PEG10 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description paternally expressed 10|This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene. [provided by RefSeq, Oct 2014] (NCBI Entrez Gene Database, 23089)
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Genes

309 genes differentially expressed following the PEG10 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SCGN secretagogin, EF-hand calcium binding protein 2.56667
SPATA31H1 SPATA31 subfamily H member 1 2.45124
PEAR1 platelet endothelial aggregation receptor 1 2.45124
OTOS otospiralin 2.45124
FRMPD2 FERM and PDZ domain containing 2 2.45124
PCDHGB1 protocadherin gamma subfamily B, 1 2.45124
ZBED6 zinc finger, BED-type containing 6 2.45124
AANAT aralkylamine N-acetyltransferase 2.45124
PCDHGA2 protocadherin gamma subfamily A, 2 2.45124
PRSS21 protease, serine, 21 (testisin) 2.45124
RAB40A RAB40A, member RAS oncogene family 2.45124
GLIPR1L2 GLI pathogenesis-related 1 like 2 2.45124
TIMD4 T-cell immunoglobulin and mucin domain containing 4 2.45124
DLK2 delta-like 2 homolog (Drosophila) 2.45124
LAMP3 lysosomal-associated membrane protein 3 2.45124
NME8 NME/NM23 family member 8 2.45124
IGIP IgA-inducing protein 2.45124
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.45124
LGI1 leucine-rich, glioma inactivated 1 2.45124
OR11A1 olfactory receptor, family 11, subfamily A, member 1 2.45124
DNAI7 dynein axonemal intermediate chain 7 2.45124
TMEM200C transmembrane protein 200C 2.45124
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 2.40482
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.40482
OR52H1 olfactory receptor, family 52, subfamily H, member 1 2.40482
SLCO1B3 solute carrier organic anion transporter family, member 1B3 2.40482
RNF17 ring finger protein 17 2.40482
ZNF98 zinc finger protein 98 2.40482
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 2.40482
MAP3K7CL MAP3K7 C-terminal like 2.40482
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 2.40482
MYBPHL myosin binding protein H-like 2.40482
NAPSA napsin A aspartic peptidase 2.40482
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 2.40482
PKP1 plakophilin 1 2.40482
BSND barttin CLCNK-type chloride channel accessory beta subunit 2.40482
OR10A2 olfactory receptor, family 10, subfamily A, member 2 2.40482
FFAR4 free fatty acid receptor 4 2.40482
SLC30A4 solute carrier family 30 (zinc transporter), member 4 2.40482
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.40482
MFAP4 microfibrillar-associated protein 4 2.40482
CA8 carbonic anhydrase VIII 2.40482
ANKRD34A ankyrin repeat domain 34A 2.40482
CXCL3 chemokine (C-X-C motif) ligand 3 2.40482
ADAMTSL2 ADAMTS-like 2 2.40482
SIRPB2 signal-regulatory protein beta 2 2.40482
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like 2.40482
OR52A5 olfactory receptor, family 52, subfamily A, member 5 2.40482
NEK10 NIMA-related kinase 10 2.40482
CX3CL1 chemokine (C-X3-C motif) ligand 1 2.40482
AKR1C2 aldo-keto reductase family 1, member C2 2.40482
MUC6 mucin 6, oligomeric mucus/gel-forming 2.40482
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.40482
OR1A1 olfactory receptor, family 1, subfamily A, member 1 2.40482
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 2.40482
SLC35G6 solute carrier family 35, member G6 2.40482
C1ORF141 chromosome 1 open reading frame 141 2.40482
STRIT1 small transmembrane regulator of ion transport 1 2.40482
SMIM41 small integral membrane protein 41 2.40482
H2BC1 H2B clustered histone 1 2.40482
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 2.40482
DEFB108B defensin, beta 108B 2.40482
YIPF7 Yip1 domain family, member 7 2.40482
LTB4R2 leukotriene B4 receptor 2 2.40482
EVPLL envoplakin-like 2.40482
VN1R1 vomeronasal 1 receptor 1 2.40482
HTRA4 HtrA serine peptidase 4 2.40482
GASK1B golgi associated kinase 1B 2.40482
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 2.40482
