PEG3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description paternally expressed 3|In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009] (NCBI Entrez Gene Database, 5178)
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Genes

279 genes differentially expressed following the PEG3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
HLA-DOB major histocompatibility complex, class II, DO beta 2.46852
OR2A12 olfactory receptor, family 2, subfamily A, member 12 2.46852
LOXL4 lysyl oxidase-like 4 2.46852
FZD1 frizzled class receptor 1 2.46852
AGXT2 alanine--glyoxylate aminotransferase 2 2.46852
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.46852
NIPAL4 NIPA-like domain containing 4 2.46852
C9ORF152 chromosome 9 open reading frame 152 2.46852
BMX BMX non-receptor tyrosine kinase 2.46852
THSD1 thrombospondin, type I, domain containing 1 2.46852
TMEM212 transmembrane protein 212 2.46852
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.46852
GASK1B golgi associated kinase 1B 2.46852
FGF9 fibroblast growth factor 9 2.46852
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 2.46691
ARSF arylsulfatase F 2.46691
DNAJC5B DnaJ (Hsp40) homolog, subfamily C, member 5 beta 2.46691
FABP1 fatty acid binding protein 1, liver 2.46691
AKR1C2 aldo-keto reductase family 1, member C2 2.46691
IGFL3 IGF-like family member 3 2.46691
CARD18 caspase recruitment domain family, member 18 2.46691
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 2.46691
RXFP2 relaxin/insulin-like family peptide receptor 2 2.46691
GPR55 G protein-coupled receptor 55 2.46691
FGL1 fibrinogen-like 1 2.46691
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 2.46691
TAS2R13 taste receptor, type 2, member 13 2.46691
C8ORF74 chromosome 8 open reading frame 74 2.46691
POLQ polymerase (DNA directed), theta 2.46691
TNS4 tensin 4 2.46691
TAS2R10 taste receptor, type 2, member 10 2.46691
OR2J3 olfactory receptor, family 2, subfamily J, member 3 2.46691
TMEM71 transmembrane protein 71 2.46691
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 2.46691
SLC9C2 solute carrier family 9, member C2 (putative) 2.46691
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.46691
CEP295NL CEP295 N-terminal like 2.46691
DMRTC1B DMRT-like family C1B 2.46691
SLC25A41 solute carrier family 25, member 41 2.46691
AFM afamin 2.46691
PGBDF plakoglobin binding and degradation factor 2.46691
OR2B11 olfactory receptor, family 2, subfamily B, member 11 2.46691
NAPSA napsin A aspartic peptidase 2.46691
VCX2 variable charge, X-linked 2 2.46691
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 2.46691
TBC1D30 TBC1 domain family, member 30 2.46691
ROPN1B rhophilin associated tail protein 1B 2.46691
GBP2 guanylate binding protein 2, interferon-inducible 2.46691
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 2.46691
PNMA8B PNMA family member 8B 2.46691
TCIM transcriptional and immune response regulator 2.46691
CCDC198 coiled-coil domain containing 198 2.46691
JAML junction adhesion molecule like 2.46691
DIPK1C divergent protein kinase domain 1C 2.46691
NFILZ NFIL3 like basic leucine zipper 2.46691
H3C11 H3 clustered histone 11 2.46691
H3C3 H3 clustered histone 3 2.46691
H2BC12L H2B clustered histone 12 like 2.46691
REELD1 reeler domain containing 1 2.46691
ERLN endoregulin 2.46691
TMPRSS3 transmembrane protease, serine 3 2.46691
IQCF1 IQ motif containing F1 2.46691
COL19A1 collagen, type XIX, alpha 1 2.46691
OR5H2 olfactory receptor, family 5, subfamily H, member 2 2.46691
