing family A, member 3 1.7453
RAB5A RAB5A, member RAS oncogene family 1.74494
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 1.74333
CHP1 calcineurin-like EF-hand protein 1 1.73938
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 1.73821
MEIS2 Meis homeobox 2 1.73636
RNF144B ring finger protein 144B 1.73132
SLC45A1 solute carrier family 45, member 1 1.72496
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 1.72469
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 1.72441
SNAP23 synaptosomal-associated protein, 23kDa 1.72159
PTP4A2 protein tyrosine phosphatase type IVA, member 2 1.71828
EIF4E1B eukaryotic translation initiation factor 4E family member 1B 1.71694
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 1.71544
STK19 serine/threonine kinase 19 1.71461
IFRD1 interferon-related developmental regulator 1 1.71278
ETV1 ets variant 1 1.7112
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.70675
SLC25A18 solute carrier family 25 (glutamate carrier), member 18 1.70576
HBS1L HBS1-like translational GTPase 1.70289
TMEM33 transmembrane protein 33 1.69891
TMEM60 transmembrane protein 60 1.69685
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 1.69513
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 1.69505
RPS4Y1 ribosomal protein S4, Y-linked 1 1.69439
BICD1 bicaudal D homolog 1 (Drosophila) 1.69023
SRPK2 SRSF protein kinase 2 1.68882
FAM78B family with sequence similarity 78, member B 1.68207
RFX3 regulatory factor X, 3 (influences HLA class II expression) 1.68128
TGDS TDP-glucose 4,6-dehydratase 1.6804
TXNDC11 thioredoxin domain containing 11 1.67941
SLC25A27 solute carrier family 25, member 27 1.679
ACTC1 actin, alpha, cardiac muscle 1 1.67861
MFN2 mitofusin 2 1.67202
PKLR pyruvate kinase, liver and RBC 1.67191
OR8D2 olfactory receptor, family 8, subfamily D, member 2 (gene/pseudogene) 1.66772
ZC3H14 zinc finger CCCH-type containing 14 1.66685
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 1.66565
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 1.66467
SDCBP syndecan binding protein (syntenin) 1.66431
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 1.66427
NCLN nicalin 1.66401
PLAA phospholipase A2-activating protein 1.65656
ATL3 atlastin GTPase 3 1.65586
SMIM14 small integral membrane protein 14 1.65279
PEX5 peroxisomal biogenesis factor 5 1.65251
GNS glucosamine (N-acetyl)-6-sulfatase 1.65239
IRF2BPL interferon regulatory factor 2 binding protein-like 1.65055
TRIT1 tRNA isopentenyltransferase 1 1.64847
PLAGL1 pleiomorphic adenoma gene-like 1 1.64845
SBDS Shwachman-Bodian-Diamond syndrome 1.64733
WDR45 WD repeat domain 45 1.64665
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 1.64651
CNOT2 CCR4-NOT transcription complex, subunit 2 1.64324
PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) 1.64271
CALB2 calbindin 2 1.6392
WBP1L WW domain binding protein 1-like 1.63905
SP9 Sp9 transcription factor 1.63624
KIF2A kinesin heavy chain member 2A 1.6361
TRIM23 tripartite motif containing 23 1.63481
KATNA1 katanin p60 (ATPase containing) subunit A 1 1.63452
PLXNA4 plexin A4 1.62931
RICTOR RPTOR independent companion of MTOR, complex 2 1.62206
IFNA4 interferon, alpha 4 1.61882
WDR60 WD repeat domain 60 1.61571
AMPD3 adenosine monophosphate deaminase 3 1.61499
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 1.61359
NXNL2 nucleoredoxin-like 2 1.60913
ATG2A autophagy related 2A 1.60691
ZBTB37 zinc finger and BTB domain containing 37 1.60356
UCN urocortin 1.60226
YME1L1 YME1-like 1 ATPase 1.59994
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 1.59546
F2R coagulation factor II (thrombin) receptor 1.5939
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 1.59311
SAT1 spermidine/spermine N1-acetyltransferase 1 1.5926
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 1.59215
TXNDC17 thioredoxin domain containing 17 1.59142
EPS8L3 EPS8-like 3 1.591
RHOD ras homolog family member D 1.59077
MED7 mediator complex subunit 7 1.58647