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 2.40482
SYT15B synaptotagmin 15B 2.40482
CIMAP1D CIMAP1 family member D 2.40482
EZHIP EZH inhibitory protein 2.40482
CFAP107 cilia and flagella associated protein 107 2.40482
DNAAF6 dynein axonemal assembly factor 6 2.40482
GARIN6 golgi associated RAB2 interactor family member 6 2.40482
DEFB131B defensin beta 131B 2.40482
RTL5 retrotransposon Gag like 5 2.40482
FRG2C FSHD region gene 2 family, member C 2.40482
PAPOLB poly(A) polymerase beta (testis specific) 2.40482
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.40482
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 2.40482
MYH13 myosin, heavy chain 13, skeletal muscle 2.40482
TLR6 toll-like receptor 6 2.40482
PLPP4 phospholipid phosphatase 4 2.40482
GOLGA6L4 golgin A6 family-like 4 2.40482
C3ORF80 chromosome 3 open reading frame 80 2.40482
ZNF436 zinc finger protein 436 2.40482
LIPJ lipase, family member J 2.40482
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.40482
CLDN22 claudin 22 2.40482
SRPK3 SRSF protein kinase 3 2.40482
ZNF441 zinc finger protein 441 2.40482
OR52E5 olfactory receptor, family 52, subfamily E, member 5 2.40482
SPATA22 spermatogenesis associated 22 2.40482
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.40482
C4ORF50 chromosome 4 open reading frame 50 2.40482
GPR84 G protein-coupled receptor 84 2.40482
ARHGAP15 Rho GTPase activating protein 15 2.40482
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 2.40482
RS1 retinoschisin 1 2.40482
SLC36A3 solute carrier family 36, member 3 2.40482
IL17REL interleukin 17 receptor E-like 2.40482
TMEM132E transmembrane protein 132E 2.40482
EDN3 endothelin 3 2.40482
CSTA cystatin A (stefin A) 2.40482
HCRT hypocretin (orexin) neuropeptide precursor 2.40482
CXCR6 chemokine (C-X-C motif) receptor 6 2.40482
C9ORF64 chromosome 9 open reading frame 64 2.40482
DGCR6 DiGeorge syndrome critical region gene 6 2.40482
PRF1 perforin 1 (pore forming protein) 2.40482
APOF apolipoprotein F 2.40482
SLITRK6 SLIT and NTRK-like family, member 6 2.40482
AZIN2 antizyme inhibitor 2 2.40482
CD177 CD177 molecule 2.40482
KIF4B kinesin family member 4B 2.40482
ARR3 arrestin 3, retinal (X-arrestin) 2.40482
SPAG11B sperm associated antigen 11B 2.40482
TTBK2 tau tubulin kinase 2 2.40482
CABP5 calcium binding protein 5 2.40482
LCN1 lipocalin 1 2.40482
RNASE10 ribonuclease, RNase A family, 10 (non-active) 2.40482
PSG8 pregnancy specific beta-1-glycoprotein 8 2.40482
CAPSL calcyphosine-like 2.40482
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 2.40482
GAS2L2 growth arrest-specific 2 like 2 2.40482
MGA MGA, MAX dimerization protein 2.40482
EVI2A ecotropic viral integration site 2A 2.40482
NR1D1 nuclear receptor subfamily 1, group D, member 1 2.40482
CFI complement factor I 2.40482
UBXN10 UBX domain protein 10 2.40482
CA5A carbonic anhydrase VA, mitochondrial 2.40482
FAM177B family with sequence similarity 177, member B 2.40482
EEA1 early endosome antigen 1 2.40482
CPA3 carboxypeptidase A3 (mast cell) 2.40482
IRGM immunity-related GTPase family, M 2.40482
DNTT DNA nucleotidylexotransferase 2.40482
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 2.40482
TPPP2 tubulin polymerization-promoting protein family member 2 2.40482
GPR62 G protein-coupled receptor 62 2.40482
CHRM1 cholinergic receptor, muscarinic 1 2.40482
RGPD4 RANBP2-like and GRIP domain containing 4 2.40482
BANF2 barrier to autointegration factor 2 2.40482
LKAAEAR1 LKAAEAR motif containing 1 2.40482
SLC10A5 solute carrier family 10, member 5 2.40482
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.40482
TPPP tubulin polymerization promoting protein 2.40482
SHISA7 shisa family member 7 2.40482
GYS2 glycogen synthase 2 (liver) 2.40482
TMC3 transmembrane channel-like 3 2.40482
PF4V1 platelet factor 4 variant 1 2.40482
AVP arginine vasopressin 2.40482