TMEM95 transmembrane protein 95 2.46691
C4ORF17 chromosome 4 open reading frame 17 2.46691
MAGEB3 melanoma antigen family B3 2.46691
TRIM60 tripartite motif containing 60 2.46691
NXPE1 neurexophilin and PC-esterase domain family, member 1 2.46691
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 2.46691
OR8D4 olfactory receptor, family 8, subfamily D, member 4 2.46691
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.46691
ARNT aryl hydrocarbon receptor nuclear translocator 2.46691
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 2.46691
SAMD11 sterile alpha motif domain containing 11 2.46691
LY6K lymphocyte antigen 6 complex, locus K 2.46691
OR52E6 olfactory receptor, family 52, subfamily E, member 6 2.46691
CPNE8-AS1 CPNE8 antisense RNA 1 2.46691
VWA3B von Willebrand factor A domain containing 3B 2.46691
NOG noggin 2.46691
IGF1 insulin-like growth factor 1 (somatomedin C) 2.46691
FAM135A family with sequence similarity 135, member A 2.46691
SIDT1 SID1 transmembrane family, member 1 2.46691
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 2.46691
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.46691
DYTN dystrotelin 2.46691
OR3A1 olfactory receptor, family 3, subfamily A, member 1 2.46691
ALOX5AP arachidonate 5-lipoxygenase-activating protein 2.46691
EPO erythropoietin 2.46691
GFRAL GDNF family receptor alpha like 2.46691
GSTA3 glutathione S-transferase alpha 3 2.46691
EDN2 endothelin 2 2.46691
CATIP ciliogenesis associated TTC17 interacting protein 2.46691
GP2 glycoprotein 2 (zymogen granule membrane) 2.46691
C16ORF78 chromosome 16 open reading frame 78 2.46691
SEC14L3 SEC14-like 3 (S. cerevisiae) 2.46691
WFDC9 WAP four-disulfide core domain 9 2.46691
RNASE11 ribonuclease, RNase A family, 11 (non-active) 2.46691
KLHL41 kelch-like family member 41 2.46691
KLF3 Kruppel-like factor 3 (basic) 2.46691
PATE4 prostate and testis expressed 4 2.46691
F11 coagulation factor XI 2.46691
KIAA1210 KIAA1210 2.46691
GLOD5 glyoxalase domain containing 5 2.46691
CYSLTR1 cysteinyl leukotriene receptor 1 2.46691
ARR3 arrestin 3, retinal (X-arrestin) 2.46691
LST1 leukocyte specific transcript 1 2.46691
FITM1 fat storage-inducing transmembrane protein 1 2.46691
DMRTC1 DMRT-like family C1 2.46691
TM4SF19 transmembrane 4 L six family member 19 2.46691
RGS4 regulator of G-protein signaling 4 2.46691
NLRP4 NLR family, pyrin domain containing 4 2.46691
FXYD3 FXYD domain containing ion transport regulator 3 2.46691
GJC2 gap junction protein, gamma 2, 47kDa 2.46691
NR2F1 nuclear receptor subfamily 2, group F, member 1 2.46691
PRSS22 protease, serine, 22 2.46691
PMCH pro-melanin-concentrating hormone 2.46691
KRTAP5-2 keratin associated protein 5-2 2.46691
FAM9B family with sequence similarity 9, member B 2.46691
GOLGA8R golgin A8 family, member R 2.46691
CASQ2 calsequestrin 2 (cardiac muscle) 2.46691
SLN sarcolipin 2.46691
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.46691
TMEM86A transmembrane protein 86A 2.46691
BCAS1 breast carcinoma amplified sequence 1 2.46691
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 2.46691
OR5B2 olfactory receptor, family 5, subfamily B, member 2 2.46691
LHX5 LIM homeobox 5 2.46691
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 2.46691
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 2.46691
TEX35 testis expressed 35 2.46691
GCGR glucagon receptor 2.46691
TDRD3 tudor domain containing 3 2.46346
LOC124904542 uncharacterized LOC124904542 2.45794