ADIPOR1 adiponectin receptor 1 1.58107
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 1.57806
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.57744
SCAMP4 secretory carrier membrane protein 4 1.57689
OR6K2 olfactory receptor, family 6, subfamily K, member 2 1.57148
CLCN7 chloride channel, voltage-sensitive 7 1.56999
SCAMP1 secretory carrier membrane protein 1 1.56254
STYXL1 serine/threonine/tyrosine interacting-like 1 1.56237
RNF10 ring finger protein 10 1.56094
PLA2G1B phospholipase A2, group IB (pancreas) 1.56073
TGFBR1 transforming growth factor, beta receptor 1 1.55666
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 1.55412
SMIM8 small integral membrane protein 8 1.55242
OR4Q3 olfactory receptor, family 4, subfamily Q, member 3 1.54936
TLK1 tousled-like kinase 1 1.5474
TSHB thyroid stimulating hormone, beta 1.54348
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 1.53899
KAT8 K(lysine) acetyltransferase 8 1.53574
TBL1X transducin (beta)-like 1X-linked 1.53148
SYAP1 synapse associated protein 1 1.53001
DAZAP2 DAZ associated protein 2 1.52955
EFHD2 EF-hand domain family, member D2 1.52867
SH3GLB1 SH3-domain GRB2-like endophilin B1 1.52842
DUSP1 dual specificity phosphatase 1 1.52761
RAB18 RAB18, member RAS oncogene family 1.52453
EIF5A2 eukaryotic translation initiation factor 5A2 1.52198
ASCC1 activating signal cointegrator 1 complex subunit 1 1.52115
RUSC2 RUN and SH3 domain containing 2 1.51755
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 1.51555
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 1.5124
SULT1C3 sulfotransferase family, cytosolic, 1C, member 3 1.51175
UPP2 uridine phosphorylase 2 1.51044
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 1.50876
HOOK2 hook microtubule-tethering protein 2 1.50803
GNL1 guanine nucleotide binding protein-like 1 1.5063
SWT1 SWT1 RNA endoribonuclease homolog (S. cerevisiae) 1.50585
CR1L complement component (3b/4b) receptor 1-like 1.50339
ACSL6 acyl-CoA synthetase long-chain family member 6 1.49968
NFYB nuclear transcription factor Y, beta 1.49266
CUL3 cullin 3 1.49253
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2 1.4894
CD47 CD47 molecule 1.48759
ZC3H3 zinc finger CCCH-type containing 3 1.48717
NCOA2 nuclear receptor coactivator 2 1.48511
RFK riboflavin kinase 1.48274
TBCA tubulin folding cofactor A 1.4809
UBASH3B ubiquitin associated and SH3 domain containing B 1.48063
VWC2 von Willebrand factor C domain containing 2 1.47726
FAS Fas cell surface death receptor 1.47588
UBXN10 UBX domain protein 10 1.47565
EIF5 eukaryotic translation initiation factor 5 1.47562
KLHL24 kelch-like family member 24 1.47543
FURIN furin (paired basic amino acid cleaving enzyme) 1.47359
HNRNPF heterogeneous nuclear ribonucleoprotein F 1.47085
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 1.47002
CBLN2 cerebellin 2 precursor 1.46287
UNC45A unc-45 homolog A (C. elegans) 1.45811
C17ORF62 chromosome 17 open reading frame 62 1.45655
FMO3 flavin containing monooxygenase 3 1.45206
EGFL6 EGF-like-domain, multiple 6 1.45204
OR6C70 olfactory receptor, family 6, subfamily C, member 70 1.45159
LPIN1 lipin 1 1.44979
EXOC2 exocyst complex component 2 1.44821
OR5B12 olfactory receptor, family 5, subfamily B, member 12 1.44252
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 1.43926
PRDM4 PR domain containing 4 1.43792
UBXN6 UBX domain protein 6 1.43713
ITGAV integrin, alpha V 1.43612
KIF3B kinesin family member 3B 1.43589
AEBP2 AE binding protein 2 1.43503
PPT2 palmitoyl-protein thioesterase 2 1.4323
TRIOBP TRIO and F-actin binding protein 1.4276
ASB6 ankyrin repeat and SOCS box containing 6 1.42685
LDLRAD4 low density lipoprotein receptor class A domain containing 4 1.42428
STK11 serine/threonine kinase 11 1.42364
TMPRSS6 transmembrane protease, serine 6 1.42346
OSBPL9 oxysterol binding protein-like 9 1.42259
USP8 ubiquitin specific peptidase 8 1.42182
MAP2K4 mitogen-activated protein kinase kinase 4 1.42112