ACOT12 acyl-CoA thioesterase 12 2.40482
IL2RA interleukin 2 receptor, alpha 2.40482
MISP mitotic spindle positioning 2.40482
C1GALT1C1L C1GALT1-specific chaperone 1 like 2.40482
DLL4 delta-like 4 (Drosophila) 2.40482
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 2.40482
OR10G3 olfactory receptor, family 10, subfamily G, member 3 2.40482
LRRC38 leucine rich repeat containing 38 2.40482
ITPKA inositol-trisphosphate 3-kinase A 2.40482
LYZL4 lysozyme-like 4 2.40482
TRPM6 transient receptor potential cation channel, subfamily M, member 6 2.40482
GPBAR1 G protein-coupled bile acid receptor 1 2.40482
ZNF534 zinc finger protein 534 2.40482
MMP3 matrix metallopeptidase 3 2.40482
GPR176 G protein-coupled receptor 176 2.37988
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 2.36498
PRPF3 pre-mRNA processing factor 3 2.36498
NBPF8 neuroblastoma breakpoint family, member 8 2.36498
NRIP1 nuclear receptor interacting protein 1 2.36498
GLMN glomulin, FKBP associated protein 2.35691
TMEM182 transmembrane protein 182 2.35691
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 2.35093
DDA1 DET1 and DDB1 associated 1 2.33188
RWDD3 RWD domain containing 3 2.30728
GALR1 galanin receptor 1 2.27968
LOC124902436 talanin 2.27439
PRUNE2 prune homolog 2 (Drosophila) 2.27439
SIK1 salt-inducible kinase 1 2.2587
CDCA7 cell division cycle associated 7 2.25392
ZSCAN5A zinc finger and SCAN domain containing 5A 2.24147
RAE1 ribonucleic acid export 1 2.24024
TMEM44 transmembrane protein 44 2.20928
SEC14L2 SEC14-like 2 (S. cerevisiae) 2.18103
MAPT microtubule-associated protein tau 2.16438
CAPNS1 calpain, small subunit 1 2.15544
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 2.15544
ANGEL2 angel homolog 2 (Drosophila) 2.15328
ZBTB6 zinc finger and BTB domain containing 6 2.14597
ZNF202 zinc finger protein 202 2.13193
HNRNPK heterogeneous nuclear ribonucleoprotein K 2.1316
CCDC122 coiled-coil domain containing 122 2.09898
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 2.09642
VCAN versican 2.09642
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa 2.09498
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 2.09023
DHRS1 dehydrogenase/reductase (SDR family) member 1 2.08843
KANK1 KN motif and ankyrin repeat domains 1 2.06084
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 2.05692
NTMT2 N-terminal Xaa-Pro-Lys N-methyltransferase 2 2.00989
GRIK4 glutamate receptor, ionotropic, kainate 4 2.00506

decreased expression

Symbol Name Standardized Value
PEG10 paternally expressed 10 -3.09829
PRKG2 protein kinase, cGMP-dependent, type II -2.45124
SPMIP5 sperm microtubule inner protein 5 -2.45124
SPIRE2 spire-type actin nucleation factor 2 -2.40482
TMEM132A transmembrane protein 132A -2.40482
FOXP2 forkhead box P2 -2.40482
FDXACB1 ferredoxin-fold anticodon binding domain containing 1 -2.40482
RAB30 RAB30, member RAS oncogene family -2.40482
PDCD2 programmed cell death 2 -2.40482
COG6 component of oligomeric golgi complex 6 -2.40482
STKLD1 serine/threonine kinase-like domain containing 1 -2.40482
GHR growth hormone receptor -2.40482
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 -2.40482
PLCB4 phospholipase C, beta 4 -2.40482
LRRC66 leucine rich repeat containing 66 -2.40482
C19ORF53 chromosome 19 open reading frame 53 -2.40482
BBOF1 basal body orientation factor 1 -2.40482
RPL39 ribosomal protein L39 -2.40482
PCSK1 proprotein convertase subtilisin/kexin type 1 -2.40482
CHP1 calcineurin-like EF-hand protein 1 -2.40482
CYTIP cytohesin 1 interacting protein -2.40482
AKT1 v-akt murine thymoma viral oncogene homolog 1 -2.40482
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C -2.40482
IFFO2 intermediate filament family orphan 2 -2.40482
CDH12 cadherin 12, type 2 (N-cadherin 2) -2.40482
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 -2.40482
WASF3 WAS protein family, member 3 -2.40482
