PDK2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description pyruvate dehydrogenase kinase, isozyme 2|This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] (NCBI Entrez Gene Database, 5164)
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Genes

359 genes differentially expressed following the PDK2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 3.36015
IL5RA interleukin 5 receptor, alpha 3.36015
CLEC19A C-type lectin domain family 19, member A 3.36015
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 3.36015
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 3.36015
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 3.36015
PAX6 paired box 6 3.36015
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 3.36015
PLCH2 phospholipase C, eta 2 3.36015
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 3.36015
DIRAS3 DIRAS family, GTP-binding RAS-like 3 3.36015
AZGP1 alpha-2-glycoprotein 1, zinc-binding 3.36015
NOD2 nucleotide-binding oligomerization domain containing 2 3.36015
STKLD1 serine/threonine kinase-like domain containing 1 3.36015
INHBC inhibin, beta C 3.36015
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 3.36015
CARD18 caspase recruitment domain family, member 18 3.36015
COLEC10 collectin sub-family member 10 (C-type lectin) 3.36015
ADGRE1 adhesion G protein-coupled receptor E1 3.36015
DUXB double homeobox B 3.36015
CD1C CD1c molecule 3.36015
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) 3.36015
KRT27 keratin 27, type I 3.36015
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 3.36015
C19ORF67 chromosome 19 open reading frame 67 3.36015
GPR26 G protein-coupled receptor 26 3.36015
HYPK huntingtin interacting protein K 3.36015
AVP arginine vasopressin 3.36015
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.36015
LGALS4 lectin, galactoside-binding, soluble, 4 3.36015
LGALS2 lectin, galactoside-binding, soluble, 2 3.36015
CSNK2A3 casein kinase 2, alpha 3 polypeptide 3.36015
PODNL1 podocan-like 1 3.36015
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 3.36015
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 3.36015
LOC102724877 uncharacterized LOC102724877 3.36015
SLC44A4 solute carrier family 44, member 4 3.36015
HBD hemoglobin, delta 3.36015
UBE2U ubiquitin-conjugating enzyme E2U (putative) 3.36015
NCKAP1L NCK-associated protein 1-like 3.36015
GUCY2F guanylate cyclase 2F, retinal 3.36015
CD68 CD68 molecule 3.36015
MAGED4 melanoma antigen family D4 3.36015
TCP11 t-complex 11, testis-specific 3.36015
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 3.36015
DLL4 delta-like 4 (Drosophila) 3.36015
COPZ2 coatomer protein complex, subunit zeta 2 3.36015
GNRHR gonadotropin-releasing hormone receptor 3.36015
STAP1 signal transducing adaptor family member 1 3.36015
FAM90A26 family with sequence similarity 90, member A26, pseudogene 3.36015
LOC128125816 uncharacterized LOC128125816 3.36015
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 3.36015
MYH1 myosin, heavy chain 1, skeletal muscle, adult 3.36015
SPATA31C2 SPATA31 subfamily C, member 2 3.36015
TMPRSS4 transmembrane protease, serine 4 3.36015
WDR64 WD repeat domain 64 3.36015
TREX2 three prime repair exonuclease 2 3.36015
FCMR Fc fragment of IgM receptor 3.36015
LY6H lymphocyte antigen 6 complex, locus H 3.36015
PRDM7 PR domain containing 7 3.36015
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 3.36015
SEPTIN14 septin 14 3.36015
CFAP119 cilia and flagella associated protein 119 3.36015
SPMIP1 sperm microtubule inner protein 1 3.36015
CIMAP1B ciliary microtubule associated protein 1B 3.36015
