PDX1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description pancreatic and duodenal homeobox 1|The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3651)
External Link http://www.ncbi.nlm.nih.gov/gene/3651
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65 interacting proteins for PDX1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ALK anaplastic lymphoma receptor tyrosine kinase
ARHGAP9 Rho GTPase activating protein 9
ATF3 activating transcription factor 3
CDK13 cyclin-dependent kinase 13
CENPF centromere protein F, 350/400kDa
CREB1 cAMP responsive element binding protein 1
DGKZ diacylglycerol kinase, zeta
EIF4B eukaryotic translation initiation factor 4B
EPHA1 EPH receptor A1
EPHB3 EPH receptor B3
FN3K fructosamine 3 kinase
GAK cyclin G associated kinase
HMGA1 high mobility group AT-hook 1
IAPP islet amyloid polypeptide
INSL6 insulin-like 6
IRF7 interferon regulatory factor 7
IRS4 insulin receptor substrate 4
ITK IL2-inducible T-cell kinase
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KRT18 keratin 18, type I
KRT74 keratin 74, type II
LMNB1 lamin B1
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MAPK9 mitogen-activated protein kinase 9
MARK1 MAP/microtubule affinity-regulating kinase 1
MEIS2 Meis homeobox 2
MEP1B meprin A, beta
MTIF2 mitochondrial translational initiation factor 2
MYLK myosin light chain kinase
NEUROD1 neuronal differentiation 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PASK PAS domain containing serine/threonine kinase
PBX1 pre-B-cell leukemia homeobox 1
PCIF1 PDX1 C-terminal inhibiting factor 1
PDLIM5 PDZ and LIM domain 5
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PKNOX1 PBX/knotted 1 homeobox 1
PLCB2 phospholipase C, beta 2
PLCG1 phospholipase C, gamma 1
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTPRK protein tyrosine phosphatase, receptor type, K
RAB35 RAB35, member RAS oncogene family
RAD17 RAD17 homolog (S. pombe)
SH3GL3 SH3-domain GRB2-like 3
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SMC6 structural maintenance of chromosomes 6
SOCS1 suppressor of cytokine signaling 1
SOCS5 suppressor of cytokine signaling 5
SPOP speckle-type POZ protein
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TCF3 transcription factor 3
UBASH3A ubiquitin associated and SH3 domain containing A
UBC ubiquitin C
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6