RPS20 ribosomal protein S20 -2.40482
TDRD7 tudor domain containing 7 -2.39826
ZFAND3 zinc finger, AN1-type domain 3 -2.39673
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.39259
RTEL1 regulator of telomere elongation helicase 1 -2.38612
UNC13C unc-13 homolog C (C. elegans) -2.36498
NOXA1 NADPH oxidase activator 1 -2.36498
GADL1 glutamate decarboxylase-like 1 -2.36498
CCDC92 coiled-coil domain containing 92 -2.36498
IZUMO4 IZUMO family member 4 -2.36498
SLC46A3 solute carrier family 46, member 3 -2.36498
PDE7B phosphodiesterase 7B -2.36498
CD164L2 CD164 sialomucin-like 2 -2.36498
BMP8B bone morphogenetic protein 8b -2.36498
POSTN periostin, osteoblast specific factor -2.36498
CA7 carbonic anhydrase VII -2.36498
CRYGA crystallin, gamma A -2.36498
CFAP53 cilia and flagella associated protein 53 -2.36498
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 -2.36498
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -2.36498
TMEM139 transmembrane protein 139 -2.36498
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -2.36498
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B -2.36498
AMH anti-Mullerian hormone -2.36498
GPR68 G protein-coupled receptor 68 -2.36498
ADGRD1 adhesion G protein-coupled receptor D1 -2.36498
IDI2 isopentenyl-diphosphate delta isomerase 2 -2.36498
MOG myelin oligodendrocyte glycoprotein -2.36498
CNR2 cannabinoid receptor 2 (macrophage) -2.36498
FBP2 fructose-1,6-bisphosphatase 2 -2.36498
MYOCOS myocilin opposite strand -2.36498
ZNF471 zinc finger protein 471 -2.36498
NR4A2 nuclear receptor subfamily 4, group A, member 2 -2.36498
SLC25A41 solute carrier family 25, member 41 -2.36498
PCDHGA12 protocadherin gamma subfamily A, 12 -2.36498
DLK1 delta-like 1 homolog (Drosophila) -2.36498
CCDC42 coiled-coil domain containing 42 -2.36498
DNAH8 dynein, axonemal, heavy chain 8 -2.36498
NKPD1 NTPase, KAP family P-loop domain containing 1 -2.36498
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 -2.36498
CASC3 cancer susceptibility candidate 3 -2.36498
CMKLR1 chemerin chemokine-like receptor 1 -2.36498
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 -2.36498
RAB5A RAB5A, member RAS oncogene family -2.35691
ISCA2 iron-sulfur cluster assembly 2 -2.33188
PACRG PARK2 co-regulated -2.32615
RPL28 ribosomal protein L28 -2.31671
NME3 NME/NM23 nucleoside diphosphate kinase 3 -2.29693
TIGD6 tigger transposable element derived 6 -2.28807
ABI3BP ABI family, member 3 (NESH) binding protein -2.27439
PFDN4 prefoldin subunit 4 -2.27439
FOXL2 forkhead box L2 -2.27439
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.27439
TMEM14B transmembrane protein 14B -2.25464
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -2.23715
CCDC175 coiled-coil domain containing 175 -2.23486
BATF3 basic leucine zipper transcription factor, ATF-like 3 -2.23486
RPS11 ribosomal protein S11 -2.21943
WDR88 WD repeat domain 88 -2.21273
RGN regucalcin -2.17375
ANKLE2 ankyrin repeat and LEM domain containing 2 -2.17107
CORO2A coronin, actin binding protein, 2A -2.1588
ACBD4 acyl-CoA binding domain containing 4 -2.15543
ZNF76 zinc finger protein 76 -2.15328
RPL37 ribosomal protein L37 -2.14948
RSPO4 R-spondin 4 -2.10955
MYO10 myosin X -2.10388
KDM4B lysine (K)-specific demethylase 4B -2.09898
ERN2 endoplasmic reticulum to nucleus signaling 2 -2.09023
LOC107985101 uncharacterized LOC107985101 -2.09023
RBP5 retinol binding protein 5, cellular -2.09023
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -2.08969
RPGR retinitis pigmentosa GTPase regulator -2.08536
ZNF284 zinc finger protein 284 -2.05692
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 -2.05106
CTRL chymotrypsin-like -2.00506
LIPT2-AS1 LIPT2 antisense RNA 1 -2.00506
ENKUR enkurin, TRPC channel interacting protein -2.00506
FAM89A family with sequence similarity 89, member A -2.00117
PUM2 pumilio RNA-binding family member 2 -2.00117