C20ORF204 chromosome 20 open reading frame 204 3.36015
H4C14 H4 clustered histone 14 3.36015
LHFPL7 LHFPL tetraspan subfamily member 7 3.36015
CFAP107 cilia and flagella associated protein 107 3.36015
DNAAF6 dynein axonemal assembly factor 6 3.36015
TERB1 telomere repeat binding bouquet formation protein 1 3.36015
CABCOCO1 ciliary associated calcium binding coiled-coil 1 3.36015
RTL9 retrotransposon Gag like 9 3.36015
CNTN6 contactin 6 3.36015
PRG4 proteoglycan 4 3.36015
LRRC72 leucine rich repeat containing 72 3.36015
MAL mal, T-cell differentiation protein 3.36015
NXPE1 neurexophilin and PC-esterase domain family, member 1 3.36015
PTGDR2 prostaglandin D2 receptor 2 3.36015
IRF8 interferon regulatory factor 8 3.36015
CCDC17 coiled-coil domain containing 17 3.36015
TMIE transmembrane inner ear 3.36015
ARL5C ADP-ribosylation factor-like 5C 3.36015
SLFN14 schlafen family member 14 3.36015
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 3.36015
TBX20 T-box 20 3.36015
ANXA10 annexin A10 3.36015
LDHAL6B lactate dehydrogenase A-like 6B 3.36015
LRRC71 leucine rich repeat containing 71 3.36015
C9 complement component 9 3.36015
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 3.36015
TCF23 transcription factor 23 3.36015
PRR18 proline rich 18 3.36015
LECT2 leukocyte cell-derived chemotaxin 2 3.36015
PRRT4 proline-rich transmembrane protein 4 3.36015
KLRF2 killer cell lectin-like receptor subfamily F, member 2 3.36015
BHLHA9 basic helix-loop-helix family, member a9 3.36015
TLR7 toll-like receptor 7 3.36015
ZNF98 zinc finger protein 98 3.36015
IHH indian hedgehog 3.36015
SV2B synaptic vesicle glycoprotein 2B 3.36015
BTNL3 butyrophilin-like 3 3.36015
TSLP thymic stromal lymphopoietin 3.36015
KLF4 Kruppel-like factor 4 (gut) 3.36015
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3.36015
NIPAL4 NIPA-like domain containing 4 3.36015
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 3.36015
AGXT2 alanine--glyoxylate aminotransferase 2 3.36015
EVPLL envoplakin-like 3.36015
TMEM132E transmembrane protein 132E 3.36015
GP2 glycoprotein 2 (zymogen granule membrane) 3.36015
KIF4B kinesin family member 4B 3.36015
SLFN12L schlafen family member 12-like 3.36015
HSPB9 heat shock protein, alpha-crystallin-related, B9 3.36015
TMEM150B transmembrane protein 150B 3.36015
DES desmin 3.36015
PCDHGB4 protocadherin gamma subfamily B, 4 3.36015
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.36015
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 3.36015
SHOX2 short stature homeobox 2 3.36015
TAT tyrosine aminotransferase 3.36015
IL1A interleukin 1, alpha 3.36015
CDK20 cyclin-dependent kinase 20 3.36015
HFE hemochromatosis 3.36015
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 3.36015
KRT35 keratin 35, type I 3.36015
TM4SF19 transmembrane 4 L six family member 19 3.36015
CCNA1 cyclin A1 3.36015
ADAM18 ADAM metallopeptidase domain 18 3.36015
WNT2 wingless-type MMTV integration site family member 2 3.36015
UPK1B uroplakin 1B 3.36015
NLRP14 NLR family, pyrin domain containing 14 3.36015
FAIM2 Fas apoptotic inhibitory molecule 2 3.36015
LRRC25 leucine rich repeat containing 25 3.36015
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 3.36015
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 3.36015
LRRK2 leucine-rich repeat kinase 2 3.36015
SVOP SV2 related protein homolog (rat) 3.36015
PRR35 proline rich 35 3.36015
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 3.36015
LY96 lymphocyte antigen 96 3.36015
FGR FGR proto-oncogene, Src family tyrosine kinase 3.36015
ARL13A ADP-ribosylation factor-like 13A 3.36015
