PEO1 Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
External Link https://depmap.org/portal/cell_line/ACH-001630
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Genes

162 gene knockdowns changing fitness of PEO1 relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
SPPL3 signal peptide peptidase like 3 8.80525
ESR1 estrogen receptor 1 8.43511
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 7.55046
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 7.24213
CD46 CD46 molecule, complement regulatory protein 7.03129
REXO1 REX1, RNA exonuclease 1 homolog (S. cerevisiae) 5.44617
SLC39A9 solute carrier family 39, member 9 5.4013
AP2A1 adaptor-related protein complex 2, alpha 1 subunit 5.27622
GORASP2 golgi reassembly stacking protein 2, 55kDa 5.20829
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 5.16828
TM9SF2 transmembrane 9 superfamily member 2 5.15045
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 5.05467
ARL4C ADP-ribosylation factor-like 4C 4.98481
FRG1 FSHD region gene 1 4.94527
FRA10AC1 fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 4.86794
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A 4.65146
MCTS1 malignant T cell amplified sequence 1 4.60646
TUT7 terminal uridylyl transferase 7 4.59618
STYX serine/threonine/tyrosine interacting protein 4.38239
DND1 DND microRNA-mediated repression inhibitor 1 4.20287
CLUH clustered mitochondria (cluA/CLU1) homolog 4.16319
LSM1 LSM1, U6 small nuclear RNA associated 4.16031
KAT6A K(lysine) acetyltransferase 6A 4.07272
ARHGAP29 Rho GTPase activating protein 29 3.9725
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 3.9464
USB1 U6 snRNA biogenesis 1 3.92996
PIGK phosphatidylinositol glycan anchor biosynthesis, class K 3.91505
CSNK2A1 casein kinase 2, alpha 1 polypeptide 3.89137
RIC8A RIC8 guanine nucleotide exchange factor A 3.80667
GLS glutaminase 3.75746
HSPA4 heat shock 70kDa protein 4 3.74861
ASB14 ankyrin repeat and SOCS box containing 14 3.66504
TTC5 tetratricopeptide repeat domain 5 3.62908
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 3.62621
TTC37 tetratricopeptide repeat domain 37 3.59826
GTF2H5 general transcription factor IIH, polypeptide 5 3.42219
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 3.40339
DOT1L DOT1-like histone H3K79 methyltransferase 3.36007
KLF13 Kruppel-like factor 13 3.34464
PAX8 paired box 8 3.29379
FCHO2 FCH domain only 2 3.28004
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 3.17651
CNOT4 CCR4-NOT transcription complex, subunit 4 3.14353
FHL2 four and a half LIM domains 2 3.11364
GIGYF2 GRB10 interacting GYF protein 2 3.10596
XPO4 exportin 4 3.10156
OR51A4 olfactory receptor, family 51, subfamily A, member 4 3.09231
ZNF141 zinc finger protein 141 3.0668
NCOA5 nuclear receptor coactivator 5 3.0628
WT1 Wilms tumor 1 3.06229
NONO non-POU domain containing, octamer-binding 3.05597
PPP1R35 protein phosphatase 1, regulatory subunit 35 2.97981
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 2.94867
DIS3L DIS3 like exosome 3'-5' exoribonuclease 2.93931
EIF3K eukaryotic translation initiation factor 3, subunit K 2.90999
NSRP1 nuclear speckle splicing regulatory protein 1 2.89942
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 2.88452
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 2.88394
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa 2.88389
NUP42 nucleoporin 42 2.87558
ANKRD17 ankyrin repeat domain 17 2.84712
NCOR1 nuclear receptor corepressor 1 2.82471
HBS1L HBS1-like translational GTPase 2.81961
EXOC2 exocyst complex component 2 2.80608
PLA2G12B phospholipase A2, group XIIB 2.80161
CFDP1 craniofacial development protein 1 2.80056
ERBB3 erb-b2 receptor tyrosine kinase 3 2.78412
CARNMT1 carnosine N-methyltransferase 1 2.73609
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 2.72447
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 2.70643
HEATR6 HEAT repeat containing 6 2.7054
WDR4 WD repeat domain 4 2.69353
ATG16L2 autophagy related 16-like 2 (S. cerevisiae) 2.67337
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 2.66406
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 2.6304