ITGAD integrin, alpha D 1.4201
FANCB Fanconi anemia, complementation group B 1.41947
TSG101 tumor susceptibility 101 1.41937
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 1.4181
ACER2 alkaline ceramidase 2 1.41391
ANGPT1 angiopoietin 1 1.40956
CLK4 CDC-like kinase 4 1.40786
NRBF2 nuclear receptor binding factor 2 1.40742
SNX14 sorting nexin 14 1.40708

decreased expression

Symbol Name Standardized Value
RFC2 replication factor C (activator 1) 2, 40kDa -3.9864
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) -3.60638
SF3B5 splicing factor 3b, subunit 5, 10kDa -3.3717
ETFB electron-transfer-flavoprotein, beta polypeptide -3.19166
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme -3.18011
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -3.16164
NAGK N-acetylglucosamine kinase -3.00649
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -2.88701
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 -2.87297
DDO D-aspartate oxidase -2.77641
INTS9 integrator complex subunit 9 -2.73333
ASPHD2 aspartate beta-hydroxylase domain containing 2 -2.71289
MRPL47 mitochondrial ribosomal protein L47 -2.68137
CCDC80 coiled-coil domain containing 80 -2.67297
CEP78 centrosomal protein 78kDa -2.64833
TPRKB TP53RK binding protein -2.64391
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -2.60016
STARD7 StAR-related lipid transfer (START) domain containing 7 -2.57356
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -2.54132
POLQ polymerase (DNA directed), theta -2.51766
EFTUD2 elongation factor Tu GTP binding domain containing 2 -2.4986
PRPF19 pre-mRNA processing factor 19 -2.49603
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase -2.48627
SUMO2 small ubiquitin-like modifier 2 -2.47318
KLK3 kallikrein-related peptidase 3 -2.47299
TUBA3E tubulin, alpha 3e -2.4697
ZNF174 zinc finger protein 174 -2.44218
ELP5 elongator acetyltransferase complex subunit 5 -2.43743
CENPT centromere protein T -2.42875
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 -2.42755
MARS methionyl-tRNA synthetase -2.40349
MRPL36 mitochondrial ribosomal protein L36 -2.38265
EI24 etoposide induced 2.4 -2.38079
TFDP1 transcription factor Dp-1 -2.371
KDM1A lysine (K)-specific demethylase 1A -2.3624
BLVRA biliverdin reductase A -2.36055
FOXE1 forkhead box E1 -2.34882
SLBP stem-loop binding protein -2.29634
FDXACB1 ferredoxin-fold anticodon binding domain containing 1 -2.27617
RGS12 regulator of G-protein signaling 12 -2.26662
LRMP lymphoid-restricted membrane protein -2.25142
PPP1R35 protein phosphatase 1, regulatory subunit 35 -2.2438
SF3A3 splicing factor 3a, subunit 3, 60kDa -2.23576
SYNPO2 synaptopodin 2 -2.22929
ANKRD53 ankyrin repeat domain 53 -2.22282
PREP prolyl endopeptidase -2.20936
NAP1L4 nucleosome assembly protein 1-like 4 -2.20173
RPS12 ribosomal protein S12 -2.2008
BLOC1S5 biogenesis of lysosomal organelles complex-1, subunit 5, muted -2.18681
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae) -2.18595
RPL23 ribosomal protein L23 -2.18556
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein -2.15892
EMC6 ER membrane protein complex subunit 6 -2.15621
TMEM261 transmembrane protein 261 -2.15473
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -2.14431
HJURP Holliday junction recognition protein -2.13318
KLK14 kallikrein-related peptidase 14 -2.10931
EIF4A3 eukaryotic translation initiation factor 4A3 -2.10068
GFRAL GDNF family receptor alpha like -2.09157
HIAT1 hippocampus abundant transcript 1 -2.08728
SCGN secretagogin, EF-hand calcium binding protein -2.08532
OR13D1 olfactory receptor, family 13, subfamily D, member 1 -2.08272
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase -2.07432
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa -2.06617
PUS7 pseudouridylate synthase 7 (putative) -2.05835
CDK2 cyclin-dependent kinase 2 -2.05807
USP39 ubiquitin specific peptidase 39 -2.04877
DCK deoxycytidine kinase -2.04666
PSMC3IP PSMC3 interacting protein -2.0418