CRTAM cytotoxic and regulatory T cell molecule 3.36015
GALP galanin-like peptide 3.36015
TUBAL3 tubulin, alpha-like 3 3.36015
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 3.36015
RNF224 ring finger protein 224 3.36015
MAGEA12 melanoma antigen family A12 3.36015
NEUROD2 neuronal differentiation 2 3.36015
SLITRK6 SLIT and NTRK-like family, member 6 3.36015
OR10G3 olfactory receptor, family 10, subfamily G, member 3 3.36015
ICAM5 intercellular adhesion molecule 5, telencephalin 3.36015
TAS2R42 taste receptor, type 2, member 42 3.36015
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 3.36015
GRAP2 GRB2-related adaptor protein 2 3.36015
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 3.36015
SMCO3 single-pass membrane protein with coiled-coil domains 3 3.36015
ZBED6 zinc finger, BED-type containing 6 3.36015
DHRS9 dehydrogenase/reductase (SDR family) member 9 3.36015
SP100 SP100 nuclear antigen 3.36015
CIB4 calcium and integrin binding family member 4 3.36015
RHAG Rh-associated glycoprotein 3.36015
SLC51B solute carrier family 51, beta subunit 3.36015
PADI6 peptidyl arginine deiminase, type VI 3.36015
CRTAC1 cartilage acidic protein 1 3.33667
DUT deoxyuridine triphosphatase 3.12794
MAGEA4 melanoma antigen family A4 3.08621
CCDC92 coiled-coil domain containing 92 3.04324
RAMACL RNA guanine-7 methyltransferase activating subunit like 3.04324
MITF microphthalmia-associated transcription factor 2.97243
TRIR telomerase RNA component interacting RNase 2.93388
PDLIM4 PDZ and LIM domain 4 2.88611
TSACC TSSK6 activating co-chaperone 2.86509
AP1G2 adaptor-related protein complex 1, gamma 2 subunit 2.75921
ZNF680 zinc finger protein 680 2.73986
LARS2 leucyl-tRNA synthetase 2, mitochondrial 2.73986
SPRY2 sprouty homolog 2 (Drosophila) 2.72143
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 2.69725
SH3GL1 SH3-domain GRB2-like 1 2.68512
ZNF273 zinc finger protein 273 2.59726
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 2.57329
ATXN2 ataxin 2 2.50283
SPON1 spondin 1, extracellular matrix protein 2.48826
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) 2.48826
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 2.48826
FYTTD1 forty-two-three domain containing 1 2.45607
ARLN allregulin 2.43275
TMIGD1 transmembrane and immunoglobulin domain containing 1 2.42422
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 2.41703
PFKL phosphofructokinase, liver 2.4056
ZSCAN2 zinc finger and SCAN domain containing 2 2.4056
ZNF557 zinc finger protein 557 2.40493
FGFR3 fibroblast growth factor receptor 3 2.399
SLC39A12 solute carrier family 39 (zinc transporter), member 12 2.3943
SPNS1 spinster homolog 1 (Drosophila) 2.37146
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) 2.3654
LRRC19 leucine rich repeat containing 19 2.36425
STRIT1 small transmembrane regulator of ion transport 1 2.36425
SLCO2B1 solute carrier organic anion transporter family, member 2B1 2.36425
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.36425
FASN fatty acid synthase 2.36425
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 2.35207
ADRA2A adrenoceptor alpha 2A 2.33762
SYF2 SYF2 pre-mRNA-splicing factor 2.31069
ZNF514 zinc finger protein 514 2.30781
MAEA macrophage erythroblast attacher 2.29285
SARAF store-operated calcium entry-associated regulatory factor 2.25659
REEP5 receptor accessory protein 5 2.25273
MAP3K14 mitogen-activated protein kinase kinase kinase 14 2.24821
EPS8L2 EPS8-like 2 2.2476
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) 2.24155
AACS acetoacetyl-CoA synthetase 2.23968
