PER2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description period circadian clock 2|This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014] (NCBI Entrez Gene Database, 8864)
External Link http://www.ncbi.nlm.nih.gov/gene/8864
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Genes

50 interacting proteins for PER2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AHNAK AHNAK nucleoprotein
AP2A1 adaptor-related protein complex 2, alpha 1 subunit
AP2M1 adaptor-related protein complex 2, mu 1 subunit
ARNTL aryl hydrocarbon receptor nuclear translocator-like
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C1QBP complement component 1, q subcomponent binding protein
CLOCK clock circadian regulator
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRY1 cryptochrome circadian clock 1
CRY2 cryptochrome circadian clock 2
CSNK1D casein kinase 1, delta
CSNK1E casein kinase 1, epsilon
CUL1 cullin 1
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5A eukaryotic translation initiation factor 5A
ELAVL1 ELAV like RNA binding protein 1
FAM110A family with sequence similarity 110, member A
FAM110B family with sequence similarity 110, member B
GAPVD1 GTPase activating protein and VPS9 domains 1
GPI glucose-6-phosphate isomerase
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
LTV1 LTV1 ribosome biogenesis factor
MCC mutated in colorectal cancers
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
NACAP1 nascent-polypeptide-associated complex alpha polypeptide pseudogene 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME2P1 NME/NM23 nucleoside diphosphate kinase 2 pseudogene 1
PCBP1 poly(rC) binding protein 1
PER1 period circadian clock 1
PER3 period circadian clock 3
PFN1 profilin 1
PGK1 phosphoglycerate kinase 1
PKM pyruvate kinase, muscle
PPIA peptidylprolyl isomerase A (cyclophilin A)
RAN RAN, member RAS oncogene family
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SACK1H scaffolding CK1 anchoring protein H
SKP1 S-phase kinase-associated protein 1
SNX24 sorting nexin 24
STOX2 storkhead box 2
TAGLN2 transgelin 2
TIMELESS timeless circadian clock
TKT transketolase
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TP53 tumor protein p53
TPT1 tumor protein, translationally-controlled 1
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
UBC ubiquitin C
VPS13B vacuolar protein sorting 13 homolog B (yeast)