COX20 COX20 cytochrome c oxidase assembly factor -2.03615
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 -2.02415
KRAS Kirsten rat sarcoma viral oncogene homolog -2.02166
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae) -2.01931
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 -2.01334
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.01189
PFDN1 prefoldin subunit 1 -2.00062
TSEN34 TSEN34 tRNA splicing endonuclease subunit -1.9995
CDC6 cell division cycle 6 -1.99705
H1FX H1 histone family, member X -1.9877
GNPAT glyceronephosphate O-acyltransferase -1.98698
HCFC1 host cell factor C1 -1.98231
C14ORF1 chromosome 14 open reading frame 1 -1.9782
BOLA1 bolA family member 1 -1.97526
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase -1.94939
GPX6 glutathione peroxidase 6 -1.94385
ALAD aminolevulinate dehydratase -1.94156
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4 -1.93963
NANS N-acetylneuraminic acid synthase -1.92467
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) -1.91579
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -1.9056
AVEN apoptosis, caspase activation inhibitor -1.9044
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -1.89952
BOP1 block of proliferation 1 -1.89934
FTH1 ferritin, heavy polypeptide 1 -1.88999
EIF4H eukaryotic translation initiation factor 4H -1.88438
UBAP2 ubiquitin associated protein 2 -1.88317
CTNNBL1 catenin, beta like 1 -1.86838
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) -1.8652
CPNE3 copine III -1.8639
STAT5B signal transducer and activator of transcription 5B -1.85961
SKA1 spindle and kinetochore associated complex subunit 1 -1.85605
FASTKD1 FAST kinase domains 1 -1.84657
DIABLO diablo, IAP-binding mitochondrial protein -1.8342
HDAC3 histone deacetylase 3 -1.82749
CSNK1G2 casein kinase 1, gamma 2 -1.82715
RBM4B RNA binding motif protein 4B -1.8255
TXNL1 thioredoxin-like 1 -1.82353
PHF6 PHD finger protein 6 -1.8172
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit -1.81158
ZCCHC17 zinc finger, CCHC domain containing 17 -1.8089
VRK2 vaccinia related kinase 2 -1.80648
INTS1 integrator complex subunit 1 -1.79259
SFTPA1 surfactant protein A1 -1.78496
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 -1.7786
FAM216B family with sequence similarity 216, member B -1.77665
TRPM5 transient receptor potential cation channel, subfamily M, member 5 -1.77298
C9ORF156 chromosome 9 open reading frame 156 -1.76814
PLIN5 perilipin 5 -1.76624
NSMCE1 non-SMC element 1 homolog (S. cerevisiae) -1.7526
CUTA cutA divalent cation tolerance homolog (E. coli) -1.75081
SLC35A4 solute carrier family 35, member A4 -1.7481
ETV6 ets variant 6 -1.74773
LRRN4 leucine rich repeat neuronal 4 -1.74757
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 -1.7417
PURB purine-rich element binding protein B -1.73986
KDM5D lysine (K)-specific demethylase 5D -1.73962
LIN54 lin-54 DREAM MuvB core complex component -1.73617
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 -1.73528
SYTL2 synaptotagmin-like 2 -1.73258
TUBGCP2 tubulin, gamma complex associated protein 2 -1.72988
FAM206A family with sequence similarity 206, member A -1.72974
TPK1 thiamin pyrophosphokinase 1 -1.71931
HNRNPM heterogeneous nuclear ribonucleoprotein M -1.71174
PRPS1L1 phosphoribosyl pyrophosphate synthetase 1-like 1 -1.7099
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) -1.70098
CABP7 calcium binding protein 7 -1.699
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa -1.69388
PARS2 prolyl-tRNA synthetase 2, mitochondrial (putative) -1.69093
MRPL48 mitochondrial ribosomal protein L48 -1.68763
ESRRG estrogen-related receptor gamma -1.68762
THYN1 thymocyte nuclear protein 1 -1.68731
PLTP phospholipid transfer protein -1.68381
C11ORF73 chromosome 11 open reading frame 73 -1.68111
TMEM256 transmembrane protein 256 -1.67285
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -1.67182
PTBP1 polypyrimidine tract binding protein 1 -1.67121