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 2.62536
ZNF443 zinc finger protein 443 2.61515
SECISBP2 SECIS binding protein 2 2.60842
IL17C interleukin 17C 2.60321
CEP85 centrosomal protein 85kDa 2.59654
CEP350 centrosomal protein 350kDa 2.57799
ATXN7L3 ataxin 7-like 3 2.57752
BRPF1 bromodomain and PHD finger containing, 1 2.55805
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 2.54691
OR1L1 olfactory receptor, family 1, subfamily L, member 1 2.54396
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 2.54085
EDC4 enhancer of mRNA decapping 4 2.54073
KCTD5 potassium channel tetramerization domain containing 5 2.52469
ANAPC13 anaphase promoting complex subunit 13 2.52035
TMEM41B transmembrane protein 41B 2.51402
C1ORF168 chromosome 1 open reading frame 168 2.50598
CENPJ centromere protein J 2.50299
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) 2.48063
PMEPA1 prostate transmembrane protein, androgen induced 1 2.47286
ZCCHC2 zinc finger, CCHC domain containing 2 2.47097
CAB39 calcium binding protein 39 2.4677
NUP37 nucleoporin 37kDa 2.45673
DIAPH1 diaphanous-related formin 1 2.4504
RIF1 replication timing regulatory factor 1 2.41864
ENDOG endonuclease G 2.41495
MBNL1 muscleblind-like splicing regulator 1 2.41394
PIGT phosphatidylinositol glycan anchor biosynthesis, class T 2.40571
UGP2 UDP-glucose pyrophosphorylase 2 2.40007
ATAD3B ATPase family, AAA domain containing 3B 2.37467
SCAF1 SR-related CTD-associated factor 1 2.3746
PITRM1 pitrilysin metallopeptidase 1 2.35647
CXCL6 chemokine (C-X-C motif) ligand 6 2.34868
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa 2.34558
ANKRD28 ankyrin repeat domain 28 2.33985
CKAP2L cytoskeleton associated protein 2-like 2.33036
CISD3 CDGSH iron sulfur domain 3 2.33024
GLRX3 glutaredoxin 3 2.30927
PGM3 phosphoglucomutase 3 2.30464
HOXB4 homeobox B4 2.304
LEMD3 LEM domain containing 3 2.29928
PDE12 phosphodiesterase 12 2.29834
CCL28 chemokine (C-C motif) ligand 28 2.29322
LUC7L2 LUC7-like 2 (S. cerevisiae) 2.29292
CLEC4M C-type lectin domain family 4, member M 2.2737
EIF3L eukaryotic translation initiation factor 3, subunit L 2.27065
MSL2 male-specific lethal 2 homolog (Drosophila) 2.25464
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 2.25163
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 2.2414
RBM12 RNA binding motif protein 12 2.23626
NUP188 nucleoporin 188kDa 2.23589
ERBB2 erb-b2 receptor tyrosine kinase 2 2.23083
PDLIM7 PDZ and LIM domain 7 (enigma) 2.22322
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae) 2.21208
CCDC12 coiled-coil domain containing 12 2.21146
CHD8 chromodomain helicase DNA binding protein 8 2.21134
KLHL21 kelch-like family member 21 2.20587
MTF1 metal-regulatory transcription factor 1 2.1989
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 2.19551
CNOT11 CCR4-NOT transcription complex, subunit 11 2.19205
GPR62 G protein-coupled receptor 62 2.17677
AMN amnion associated transmembrane protein 2.16754
TRNAU1AP tRNA selenocysteine 1 associated protein 1 2.16568
PNMA6A paraneoplastic Ma antigen family member 6A 2.16046
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 2.1479
AMBRA1 autophagy/beclin-1 regulator 1 2.14704
FOXK1 forkhead box K1 2.1439
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 2.14385
TEDC1 tubulin epsilon and delta complex 1 2.13105
CPEB3 cytoplasmic polyadenylation element binding protein 3 2.12355
COG4 component of oligomeric golgi complex 4 2.11652
SCAF4 SR-related CTD-associated factor 4 2.11618
DCP2 decapping mRNA 2 2.1087
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B 2.10045
TP53TG5 TP53 target 5 2.0823
DOLK dolichol kinase 2.07958
BCL10 B-cell CLL/lymphoma 10 2.06803
CEP43 centrosomal protein 43 2.06515
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) 2.06401
AGGF1 angiogenic factor with G patch and FHA domains 1 2.05683
GHDC GH3 domain containing 2.05634
KRTAP3-3 keratin associated protein 3-3 2.05507
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.05069
CMC1 C-x(9)-C motif containing 1 2.03892
CBX4 chromobox homolog 4 2.03029
STXBP3 syntaxin binding protein 3 2.01945
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 2.01334
TUBD1 tubulin, delta 1 2.00905