MINDY2 MINDY lysine 48 deubiquitinase 2 2.23459
CHMP7 charged multivesicular body protein 7 2.22822
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 2.18625
H4C1 H4 clustered histone 1 2.16981
RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) 2.16966
IGFBP4 insulin-like growth factor binding protein 4 2.14743
ART5 ADP-ribosyltransferase 5 2.14743
XPO6 exportin 6 2.14112
TXNIP thioredoxin interacting protein 2.1403
ILK integrin-linked kinase 2.12444
ACO2 aconitase 2, mitochondrial 2.11778
CIBAR1 CBY1 interacting BAR domain containing 1 2.10615
DNHD1 dynein heavy chain domain 1 2.10615
MED13 mediator complex subunit 13 2.09351
CNOT12 CCR4-NOT transcription complex subunit 12 2.08426
PGPEP1 pyroglutamyl-peptidase I 2.08238
SORBS1 sorbin and SH3 domain containing 1 2.07778
EPDR1 ependymin related 1 2.06286
NDN necdin, melanoma antigen (MAGE) family member 2.06286
HAP1 huntingtin-associated protein 1 2.05988
SHARPIN SHANK-associated RH domain interactor 2.05988
SGK3 serum/glucocorticoid regulated kinase family, member 3 2.04456
GAL3ST1 galactose-3-O-sulfotransferase 1 2.0378
UNC13D unc-13 homolog D (C. elegans) 2.0378
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 2.02134
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 2.01367
PRX periaxin 2.01218
RAB18 RAB18, member RAS oncogene family 2.0121
PACRG PARK2 co-regulated 2.00057

decreased expression

Symbol Name Standardized Value
PCDHGA6 protocadherin gamma subfamily A, 6 -3.36015
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -3.36015
PPP1R42 protein phosphatase 1, regulatory subunit 42 -3.36015
TET2 tet methylcytosine dioxygenase 2 -3.36015
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa -3.36015
CD86 CD86 molecule -3.36015
LCP1 lymphocyte cytosolic protein 1 (L-plastin) -3.36015
AMDHD1 amidohydrolase domain containing 1 -3.33667
KCNIP3 Kv channel interacting protein 3, calsenilin -3.33667
TTLL9 tubulin tyrosine ligase-like family member 9 -3.33667
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) -3.33667
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 -3.33667
NRSN1 neurensin 1 -3.33667
FXYD3 FXYD domain containing ion transport regulator 3 -3.33667
PRAP1 proline-rich acidic protein 1 -3.33667
EXOC1L exocyst complex component 1 like -3.33667
ZNF610 zinc finger protein 610 -3.33667
SAPCD1 suppressor APC domain containing 1 -3.33667
MYZAP myocardial zonula adherens protein -3.33667
ARHGAP15 Rho GTPase activating protein 15 -3.33667
IL1R1 interleukin 1 receptor, type I -3.33667
SPMAP1 sperm microtubule associated protein 1 -3.33667
MSX1 msh homeobox 1 -3.33667
FAM178B family with sequence similarity 178, member B -3.33667
LBHD1 LBH domain containing 1 -3.33667
TMPRSS11D transmembrane protease, serine 11D -3.33667
LURAP1L leucine rich adaptor protein 1-like -3.33667
DRICH1 aspartate-rich 1 -3.33667
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -3.33667
EDN1 endothelin 1 -3.33667
PDZRN4 PDZ domain containing ring finger 4 -3.33667
EFCAB3 EF-hand calcium binding domain 3 -3.33667
KISS1 KiSS-1 metastasis-suppressor -3.33667
SMIM17 small integral membrane protein 17 -3.33667
NLRC3 NLR family, CARD domain containing 3 -3.33667
KLHL10 kelch-like family member 10 -3.33667
EIF4E1B eukaryotic translation initiation factor 4E family member 1B -3.33667
STRC stereocilin -3.33667
FBXL22 F-box and leucine-rich repeat protein 22 -3.33667
GPR12 G protein-coupled receptor 12 -3.33667
PATL1 protein associated with topoisomerase II homolog 1 (yeast) -3.33544
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 -3.33544
C2 complement component 2 -3.2538