ADCY8 adenylate cyclase 8 (brain) -1.66935
NLN neurolysin (metallopeptidase M3 family) -1.66854
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -1.66326
STAB1 stabilin 1 -1.65887
MOV10L1 Mov10 RISC complex RNA helicase like 1 -1.65839
NEFL neurofilament, light polypeptide -1.65511
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 -1.6534
MRPL14 mitochondrial ribosomal protein L14 -1.65313
CETN3 centrin, EF-hand protein, 3 -1.65185
CNTLN centlein, centrosomal protein -1.64693
CD8A CD8a molecule -1.64592
TUBG1 tubulin, gamma 1 -1.64393
IGSF5 immunoglobulin superfamily, member 5 -1.64347
OPRL1 opiate receptor-like 1 -1.64345
EXOSC7 exosome component 7 -1.64295
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 -1.63915
MAGED2 melanoma antigen family D2 -1.63385
MORN2 MORN repeat containing 2 -1.6322
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -1.6302
POLD2 polymerase (DNA directed), delta 2, accessory subunit -1.62821
SEPT9 septin 9 -1.62761
RHOBTB2 Rho-related BTB domain containing 2 -1.62618
PCCA propionyl CoA carboxylase, alpha polypeptide -1.62592
SKA2 spindle and kinetochore associated complex subunit 2 -1.62553
DBT dihydrolipoamide branched chain transacylase E2 -1.624
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -1.62218
FMOD fibromodulin -1.61265
ZBTB8A zinc finger and BTB domain containing 8A -1.61255
SEC13 SEC13 homolog (S. cerevisiae) -1.61208
MRPL50 mitochondrial ribosomal protein L50 -1.61111
TOP3A topoisomerase (DNA) III alpha -1.60842
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) -1.60793
SLC35G6 solute carrier family 35, member G6 -1.60611
EPPIN-WFDC6 EPPIN-WFDC6 readthrough -1.60129
CDK16 cyclin-dependent kinase 16 -1.60124
TUBA4A tubulin, alpha 4a -1.59843
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa -1.59792
XPO4 exportin 4 -1.58915
PASK PAS domain containing serine/threonine kinase -1.58593
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein -1.58036
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 -1.57741
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 -1.57548
ATMIN ATM interactor -1.57231
ATRIP ATR interacting protein -1.56492
TBC1D2B TBC1 domain family, member 2B -1.56485
PNLIPRP2 pancreatic lipase-related protein 2 -1.56437
NASP nuclear autoantigenic sperm protein (histone-binding) -1.56152
MLXIP MLX interacting protein -1.56053
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 -1.55961
NME1 NME/NM23 nucleoside diphosphate kinase 1 -1.55737
RLN3 relaxin 3 -1.55611
TMEM208 transmembrane protein 208 -1.55553
TLN2 talin 2 -1.55414
SZRD1 SUZ RNA binding domain containing 1 -1.54978
C19ORF43 chromosome 19 open reading frame 43 -1.54809
ZBTB9 zinc finger and BTB domain containing 9 -1.5477
HACL1 2-hydroxyacyl-CoA lyase 1 -1.54306
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 -1.54189
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -1.54118
APLN apelin -1.53936
VCP valosin containing protein -1.53818
TTC24 tetratricopeptide repeat domain 24 -1.53752
STYK1 serine/threonine/tyrosine kinase 1 -1.53463
WWP2 WW domain containing E3 ubiquitin protein ligase 2 -1.53422
GTF3C6 general transcription factor IIIC, polypeptide 6, alpha 35kDa -1.53271
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase -1.53115
GDAP1L1 ganglioside induced differentiation associated protein 1-like 1 -1.52936
ECD ecdysoneless homolog (Drosophila) -1.52738
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -1.52523
ZNF398 zinc finger protein 398 -1.52518
HEATR3 HEAT repeat containing 3 -1.52303
DNAJC19 DnaJ (Hsp40) homolog, subfamily C, member 19 -1.52035
C16ORF74 chromosome 16 open reading frame 74 -1.51918
OR7G2 olfactory receptor, family 7, subfamily G, member 2 -1.51848
ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit -1.51817
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha -1.51601
UMPS uridine monophosphate synthetase -1.51583
NENF neudesin neurotrophic factor -1.51447
BCCIP BRCA2 and CDKN1A interacting protein -1.51417