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 2.45794
VN1R1 vomeronasal 1 receptor 1 2.45794
LARS1 leucyl-tRNA synthetase 1 2.45397
MED11 mediator complex subunit 11 2.40317
DNAL1 dynein, axonemal, light chain 1 2.37664
RPE ribulose-5-phosphate-3-epimerase 2.33925
MIP major intrinsic protein of lens fiber 2.33918
TTF1 transcription termination factor, RNA polymerase I 2.33918
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 2.33918
HBEGF heparin-binding EGF-like growth factor 2.32718
TMEM9B TMEM9 domain family, member B 2.31132
NPIPB4 nuclear pore complex interacting protein family, member B4 2.30751
NOTO notochord homeobox 2.30349
SHISA6 shisa family member 6 2.28402
DENND1C DENN/MADD domain containing 1C 2.28402
CRYBA4 crystallin, beta A4 2.27522
DCTD dCMP deaminase 2.2631
BRD8 bromodomain containing 8 2.24619
FPR2 formyl peptide receptor 2 2.23558
EPHA4 EPH receptor A4 2.21932
SYNGR2 synaptogyrin 2 2.21932
CCND2 cyclin D2 2.1814
MNS1 meiosis-specific nuclear structural 1 2.14526
CCDC57 coiled-coil domain containing 57 2.13925
INTS2 integrator complex subunit 2 2.13925
PGBD1 piggyBac transposable element derived 1 2.13823
EGFR epidermal growth factor receptor 2.13092
MTPN myotrophin 2.13092
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) 2.13061
PML promyelocytic leukemia 2.112
ZNF367 zinc finger protein 367 2.10725
TUBA1A tubulin, alpha 1a 2.1052
LYPD6 LY6/PLAUR domain containing 6 2.1052
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 2.1052
FSTL5 follistatin-like 5 2.08293
MMP21 matrix metallopeptidase 21 2.07711
H2BC12 H2B clustered histone 12 2.07574
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 2.05467
SLC66A3 solute carrier family 66 member 3 2.05046
LRRC75A leucine rich repeat containing 75A 2.04993
TMED6 transmembrane emp24 protein transport domain containing 6 2.03945
TLNRD1 talin rod domain containing 1 2.01273
PGAP1 post-GPI attachment to proteins 1 2.01273
CLSTN1 calsyntenin 1 2.00816
FRA10AC1 fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 2.00671

decreased expression

Symbol Name Standardized Value
HIGD1C HIG1 hypoxia inducible domain family, member 1C -2.46852
URM1 ubiquitin related modifier 1 -2.46852
STAB1 stabilin 1 -2.46852
FAM186A family with sequence similarity 186, member A -2.46852
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 -2.46852
ACTG2 actin, gamma 2, smooth muscle, enteric -2.46852
GRM2 glutamate receptor, metabotropic 2 -2.46852
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 -2.46852
ZNF75A zinc finger protein 75a -2.46691
BAIAP3 BAI1-associated protein 3 -2.46691
PYGM phosphorylase, glycogen, muscle -2.46691
SLC30A6 solute carrier family 30 (zinc transporter), member 6 -2.46691
SERTM1 serine-rich and transmembrane domain containing 1 -2.46691
HFM1 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) -2.46691
PLA2G10 phospholipase A2, group X -2.46691
SNAP91 synaptosomal-associated protein, 91kDa -2.46691
CCNQ cyclin Q -2.46691
LPIN3 lipin 3 -2.46691
RYK receptor-like tyrosine kinase -2.46691
CD99 CD99 molecule -2.46691
ARG1 arginase 1 -2.46691
IZUMO4 IZUMO family member 4 -2.46346
CFAP157 cilia and flagella associated protein 157 -2.46346
SPDEF SAM pointed domain containing ETS transcription factor -2.46346
RNF227 ring finger protein 227 -2.46346
CELF6 CUGBP, Elav-like family member 6 -2.46346
DHRS9 dehydrogenase/reductase (SDR family) member 9 -2.46346
RHCG Rh family, C glycoprotein -2.46346
SPAG8 sperm associated antigen 8 -2.46346