NSUN5 NOP2/Sun domain family, member 5 -3.23306
APOLD1 apolipoprotein L domain containing 1 -3.21673
MANEAL mannosidase, endo-alpha-like -3.21673
PCDHGB6 protocadherin gamma subfamily B, 6 -3.21673
TEAD2 TEA domain family member 2 -3.08032
EHD3 EH-domain containing 3 -3.04277
SERINC5 serine incorporator 5 -2.8672
RABGGTA Rab geranylgeranyltransferase, alpha subunit -2.73986
FIGNL1 fidgetin-like 1 -2.65697
L3MBTL3 l(3)mbt-like 3 (Drosophila) -2.63707
AK4 adenylate kinase 4 -2.63707
TIPE3 TNF alpha induced protein 8 like 3 -2.63152
TMEM81 transmembrane protein 81 -2.55424
IKBIP IKBKB interacting protein -2.55424
LIN37 lin-37 DREAM MuvB core complex component -2.51745
TYMS thymidylate synthetase -2.50881
TMEM14B transmembrane protein 14B -2.50399
PGBD4 piggyBac transposable element derived 4 -2.49048
BRICD5 BRICHOS domain containing 5 -2.49048
KIF1B kinesin family member 1B -2.49048
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -2.49048
COG7 component of oligomeric golgi complex 7 -2.49048
MGAT4C MGAT4 family, member C -2.4897
TLN2 talin 2 -2.4056
NAMPT nicotinamide phosphoribosyltransferase -2.4056
AK1 adenylate kinase 1 -2.3943
GLUL glutamate-ammonia ligase -2.3943
BSN bassoon presynaptic cytomatrix protein -2.36425
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2 -2.36425
RFC4 replication factor C (activator 1) 4, 37kDa -2.35287
NEK1 NIMA-related kinase 1 -2.35263
SPATA2L spermatogenesis associated 2-like -2.33993
CADM2 cell adhesion molecule 2 -2.33277
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 -2.30545
SLC12A9 solute carrier family 12, member 9 -2.29384
PRKCH protein kinase C, eta -2.29384
CRLF2 cytokine receptor-like factor 2 -2.29285
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -2.29285
IER5L immediate early response 5-like -2.29285
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 -2.29112
MARVELD2 MARVEL domain containing 2 -2.28718
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -2.28561
FOXO4 forkhead box O4 -2.277
COLEC12 collectin sub-family member 12 -2.25323
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -2.25273
TMEM260 transmembrane protein 260 -2.2476
EFNA1 ephrin-A1 -2.23809
YAE1 YAE1 maturation factor of ABCE1 -2.22556
TRIM65 tripartite motif containing 65 -2.22552
SNX2 sorting nexin 2 -2.18939
SPOP speckle-type POZ protein -2.18625
BST1 bone marrow stromal cell antigen 1 -2.18302
C11ORF42 chromosome 11 open reading frame 42 -2.18302
MYH11 myosin, heavy chain 11, smooth muscle -2.18302
INKA1 inka box actin regulator 1 -2.18302
LRP10 low density lipoprotein receptor-related protein 10 -2.16966
KMT2A lysine (K)-specific methyltransferase 2A -2.16729
TMEM164 transmembrane protein 164 -2.16423
LRP2 low density lipoprotein receptor-related protein 2 -2.15012
PILRB paired immunoglobin-like type 2 receptor beta -2.12982
SF3A1 splicing factor 3a, subunit 1, 120kDa -2.12642
OTUD5 OTU deubiquitinase 5 -2.10615
SLX4 SLX4 structure-specific endonuclease subunit -2.07959
ZIM3 zinc finger, imprinted 3 -2.07125
LEPROTL1 leptin receptor overlapping transcript-like 1 -2.06647
ATP13A3 ATPase type 13A3 -2.05496
MAST3 microtubule associated serine/threonine kinase 3 -2.05174
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -2.04059
PCYOX1L prenylcysteine oxidase 1 like -2.03694
DENND5B DENN/MADD domain containing 5B -2.02438
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast) -2.02438
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -2.01218
CLEC2L C-type lectin domain family 2, member L -2.0121
PALS1 protein associated with LIN7 1, MAGUK p55 family member -2.01167