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 -1.50926
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 -1.50253
NELFB negative elongation factor complex member B -1.5023
PIGK phosphatidylinositol glycan anchor biosynthesis, class K -1.49466
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -1.49415
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) -1.49316
DPP6 dipeptidyl-peptidase 6 -1.49261
TSEN15 TSEN15 tRNA splicing endonuclease subunit -1.49159
GSS glutathione synthetase -1.48852
FAM19A3 family with sequence similarity 19 (chemokine (C-C motif)-like), member A3 -1.48712
ZMAT5 zinc finger, matrin-type 5 -1.48275
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit -1.48159
FADD Fas (TNFRSF6)-associated via death domain -1.4804
HN1 hematological and neurological expressed 1 -1.47973
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 -1.47967
OR1L6 olfactory receptor, family 1, subfamily L, member 6 -1.47855
HAUS2 HAUS augmin-like complex, subunit 2 -1.47833
PGP phosphoglycolate phosphatase -1.4769
EYA3 EYA transcriptional coactivator and phosphatase 3 -1.47642
HCN3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 -1.47459
ACOX1 acyl-CoA oxidase 1, palmitoyl -1.47386
MCM3 minichromosome maintenance complex component 3 -1.47067
PPP1R13B protein phosphatase 1, regulatory subunit 13B -1.46521
SLC30A3 solute carrier family 30 (zinc transporter), member 3 -1.46492
ZDHHC16 zinc finger, DHHC-type containing 16 -1.46188
VIL1 villin 1 -1.45929
PHB2 prohibitin 2 -1.45804
GLO1 glyoxalase I -1.4553
C1ORF86 chromosome 1 open reading frame 86 -1.45412
RAB30 RAB30, member RAS oncogene family -1.45281
CTC1 CTS telomere maintenance complex component 1 -1.45169
BRCA2 breast cancer 2, early onset -1.44415
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 -1.44265
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial -1.43966
LYZ lysozyme -1.43716
TGS1 trimethylguanosine synthase 1 -1.43623
OLFM3 olfactomedin 3 -1.4345
ELAC2 elaC ribonuclease Z 2 -1.43305
MMS22L MMS22-like, DNA repair protein -1.43272
NUP107 nucleoporin 107kDa -1.43062
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -1.42955
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 -1.42906
SREBF2 sterol regulatory element binding transcription factor 2 -1.42739
CDC42SE2 CDC42 small effector 2 -1.42463
RPA3 replication protein A3, 14kDa -1.42149
ZMYM3 zinc finger, MYM-type 3 -1.41425
UPB1 ureidopropionase, beta -1.41207
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -1.41093
ZNF462 zinc finger protein 462 -1.40956
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -1.40757
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -1.4035
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 -1.40332
RPA2 replication protein A2, 32kDa -1.40155
UNG uracil-DNA glycosylase -1.39786
RPL3 ribosomal protein L3 -1.39734
TSC2 tuberous sclerosis 2 -1.39729
TUBB4B tubulin, beta 4B class IVb -1.39481
APMAP adipocyte plasma membrane associated protein -1.39477
FSCN1 fascin actin-bundling protein 1 -1.39463
BHMT2 betaine--homocysteine S-methyltransferase 2 -1.39391
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) -1.39356
CDCA7 cell division cycle associated 7 -1.39248
SIKE1 suppressor of IKBKE 1 -1.39173
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 -1.38749
OR5H14 olfactory receptor, family 5, subfamily H, member 14 -1.38629
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -1.3801
GMDS GDP-mannose 4,6-dehydratase -1.37988
WASF3 WAS protein family, member 3 -1.37932
SLAMF1 signaling lymphocytic activation molecule family member 1 -1.37883
YDJC YdjC homolog (bacterial) -1.37811
RBM10 RNA binding motif protein 10 -1.37773
TAMM41 TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae) -1.37689
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -1.37653
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 -1.37618
C17ORF85 chromosome 17 open reading frame 85 -1.37601