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 -2.46346
H3C13 H3 clustered histone 13 -2.46346
SP6 Sp6 transcription factor -2.46346
VCX variable charge, X-linked -2.46346
GNAT3 guanine nucleotide binding protein, alpha transducing 3 -2.46346
RNF113B ring finger protein 113B -2.46346
FAM167B family with sequence similarity 167, member B -2.46346
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 -2.46346
LRRN4 leucine rich repeat neuronal 4 -2.46346
SP100 SP100 nuclear antigen -2.46346
MYADML2 myeloid-associated differentiation marker-like 2 -2.46346
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 -2.46346
TRADD TNFRSF1A-associated via death domain -2.46346
APOC2 apolipoprotein C-II -2.46346
KRTAP13-4 keratin associated protein 13-4 -2.46346
CCNI2 cyclin I family, member 2 -2.46346
NT5C1B 5'-nucleotidase, cytosolic IB -2.46346
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -2.45794
CLPSL2 colipase-like 2 -2.45464
HDAC6 histone deacetylase 6 -2.44088
CNTN5 contactin 5 -2.43189
DUSP10 dual specificity phosphatase 10 -2.43189
OXCT2 3-oxoacid CoA transferase 2 -2.43189
FNDC7 fibronectin type III domain containing 7 -2.37277
PARP16 poly (ADP-ribose) polymerase family, member 16 -2.33925
MSRA methionine sulfoxide reductase A -2.33918
ATF2 activating transcription factor 2 -2.32982
LAMA2 laminin, alpha 2 -2.31202
FAM131B family with sequence similarity 131, member B -2.31132
CRBN cereblon -2.30349
KDM5B lysine (K)-specific demethylase 5B -2.28402
ATG4A autophagy related 4A, cysteine peptidase -2.28402
UTP4 UTP4 small subunit processome component -2.28402
GDPGP1 GDP-D-glucose phosphorylase 1 -2.25381
PARVG parvin, gamma -2.25381
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 -2.25381
CES3 carboxylesterase 3 -2.25381
TM2D3 TM2 domain containing 3 -2.25381
AKNAD1 AKNA domain containing 1 -2.25381
TMC3 transmembrane channel-like 3 -2.25381
PROKR1 prokineticin receptor 1 -2.24619
TRPM2 transient receptor potential cation channel, subfamily M, member 2 -2.24619
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa -2.23558
HSF5 heat shock transcription factor family member 5 -2.23324
C6ORF89 chromosome 6 open reading frame 89 -2.21617
RUBCN rubicon autophagy regulator -2.21563
CRIPT cysteine-rich PDZ-binding protein -2.21563
SFXN5 sideroflexin 5 -2.21142
ALG8 ALG8, alpha-1,3-glucosyltransferase -2.20273
PPM1N protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) -2.15331
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -2.14776
DSCAM Down syndrome cell adhesion molecule -2.14776
RHOF ras homolog family member F (in filopodia) -2.14202
EFNA1 ephrin-A1 -2.08293
TNPO2 transportin 2 -2.08261
HSPA8 heat shock 70kDa protein 8 -2.07711
CDT1 chromatin licensing and DNA replication factor 1 -2.07711
CCR10 chemokine (C-C motif) receptor 10 -2.0699
FAM24B family with sequence similarity 24, member B -2.0699
LRP10 low density lipoprotein receptor-related protein 10 -2.0603
CDH3 cadherin 3, type 1, P-cadherin (placental) -2.05384
RPRM reprimo, TP53 dependent G2 arrest mediator candidate -2.05046
FRMD4B FERM domain containing 4B -2.04801
OR2A7 olfactory receptor, family 2, subfamily A, member 7 -2.04801
CEP97 centrosomal protein 97kDa -2.0467
ZC3H8 zinc finger CCCH-type containing 8 -2.03465
FAM174B family with sequence similarity 174, member B -2.02411
BTBD3 BTB (POZ) domain containing 3 -2.01273
ZBTB42 zinc finger and BTB domain containing 42 -2.01273
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -2.00845
TSPAN14 tetraspanin 14 -2.00289